Institute for Ageing

Staff Profile

Dr Simon Bomken

Clinical Fellow & Honorary Consultant

Background

I am a Sir Bobby Robson Foundation Clinical Fellow and Honorary Consultant Paediatric Oncologist, providing a clinical service for young people with lymphoma or Langerhans cell histiocytosis at the Great North Children's Hospital, Newcastle. 

Qualifications

2015 CCT Paediatrics (Paediatric Oncology)

2013 PhD, Newcastle University

2005 Membership of the Royal College of Paediatrics and Child Health, UK

2002 MBBS (Hons), Newcastle University

1999 BMedSci (Hons), Newcastle University 

Memberships

Academic Paediatric Association GBI

British Association for Cancer Research

Children's Cancer & Leukaemia Group (CCLG)

European Intergroup Collaboration for Childhood Non-Hodgkin Lymphoma (EICNHL)

International BFM Study Group - Genetic variation task force

Honours and Awards

2014    Lindau Nobel Laureate meeting alumnus, Royal Society nominee

2002    Mona McNaughton Prize - MBBS (Hons) final examination results 2002

1998    Wolfson Scholar - BMedSci (Hons)


Research

Research Interests

Together with Dr Vikki Rand and Dr Chris Bacon I run the Lymphoma Research Group within the Wolfson Childhood Cancer Research Centre. Our aim is to deeply characterise paediatric B-cell non-Hodgkin lymphoma to provide a comprehensive understanding of disease initiation and evolution in response to therapy. My particular interests include understanding the molecular drivers of therapy resistance and the role that clonal evolution has to play in this clinically important phenomenon. Using sporadic Burkitt lymphoma as our principle disease, we are studying the genetic, transcriptomic and clonal changes which occur in response to therapeutic pressure within patient-derived xenograft models.  Through understanding the drivers of clonal evolution we want to be able to predict patients more likely to develop therapy resistance and develop treatment strategies to target key resistance mechanisms.

I also work closely with UK and European colleagues (iBFM, EICNHL, ESID) to develop our understanding of development of lymphoid malignancy in children with inherited immune deficiency or DNA repair disorders and provide the paediatric clinical service for Langerhans cell histiocytosis and collaborate with Newcastle Human Dendritic Cell Laboratory (http://www.hudendritic.org/) run by Professor Matt Collin.

Funding - Current Projects 

The Good Will Cause

North of England Children's Cancer Research Fund

Funding - Training

My current Clinical Fellow position is generously funded by the Sir Bobby Robson Foundation

ACF/ACL posts funded by NIHR

MRC Centenary Early Career Award

MRC Clinical Research Training Fellowship


Teaching

I supervise undergraduate, masters and PhD students within the Northern Institute for Cancer Research, as well as providing clinical teaching for medical students within the Great North Children's Hospital.

I have contributed a chapter on clinical research to the recently published MRCPCH Science of Paedaitrics Mastercourse book for candidates of the Royal College of Paediatrics and Child Health membership exam.  I am also currently revising chapters on childhood lymphoma and tumour lysis syndrome for the second edition of the Oxford University Handbook of Paediatric Haematology and Oncology.

Publications