Dr Paul Dean
- Email: firstname.lastname@example.org
- Telephone: +44 (0) 191 208 3481
- Fax: +44 (0) 191 208 8147
- Personal Website: http://www.staff.ncl.ac.uk/p.dean/body_index.html
- Address: Institute for Cell & Molecular Biosciences
M4.061, Medical School
University of Newcastle upon Tyne
Newcastle upon Tyne
Please visit my previous lab website above for details about the research, for host-pathogen images, videos and our own lab resources.Click here.
- Dean P, Sendra KM, Williams TA, Watson AK, Major P, Nakjang S, Kozhevnikova E, Goldberg AV, Kunji ERS, Hirt RP, Embley TM. Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites. Nature Communications 2018, 9, 1709.
- Freibert SA, Goldberg AV, Hacker C, Molik S, Dean P, Williams TA, Nakjang S, Long SJ, Sendra K, Bill E, Heinz E, Hirt RP, Lucocq JM, Embley TM, Lill R. Evolutionary conservation and in vitro reconstitution of microsporidian iron–sulfur cluster biosynthesis. Nature Communcations 2017, 8, 13932.
- Dean P, Hirt RP, Embley TM. Microsporidia: why make nucleotides if you can steal them?. PLoS Pathogens 2016, 12(11), e1005870.
- Gawthorne JA, Audry L, McQuitty C, Dean P, Christie JM, Enninga J, Roe AJ. Visualizing translocation and localization of bacterial type III effector proteins using a genetically encoded reporter system. Applied and Environmental Microbiology 2016, 82(9), 2700-2708.
- Dean P, Quitard S, Bulmer D, Roe AJ, Kenny B. Cultured enterocytes internalise bacteria across their basolateral surface for, pathogen-inhibitable, trafficking to the apical compartment. Scientific Reports 2015, 5, 17359.
- Heinz E, Hacker C, Dean P, Mifsud J, Goldberg AV, Williams TA, Nakjang S, Gregory A, Hirt RP, Lucocq JM, Kunji ER, Embley TM. Plasma Membrane-Located Purine Nucleotide Transport Proteins are Key Components for Host Exploitation by Microsporidian Intracellular Parasites. PLoS Pathogens 2014, 10(12), e1004547.
- Dean P, Major P, Nakjang S, Hirt RP, Embley TM. Transport proteins of parasitic protists and their role in nutrient salvage. Frontiers in Plant Science 2014, 5, 153.
- Dean P, Kenny B. A bacterial encoded protein induces extreme multinucleation and cell-cell internalization in intestinal cells. Tissue Barriers 2013, 1(1), e22639.
- Kenny B, Dean P. Do Caco-2 subclones provide more appropriate in vitro models for understanding how human enteric pathogens cause disease?. Future Microbiology 2013, 8(6), 701-703.
- Dean P, Young L, Quitard S, Kenny B. Insights into the Pathogenesis of Enteropathogenic E. coli Using an Improved Intestinal Enterocyte Model. PLoS One 2013, 8(1), e55284.
- Bulmer DM, Kharraz L, Grant AJ, Dean P, Morgan FJ, Karavolos MH, Doble AC, McGhie EJ, Koronakis V, Daniel RA, Mastroeni P, Khan CMA. The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella. PLoS Pathogens 2012, 8(1), e1002500.
- Dean P, Kenny B. Cell-surface nucleolin is sequestered into EPEC microcolonies and may play a role during infection. Microbiology 2011, 157(6), 1761-1767.
- Dean P. Functional domains and motifs of bacterial type III effector proteins and their roles in infection. FEMS Microbiology Reviews 2011, 35(6), 1100-1125.
- Ruchaud-Sparagano MH, Mühlen S, Dean P, Kenny B. The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors. PLoS Pathogens 2011, 7(12), e1002414.
- Dean P, Mühlen S, Quitard S, Kenny B. The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector. Cellular Microbiology 2010, 12(9), 1308-1321.
- Dean P, Scott JA, Knox AA, Quitard S, Watkins NJ, Kenny B. The Enteropathogenic E. coli Effector EspF Targets and Disrupts the Nucleolus by a Process Regulated by Mitochondrial Dysfunction. PLoS Pathogens 2010, 6(6), e1000961.
- Holmes A, Muhlen S, Roe AJ, Dean P. The EspF effector - a bacterial pathogen's Swiss army knife. Infection and Immunity 2010, 78(11), 4445-4453.
- Iguchi A, Thomson NR, Ogura Y, Saunders D, Ooka T, Henderson IR, Harris D, Asadulghani M, Kurokawa K, Dean P, Kenny B, Quail MA, Thurston S, Dougan G, Hayashi T, Parkhill J, Frankel G. Complete Genome Sequence and Comparative Genome Analysis of Enteropathogenic Escherichia coli O127:H6 Strain E2348/69. Journal of Bacteriology 2009, 191(1), 347-354.
- Dean P, Kenny B. The effector repertoire of enteropathogenic E-coli: ganging up on the host cell. Current Opinion in Microbiology 2009, 12(1), 101-109.
- Dean P, Maresca M, Schüller S, Phillips A, Kenny B. Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(6), 1876-1881.
- Quitard S, Dean P, Maresca M, Kenny B. The enteropathogenic Escherichia coli EspF effector molecule inhibits PI-3 kinase-mediated uptake independently of mitochondrial targeting. Cellular Microbiology 2006, 8(6), 972-981.
- Maresca M, Miller D, Quitard S, Dean P, Kenny B. Enteropathogenic Escherichia coli (EPEC) effector-mediated suppression of antimicrobial nitric oxide production in a small intestinal epithelial model system. Cellular Microbiology 2005, 7(12), 1749-1762.
- Dean P, Maresca M, Kenny B. EPEC's weapons of mass subversion. Current Opinion in Microbiology 2005, 8(1), 28-34.
- Dean P, Kenny B. Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein. Molecular Microbiology 2004, 54(3), 665–675.