Centre for Health and Bioinformatics

Event items

CHaBi Lecture series - Prof. Marcus Kaiser

Prof. Marcus Kaiser presents The Human Connectome: Linking Brain Network Features to Healthy and Pathological Information Processing

Date/Time: 19th October 2017, 16.00 - 17:00

Venue: Percy Building G.05

Our work on connectomics over the last 15 years has shown a small-world, modular, and hub architecture of brain networks. Small-world features enable the brain to rapidly integrate and bind information while the modular architecture, present at different hierarchical levels, allows separate processing of various kinds of information (e.g. visual or auditory) while preventing wide-scale spreading of activation. Hub nodes play critical roles in information processing and are involved in many brain diseases.

Nonetheless, general observations of human brain connectivity, or of patients at the group-level, have so far had little impact on understanding cognition, or deficiencies in cognition, in individual subjects. As a result, human connectome information is not used as a biomarker for diagnosis or a predictor of the most suitable treatment strategy. After discussing the organisation of brain networks, we will show how connectivity can be used to determine the disease type of individual dementia patients. An important aspect of these brain networks is their spatial organisation in terms of the length of fibre tracts and the location of brain regions. However, simply observing connectivity is insufficient as small changes in network organisation might lead to large changes in network behaviour (dynamics). We therefore show how simulations can be applied to predict regions that are involved in pathological processes. We conclude with the role of simulations in understanding the developmental origin of diseases as determining these origins will again inform diagnosis and treatment (http://www.greenbrainproject.org/ ).

These are first steps towards using connectome-based computer simulations as a tool to understand normal and pathological processing. Developing models that are based on anatomy will be crucial to find the most suitable intervention.

Followed by:

Post lecture networking at 17.00 in the Percy Building Foyer

To attend the lecture, please book a place at: