Newcastle Clinical Research Facility

Publications

Core and affiliate CRF staff have contributed directly to the following high-quality peer-reviewed clinical trial publications, which all relate to NIHR funded trials

2020/21

Bellini G., Best L.A.Brechany U., Mills R., Pavese N. Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's DiseaseMovement Disorders Clinical Practice. 2020; 7:4 373-382. DOI: 10.1002/mdc3.12938 

Campanilho-Marques R., Deakin, C.T., Simou S., Papadopoulou C., Wedderburn L.R., et al. incl. Foster H. Retrospective analysis of infliximab and adalimumab treatment in a large cohort of juvenile dermatomyositis patientsArthritis Research and Therapy. 2020; 22:1. DOI: 10.1186/s13075-020-02164-5 

Hester K.L.M., Ryan V., Newton J.Rapley T., De Soyza A. Bronchiectasis Information and Education: A randomised, controlled feasibility trialTrials. 2020; 21:1. DOI: 10.1186/s13063-020-4134-5 

Hogrel J.-Y., Decostre V., Ledoux I., de Antonio M., Niks E.H., et al. incl. Straub V. Normalized grip strength is a sensitive outcome measure through all stages of Duchenne muscular dystrophyJournal of Neurology. 2020; 267:7 2022-2028. DOI: 10.1007/s00415-020-09800-9 

Kearsley-Fleet L., Heaf E., Davies R., Baildam E., Beresford M.W., Foster H.E.et al. Frequency of biologic switching and the outcomes of switching in children and young people with juvenile idiopathic arthritis: a national cohort studyThe Lancet Rheumatology. 2020. DOI: 10.1016/S2665-9913(20)30025-4 

McCay K.D., Ho E.S.L., Shum H.P.H., Fehringer G., Marcroft C., Embleton N.D. Abnormal Infant Movements Classification with Deep Learning on Pose-Based FeaturesIEEE Access. 2020. DOI: 10.1109/ACCESS.2020.2980269 

McInnes L., Jones E., Rochester L., Lord S., Chastin S.F.M., Watson A.W., Little L., Briggs P. Mobility in Community Dwelling Older Adults: Predicting Successful Mobility Using an Instrumented Battery of Novel MeasuresThe Journal of frailty & aging. 2020; 9:2 68-73. DOI: 10.14283/jfa.2019.35 

Moore S.A.Hrisos N., Errington L., Rochester L.Rodgers H. Exercise as a treatment for sarcopenia: an umbrella review of systematic review evidencePhysiotherapy (United Kingdom). 2020. DOI: 10.1016/j.physio.2019.08.005 

Myat A., Papachristofi O., Trivedi U., Bapat V., Young C., et al. incl. Zaman A. Transcatheter aortic valve implantation via surgical subclavian versus direct aortic access: A United Kingdom analysisInternational Journal of Cardiology2020; 308 67-72. DOI: 10.1016/j.ijcard.2020.03.059 

O'brien J., Taylor J.P., Ballard C., Barker R.A., Bradley C., et al. Visual hallucinations in neurological and ophthalmological disease: Pathophysiology and managementJournal of Neurology, Neurosurgery and Psychiatry. 2020; 91:5 512-519. DOI: 10.1136/jnnp-2019-322702 

Razvi S., Leng O., Jabbar A., Bano A., Ingoe L., et al. incl. Zaman A. Sample Timing, Diagnosis of Subclinical Thyroid Dysfunction and Mortality in Acute Myocardial Infarction: ThyrAMI1 StudyThe Journal of clinical endocrinology and metabolism. 2020. DOI: 10.1210/clinem/dgz143 

Rodrigues A.M., Haste A., Penn L., Bell R., Summerbell C., et al. Stakeholders' perceptions and experiences of the National Health Service diabetes prevention programme in England: Qualitative study with service users, intervention providers and deliverers, commissioners and referrersBMC Health Services Research. 2020; 20:1. DOI: 10.1186/s12913-020-05160-2 

Russell O.M., Gorman G.S.Lightowlers R.N., Turnbull D.M. Mitochondrial Diseases: Hope for the FutureCell202010.1016/j.cell.2020.02.051 

Shea C., Witham M.D. Association between the Use of Angiotensin-Blocking Medications with Hip Fracture and Death in Older PeopleThe Journal of frailty & aging. 2020; 9:2 107-110. DOI: 10.14283/jfa.2019.38 

Shoop-Worrall S.J.W., Hyrich K.L., Verstappen S.M.M., Sergeant J.C., Baildam E., et al. incl. Foster H. Comparing Proxy, Adolescent, and Adult Assessments of Functional Ability in Adolescents With Juvenile Idiopathic ArthritisArthritis Care and Research. 2020. DOI: 10.1002/acr.23877 

Tahir W., Monahan M., Dorling J., Hewer O., Bowler U., et al. incl. Embleton N. Economic evaluation alongside the Speed of Increasing milk Feeds Trial (SIFT)Archives of Disease in Childhood: Fetal and Neonatal Edition2020; 105:6 587-592. DOI: 10.1136/archdischild-2019-318346 

Warmerdam E., Hausdorff J.M., Atrsaei A., Zhou Y., Mirelman A., et al. incl. Rochester L. Long-term unsupervised mobility assessment in movement disordersThe Lancet Neurology. 2020; 19:5 462-470. DOI: 10.1016/S1474-4422(19)30397-7 

Witham M.D., Band M., Ahmed A., Almond M.K., Balasubramaniam G., et al. Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): A pragmatic randomised, double-blind, placebo-controlled trialBMC Medicine. 2020; 18:1. DOI: 10.1186/s12916-020-01542-9 

Yiu Z.Z.N., Mason K.J., Hampton P.J., Reynolds N.J., Smith C.H., et al. Drug survival of adalimumabustekinumab and secukinumab in patients with psoriasis: a prospective cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR)British Journal of Dermatology2020; 183:2 294-302. DOI: 10.1111/bjd.18981 

2019/20

Aitken S., Firth H.V., McRae J., Halachev M., Kini U., et al. incl. Burn JFinding Diagnostically Useful Patterns in Quantitative Phenotypic DataAmerican Journal of Human Genetics2019. DOI: 10.1016/j.ajhg.2019.09.015. 

Al-Banaa I., Hawkins L., Hill S.L., Lupton D.J., Jackson G., et al. incl. Thomas S.H.L. Effect of the UK Psychoactive Substances Act 2016 on episodes of toxicity related to new psychoactive substances as reported to the National Poisons Information Service. A time series analysis. International Journal of Drug Policy. 2020. DOI: 10.1016/j.drugpo.2020.102672 

Al-bayati A., Brown A., Walker M. Impaired enhancement of insulin action in cultured skeletal muscle cells from insulin resistant type 2 diabetic patients in response to contraction using electrical pulse stimulationJournal of Diabetes and its Complications. 2019. DOI: 10.1016/j.jdiacomp.2019.107412 

Al-Laith M., Jasenecova M., Abraham S. et al inc.  Pratt A.G. and Isaacs J.D. Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): A multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocolTrials.  20:1. 2019. DOI: 10.1186/s13063-019-3403-7 

Allan L.M., Wheatley A., Smith A., Flynn E., Homer T., et al. incl. Barber RAn intervention to improve outcomes of falls in dementia: The DIFRID mixed-methods feasibility studyHealth Technology Assessment2019. DOI: 10.3310/hta23590 

Alston C.L., Veling M.T., Heidler J., Taylor L.S., Alaimo J.T., et al. incl. McFarland R. Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I DeficiencyAmerican Journal of Human Genetics. 2020. DOI: 10.1016/j.ajhg.2019.12.001 

Alwan F., Vendramin C., Liesner R., Clark A., Lester W., et al. incl. Biss T. Characterization and treatment of congenital thrombotic thrombocytopenic purpuraBlood. 2019. 133.15 DOI: 10.1182/blood-2018-11-884700 

Ambrosini A., Quinlivan R., Sansone V.A., Meijer I. et al inc. Lochmüller HBe an ambassador for change that you would like to see: A call to action to all stakeholders for co-creation in healthcare and medical research to improve quality of life of people with a neuromuscular diseaseOrphanet Journal of Rare Diseases14:1. 2019. DOI: 10.1186/s13023-019-1103-8 

an M.M.X., Malek N., Lawton M.A., Hubbard L., et al incl. Burn D.J., Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease studyBrain : a journal of neurology.  2019. 142:0 2828-2844. DOI: 10.1093/brain/awz191 

Anderson A.E., Maney N.J., Nair N., et al inc. Isaacs J.D. and Pratt A.G. Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritisRheumatology (United Kingdom). 58:7. 1250-1258. 2019. DOI: 10.1093/rheumatology/kez003 

Andreazza S., Samstag C.L., Sanchez-Martinez A., Fernandez-Vizarra E. et al inc. Chinnery P.F. Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in DrosophilaNature Communications. 10:1 2019. DOI: 10.1038/s41467-019-10857-y 

Anstee Q.M.Lawitz E.J., Alkhouri N., Wong V.W.-S., Romero-Gomez M., et al. Noninvasive Tests Accurately Identify Advanced Fibrosis due to NASH: Baseline Data From the STELLAR TrialsHepatology2019. DOI: 10.1002/hep.30842 

Arefi M., Wilson V., Muthiah S., Zwolinski S., Bajwa D., et al. incl. Burn JDiverse presentations of cutaneous mosaicism occur in CYLD cutaneous syndrome and may result in parent-to-child transmissionJournal of the American Academy of Dermatology. 2019. DOI: 10.1016/j.jaad.2019.05.021. 

Ashburn A., Pickering R., McIntosh E., Hulbert S., et al inc. Rochester LExercise- and strategy-based physiotherapy-delivered intervention for preventing repeat falls in people with Parkinson's: the PDSAFE RCT.  Health technology assessment (Winchester, England).  23:36. 1-150. 2019. DOI: 10.3310/hta23360 

Baker K.F., Skelton A.J., Lendrem D.W., et al Inc., Pratt A.G. and Isaacs J.D. Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.  Journal of Autoimmunity.  2019. DOI: 10.1016/j.jaut.2019.06.009 

Bano A., Gan E., Addison C., Narayanan K., Weaver J.U., Tsatlidis V., Razvi S. Age May Influence the Impact of TRAbs on Thyroid Function and Relapse-Risk in Patients With Graves DiseaseThe Journal of clinical endocrinology and metabolism. 2019; 104:5 1378-1385 DOI: 10.1210/jc.2018-01738 

Bennett J.L., Wood A., Smith N., Mistry R., Allen K., et al. incl. Foster H.ECan quantitative MRI be used in the clinical setting to quantify the impact of intra-articular glucocorticoid injection on synovial disease activity in juvenile idiopathic arthritis? Pediatric Rheumatology. 2019. DOI: 10.1186/s12969-019-0377-7 

Bernier M.-O., Baysson H., Moissonnier M., Cardis E., et al inc. Pearce M.S. Cohort profile: The EPI-CT study: A European pooled epidemiological study to quantify the risk of radiation-induced cancer from paediatric CTInternational Journal of Epidemiology.  48:2. 379-381. 2019.  DOI: 10.1093/ije/dyy231 

Beska B., Chan D., Gu S., et al incl. Kunadian V. and Neely D.  The association between Vitamin D status and clinical events in high-risk older patients with non-ST elevation acute coronary syndrome undergoing invasive managementPLoS ONE.  14:6. 2019. DOI: 10.1371/journal.pone.0217476 

Blackstock S., Witham M.D., Wade A.N., Crampin A., Beran D. Ability of verbal autopsy data to detect deaths due to uncontrolled hyperglycaemia: Testing existing methods and development and validation of a novel weighted scoreBMJ Open. 2019. DOI: 10.1136/bmjopen-2018-026331 

Blakeway H., Van-de-Velde V., Allen V.B., Kravvas G., et al. incl. Reynolds N. What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic reviewBritish Journal of Dermatology. 2019. DOI: 10.1111/bjd.18778 

Boal R.L., Ng Y.S., Pickett S.J., Schaefer A.M., et al  incl. McFarland R. and Gorman G. Height as a Clinical Biomarker of Disease Burden in Adult Mitochondrial DiseaseThe Journal of clinical endocrinology and metabolism2019; 104:6 2057-2066. DOI: 10.1210/jc.2018-00957 

Bonnemaijer P.W.M., Leeuwen E.M., Iglesias A.I., Gharahkhani P., et al. incl. Steel D. Multi-trait genome-wide association study identifies new loci associated with optic disc parametersCommunications Biology. 2019. DOI: 10.1038/s42003-019-0634-9 

Bradley J.M., Anand R., O'Neill B., Ferguson K., Clarke M., et al. incl. De Soyza AA 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: A protocol for the CLEAR clinical trialTrials. 2019. DOI: 10.1186/s13063-019-3766-9 

Bronsky J., Campoy C., Fewtrell M., Mis N.F., et al. inc.  Embleton N., Palm Oil and Beta-palmitate in Infant Formula: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition, Journal of pediatric gastroenterology and nutritionMay 2019. 68:5. DOI: 10.1097/MPG.0000000000002307 

Buckley C., Micó-Amigo M.E., Dunne-Willows M., Godfrey A., Hickey A., et al. incl. Rochester L. Gait asymmetry post-stroke: Determining valid and reliable methods using a single accelerometer located on the trunk. Sensors (Switzerland). 2020. DOI: 10.3390/s20010037 

Burn J. Molecular diagnostics in the screening, detection and diagnosis of cancerEuropean Oncology and Haematology. 2019. DOI: 10.17925/eoh.2019.15.2.84 

Campbell P., Lewis M., Chen Y., Lacey R.J. et al inc. Rowlands G. Can patients with low health literacy be identified from routine primary care health records? A cross-sectional and prospective analysisBMC family practice20:1 2019. DOI: 10.1186/s12875-019-0994-8 

 

Cassidy S., Okwose N., Scragg J., Houghton D., Ashley K., et al. incl. Hallsworth K and Jakovljevic D.G. Assessing the feasibility and acceptability of Changing Health for the management of prediabetes: Protocol for a pilot study of a digital behavioural interventionPilot and Feasibility Studies. 2019. DOI: 10.1186/s40814-019-0519-1 

Cassidy S., Okwose N., Scragg J., Houghton D., Ashley K., Trenell M.I. Assessing the feasibility and acceptability of Changing Health for the management of prediabetes: Protocol for a pilot study of a digital behavioural interventionPilot and Feasibility Studies. 2019. DOI: 10.1186/s40814-019-0519-1 

Cegla J., Neely R.D.G., France M., Ferns G., Byrne C.D., Halcox J. HEART UK consensus statement on Lipoprotein(a): A call to actionAtherosclerosis. 2019. DOI: 10.1016/j.atherosclerosis.2019.10.011 

Chan D., Martin-Ruiz C., Saretzki G., Neely D.Qiu W., Kunadian V. The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndromePLoS ONE. 2020. DOI: 10.1371/journal.pone.0227616 

Chapman M.H., Thorburn D., Hirschfield G.M., Webster G.G.J., et al inc. Dyson J. British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis Gut.  2019. DOI: 10.1136/gutjnl-2018-317993 

Chappell L.C., Brocklehurst P., Green M.E., Hunter R., Hardy P., et al. incl. Robson S. Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trialThe Lancet. 2019. DOI: 10.1016/S0140-6736(19)31963-4 

Charman S., Okwose N., Maniatopoulos G., Graziadio S., Metzler T. et al. incl. Jakovljevic D.G. Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: Qualitative studyBMJ Open2019; 9:4 e028122 DOI: 10.1136/bmjopen-2018-028122 

 

Chen Y.-L., Gomes T., Hardman C.S., Vieira Braga F.A., Gutowska-Owsiak D., et al. incl. Reynolds G. Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammationThe Journal of experimental medicine. 2020. DOI: 10.1084/jem.20190811 

 

Chua S.Y.L., Dhillon B., Aslam T., Balaskas K., Yang Q., et al incl. Steel M.D. Associations with photoreceptor thickness measures in the UK BiobankScientific Reports. 2019. DOI: 10.1038/s41598-019-55484-1 

Ciafone J., Little B., Thomas A.J., Gallagher P. The Neuropsychological Profile of Mild Cognitive Impairment in Lewy Body DementiasJournal of the International Neuropsychological Society. 2019. DOI: 10.1017/S1355617719001103 

Clark A.D., Nair N., Anderson A.E., Thalayasingam N., Naamane N., et al. incl. Pratt A.G. Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease lociJournal of Allergy and Clinical Immunology. 2020. DOI: 10.1016/j.jaci.2019.12.910 

Clifford T., Babateen A., Shannon O.M., et al inc.  Mathers J.C., Siervo. M. Effects of inorganic nitrate and nitrite consumption on cognitive function and cerebral blood flow: A systematic review and meta-analysis of randomized clinical trials.  Critical Reviews in Food Science and Nutrition.  59:15 2400-2410.  2019. DOI: 10.1080/10408398.2018.1453779 

Colver A., Rapley T., Parr J.R.McConachie H., Dovey-Pearce GFacilitating transition of young people with long-term health conditions from children's to adults' healthcare services - implications of a 5-year research programmeClinical medicine (London, England). 2020. DOI: 10.7861/clinmed.2019-0077 

Conrado D.J., Larkindale J., Berg A., Hill M., et al. incl. Guglieri M. Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophyJournal of Pharmacokinetics and Pharmacodynamics.  2019. DOI: 10.1007/s10928-019-09642-7 

Cro S., Patel P., Barker J., Burden D.A., Griffiths C.E.M., et al. incl. Reynolds N.J. A randomised placebo controlled trial of anakinra for treating pustular psoriasis: Statistical analysis plan for stage two of the APRICOT trialTrials. 2020. DOI: 10.1186/s13063-020-4103-z 

Crosbie E.J., Ryan N.A.J., Arends M.J., Bosse T., Burn JManchester International Consensus Group 

The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndromeGenetics in Medicine2019. DOI: 10.1038/s41436-019-0489-y. 

Cunningham P.S., Meijer P., Nazgiewicz A., Anderson S.G., Borthwick L.A., et al. incl. Fisher A.J. The circadian clock protein REVERBα inhibits pulmonary fibrosis developmentProceedings of the National Academy of Sciences of the United States of America. 2020. DOI: 10.1073/pnas.1912109117 

Cunningham P.S., Meijer P., Nazgiewicz A., Anderson S.G., Borthwick L.A. The circadian clock protein REVERBα inhibits pulmonary fibrosis developmentProceedings of the National Academy of Sciences of the United States of America. 2020. DOI: 10.1073/pnas.1912109117 

Davies K., Mirza K., Tarn J., Howard-Tripp N.et al. incl. Ng W.-F. Fatigue in primary Sjögren’s syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation studyRheumatology International. 2019. DOI: 10.1007/s00296-019-04354-0 

De Vries M.C., Brown D.A., Allen M.E., Bindoff L., Gorman G.S., et al. incl. McFarland R. Safety of drug use in patients with a primary mitochondrial disease: An international Delphi-based consensusJournal of Inherited Metabolic Disease. 2020. DOI: 10.1002/jimd.12196 

Del Din S., Elshehabi M., Galna B., Hobert M.A., et al inc. Rochester L., Gait analysis with wearables predicts conversion to parkinson disease.  Annals of Neurology.  86:3. 357-367.  2019. DOI: 10.1002/ana.25548 

Del Din S., Yarnall A.J., Barber T.R., Lo C., Crabbe M., et al. incl. Rochester L. Continuous Real-World Gait Monitoring in Idiopathic REM Sleep Behavior DisorderJournal of Parkinson's Disease. 2020. DOI: 10.3233/JPD-191773 

Dismore L.L.Echevarria C., Van Wersch A., Gibson J., Bourke S. What are the positive drivers and potential barriers to implementation of hospital at home selected by low-risk DECAF score in the UK: A qualitative study embedded within a randomised controlled trial. BMJ Open2019; 9:4 e026609 DOI: 10.1136/bmjopen-2018-026609 

Dlay J.K., Duncan G.W., Khoo T.K., Williams-Gray C.H., et al. incl. Burn D.J. and Yarnall A.J. Progression of neuropsychiatric symptoms over time in an incident parkinson’s disease cohort (ICICLE-PD)Brain Sciences. 2020. DOI: 10.3390/brainsci10020078 

Dominguez-Valentin M., Seppälä T.T., Sampson J.R., MacRae F., Winship I., et al. incl. Burn JSurvival by colon cancer stage and screening interval in Lynch syndrome: A prospective Lynch syndrome database reportHereditary Cancer in Clinical Practice2019. DOI: 10.1186/s13053-019-0127-3 

Dominguez-Valentin M., Sampson J.R., Seppälä T.T., ten Broeke S.W., Plazzer J.-P., et al inc. Burn J. Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.  Genetics in Medicine2019. DOI: 10.1038/s41436-019-0596-9 

Dorling J., Abbott J., Berrington J., Bosiak B., Bowler U., et al. incl. Embleton NControlled trial of two incremental milk-feeding rates in preterm infantsNew England Journal of Medicine. 2019. DOI: 10.1056/NEJMoa1816654 

Durcan R., Donaghy P.C., Barnett N.A., Olsen K., Yarnall A.J. et al. incl. Taylor J.-P. Prevalence and severity of symptoms suggestive of gastroparesis in prodromal dementia with Lewy bodies. International Journal of Geriatric Psychiatry. 2019. DOI: 10.1002/gps.5100 

Ellis R., Tang D., Nasr B., Greenwood A.,et al inc. Reynolds N.J. Epidermal autophagy and beclin 1 regulator 1 and loricrin: a paradigm shift in the prognostication and stratification of the American Joint Committee on Cancer stage I melanomas.  British Journal of Dermatology.  2019. DOI: 10.1111/bjd.18086 

Ellis R., Tang D., Nasr B., Greenwood A., McConnell A., et al. incl. Reynolds N.J. Epidermal autophagy and beclin 1 regulator 1 and loricrin: a paradigm shift in the prognostication and stratification of the American Joint Committee on Cancer stage I melanomasBritish Journal of Dermatology. 2020. DOI: 10.1111/bjd.18086 

Embleton N.D., McGuire W.Commentary on "higher versus Lower Amino Acid Intake in Parenteral Nutrition for Newborn Infants" Neonatology.  92:96. 2019. DOI: 10.1159/000495913 

Erskine D., Taylor J.-P., Bakker G., Brown A.J.H., Tasker T. Cholinergic muscarinic M1 and M4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disordersDrug Discovery Today. 2019. DOI: 10.1016/j.drudis.2019.08.009 

Farina N., Hicks B., Baxter K., Birks Y., Brayne C., et al. incl. Thomas A. DETERMinants of quality of life, care and costs, and consequences of INequalities in people with Dementia and their carers (DETERMIND): A protocol paperInternational Journal of Geriatric Psychiatry. 2019. DOI: 10.1002/gps.5246 

 

Feeney C.L., Lim A.Z., Fagan E., Blain A., Bright A., et al. incl. McFarland R and Turnbull D.M. A case-comparison study of pregnant women with mitochondrial disease – what to expect? BJOG: An International Journal of Obstetrics and Gynaecology. 2019. DOI: 10.1111/1471-0528.15667 

Fellermann H., Shirt-Ediss B., Kozyra J., Linsley M., et al inc. Isaacs J. Design of experiments and the virtual PCR simulator: An online game for pharmaceutical scientists and biotechnologistsPharmaceutical Statistics.  18:4 402-406. 2019. DOI: 10.1002/pst.1932 

Ferreras L., Moles A., Situmorang G.R., el Masri R., Wilson I.L. et al. incl. Sheerin N.SHeparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfationBiochimica et Biophysica Acta - General Subjects. 2019; 1863: 5 839-848 DOI: 10.1016/j.bbagen.2019.02.009 

Flatt A.J.S., Bennett D., Counter C., Brown A.L., White S.A.Shaw J.A.M. β-Cell and renal transplantation options for diabetesDiabetic Medicine. 2019. DOI: 10.1111/dme.14177 

Flatt A.J.S., Little S.A., Speight J., Leelarathna L., Walkinshaw E. Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS StudyDiabetes care. 2020. DOI: 10.2337/dc19-0630 

Flatt A.J.S., Little S.A., Speight J., Leelarathna L., Walkinshaw E., et al. incl. Shaw J.A.M. Predictors of recurrent severe hypoglycemia in adults with type 1 diabetes and impaired awareness of hypoglycemia during the hypocompass studyDiabetes Care. 2020. DOI: 10.2337/dc19-0630 

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Romagnoni A., Jégou S., Van Steen K., Wainrib G., Hugot J.-P., et al. incl. Mansfield J. Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping dataScientific Reports. 2019. DOI: 10.1038/s41598-019-46649-z 

Romagnoni A., Jégou S., Van Steen K., Wainrib G., et al inc. Walker M., Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.  Scientific Reports9:1. 2019. DOI: 10.1038/s41598-019-46649-z 

Rowlands G.Tabassum B., Campbell P., Harvey S., Vaittinen A., et al. The evidence‐based development of an intervention to improve clinical health literacy practice. International Journal of Environmental Research and Public Health. 2020. DOI: 10.3390/ijerph17051513 

Russell A., Gaunt D., Cooper K., Horwood J., Barton S., et al. incl. Parr J. Guided self-help for depression in autistic adults: The ADEPT feasibility RCTHealth Technology Assessment. 2019. DOI: 10.3310/hta23680 

Saoura M., Powell C.A., Kopajtich R., Alahmad A., AL-Balool H.H., et al. incl. McFarland RMutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3′-end processingHuman Mutation. 2019. DOI: 10.1002/humu.23777 

Saoura M., Powell C.A., Kopajtich R., Alahmad A., AL-Balool H.H., et al. incl. Horvath R. Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3′-end processingHuman Mutation. 2019. DOI: 10.1002/humu.23777 

Sazonovs A., Kennedy N.A., Moutsianas L., Heap G.A., Rice D.L., et al. incl. Mansfield J. HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's DiseaseGastroenterology. 2020. DOI: 10.1053/j.gastro.2019.09.041 

Schumacher J., Cromarty R., Gallagher P., Firbank M.J., Thomas A.J., et al. inc. Taylor J.-P. Structural correlates of attention dysfunction in Lewy body dementia and Alzheimer’s disease: an ex-Gaussian analysisJournal of Neurology2019. DOI: 10.1007/s00415-019-09323-y 

Schumacher J., Peraza L.R., Firbank M., Thomas A.J. et al inc. Taylor J.-P. Dysfunctional brain dynamics and their origin in Lewy body dementiaBrain : a journal of neurology142:6. 1767-1782. 2019. DOI: 10.1093/brain/awz069 

Schumacher J., Thomas A.J., Taylor J.-P. Dynamic functional connectivity changes in Lewy body diseaseBrain : a journal of neurology. 2019. DOI: 10.1093/brain/awz315 

Sevinc M., Stamp S., Ling J., Carter N., et al inc. Sheerin N.S. Comparison of the Outcome of Kidney Transplant After Pulsatile or Continuous Ex Vivo Hypothermic Machine Perfusion of Kidneys Donated After Cardiac Death: Analysis of Kidney Pairs.  Transplantation proceedings.  51:6. 1785-1790. 2019. DOI: 10.1016/j.transproceed.2019.03.025 

Signorelli M., Ayoglu B., Johansson C., Lochmüller H., Straub V., Muntoni F. Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophyJournal of Cachexia, Sarcopenia and Muscle. 2019. DOI: 10.1002/jcsm.12517 

Sleeman I., Lawson R.A., Duncan G.W et al inc.  Burn D and Yarnall A.JUrate and Homocysteine: Predicting Motor and Cognitive Changes in Newly Diagnosed Parkinson's Disease. Journal of Parkinson's Disease. Volume 9:2. Pages 351-359. 2019. DOI: 10.3233/JPD-181535 

Speight J., Holmes-Truscott E., Little S.A., Leelarathna L., Walkinshaw E. Satisfaction with the use of different technologies for insulin delivery and glucose monitoring among adults with long-standing type 1 diabetes and problematic hypoglycemia: 2-Year follow-up in the HypoCOMPaSS randomized clinical trialDiabetes Technology and Therapeutics. 2019. DOI: 10.1089/dia.2019.0152 

Spiering R., Jansen M.A.A., Wood M.J., Fath A.A., Eltherington O., et al. incl. Pratt A.G. Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritisJournal of Translational Medicine. 2019. DOI: 10.1186/s12967-019-2128-4 

Spiliopoulou A., Colombo M., Plant D., Nair N., Cui J. et al. incl. Isaacs J.DAssociation of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39Annals of the Rheumatic Diseases 1:1 2019. DOI: 10.1136/annrheumdis-2018-214877 

Stapleton C.P., Heinzel A., Guan W., van der Most P.J., van Setten J, et al. incl.  Sheerin NThe impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population. American Journal of Transplantation. 2019. DOI: 10.1111/ajt.15326 

Steele H., Gomez-Duran A., Pyle A., Hopton S., Newman J., et al. incl. Chinnery P.F. and Horvath R. Metabolic effects of bezafibrate in mitochondrial diseaseEMBO Molecular Medicine. 2020. DOI: 10.15252/emmm.201911589 

Stuart S., Lawson R.A., Yarnall A.J.., Rochester L., et al inc. Burn D.J., Pro-Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE-PD.  Movement Disorders.  2019. DOI: 10.1002/mds.27813 

Stuart S., Lawson R.A., Yarnall A.J., Nell J. et al inc. Alcock L and Rochester, L. Pro-Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE-PD.  Movement Disorders.  2019. DOI: 10.1002/mds.27813 

Taylor L.J., Charman T., Howlin P., Slonims V., Green J., et al. incl. Parr J.R. Brief Report: Associations Between Preverbal Social Communication Skills, Language and Symptom Severity in Children with Autism: An Investigation Using the Early Sociocognitive BatteryJournal of Autism and Developmental Disorders. 2020. DOI: 10.1007/s10803-020-04364-z 

Taylor J.J., Jaedicke K.M., van de Merwe R.C., Bissett S.M., Landsdowne N. et al. incl. Preshaw P.M. A Prototype Antibody-based Biosensor for Measurement of Salivary MMP-8 in Periodontitis using Surface Acoustic Wave TechnologyScientific Reports2019. DOI: 10.1038/s41598-019-47513-w 

Taylor J.-P.McKeith I.G., Burn D.J., Boeve B.F., Weintraub D. New evidence on the management of Lewy body dementiaThe Lancet Neurology. 2020. DOI: 10.1016/S1474-4422(19)30153-X 

Taylor L., Parsons J., Taylor D., Binns E., Lord S., et al. incl. Rochester LEvaluating the effects of an exercise program (Staying UpRight) for older adults in long-term care on rates of falls: Study protocol for a randomised controlled trialTrials. 2020. DOI: 10.1186/s13063-019-3949-4 

Terziroli Beretta-Piccoli B., Mieli-Vergani G., Vergani D., Vierling J.M., Adams D., et al. incl. Jones D. The challenges of primary biliary cholangitis: What is new and what needs to be doneJournal of Autoimmunity. 2019. DOI: 10.1016/j.jaut.2019.102328 

Traianos E.Y., Locke J., Lendrem D., Bowman S., Hargreaves B., et al. incl. Ng W.-F. Serum CXCL13 levels are associated with lymphoma risk and lymphoma occurrence in primary Sjögren’s syndromeRheumatology International. 2020. DOI: 10.1007/s00296-020-04524-5 

Tsakok T., Wilson N., Dand N., Loeff F.C., Bloem K., et al. incl. Reynolds N.JAssociation of Serum Ustekinumab Levels with Clinical Response in PsoriasisJAMA Dermatology. 2019. DOI: 10.1001/jamadermatol.2019.1783 

Ur Rehman R.Z., Del Din S., Shi J.Q., Galna B., Lord S., Yarnall A.J., Guan Y., Rochester L. Comparison of walking protocols and gait assessment systems for machine learning-based classification of parkinson’s diseaseSensors (Switzerland). 2019. DOI: 10.3390/s19245363 

Vallance A.E., Harji D., Fearnhead N.S., Acheson A., Adams K. et al. inc. Griffiths B., Making an IMPACT: A priority setting consultation exercise to improve outcomes in patients with locally advanced, recurrent and metastatic colorectal cancerEuropean Journal of Surgical Oncology. 2019. DOI: 10.1016/j.ejso.2019.04.005 

Vallance A.E., Harji D., Fearnhead N.S., Acheson A., Adams K., et al. incl. Griffiths BMaking an IMPACT: A priority setting consultation exercise to improve outcomes in patients with locally advanced, recurrent and metastatic colorectal cancerEuropean Journal of Surgical Oncology. 2019. DOI: 10.1016/j.ejso.2019.04.005 

Van der Lee S.J., Conway O.J., Jansen I., Carrasquillo M. et al inc. Chinnery P.F. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.  Acta Neuropathologica.  2019. DOI: 10.1007/s00401-019-02026-8 

Van Eimeren T., Antonini A., Berg D., Bohnen N., Ceravolo R., et al. incl. Pavese N. Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility SystemAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019. DOI: 10.1016/j.dadm.2019.01.011 

Venter M., Tomas C., Pienaar I.S., Strassheim V., Erasmus E., et al. incl. Newton J.L. MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variantsScientific Reports. 2019. DOI: 10.1038/s41598-019-39060-1 

Walker L., Stefanis L., Attems J. Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies – current issues and future directionsJournal of Neurochemistry2019. 68:1 DOI: 10.1111/jnc.14698 

Wallace A., Pietrusz A., Dewar E., Dudziec M., Jones K. et al. incl. Trenell M. Community exercise is feasible for neuromuscular diseases and can improve aerobic capacity. Neurology. 2019; 92:15 e1773-e1785. DOI: 10.1212/WNL.0000000000007265 

Wei W., Tuna S., Keogh M.J., Smith K.R., et al inc.Chinnery P.F. Germline selection shapes human mitochondrial DNA diversityScience (New York, N.Y.)364:6442. 2019. DOI: 10.1126/science.aau6520 

Wilman H.R., Parisinos C.A., Atabaki-Pasdar N., Kelly M. et al inc. Walker M., Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentrationJournal of Hepatology.  2019. DOI: 10.1016/j.jhep.2019.05.032 

Witham M.D., Price R.J.G., Band M.M., Hannah M.S., Fulton R.L. Effect of Vitamin K2 on Postural Sway in Older People Who Fall: A Randomized Controlled TrialJournal of the American Geriatrics Society. 2019. DOI: 10.1111/jgs.16024 

Yiu Z.Z.N., Mason K.J., Barker J.N.W.N., Hampton P.J. A standardization approach to compare treatment safety and effectiveness outcomes between clinical trials and real-world populations in psoriasisBritish Journal of Dermatology. 2019. DOI: 10.1111/bjd.17849 

Younossi Z.M., Ratziu V., Loomba R., Rinella M., Anstee Q.M., Goodman Z. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trialThe Lancet. 2019. DOI: 10.1016/S0140-6736(19)33041 

Younossi Z.M., Stepanova M., Anstee Q.M., Lawitz E.J., Wai-Sun Wong V et al. Reduced Patient-Reported Outcome Scores Associate With Level of Fibrosis in Patients With Nonalcoholic SteatohepatitisClinical Gastroenterology and Hepatology2019. DOI: 10.1016/j.cgh.2019.02.024 

Zhu G., Catt M., Cassidy S., Birch-Machin M., Trenell M.Hiden HObjective sleep assessment in >80,000 UK mid-life adults: Associations with sociodemographic characteristics, physical activity and caffeinePLoS ONE. 2019. DOI: 10.1371/journal.pone.0226220 

2018/19

Abohelaika S., Wynne H., Avery P., Kampouraki E., Kamali F. Effect of genetic and patient factors on warfarin pharmacodynamics following warfarin withdrawal: Implications for patients undergoing surgery. Thrombosis Research. 2018; 171 167-170 DOI: 10.1016/j.thromres.2018.09.064

Ahmed Z., Preshaw P.M., Bauld L., Holliday R. Dental professionals’ opinions and knowledge of smoking cessation and electronic cigarettes: A cross-sectional survey in the north of England. British Dental Journal. 2018; 225:10 DOI: 10.1038/sj.bdj.2018.1026

Allen S.F., Elder G.J., Longstaff L.F., Gotts Z.M., Sharman R. et al. Exploration of potential objective and subjective daily indicators of sleep health in normal sleepers. Nature and Science of Sleep. 2018; 10 303-312 DOI: 10.2147/NSS.S168841

Alston C.L., Heidler J., Dibley M.G., Kremer L.S., Taylor L.S. et al. incl. McFarland R. Bi-allelic Mutations in NDUFA6 Establish Its Role in Early-Onset Isolated Mitochondrial Complex I Deficiency. American Journal of Human Genetics. 2018; 103:4 592-601  DOI: 10.1016/j.ajhg.2018.08.013

Anstee Q.M., Mantovani A., Tilg H., Targher G. Risk of cardiomyopathy and cardiac arrhythmias in patients with nonalcoholic fatty liver disease. Nature Reviews Gastroenterology and Hepatology. 2018; 1-15 DOI: 10.1038/s41575-018-0010-0.

Aspray T.J., Chadwick T., Francis R.M., McColl E., Stamp E. et al. Randomized controlled trial of vitamin D supplementation in older people to optimize bone health. The American journal of clinical nutrition. 2019; 109:1 207-217 DOI: 10.1093/ajcn/nqy280

Bansagi B., Phan V., Baker M.R., O'Sullivan J., Jennings M.J. et al. incl. Horvath R. Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation. Neurology. 2018; 90:21 e1842-e1848 DOI: 10.1212/WNL.0000000000005566

Bartsakoulia M., Pyle A., Troncoso-Chandía D., Vial-Brizzi J., Paz-Fiblas M.V. et al. incl. Lochmüller H. A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies. Human Molecular Genetics. 2018; 27:7 1186-1195 DOI: 10.1093/hmg/ddy033

Basu A.P., Pearse J., Watson R., Dulson P., Baggaley J. et.al. incl. Embleton N. Feasibility trial of an early therapy in perinatal stroke (eTIPS). BMC Neurology. 2018; 18:1 102 DOI: 10.1186/s12883-018-1106-4

Bate J., Baker S., Breuer J., Chisholm J.C., Gray J. et al. incl. Skinner R. PEPtalk2: Results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer. Archives of Disease in Childhood. 2018; DOI: 10.1136/archdischild-2017-314212

Batty J., Qiu W., Gu S., Sinclair H., Veerasamy M. et al incl. Kunadian V., ICON-1 Study Investigators. One-year clinical outcomes in older patients with non-ST elevation acute coronary syndrome undergoing coronary angiography: An analysis of the ICON1 study. International Journal of Cardiology. 2018; DOI: 10.1016/j.ijcard.2018.09.086

Beltran-Valls M.R., Janssen X., Farooq A., Adamson A.J., Pearce M.S. et al. Longitudinal changes in vigorous intensity physical activity from childhood to adolescence: Gateshead Millennium Study. Journal of Science and Medicine in Sport. 2018; DOI: 10.1016/j.jsams.2018.10.010

Bertoli M., Cereatti A., Trojaniello D., Avanzino L., Pelosin E., Del Din S. et al. incl Rochester L. Estimation of spatio-temporal parameters of gait from magneto-inertial measurement units: Multicenter validation among Parkinson, mildly cognitively impaired and healthy older adults. BioMedical Engineering Online. 2018; 17:1 58 DOI: 10.1186/s12938-018-0488-2

Birch J., Sunny S.S., Hester K.L.M., Parry G., Kate Gould F. et al. incl. Corris P.A. Outcomes of lung transplantation in adults with bronchiectasis. BMC Pulmonary Medicine. 2018; 18:1 82 DOI: 10.1186/s12890-018-0634-4

Bissett S.M., Presseau J., Rapley T., Preshaw P.M. Uptake of best practice recommendations in the management of patients with diabetes and periodontitis: A cross-sectional survey of dental clinicians British Dental Journal. 2019; 226:2 131-137 DOI: 10.1038/sj.bdj.2019.48

Blagojevic-Bucknall M., Mallen C., Muller S., Hayward R., West S. et al. The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study. Arthritis and Rheumatology. 2019; 71:1 154-160. DOI: 10.1002/art.40662

Bourke J.P., Watson G., Muntoni F., Spinty S., Roper H. et al. incl. Bushby K. Randomised placebo-controlled trial of combination ACE inhibitor and beta-blocker therapy to prevent cardiomyopathy in children with Duchenne muscular dystrophy? (DMD Heart Protection Study): A protocol study. BMJ Open. 2018; 8:12 e022572. DOI: 10.1136/bmjopen-2018-022572

Brown A.E., Dibnah B., Fisher E., Newton J.L., Walker M. Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS. Bioscience Reports. 2018; 38:3  BSR20180242 DOI: 10.1042/BSR20180242

Buckley C., Alcock L., McArdle R., Ur Rehman R.Z., Del Din S. et al. incl. Yarnall A.J. The role of movement analysis in diagnosing and monitoring neurodegenerative conditions: Insights from gait and postural control. Brain Sciences. 2019; 9:2 DOI: 10.3390/brainsci9020034

Buckley C., Galna B., Rochester L., Mazzà C. Upper body accelerations as a biomarker of gait impairment in the early stages of Parkinson's disease. Gait and Posture. 2018; DOI: 10.1016/j.gaitpost.2018.06.166

Bugiardini E., Morrow J.M., Shah S., Wood C.L., Lynch D.S. et al. incl. Straub V. The diagnostic value of MRI pattern recognition in distal myopathies. Frontiers in Neurology. 2018; 9:JUN 456 DOI: 10.3389/fneur.2018.00456

Cassidy S., Fuller H., Chau J., Catt M., Bauman A., Trenell M.I. Accelerometer-derived physical activity in those with cardio-metabolic disease compared to healthy adults: a UK Biobank study of 52,556 participants. Acta Diabetologica. 2018; 1-5 DOI: 10.1007/s00592-018-1161-8

Cassidy S., Vaidya V., Houghton D., Zalewski P., Seferovic J.P. et al. incl Jakovljevic D.G. Unsupervised high-intensity interval training improves glycaemic control but not cardiovascular autonomic function in type 2 diabetes patients: A randomised controlled trial. Diabetes and Vascular Disease Research. 2018; DOI: 10.1177/1479164118816223

Chan F., Lax N.Z., Voss C.M., Aldana B.I., Whyte S. et al. incl. Turnbull D.M. The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction. Brain : a journal of neurology. 2019; 142:2 391-411 DOI: 10.1093/brain/awy320

Chinnery P.F., Gomez-Duran A. Oldies but goldies mtDNA population variants and neurodegenerative diseases. Frontiers in Neuroscience. 2018; 12: OCT 682 DOI: 10.3389/fnins.2018.00682

Chivers Seymour K., Pickering R., Rochester L., Roberts H.C., Ballinger C. et al. Multicentre, randomised controlled trial of PDSAFE, a physiotherapist-delivered fall prevention programme for people with Parkinson's. Journal of Neurology, Neurosurgery and Psychiatry. 2019; DOI: 10.1136/jnnp-2018-319448

Chua S.Y.L., Thomas D., Allen N., Lotery A., Desai P. et al. incl. Steel D. Cohort profile: Design and methods in the eye and vision consortium of UK Biobank. BMJ Open. 2019; 9:2 e025077 DOI: 10.1136/bmjopen-2018-025077

Codd A., Burford B., Petruso G., Davidson N., Vance G. Development and evaluation of a digistory about autistic spectrum disorder – a pilot study. Education for Primary Care. 2018;1-5 DOI: 10.1080/14739879.2018.1470906

Colver A., McConachie H., Le Couteur A., Dovey-Pearce G., Mann K.D. et al. incl. Pearce M.S. A longitudinal, observational study of the features of transitional healthcare associated with better outcomes for young people with long-term conditions. BMC Medicine. 2018; 16:1 111 DOI: 10.1186/s12916-018-1102-y

Cooles F.A.H., Anderson A.E., Skelton A., Pratt A.G., Kurowska-Stolarska M.S. et al. incl. Isaacs J.D. Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis. Frontiers in Immunology. 2018; 9(MAY) 795 DOI: 10.3389/fimmu.2018.00755

Crosbie E.J., Ryan N.A.J., Arends M.J., Bosse T., Burn J. et al. Manchester International Consensus Group. The Manchester International Consensus Group recommendations for the management of gynaecological cancers in Lynch syndrome. Genetics in Medicine.2019; DOI:  10.1038/s41436-019-0489-y

Da-Silva R.H., Moore S.A., Price C.I. Self-directed therapy programmes for arm rehabilitation after stroke: a systematic review. Clinical Rehabilitation. 2018; DOI: 10.1177/0269215518775170

daSilva Morgan K., Elder G.J., ffytche D.H., Collerton D., Taylor J.-P. The utility and application of electrophysiological methods in the study of visual hallucinations. Clinical Neurophysiology. 2018; 129:11 2361-2371 DOI: 10.1016/j.clinph.2018.08.019

Da Silva R., Rodgers H., Shaw L., van Wijck F., Moore S.A. et al. Wristband accelerometers to motivate arm exercise after stroke (WAVES): Activity data from a pilot randomised controlled trial. Annals of Physical and Rehabilitation Medicine. 2018; DOI: 10.1016/j.rehab.2018.05.067

Dand N., Duckworth M., Baudry D., Russell A., Curtis C.J. et al. incl. Reynolds N.J. BADBIR Study Group, BSTOP Study Group, The members of the PSORT consortium . HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. Journal of Allergy and Clinical Immunology. 2019; DOI: 10.1016/j.jaci.2018.11.038

Dew R., King K., Okosieme O.E., Pearce S.H., Donovan G. et al. incl. Razvi S. Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: A qualitative interview study. BMJ Open. 8:2 e019970 DOI: 10.1136/bmjopen-2017-019970

Dhar A., Sadiq F., Anstee Q.M., Levene A.P., Goldin R.D., Thursz M.R. Thrombin and factor Xa link the coagulation system with liver fibrosis. BMC Gastroenterology. 18:1 60 DOI: 10.1186/s12876-018-0789-8

Dodds R.M., Davies K., Granic A., Hollingsworth K.G., Warren C. et al. incl Sayer A.A. Mitochondrial respiratory chain function and content are preserved in the skeletal muscle of active very old men and women. Experimental Gerontology. 2018; 113 80-85 DOI: 10.1016/j.exger.2018.09.020

Donaghy P.C., Firbank M.J., Thomas A.J., Lloyd J., Petrides G. et al. Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies. Movement Disorders. 2018; 33:7 1130-1138 DOI: 10.1002/mds.27403

Dudley R., Aynsworth C., Mosimann U., Taylor J.-P., Smailes D. et al. A comparison of visual hallucinations across disorders. Psychiatry Research. 2019; 272 86-92. DOI: 10.1016/j.psychres.2018.12.052

Durcan R., Wiblin L., Lawson R.A., Khoo T.K., Yarnall A.J. et al. the ICICLE-PD Study Group. Prevalence and duration of non-motor symptoms in prodromal Parkinson's disease. European Journal of Neurology. 2019;DOI: 10.1111/ene.13919

Dutta P., Funston W., Mossop H., Ryan V., Jones R.Pearson J. et al.Randomised, double-blind, placebo-controlled pilot trial of omeprazole in idiopathic pulmonary fibrosis. Thorax. DOI:10.1136/thoraxjnl-2018-212102

Dyson J.K., Wong L.L., Bigirumurame T., Hirschfield G.M., Kendrick S. et al. on behalf of the UK-AIH Consortium. Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom. Alimentary Pharmacology and Therapeutics. 2018; DOI: 10.1111/apt.14968

Dyson J.K., De Martin E., Dalekos G.N., Drenth J.P.H., Herkel J. et al. the IAIHG Consortium. Review article: unanswered clinical and research questions in autoimmune hepatitis-conclusions of the International Autoimmune Hepatitis Group Research Workshop. Alimentary Pharmacology and Therapeutics. 2018; DOI: 10.1111/apt.15111

Elder G.J., Colloby S.J., Firbank M.J., McKeith I.G., Taylor J.-P. Consecutive sessions of transcranial direct current stimulation do not remediate visual hallucinations in Lewy body dementia: A randomised controlled trial. Alzheimer's Research and Therapy. 2019; 11:1:9 DOI: 10.1186/s13195-018-0465-9

Embleton N.D., Wood C.  Metabolic outcomes in very low birthweight and preterm infants in later life [Desfechos metabólicos posteriores em recém-nascidos de muito baixo peso ao nascer e pré-termos]. Jornal de Pediatria. 2018; DOI: 10.1016/j.jped.2018.06.002

Erskine D., Ding J., Thomas A.J., Kaganovich A., Khundakar A.A. et al. incl. Attems J. Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies. Movement Disorders. 2018; DOI: 10.1002/mds.27333

Feeney C.L., Lim A.Z., Fagan E., Blain A., Bright A. et al. incl. Turnbull D.M. A case-comparison study of pregnant women with mitochondrial disease – what to expect? BJOG: An International Journal of Obstetrics and Gynaecology. 2019; DOI: 10.1111/1471-0528.15667

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Patterson L., Rushton S.P., Attems J., Thomas A.J., Morris C.M. Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders. Brain Pathology. 2019; DOI: 10.1111/bpa.12697

Penn L., Goffe L., Haste A., Moffatt S. Management information systems for community based interventions to improve health: Qualitative study of stakeholder perspectives. BMC Public Health. 2019; 919:1 105 DOI: 10.1186/s12889-018-6363-z

Peraza L.R., Cromarty R., Kobeleva X., Firbank M.J., Killen A. et al. incl. Thomas A.J., Taylor J.P. Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer's disease patients. Scientific Reports. 2018; 8:1 4637 DOI: 10.1038/s41598-018-22984-5

Peraza L.R., Díaz-Parra A., Kennion O., Moratal D., Taylor J.-P. et al. Alzheimer's Disease Neuroimaging Initiative. Structural connectivity centrality changes mark the path toward Alzheimer's disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2018;11 98-107 DOI: 10.1016/j.dadm.2018.12.004

Pera M.C., Coratti G., Mazzone E.S., Montes J., Scoto M. et al. incl. Straub V.for the iSMAC Consortium Group. Revised upper limb module for spinal muscular atrophy: 12 month changes. Muscle and Nerve. 2019; DOI: 10.1002/mus.26419

Pinder E.M., Rostron A.J., Hellyer T.P., Ruchaud-Sparagano M.-H. et al. incl. Baudouin S.V.  Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis. Thorax. 2018; DOI: 10.1136/thoraxjnl-2017-211323

Piper C.J., Wilkinson M.G.L., Deakin C.T., Otto G.W., Dowle S. et al. incl. Foster H.  CD19+CD24hiCD38hi B cells are expanded in juvenile dermatomyositis and exhibit a pro-inflammatory phenotype after activation through toll-like receptor 7 and interferon-α. Frontiers in Immunology.  2018; 9:Jun 1371 DOI: 10.3389/fimmu.2018.01372

Potter S., Conroy E.J., Cutress R.I., Williamson P.R., Whisker L. et al. incl. Collis N. iBRA Steering Group, Breast Reconstruction Research Collaborative. Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective cohort study. The Lancet Oncology. 20:2 254-266 DOI: 10.1016/S1470-2045(18)30781-2

Preshaw P.M. Mouthwash use and risk of diabetes. British Dental Journal. 2018; 225:10 DOI: 10.1038/ssj.bdj.2018.1020

Price D., Devereux G., Cotton S., Fielding S., McMeekin N. et al. incl. De Soyza A. Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients with COPD: A Randomized Clinical Trial. JAMA - Journal of the American Medical Association. 2018; 320:15 1548-1559 DOI: 10.1001/jama.2018.14432

Ramsbottom S.A., Molinari E., Srivastava S., Silberman F., Henry C. et al. incl. Steel D.H. Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115:49 12489-12494. DOI: 10.1073/pnas.1809432115

Ranathunga R.M.T.K., Hill T.R., Mathers J.C., Francis R.M., Prentice A. et al. incl. Aspray T.J. for the Vitamin D in Older People Study group. No effect of monthly supplementation with 12000 IU, 24000 IU or 48000 IU vitamin D3 for one year on muscle function: The vitamin D in older people study. Journal of Steroid Biochemistry and Molecular Biology. 2019; DOI: 10.1016/j.jsbmb.2018.12.008

Rashid A., Cordingley L., Carrasco R., Foster H.E., Baildam E.M. et al. Patterns of pain over time among children with juvenile idiopathic arthritis. Archives of Disease in Childhood. 2018; 103:5 437-443 DOI: 10.1136/archdischild-2017-313337

Rayner F., Isaacs J.D. Therapeutic tolerance in autoimmune disease. Seminars in Arthritis and Rheumatism. 2018; DOI: 10.1016/j.semarthrit.2018.09.008

Rhodes C.J., Batai K., Bleda M., Haimel M., Southgate L. et al. incl. Corris P.A. UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. The Lancet Respiratory Medicine. 2019; 7:3 227-238 DOI: 10.1016/S2213-2600(18)30409-0

Ricotti V., Selby V., Ridout D., Domingos J., Decostre V. et al. incl. Straub V. Respiratory and upper limb function as outcome measures in ambulant and non-ambulant subjects with Duchenne muscular dystrophy: A prospective multicentre study. Neuromuscular Disorders. 2019; DOI: 10.1016/j.nmd.2019.02.002

Roberts G., Lloyd J.J., Petrides G.S., Donaghy P.C., Kane J.P.M. et al. incl. Taylor J.-P. 123 I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults. Annals of Nuclear Medicine. DOI: 10.1007/s12149-019-01352-x

Robinson S.M., Westbury L.D., Cooper R., Kuh D., Ward K. et al. incl. Sayer A.A. Adult Lifetime Diet Quality and Physical Performance in Older Age: Findings from a British Birth Cohort. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2018; 73:11 1532-1537 DOI: 10.1093/gerona/glx179

Rudman H.A., Birrell F., Pearce M.S., Tuck S.P., Francis R.M. et al. Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62 years: the Newcastle thousand families study. Osteoporosis International. 2019; DOI: 10.1007/s00198-018-04817-3

Sarkozy A., Torelli S., Mein R., Henderson M., Phadke R.et al. incl. Straub V. Mobility shift of beta-dystroglycan as a marker of GMPPB gene-related muscular dystrophy. Journal of Neurology, Neurosurgery and Psychiatry. 2018; 89:7 762-768 DOI: 10.1136/jnnp-2017-316956

Schumacher J., Peraza L.R., Firbank M., Thomas A.J., Kaiser M. et al. incl. Taylor J.-P. Dynamic functional connectivity changes in dementia with Lewy bodies and Alzheimer's disease. NeuroImage: Clinical. 2019; 20: 101812 DOI: 10.1016/j.nicl.2019.101812

Shaw A., Houghton D., Hallsworth K., Jakovljevic D.G., Trenell M.I., Cassidy S.  Adiposity predicts low cardiorespiratory fitness in individuals with metabolic diseases. Diabetes Research and Clinical Practice. 2018; 146: 300-304. DOI: 10.1016/j.diabres.2018.10.022

Sherratt F.C., Roper L., Stones S.R., McErlane F., Peak M. et al. incl. Foster H. Protective parents and permissive children: What qualitative interviews with parents and children can tell us about the feasibility of juvenile idiopathic arthritis trials. Pediatric Rheumatology. 2018; 16:1 76 DOI: 10.1186/s12969-018-0293-2

Shoop-Worrall S.J.W., Verstappen S.M.M., McDonagh J.E., Baildam E., Chieng A. et al. incl. Foster H. Long-Term Outcomes Following Achievement of Clinically Inactive Disease in Juvenile Idiopathic Arthritis: The Importance of Definition. Arthritis and Rheumatology. 2018; 70:9 1519-1529 DOI: 10.1002/art.40519

Sommerville E.W., Zhou X.-L., Oláhová M., Jenkins J., Euro L. et al. incl. McFarland R. Instability of the mitochondrial alanyl-tRNA synthetase underlies fatal infantile-onset cardiomyopathy. Human molecular genetics. 2019; 28:2 258-268 DOI: 10.1093/hmg/ddy294

Spitali P., Hettne K., Tsonaka R., Charrout M., van den Bergen J. et al. incl. Lochmüller H. Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies. Journal of Cachexia, Sarcopenia and Muscle. 2018; 9:4 715-726 DOI: 10.1002/jcsm.12304

Stamp C., Zupanic A., Sachdeva A., Stoll E.A., Shanley D.P., Mathers J.C. et al. Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts. EBioMedicine. 2018; 31 166-173 DOI: 10.1016/j.ebiom.2018.04.017

Stergiou G.S., Alpert B., Mieke S., Asmar R., Atkins N. et al. incl. Murray A. A universal standard for the validation of blood pressure measuring devices: Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Collaboration Statement. Hypertension. 2018; 71:3 368-374 DOI: 10.1161/HYPERTENSIONAHA.117.10237

Straub V., Mercuri E., DMD outcome measure study group. Report on the workshop: Meaningful outcome measures for Duchenne muscular dystrophy, London, UK, 30–31 January 2017. Neuromuscular Disorders. 2018; 28:8 690-701 DOI: 10.1016/j.nmd.2018.05.013

Stuart S., Alcock L., Rochester L., Vitorio R., Pantall A. Monitoring multiple cortical regions during walking in young and older adults: Dual-task response and comparison challenges. International Journal of Psychophysiology. 2019; 135 63-72 DOI: 10.1016/j.ijpsycho.2018.11.006

Sturrock A., Preshaw P.M., Hayes C., Wilkes S. Perceptions and attitudes of patients towards medication-related osteonecrosis of the jaw (MRONJ): A qualitative study in England. BMJ Open. 2019; 9:3 e024376 DOI: 10.1136/bmjopen-2018-024376

Stylianou M., Murphy N., Peraza L.R., Graziadio S., Cromarty R. et al. incl. Taylor, J.P. Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and an aid to differential diagnosis. Clinical Neurophysiology. 2018; 129:6 1209-1220 DOI: 10.1016/j.clinph.2018.03.013

Su T., Grady J.P., Afshar S., McDonald S.A.C. et al. incl. Turnbull D.M. Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations. Journal of Pathology. 2018; 246:4 427-432 DOI: 10.1002/path.5156

Su T., Turnbull D.M., Greaves L.C. Roles of mitochondrial DNA mutations in stem cell ageing. Genes. 2018; 9:4 182 DOI: 10.3390/genes9040182

Suryanegara J., Cassidy S., Ninkovic V., Popovic D., Grbovic M. et al. incl. Trenell M.I. High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial. Acta Diabetologica. 2018; DOI: 10.1007/s00592-018-1245-5

Tanaka C., Janssen X., Pearce M., Parkinson K., Basterfield L. et al. Bidirectional associations between adiposity, sedentary behavior, and physical activity: A longitudinal study in children. Journal of Physical Activity and Health. 2018; 15:12 918-926 DOI: 10.1123/jpah.2018-0011

Tedja M.S., Wojciechowski R., Hysi P.G., Eriksson N., Furlotte N.A. et al. incl. Steel D.H.W.  Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nature Genetics. 2018; 50:6 834-848 DOI: 10.1038/s41588-018-0127-7

Thomas A.J., Donaghy P., Roberts G., Colloby S.J., Barnett N.A. et al. incl Taylor J.-P. Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies. Psychological Medicine. 2018; 1-7 DOI: 10.1017/S0033291718000995

Thomas A.J., Taylor J.P., McKeith I., Bamford C., Burn D. et al.  Revision of assessment toolkits for improving the diagnosis of Lewy body dementia: The DIAMOND Lewy study. International Journal of Geriatric Psychiatry. 2018; DOI: 10.1002/gps.4948

Thompson K., Mai N., Oláhová M., Scialó F., Formosa L.E. et al. OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Molecular Medicine. 2018; DOI: 10.15252/emmm.201809060

Thompson E.R., Irwin E.A., Trotter P., Ibrahim I.K., Tingle S.J. et al. incl. White S.A. UK registry analysis of donor substance misuse and outcomes following pancreas transplantation. Clinical Transplantation. 2019; 33:3 e13481 DOI: 10.1111/ctr.13481

Thorneloe R.J., Griffiths C.E.M., Emsley R., Ashcroft D.M., Cordingley L. et al. incl. Reynolds N. Intentional and Unintentional Medication Non-Adherence in Psoriasis: The Role of Patients’ Medication Beliefs and Habit Strength. Journal of Investigative Dermatology. 2018; 138:4 785-794. DOI: 10.1016/j.jid.2017.11.015

Trifunov S., Pyle A., Valentino M.L., Liguori R. et al. incl. Yu-Wai-Man P. Clonal expansion of mtDNA deletions: different disease models assessed by digital droplet PCR in single muscle cells. Scientific Reports. 2018; 8:1 11682 DOI: 10.1038/s41598-018-30143-z

Tuck S., Little E.A., Aspray T.J. Implications of guidelines for osteoporosis and its treatment. Age and Ageing. 2018; 47:3 334-339 DOI: 10.1093/ageing/afx197

Twelves S., Mostafa A., Dand N., Burri E., Farkas K. et al. incl. Reynolds N. Clinical and genetic differences between pustular psoriasis subtypes. Journal of Allergy and Clinical Immunology. 2018; DOI: 10.1016/j.jaci.2018.06.038

Ugun-Klusek A., Theodosi T.S., Fitzgerald J.C., Burté F., Ufer C. et al. incl. Yu-Wai-Man P. Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation. Redox Biology. 20 167-181 DOI: 10.1016/j.redox.2018.10.003

Unni M.N.M., Elfeky R., Rao K., Nademi Z., Chiesa R. et al. incl. Skinner R. Non-posttransplant lymphoproliferative disorder malignancy after hematopoietic stem cell transplantation in patients with primary immunodeficiency: UK experience. Journal of Allergy and Clinical Immunology. 2018; DOI: 10.1016/j.jaci.2018.02.038

Vasudev A., Thomas A.J., Grunze H. Pharmacotherapy for bipolar disorder in older people. Cochrane Database of Systematic Reviews. 2018; 2018: 11 CD010495 DOI: 10.1002/14651858.CD010495.pub2

Venter M., Tomas C., Pienaar I.S., Strassheim V., Erasmus E. et al. incl.  Ng W.-F. MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variants. Scientific Reports. 2019; 9:1 2914 DOI: 10.1038/s41598-019-39060-1

Verity C., Winstone A.M., Will R., Powell A., Baxter P. et al. incl. McFarland R. Surveillance for variant CJD: Should more children with neurodegenerative diseases have autopsies? Archives of Disease in Childhood. 2018; DOI: 10.1136/archdischild-2018-315458

Vincent A.E., White K., Davey T., Philips J., Ogden R.T. et al. incl. Turnbull D.M. Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network. Cell Reports. 2019; 26:4 996 DOI: 10.1016/j.celrep.2019.01.010

Vincent A.E., Rosa H.S., Pabis K., Lawless C., Chen C. et al. incl. Turnbull D.M.  Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology. 2018; DOI: 10.1002/ana.25288

Vitorio R., Stuart S., Gobbi L.T.B., Rochester L., Alcock L., Pantall A. Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study. Neurorehabilitation and Neural Repair. 2018; 32:11 976-987. DOI: 10.1177/1545968318805159

Warren R.B., Marsden A., Tomenson B., Mason K.J., Soliman M.M. et al. incl. Reynolds N.J. Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study. British Journal of Dermatology. 2018; DOI: 10.1111/bjd.16776

Wei W., Keogh M.J., Aryaman J., Golder Z., Kullar P.J. et al. incl. Attems J. & Chinnery P.F. Frequency and signature of somatic variants in 1461 human brain exomes.  Genetics in Medicine. 2018; DOI: 10.1038/s41436-018-0274-3

West S.D., Prudon B., Hughes J., Gupta R., Mohammed S.B. et al. ROSA trial investigators. Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial. The European respiratory journal. 2018; 52: 4 DOI: 10.1183/13993003.01177-2018

Wheatley A., Bamford C., Shaw C., Flynn E., Smith A. et al. incl. Parry S.W. Developing an Intervention for Fall-Related Injuries in Dementia (DIFRID): An integrated, mixed-methods approach 11 Medical and Health Sciences 1117 Public Health and Health Services. BMC Geriatrics. 2019; 19:1 57 DOI: 10.1186/s12877-019-1066-6

Whitworth J., Smith P.S., Martin J.-E., West H., Luchetti A. et al. incl. Talks K. Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. American Journal of Human Genetics. 2018; DOI: 10.1016/j.ajhg.2018.04.013

Widdrington J.D., Gomez-Duran A., Pyle A., Ruchaud-Sparagano M.-H., Scott J. et al. incl.  Chinnery P.F. Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses. Frontiers in immunology. 2018; 9 2217 DOI: 10.3389/fimmu.2018.02217

Wildman J.M., Moffatt S., Steer M., Laing K., Penn L., O'Brien N. Service-users' perspectives of link worker social prescribing: A qualitative follow-up study. BMC Public Health. 2019; 19:1 98 DOI: 10.1186/s12889-018-6349-x

Williams N.H., Jenkins A., Goulden N., Hoare Z. et al. incl. Isaacs J. Lessons learnt from a discontinued randomised controlled trial: Adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC). Trials. 2018; 9:1 408 DOI: 10.1186/s13063-018-2801-6

Woitalla D., Dunac A., Safavi A., Ceravolo M.-G. incl. Pavese N., et al. A noninterventional study evaluating the effectiveness of rotigotine and levodopa combination therapy in younger versus older patients with Parkinson’s disease. Expert Opinion on Pharmacotherapy. 2018; 19:9 937-945 DOI: 10.1080/14656566.2018.1480721

Yasin S.A., Schutz P.W., Deakin C.T., Sag E., Varsani H. et al. incl. Foster H. The UK Juvenile Dermatomyositis Research Group (UK and Ireland). Histological heterogeneity in a large clinical cohort of juvenile idiopathic inflammatory myopathy: analysis by myositis autoantibody and pathological features. Neuropathology and Applied Neurobiology. 2018; DOI: 10.1111/nan.12528

Yiu Z.Z.N., Ashcroft D.M., Evans I., McElhone K., Lunt M. et al. incl. Reynolds N.J., BADBIR Study Group. Infliximab is associated with an increased risk of serious infection in patients with psoriasis in the U.K. and Republic of Ireland: results from the British Association of Dermatologists Biologic Interventions Register (BADBIR). British Journal of Dermatology. 2018; DOI: 10.1111/bjd.17036

Yiu Z.Z.N., Sorbe C., Lunt M., Rustenbach S.J., Kühl L. et al. incl. Reynolds N.J. the BADBIR Study Group. Development and validation of a multivariable risk prediction model for serious infection in patients with psoriasis receiving systemic therapy. British Journal of Dermatology. 2019; DOI: 10.1111/bjd.17421

Zhang H., Burr S.P., Chinnery P.F. The mitochondrial DNA genetic bottleneck: Inheritance and beyond. Essays in Biochemistry. 2018; 62:3 225-234 DOI: 10.1042/EBC20170096

2017/18

 

Aartsma-Rus A., Straub V., Hemmings R., Haas M., Schlosser-Weber G. et al.  Development of Exon Skipping Therapies for Duchenne Muscular Dystrophy: A Critical Review and a Perspective on the Outstanding Issues.  Nucleic Acid Therapeutics. 2017; 27:5 251-259 DOI: 10.1089/nat.2017.0682

Ahmed S.T., Alston C.L., Hopton S., He L., Hargreaves I.P. et al.  Using a quantitative quadruple immunofluorescent assay to diagnose isolated mitochondrial Complex i deficiency. Scientific Reports.  2017; 7:1 15676 DOI: 10.1038/s41598-017-14623-2

Alaimo J.T., Besse A., Alston C.L., Pang K., Appadurai V. et al. Loss-of-function mutations in ISCA2 disrupt 4Fe-4S cluster machinery and cause a fatal leukodystrophy with hyperglycinemia and mtDNA depletion.  Human Mutation. 2018; DOI: 10.1002/humu.23396

Alcock, L., Galna, B., Hausdorff, J.M., Lord, S., Rochester, L.  Gait & Posture Special Issue: Gait adaptations in response to obstacle type in fallers with Parkinson's disease.  Gait and Posture.  2018; 61 368-374 DOI: 10.1016/j.gaitpost.2018.01.030

Alcock, L., Galna, B., Perkins, R., Lord, S., Rochester, L.  Step length determines minimum toe clearance in older adults and people with Parkinson's disease.  Journal of Biomechanics. 2018; doi.org/10.1016/j.jbiomech.2017.12.002

Ali M.A., Liu Y.-F., Arif S., Tatovic D., Shariff H.  Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes.  Science Translational Medicine. 2017; 9:402  aaf7779 DOI: 10.1126/scitranslmed.aaf7779

Alwan F., Vendramin C., Vanhoorelbeke K., Langley K., McDonald V. et al.  Presenting ADAMTS13 antibody and antigen levels predict prognosis in immune-mediated thrombotic thrombocytopenic purpura.  Blood.  2017; 130:4 466-471 DOI: 10.1182/blood-2016-12-758656

Andreasson A.S.I., Borthwick L.A., Gillespie C., Jiwa K., Scott J., Henderson P. et al.  The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion.  Journal of Heart and Lung Transplantation.  2017; 36:9 985-995 DOI: 10.1016/j.healun.2017.05.012

Arshad Q., Bonsu A., Lobo R., Fluri A.-S., Sheriff R. et al.  Biased numerical cognition impairs economic decision-making in Parkinson's disease.  Annals of Clinical and Translational Neurology.  2017; DOI: 10.1002/acn3.449

Astuti D., Sabir A., Fulton P., Zatyka M., Williams D. et al.  Monogenic diabetes syndromes: Locus-specific databases for Alström, Wolfram, and Thiamine-responsive megaloblastic anemia.  Human Mutation. 2017; 38: 764-777 DOI: 10.1002/humu.23233

Avery L., Exley C., McPherson S., Trenell M.I., Anstee Q.M., Hallsworth K.  Lifestyle Behavior Change in Patients With Nonalcoholic Fatty Liver Disease: A Qualitative Study of Clinical Practice.  Clinical Gastroenterology and Hepatology.  2017; DOI: 10.1016/j.cgh.2017.06.011

Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S. et al. Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study.  Neurobiology of Aging. 2018; 65 18-40 DOI: 10.1016/j.neurobiolaging.2017.12.023

Baczynska A.M., Shaw S.C., Patel H.P., Sayer A.A., Roberts H.C.  Learning from older peoples' reasons for participating in demanding, intensive epidemiological studies: A qualitative study.  BMC Medical Research Methodology.  2017; 17:1 167 DOI: 10.1186/s12874-017-0439-9

Baker, K.F., Isaacs, J.D.  Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?  Annals of the Rheumatic Diseases. 2018; 77:2 175-187 DOI: 10.1136/annrheumdis-2017-211555

Bargiela, D., Burr, S.P., Chinnery, P.F.  Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions.  Trends in Endocrinology and Metabolism. 2018; doi.org/10.1016/j.tem.2018.02.002

Battersby A.C., Braggins H., Pearce M.S., Cale C.M., Burns S.O. Inflammatory and autoimmune manifestations in X-linked carriers of chronic granulomatous disease in the United Kingdom.  Journal of Allergy and Clinical Immunology. 2017; 140:2 628-630 DOI: 10.1016/j.jaci.2017.02.029

Benitez-Aguirre P.Z., Wong T.Y., Craig M.E., Davis E.A., Cotterill A. et al.  The Adolescent Cardio-Renal Intervention Trial (AdDIT): retinal vascular geometry and renal function in adolescents with type 1 diabetes. Diabetologia. 2018; 61:4 968-976. DOI: 10.1007/s00125-017-4538-2

Bezzina O.M., Gallagher P., Mitchell S., Bowman S.J., Griffiths B.  Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.  Arthritis Care and Research. 2017; 69:11 1714-1723 DOI: 10.1002/acr.23165

Bloom, I., Edwards, M., Jameson, K.A., Syddall, H.E., Dennison, E. et al. Influences on diet quality in older age: The importance of social factors. Age and Ageing. 2017; 46: 277-283 DOI: 10.1093/ageing/afw180

Bloom I., Lawrence W., Barker M., Baird J., Dennison E. What influences diet quality in older people? A qualitative study among community-dwelling older adults from the Hertfordshire Cohort Study, UK.  Public Health Nutrition. 2017; 20:15 2685-2693 DOI: 10.1017/S1368980017001203

Boyle M., Masson S., Anstee Q.M.  The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease.  Journal of Hepatology.  2017; DOI: 10.1016/j.jhep.2017.11.006

Brass D., Fouweather T., Stocken D.D., Macdonald C., Wilkinson J. et al.  An observer-blinded randomized controlled pilot trial comparing localized immersion psoralen-ultraviolet A with localized narrowband ultraviolet B for the treatment of palmar hand eczema.  British Journal of Dermatology.  2018; DOI: 10.1111/bjd.16238

Brocklebank V., Johnson S., Sheerin T.P., Marks S.D., Gilbert R.D. et al.  Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland.  Kidney International. 2017; DOI: 10.1016/j.kint.2017.04.028

Bruyère O., Buckinx F., Beaudart C., Reginster J.-Y., Bauer J. et al.  How clinical practitioners assess frailty in their daily practice: an international survey.  Aging Clinical and Experimental Research.  2017; 29:5 905-912 DOI: 10.1007/s40520-017-0806-8

Burté F., Houghton D., Lowes H., Pyle A., Nesbitt S. et al.  Metabolic profiling of Parkinson's disease and mild cognitive impairment. Movement Disorders. 2017; 32:6 927-932 DOI: 10.1002/mds.26992

Cade J.E., Warthon-Medina M., Albar S., Alwan N.A., Ness A. et al. DIET@NET: Best Practice Guidelines for dietary assessment in health research. BMC Medicine. 2017; 15:1 202 DOI: 10.1186/s12916-017-0962-x

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