Institute for Ageing

Staff Profile

Professor Konstantinos Stellos

Prof of Cardiovascular Medicine & Epitranscriptomics

Background

Chair/Professor of Cardiovascular Medicine

Chair/Professor of Epitranscriptomics

Hon. Consultant Cardiologist, Freeman Hospital, The Newcastle Upon Tyne Hospitals NHS Foundation Trust


Other roles

Head, Newcastle Cardiovascular Disease Prevention Hub

European Research Council (ERC) Grant Holder

Assistant Editor, American Heart Association journal Circulation: Genomic and Precision Medicine

Editorial Board member, European Society of Cardiology journal Cardiovascular Research

Elected Committee member at the American Heart Association and the European Society of Cardiology

Fellow of the American Heart Association (AHA)

Fellow of the European Society of Cardiology (ESC)



Research

The Konstantinos Stellos Lab studies the interplay between RNA-based mechanisms and cardiovascular resilience and disease with the scope to develop new strategies to address the residual risk in patients with atherosclerotic cardiovascular disease.

Despite the current evidence-based guidelines on clinical practice of cardiovascular medicine, the clinical manifestations of atherosclerotic heart disease remain the major causes of morbidity and mortality. Our laboratory investigates the role of RNA modifications in cardiovascular homeostasis and disease, develops precision therapies for the treatment of atherosclerotic / ischemic heart disease, and determines the clinical value of novel biomarkers for risk stratification in cardiovascular secondary prevention.

We are using high throughput deep sequencing, molecular and cellular biology approaches, and mouse disease models to investigate at a single nucleotide resolution the role of novel RNA metabolism mechanisms in gene expression, and cellular and organ function in cardiovascular homeostasis and disease. The relevance of our bench findings is further investigated in clinical studies involving patients with subclinical and manifested cardiovascular disease.

Our lab provides a supportive and challenging environment to its members enabling them to perform cutting edge research in the innovative field of epitranscriptomics and inflammation in cardiovascular disease.

Further information: https://www.StellosLab.com

Teaching

I teach to students enrolled at:

MRes Cardiovascular Science in Health and Disease, more info available here

Medicine and Surgery MB BS Honours, more info available here

and to research students and fellows of the Newcastle University

Publications