Staff Profile
Dr Manuel Pazos Don Pedro
Research Associate
- Email: manuel.pazos@ncl.ac.uk
- Telephone: 0191 2083211
- Address: Biosciences Institute,
2nd floor Centre for Bacterial Cell Biology, Newcastle University,
Baddiley-Clark Building,
Richardson Road,
NE2 4AX
Background
Education:
- (2013) PhD in Molecular Biology (Department of Molecular Biology, Universidad Autonoma de Madrid)
- Master degree, Molecular Biology (Universidad Autonoma de Madrid)
- Bachelor of Science in Biochemistry (Universidad Autonoma de Madrid)
Fellowships:
- Marie Curie Intra-European Fellowship (FP7-PEOPLE-2013-IEF-623868) of The European Comission to undertake the post-doctoral research at Prof. Waldemar Vollmer laboratory (Newcastle University, UK)
- Fellowship from the Spanish Ministry of Education and Science to stay 6 months at Prof. William Margolin laboratory (University of Texas, USA).
- Predoctoral fellowship from the Spanish Ministry of Education and Science to undertake my PhD in the Centro Nacional de Biotecnología, CNB-CSIC, Madrid.
- Collaboration fellowship from the Spanish Ministry of Education and Science to undertake the lab research developed during my last year of undergraduate student
Google Scholar: Click here.
Publications
- Pazos M, Vollmer W. Regulation and function of class A Penicillin-binding proteins. Current Opinion in Microbiology 2021, 60, 80-87.
- Pazos M, Peters K, Boes A, Safaei Y, Kenward C, Caveney NA, Laguri C, Breukink B, Strynadka NCJ, Simorre JP, Terrak M, Vollmer W. SPOR proteins are required for functionality of class A Penicillin-binding proteins in Escherichia coli. MBio 2020, 11(6), 22.
- Banzhaf M, Yau HCL, Verheul J, Lodge A, Kritikos G, Mateus A, Hov AK, Stein F, Wartel M, Pazos M, Solovyova AS, Savitski MM, denBlaauwen T, Typas A, Vollmer W. Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli. EMBO Journal 2020, e2019102246.
- Pazos M, Peters K. Peptidoglycan. In: Andreas Kuhn, ed. Bacterial Cell Walls and Membranes. New York: Springer, 2019, pp.127-168.
- Peters K, Pazos M, VanNieuwenhze MS, Vollmer W. Optimized Protocol for the Incorporation of FDAA (HADA Labeling) for in situ Labeling of Peptidoglycan. Bio-protocol 2019, 9(15), e3316.
- Karinou E, Schuster CF, Pazos M, Vollmer W, Gründling A. Inactivation of the Monofunctional Peptidoglycan Glycosyltransferase SgtB Allows Staphylococcus aureus To Survive in the Absence of Lipoteichoic Acid. Journal of Bacteriology 2019, 201(1), e00574-18.
- Pazos M, Peters K, Casanova M, Palacios P, VanNieuwenhze MS, Breukink E, Vicente M, Vollmer W. Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division. Nature Communications 2018, 9, 5090.
- Peters K, Pazos M, Edoo Z, Hugonnet JE, Martorana A, Polissi A, VanNieuwenhze MS, Arthur M, Vollmer W. Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to by-pass of Penicillin-binding proteins. Proceedings of the National Academy of Sciences (USA) 2018, 115(42), 10786-10791.
- Klein TA, Pazos M, Surette MG, Vollmer W, Whitney JC. Molecular basis for immunity protein recognition of a type VII secretion system exported antibacterial toxin. Journal of Molecular Biology 2018, 430(21), 4344-4358.
- Geiger T, Pazos M, Lara-Tejero M, Vollmer W, Galán JE. Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin. Nature Microbiology 2018, 3(11), 1243-1254.
- Pazos M, Otten C, Vollmer W. Bacterial Cell Wall Precursor Phosphatase Assays Using Thin-Layer Chromatography (TLC) And High Pressure Liquid Chromatography (HPLC). Bio-protocol 2018, 8(6), e2761.
- Whitney JC, Peterson SB, Kim J, Pazos M, Radey MC, Ching MQ, Bryant D, Goo YA, Surette MG, Vollmer W, Mougous JD. A Broadly Distributed Toxin Family Mediates Contact-Dependent Antagonism Between Gram-positive Bacteria. eLife 2017, 6, e26938.
- Pazos M, Peters K, Vollmer W. Robust peptidoglycan growth by dynamic and variable multi-protein complexes. Current Opinion in Microbiology 2017, 36, 55–61.
- Pazos M, Casanova M, Palacios P, Margolin W, Natale P, Vicente M. FtsZ Placement in Nucleoid-Free Bacteria. PLoS One 2014, 9(3), e91984.
- Natale P, Pazos M, Vicente M. The Escherichia coli divisome: born to divide. Environmental Microbiology 2013, 15(12), 3169-3182.
- Pazos M, Natale P, Margolin W, Vicente M. Interactions among the early Escherichia coli divisome proteins revealed by Bimolecular Fluorescence Complementation (BiFC). Environmental Microbiology 2013, 15(12).
- Pazos M, Natale P, Vicente M. A specific role for the ZipA protein in cell division: stabilization of the FtsZ protein. The Journal of Biological Chemistry 2013, 288, 3219-3226.