Institute for Cell and Molecular Biosciences

Proteins: Structure, Function and Evolution

Proteins: Structure, Function and Evolution

The Proteins: Structure, Function and Evolution Group is united by the common goal of seeking to understand the nature of protein:protein and protein:ligand structure/function relationships at the molecular level.

In particular, our members focus on:

  • macromolecular X-ray crystallography
  • structures of proteins crucial to bacterial cell division
  • metals in cells
  • protein-carbohydrate interactions in macromolecular and cellular recognition
  • molecular and cellular evolution of eukaryotic cells, their genomes and organelles
  • membrane protein structure:function relationships
  • archaeal DNA polymerases

Research group leads and specialisms

  • Bolam: gut microbiota in health and nutrition; glycan degradation; biofuels; personalised nutrition
  • Davies: The molecular basis of mammalian meiosis: meiosis; meiotic chromosomes; synaptonemal complex; structural anlayis
  • Dennison: metals in cells; bioinorganic chemistry; metalloproteins; copper proteome
  • Embley: evolution of eukaryotic cell; hydrogenosome; mitosome; anaerobic eukaryote; parasitic eukaryote; endosymbiont; horizontal gene transfer; Bayesian statistics
  • Gilbert: gut microbiota: carbohydrate modifying enzymes; biofuels
  • Hirt: evolution of the eukaryotic cell: comparative genomics; molecular phylogenetics; host-microbe interaction; trichomonas vaginalis
  • Lakey: biophysics, membrane proteins, neutron scattering, bionanotechnology; bacterial outer membrane
  • Lewis: macromolecular structure; x-ray crystallography; bacillus subtilis; bacterial cell well
  • Salgado: clostridium difficile; cell wall proteins; sporulation; hospital acquired infections, x-ray crystallography; host-pathogen interaction; fungal biofilm
  • Van den Berg: x-ray crystallography; membrane proteins; transport of hydrophobic molecules; pseudomonas aeruginosa; antibiotic uptake
  • Waldron: metal ions in pathogenic bacteria; copper proteome; host-pathogen interface; metal ion toxicity; antibiotics resistance