Background

Research

Postdoctoral Research Associate, Strahl Lab, Newcastle University (2019-present)

Postdoctoral Research Associate, Gebhard Lab, Bath University (2016-2019)

Postdoctoral Research Associate, Murray Lab, Newcastle University (2015-2016)

PhD Student, Murray Lab, Newcastle University (2010-2015)

Summer internship, Brooks Lab, Newcastle University (2009)

Industrial internship, Hannah Research Institute (2005)

Education

PhD. Bacterial Molecular Genetics, Newcastle University (2010-2015)

B.Sc. (Hons) Medical Microbiology and Immunology, Newcastle University (2008-2010)

Dip. Biotechnology, Ngee Ann Polytechnic (2003-2006)

Awards

Overseas Research Studentship Award (2010 - 2014)

International Undergraduate Merit Scholarship (2008)

Publications

• Koh A, Gibbon M, van der Kamp M, Pudney C, Gebhard S. Conformation control of the histidine kinase BceS of Bacillus subtilis by its cognate ABC-transporter facilitates need-based activation of antibiotic resistance. Molecular Microbiology 2021, 115(1), 157-174.
• Gaimster H, Winterhalter C, Koh A, Murray H. Visualising the replisome, chromosome breaks, and replication restart in Bacillus subtilis. In: Leake M, ed. Chromosome Architecture. Berlin: Springer Nature, 2021. In Press.
• Jimmy S, Saha CK, Kurata T, Stavropoulos C, Alves Oliveira SR, Koh A, Cepauskas A, Takada H, Rejman D, Tenson T, Strahl H, Garcia-Pino A, Hauryliuk V, Atkinson GC. A widespread toxin-antitoxin system exploiting growth control via alarmone signaling. Proceedings of the National Academy of Sciences of the United States of America 2020, 117(19), 10500-10510.
• Basle A, Hewitt L, Koh A, Lamb HK, Thompson P, Burgess JG, Hall MJ, Hawkins AR, Murray H, Lewis RJ. Crystal structure of NucB, a biofilm-degrading endonuclease. Nucleic Acids Research 2018, 46(1), 473-484.
• Fisher GLM, Pastrana CL, Higman VA, Koh A, Taylor JA, Butterer A, Craggs TD, Sobott F, Murray H, Crump MP, Moreno-Herrero F, Dillingham MS. The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere. eLife 2017, 6, e28086.
• Koh A, Murray H. Probing chromosome dynamics in Bacillus subtilis. In: Methods in Molecular Biology. Springer, 2016, pp.91-108.
• Marbouty M, LeGall A, Cattoni DI, Cournac A, Koh A, Fiche JB, Mozziconacci J, Murray H, Koszul R, Nollmann M. Condensin- and replication-mediated bacterial chromosome folding and origin condensation revealed by Hi-C and super-resolution imaging. Molecular Cell 2015, 59(4), 588-602.
• Murray H, Koh A. Multiple Regulatory Systems Coordinate DNA Replication with Cell Growth in Bacillus subtilis. PLoS Genetics 2014, 10(10), e1004731.
• Gays F, Koh ASC, Mickiewicz KM, Aust JG, Brooks CG. Comprehensive analysis of transcript start sites in Ly49 genes reveals an unexpected relationship with gene function and a lack of upstream promoters. PLoS ONE 2011, 6(3), e18475.