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Staff Profile
Dr Stephen Crosier
Guest Status
- Email: stephen.crosier@ncl.ac.uk
- Telephone: +44 (0) 191 282 1303
- Fax: 0191 282 0656
- Personal Website: s.crosier@nhs.net
- Address: Neuropathology Department
Cellular Pathology Department
Level 3
New Victoria Wing
Royal Victoria Infirmary
Newcastle Hospitals NHS
Foundation Trusts
Newcastle upon Tyne
NE1 4LP
Publications
- Schwalbe EC, Hicks D, Rafiee G, Bashton M, Gohlke H, Enshaei A, Potluri S, Matthiesen J, Mather M, Taleongpong P, Chaston R, Silmon A, Curtis A, Lindsey JC, Crosier S, Smith AJ, Goschzik T, Doz F, Rutkowski S, Lannering B, Pietsch T, Bailey S, Williamson D, Clifford SC. Minimal methylation classifier (MIMIC): A novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures. Scientific Reports 2017, 7, 13421.
- Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC. Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. The Lancet Oncology 2017, 18(7), 958-971.
- Crosier S, Hicks D, Schwalbe E, Williamson D, Nicholson S, Michalski A, Pizer B, Bailey S, Bown N, Robson K, Wharton S, Jacques T, Clifford S. Centralised Molecular Pathology for Rare Tumours: A National Feasibility Study of Real-Time Medulloblastoma Diagnostics. In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO). 2016, Liverpool, UK: Oxford University Press.
- Wong JP, Todd JR, Finetti MA, McCarthy F, Broncel M, Vyse S, Luczynski MT, Crosier S, Ryall KA, Holmes K, Payne LS, Daley F, Wai P, Jenks A, Tanos B, Tan AC, Natrajan RC, Williamson D, Huang PH. Dual Targeting of PDGFR alpha and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors. Cell Reports 2016, 17(5), 1265-1275.
- Clifford SC, Crosier S, Hicks D, Nicholson S, Robson K, Jacques TS, Wharton S, Bown N, Michalski A, Pizer B. Establishment of national real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma (MB). In: 117th meeting of the British Neuropathological Society. 2016, London, UK: Wiley-Blackwell Publishing Ltd.
- Kohe S, Gill SK, Hicks D, Schwalbe EC, Crosier S, Storer L, Lourdusamy A, Bennett CD, Wilson M, Bailey S, Williamson D, Grundy RG, Clifford SC, Peet AC. Identification of medulloblastoma molecular subgroups using metabolite profiles. In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO). 2016, Liverpool, UK: Oxford University Press.
- Finetti MA, Selby MP, Pons AD, Wong JP, Bashton M, Cranston RE, Barker J, Crosier S, Smith A, Ramli RA, Grabovska Y, Bailey S, Huang PH, Clifford SC, Williamson D. Integrated pathway analysis of malignant rhabdoid tumour identifies key SMARCB1-pathways and therapeutic opportunities. In: 28 EORTC – NCI – AACR Symposium on Molecular Targets and Cancer Therapeutics. 2016, Munich, Germany: Elsevier.
- Finetti MA, Del Carpio-Pons A, Wong JP, Batting S, Barker J, Wood J, Nakjang S, Crosier S, Smith A, Selby MP, Ramli RA, Grabovska Y, Treumann A, Huang PH, Bailey S, Clifford SC, Williamson D. Integrated pathway analysis of rhabdoid tumor subtypes identifies key SMARCB1-dependencies and therapeutic opportunities. In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO). 2016, Liverpool: Oxford University Press.
- Lindsey JC, Hill RM, Schwalbe EC, Shrimpton ER, Howell CI, Rafiee G, Crosier S, Smith A, Ryan SL, Williamson D, Bailey S, Clifford SC. Molecular and Prognostic Heterogeneity within MYC and MYCN Amplified Medulloblastomas. In: International Symposium on Paediatric Neuro-Oncology (ISPNO). 2016, Liverpool, UK: Oxford University Press.
- Schwalbe E, Hicks D, Rafiee G, Bashton M, Gohlke H, Enshaei A, Potluri S, Matthiesen J, Mather M, Taleongpong P, Chaston R, Crosier S, Smith A, Bordeaut F, Doz F, Rutkowski S, Lannering B, Bailey S, Pietsch T, Williamson D, Clifford S. Routine Diagnostic Medulloblastoma Subgrouping Using Low-Cost, Low-Input DNA Methylomics: Application to Trials Cohorts Previously Refractory-to-Analysis. In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO). 2016, Liverpool, UK: Oxford University Press.
- Schwalbe E, Hicks D, Rafiee G, Bashton M, Gohlke H, Enshaei A, Potluri S, Matthiesen J, Mather M, Taleongpong P, Chaston R, Crosier S, Smith A, Williamson D, Bailey S, Clifford S. Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost, mass spectrometry-based DNA methylomics. In: 41st ESMO Congress (ESMO 2016). 2016, Copenhagen, Denmark: Oxford University Press.
- Hicks D, Rafiee G, Schwalbe E, Howell C, Lindsey J, Hill R, Smith A, Crosier S, Joshi A, Robson K, Wharton S, Jacques T, Williamson D, Bailey S, Clifford S. Subgroup-Directed Stratification of Risk in Infant Medulloblastoma. In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO). 2016, Liverpool, UK: Oxford University Press.
- Williamson D, Lindsey JC, Hicks D, Crosier S, Smith A, Bashton M, Hill R, Joshi A, Jacques TS, Schwalbe EC, Bailey S, Clifford SC. The Transcriptional Landscape of Medulloblastoma: Group 3 and Group 4 Tumours Comprise a Single Clinically Significant Expression Continuum. In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO). 2016, Liverpool, UK: Oxford University Press.
- Wade MA, Sunter NJ, Fordham SE, Long A, Masic D, Russell J, Harrison CJ, Rand V, Elstob C, Bown N, Rowe D, Lowe C, Cuthbert G, Bennett S, Crosier S, Bacon CM, Onel K, Scott K, Scott D, Travis LB, May FEB, Allan JM. c-MYC is a radiosensitive locus in human breast cells. Oncogene 2015, 34, 4985-4994.
- Hill RM, Kuijper S, Lindsey JC, Petrie K, Schwalbe EC, Barker K, Boult JKR, Williamson D, Ahmad Z, Hallsworth A, Ryan SL, Poon E, Robinson SP, Ruddle R, Raynaud FI, Howell L, Kwok C, Joshi A, Nicholson SL, Crosier S, Ellison DW, Wharton SB, Robson K, Michalski A, Hargrave D, Jacques TS, Pizer B, Bailey S, Swartling FJ, Weiss WA, Chesler L, Clifford SC. Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease. Cancer Cell 2015, 27(1), 72-84.
- Finetti M, Pons AD, Skalkoyannis B, Selby M, Smith A, Crosier S, Bailey S, Clifford S, Williamson D. A Systems Biology Approach to Identify Mechanism of Tumourigenesis Caused by Loss of SMARCB1 in Malignant Rhabdoid Tumors (BACR28). In: 2014 NCRI Cancer Conference. 2014, Liverpool: National Cancer Research Institute (NCRI).
- Finetti M, Pons AD, Selby M, Smith A, Crosier S, Wood J, Skalkoyannis B, Bailey S, Clifford S, Williamson D. Characterising critical pathways in ATRT tumourigenesis: a genome-wide analysis of primary tumours and functional genomic models. In: 16th International Symposium on Pediatric Neuro-Oncology. 2014, Singapore: Oxford University Press.
- Finetti M, Pons AD, Wood J, Skalkoyannis B, Selby M, Smith A, Crosier S, Bailey S, Clifford S, Williamson D. Mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumors. In: 23rd Biennial Congress of the European Association for Cancer Research. 2014, Munich, Germany: Elsevier.
- Hill R, Kuijper S, Lindsey J, Schwalbe E, Barker K, Boult J, Williamson D, Ahmad Z, Hallsworth A, Ryan S, Poon E, Robinson S, Ruddle R, Raynaud F, Howell L, Kwok C, Joshi A, Nicholson SL, Crosier S, Wharton S, Robson K, Michalski A, Hargrave D, Jacques T, Pizer B, Bailey S, Swartling F, Petrie K, Weiss W, Chesler L, Clifford S. MYC and TP53 defects emerge and interact at medulloblastoma relapse, define rapidly progressive disease and can be targeted therapeutically. In: 16th International Symposium on Pediatric Neuro-Oncology. 2014, Singapore: Oxford University Press.
- Hill RM, Kuijper S, Lindsey J, Schwalbe EC, Barker K, Boult J, Williamson D, Ahmad Z, Hallsworth A, Ryan S, Poon E, Robinson S, Ruddle R, Raynaud F, Howell L, Kwok C, Joshi A, Nicholson S, Crosier S, Wharton S, Jacques T, Robson K, Michalski A, Hargrave D, Pizer B, Bailey S, Swartling FJ, Petrie K, Weiss WA, Chesler L, Clifford S. MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically. In: AACR Annual Meeting. 2014, San Diego, CA, USA: American Association for Cancer Research.
- Finetti MA, Selby M, Pons AD, Wood J, Skalkoyannis B, Smith A, Crosier S, Bailey S, Clifford S, Williamson D. Next-generation sequencing identifies the mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumours. In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
- Schwalbe EC, Hicks D, Gohlke H, Rafiee G, Enshaei A, Potluri S, Matthiesen J, Mather M, Chaston R, Crosier S, Smith A, Williamson D, Bailey S, Clifford SC. Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost DNA methylomics. In: 2014 NCRI Cancer Conference. 2014, Liverpool, UK.
- Clifford S, Crosier S, Nicholson S, Robson K, Jacques T, Wharton S, Bown N, Michalski A, Pizer B. A national feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma. In: 114th Meeting of the British Neuropathological Society: Symposium on Advances in Motor Neuron Diseases. 2013, London: Wiley-Blackwell Publishing Ltd.
- Crosier S, Nicholson SL, Robson K, Jacques T, Wharton S, Bown N, Michalski A, Pizer B, Clifford S. A National Feasibility Study of Real-Time Central Pathology Review and Molecular Diagnostics for Medulloblastoma. In: 15th International Symposium on Pediatric Neuro-Oncology. 2012, Toronto, Ontario, Canada: Oxford University Press.
- Culpin RE, Proctor SJ, Angus B, Crosier S, Anderson JJ, Mainou-Fowler T. A 9 series microRNA signature differentiates between germinal centre and activated B-cell-like diffuse large B-cell lymphoma cell lines. International Journal of Oncology 2010, 37(2), 367-376.
- Anderson JJ, Fordham S, Overman L, Dignum H, Wood K, Proctor SJ, Crosier S, Angus B, Culpin RE, Mainou-Fowler T. Immunophenotyping of diffuse large B-cell lymphoma (DLBCL) defines multiple sub-groups of germinal centre-like tumours displaying different survival characteristics. International Journal of Oncology 2009, 35(5), 961-971.
- Mainou-Fowler T, Overman LM, Dignum H, Wood K, Crosier S, Angus B, Proctor SJ, Anderson JJ. A new subtype-specific monoclonal antibody for IAP-survivin identifies high-risk patients with diffuse large B-cell lymphoma and improves the prognostic value of bcl-2. International Journal of Oncology 2007, 32(1), 59-68.
- Culpin RE, Challen C, Wilkins B, Crosier S, Anderson JJ. Definitive identification of the Val617Phe mutation in myeloproliferative disorders using Real Time PCR utilising Roche Lightcycler/hybriprobe technology. 2007.
- Anderson JJ, Challen C, Atkins H, Suaeyun R, Crosier S, Lunec J. MDM2 RNA binding is blocked by novel monoclonal antibody h-MDM2-F4-14. International Journal of Oncology 2007, 31(3), 545-555.
- Wilson KE, Marouga R, Prime JE, Pashby DP, Orange PR, Crosier S, Keith AB, Lathe R, Mullins J, Estibeiro P, Bergling H, Hawkins E, Morris CM. Comparative proteomic analysis using samples obtained with laser microdissection and saturation dye labelling. Proteomics 2005, 5(15).
- Nouman GS, Anderson JJ, Crosier S, Shrimankar J, Lunec J, Angus B. Downregulation of nuclear expression of the p33ING1b inhibitor of growth protein in invasive carcinoma of the breast. Journal of Clinical Pathology 2003, 56(7), 507-511.
- Overman LM, Crosier S, Wood K, Taylor P, Proctor SJ, Dignum H, Angus B, Anderson JJ. IAP survivin in diffuse large B cell lymphoma: Evaluation as a prognostic marker. In: 2nd Joint Meeting of the British Division of the International Academy of Pathology/185th Meeting of the Pathological Society of Great Britian and Ireland. 2003, University of Bristol, Bristol, UK: Journal of Pathology: John Wiley & Sons Ltd.
- Nouman, G., Angus, B., Lunec, J., Crosier, S, Lodge, A.J., Anderson, J.J. Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues. Hybridoma and Hybridomics 2002, 21(1), 1-10.
- Nouman G, Anderson JJ, Mathers ME, Leonard N, Crosier S, Lunec J, Angus B. Nuclear to cytoplasmic compartment shift of the p33ING1b tumour suppressor protein is associated with malignancy in melanocytic lesions. Histopathology 2002, 40(4), 360-366.
- Nouman GS, Anderson JJ, Crosier S, Shrimankar J, Lunec J, Angus B. p33ING1b tumour suppressor immunohistochemical expression in invasive breast carcinomas. In: 184th Meeting of The Pathological Society of Great Britain and Ireland. 2002, Trinity College, Dublin, Ireland: Journal of Pathology: John Wiley & Sons Ltd.
- Ariffin R, Crosier S, Angus B, Anderson JJ. Use of transgenomic wave and denaturing gel electrophoresis increases the sensitivity of FR3A-FR4 PCR detection of B-cell clonality. In: 184th Meeting of The Pathological Society of Great Britain and Ireland. 2002, Trinity College, Dublin, Ireland: Journal of Pathology: John Wiley & Sons Ltd.
- Nouman, G.S., Anderson, J.J., Mathers, M.E., Leonard, N., Crosier, S., Lunec, J., Angus, B. p33(ING1b) tumour suppresser protein expression in melanocytic lesions, an immunohistochemical study of 67 cases. Journal of Pathology 2001, 195(Supplement), 12.
- Nouman GS, Anderson JJ, Crosier S, Johnson S, Lunec J, Angus B. p33ING1b tumour suppresser protein expression in thyroid lesions determined by immunohistochemistry. In: 183rd Meeting of the Pathological Society of Great Britain and Ireland. 2001, Liverpool, UK: Journal of Pathology: John Wiley & Sons Ltd.
- Eggett CJ, Crosier S, Manning P, Cookson MR, Menzies FM, McNeil CJ, Shaw PJ. Development and characterisation of a glutamate-sensitive motor neurone cell line. Journal of Neurochemistry 2000, 74(5), 1895-1902.
- Eggett CJ, Crosier S, Manning P, Cookson MR, Menzies FM, McNeil CJ, Shaw PJ. Development and characterisation of a glutamate-sensitive motor neurone cell line. Journal of Neurochemistry 2000, 74(5), 1895-1902.
- Eggett CJ, Crosier S, Cookson MR, Manning P, McNeil CJ, Shaw PJ. Motor neurones differ from cortical neurones in their response to AMPA stimulation: Furthering our understanding of selective vulnerability in motor neurone disease. In: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000.
- Cassella FP, Crosier S, Hay J. Needle-biopsy of paraffin blocks to obtain tissue for electron microscopy. Medical Laboratory Science 1989, 46(4), 378-379.