Centre for Health and Bioinformatics


Dr Matthew Bashton

Research Associate


I currently work in the area of Leukaemia genomics and bioinformatics at the Northern Institute of Cancer Research (NICR) in the Leukaemia Research Cytogenetics Groupon (LRGC).  Prior to this I worked on the INSTINCT project analysing various -omics data types on childhood brain tumours also at the NICR. 

Previously I worked as a core Bioinformatician in the Bioinformatics Support Unit (BSU) analysing many diverse types of data.  Specifically microarrays: expression, tiling, and methylation; hight-throughput sequencing data: RNA-Seq, exome and WGS variant calling, bi-sulphite, metagenomics and targeted panels. 

Whilst in Cambridge my research was in the area of structural bioinformatics, specifically how protein domains combine to generate novel functions.  I also worked in the area of protein ligand interactions and chemoinformatics.  I was a postdoc at the EBI in the group of Janet Thornton and I was a PhD student at the MRC Laboratory of Molecular Biology in the group of Cyrus Chothia.

Areas of expertise

  • Clinical bioinformatics
  • Cancer bioinformatics
  • Genomics
  • Protein domain evolution
  • Protein domain function
  • Structural bioformatics


  • B.Sc. (Hons) - Biochemistry - Newcastle University, 2000
  • Ph.D. - Bioinformatics - Cambridge University, 2004


External PhD examinations

  •  2017, Jamie J. Alnasir, "The analysis of high-throughput biological datasets utilising distributed computing" - Royal Holloway, University of London.

Professional Memberships

International Society for Computational Biology: ISCB

Google Scholar: Click here.

SCOPUS: Click here.


Research Interests

Leukaemia genomics and bioinformatics.

My main areas of research prior to Newcastle have been:

  •  Chemoinformatics: SMSD
  •   Pfam (author of over 270 Pfam domains)


I currently teach on:

CMB2000: Principles & Practice of Molecular Techniques, lecture on Microarrays

BMS3025: Bioinformatics, lecture on variant calling in genomes and exomes

CSC8309: High Throughput Technologies, lecture on variant calling in genomes and exomes

I have previously taught on:

CSC8313: Bioinformatics Theory and Practice, 2 lectures on Microarrays