Background

CURRENT POSITION

2017                    Rosetrees and Stoneygate Research Fellow

                            Institute for Cell and Molecular Biosciences, Newcastle University, U.K.

PREVIOUS POSITIONS

2016 – 2017        Senior Research Associate

                            Institute for Cell and Molecular Biosciences & Newcastle Institute for Ageing, Newcastle University, U.K.

2014 – 2015        Research Assistant Professor

                            Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, U.S.A.

2011 – 2014        Postdoctoral Fellow

                            Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, U.S.A.

QUALIFICATIONS

2006 – 2011        PhD in Health Sciences (Hons)

                            Center for Cooperative Research in Biosciences (CIC bioGUNE), Spain

2006 – 2008        MPhil (Cell Biology and Development)

                            Department of Medicine, University of the Basque Country, Spain

1999 – 2005        BSc in Biochemistry (Hons)

                            Faculty of Science and Technology, University of the Basque Country, Spain

Publications

• Martinez-Lopez N, Tarabra E, Toledo M, Garcia-Macia M, Sahu S, Coletto L, Batista-Gonzalez A, Barzilai N, Pessin JE, Schwartz GJ, Kersten S, Singh R. System-wide Benefits of Intermeal Fasting by Autophagy. Cell Metabolism 2017, 26(6), 856-871.e5.
• Martinez-Lopez N. Regulation of lipophagy. In: Autophagy and Signaling. CRC Press, 2017, pp.147-172.
• Martinez-Lopez N, Singh R. Telemetric control of peripheral lipophagy by hypothalamic autophagy. Autophagy 2016, 12(8), 1404-1405.
• Ward C, Martinez-Lopez N, Otten EG, Carroll B, Maetzel D, Singh R, Sarkar S, Korolchuk VI. Autophagy, lipophagy and lysosomal lipid storage disorders. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2016, 1861(4), 269-284.
• Martinez-Lopez N, Garcia-Macia M, Sahu S, Athonvarangkul D, Liebling E, Merlo P, Cecconi F, Schwartz GJ, Singh R. Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver. Cell Metabolism 2016, 23(1), 113–127.
• Zubiete-Franco I, Garcia-Rodriguez JL, Martínez-Uña M, Martínez-Lopez N, Woodhoo A, Gutierrez-De-Juan V, Beraza N, Lage-Medina S, Andrade F, Fernandez ML, Aldamiz-Echevarria L, Fernandez-Ramos D, Falcon-Perez JM, Lopitz-Otsoa F, Fernandez-Tussy P, Barbier-Torres L, Luka Z, Wagner C, Garcia-Monzon C, Lu SC, Aspichueta P, Mato JM, Martínez-Chantar ML, Varela-Rey M. Methionine and S-Adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis. Journal of Hepatology 2016, 64(2), 409-418.
• Martinez-Lopez N, Singh R. Autophagy and Lipid Droplets in Liver. Annual Review of Nutrition 2015, 35, 215-37.
• Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM. Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes & Development 2015, 29(9), 934-47.
• Martinez-Lopez N, Athonvarangkul D, Singh R. Autophagy and aging. Advances in Experimental Medicine and Biology 2015, 847, 73-87.
• Martinez-Lopez N, Singh R. ATGs: Scaffolds for MAPK/ERK signaling. Autophagy 2014, 10(3), 535-7.
• Martinez-Lopez N, Athonvarangkul D, Mishall P, Sahu S, Singh R. Autophagy proteins regulate ERK phosphorylation. Nature Communications 2013, 4, 2799.
• Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R. Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Reports 2013, 14(9), 795-803.
• Martinez-Lopez N, Garcia-Rodriguez JL, Varela-Rey M, Gutierrez V, Fernandez-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML. Hepatoma cells from mice deficient in Glycine N-Methyltransferase have increased Ras signaling and activation of Liver Kinase B1. Gastroenterology 2012, 143(3), 787-798.
• Woodhoo A, Iruarrizaga-Lejarreta M, Beraza N, Garcia-Rodriguez JL, Embade N, Fernandez-Ramos D, Martinez-Lopez N, Gutierrez-DeJuan V, Arteta B, Caballeria J, Lu SC, Mato JM, Varela-Rey M, Martínez-Chantar ML. Human antigen R contributes to hepatic stellate cell activation and liver fibrosis. Hepatology 2012, 56(5), 1870-82.
• Kaushik S, Arias E, Kwon H, Martinez-Lopez N, Athonvarangkul D, Sahu S, Schwartz GJ, Pessin JE, Singh R. Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO Reports 2012, 13(3), 258-65.
• Embade N, Fernandez-Ramos D, Varela-Rey M, Beraza N, Sini M, Gutierrez-DeJuan V, Woodhoo A, Martinez-Lopez N, Rodriguez-Iruretagoyena B, Bustamante FJ, DelaHoz AB, Carracedo A, Xirodimas DP, Rodriguez MS, Lu SC, Mato JM, Martinez-Chantar ML. Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology 2012, 55(4), 1237-48.
• Martinez-Lopez N, Varela-Rey M, Fernandez-Ramos D, Woodhoo A, Vazquez-Chantada M, Embade N, Espinosa-Hevia L, Bustamante FJ, Parada LA, Rodriguez MS, Lu SC, Mato JM, Martínez-Chantar ML. Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. Hepatology 2010, 52(5), 1621-31.
• Varela-Rey M, Martinez-Lopez N, Martínez-Chantar ML. Avances en la fisiopatología de la NASH . Gastroenterologia y Hepatologia Continuada 2010, 9(5), 211-16.
• Varela-Rey M, Martinez-Lopez N, Fernandez-Ramos D, Embade N, Calvisi DF, Woodhoo A, Rodriguez J, Fraga MF, Julve J, Rodriguez-Millan E, Frades I, Torres L, Luka Z, Wagner C, Esteller M, Lu SC, Martinez-Chantar ML, Mato JM. Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide. Hepatology 2010, 52(1), 105-14.
• Vazquez-Chantada M, Fernandez-Ramos D, Embade N, Martinez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballeria J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martinez-Chantar ML. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology 2010, 138(5), 1943-53.
• Varela-Rey M, Fernandez-Ramos D, Martinez-Lopez N, Embade N, Gomez-Santos L, Beraza N, Vazquez-Chantada M, Rodriguez J, Luka Z, Wagner C, Lu SC, Martinez-Chantar ML, Mato JM. Impaired liver regeneration in mice lacking glycine N-methyltransferase. Hepatology 2009, 50(2), 443-52.
• Vazquez-Chantada M, Ariz U, Varela-Rey M, Embade N, Martinez-Lopez N, Fernandez-Ramos D, Gomez-Santos L, Lamas S, Lu SC, Martínez-Chantar ML, Mato JM. Evidence for LKB1/AMP-activated protein kinase/endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation. Hepatology 2009, 49(2), 608-17.
• Martinez-Lopez N, Varela-Rey M, Ariz U, Embade N, Vazquez-Chantada M, Fernandez-Ramos D, Gomez-Santos L, Lu SC, Mato JM, Martinez-Chantar ML. S-adenosylmethionine and proliferation: new pathways, new targets. Biochemical Society Transactions 2008, 36(5), 848-52.
• Martinez-Chantar ML, Vazquez-Chantada M, Ariz U, Martinez N, Varela M, Luka Z, Capdevila A, Rodriguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology 2008, 47(4), 1191-9.
• Klinonsky DJ, et, al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Ed.). Autophagy 2016, 12(1), 1-222.