Staff Profile

Introduction

My expertise is in experimental soft matter physics applied to biological membranes, proteins and the extracellular matrix. By understanding what happens to these molecules as we age, I hope to further understand the process of ageing and diseases associated with ageing such as cancer. With collaborators in Cambridge University we use the long lived rodent, the naked mole rat, to examine the ageing process and resistance to age related diseases. More information about this unusual creature  can be found at the University of Cambridge Naked Mole Rat Initiative. I am also an associate of the Newcastle Institute for Ageing. More information on my research can be found in the biophysics of ageing group webpages.

I teach thermodynamics in the School of Engineering and biophysics in the School of Physics.

My publications/citations information can be found at: 

Google Scholar Profile for Dr Daniel Frankel

Qualifications

BEng (First Class) Queen Mary, University of London  [Subject - Bioengineering]

PhD University of St-Andrews, Scotland 

Previous Positions

Postdoc University of Cambridge

Postdoc Sandia National Labs, USA

Memberships

British Biophysical Society

Royal Society of Chemistry

Institute of Physics

Informal Interests

Electronics - Arduino, Raspberry Pi, Robotics

Science Fiction

History 

Funding

CRUK 

EPSRC

Undergraduate Teaching

Current:

Thermodynamics Stage 1

Thermodynamics stage 2

Design Project

Research Project

Past:

Fluid Mechanics Stage 1

Crystallization Stage 3

Biomaterials Stage 3/4 

• Kulaberoglu Y, Bhushan B, Hadi F, Chakrabarti S, Khaled W, Rankin KS, St-John Smith E, Frankel D. The material properties of naked mole-rat hyaluronan. Scientific Reports 2019, 9, 6632.
• Van Nieuwenhove I, Salomon A, Peters K, Graulus G-J, Martins JC, Frankel D, Kersemans K, De Vos F, Van Vlierberghe S, Dubruel P. Gelatin- and starch-based hydrogels. Part A: Hydrogel development, characterization and coating. Carbohydrate Polymers 2016, 152, 129–139.
• Rankin KS, Frankel D. Hyaluronan in cancer - from the naked mole rat to nanoparticle therapy. Soft Matter 2016, 12(17), 3841-3848.
• Papaioannou EI, Bachmann C, Neumeier JJ, Frankel D, Over H, Janek J, Metcalfe IS. The role of the three-phase boundary of the platinum-support interface in catalysis: A model catalyst kinetic study. ACS Catalysis 2016, 6, 5865-5872.
• Miles P, Cassidy P, Donlon L, Yarkoni O, Frankel D. In Vitro assembly of a viral envelope. Soft Matter 2015, 11(39), 7722-7727.
• Yarkoni O, Frankel DJ. Solving the bio-machine interface-a synthetic biology approach. In: Biomimetic Technologies: Principles and Applications. Cambridge, UK: Elsevier Inc, 2015, pp.53-66.
• Miles P, Frankel DJ. Lipid directed assembly of the HIV capsid protein. Soft Matter 2014, 10(47), 9562-9567.
• Donlon L, Penaherrera A, Frankel D. Probing interactions of the HIV protein GP120 with lipids and CD4 receptors. Soft Matter 2013, 9(10), 2803-2809.
• Donlon L, Frankel D. Self assembly and pore formation of HIV GP160 revealed at molecular resolution. Soft Matter 2013, 9(1), 283-290.
• Nordin D, Donlon L, Frankel DJ. Characterising single fibronectin-integrin complexes. Soft Matter 2012, 8(22), 6151-6160.
• Donlon L, Nordind D, Frankel DJ. Complete unfolding of fibronectin reveals surface interactions. Soft Matter 2012, 8(38), 9933-9940.
• Yarkoni O, Donlon L, Frankel D. Creating a bio-hybrid signal transduction pathway: opening a new channel of communication between cells and machines. Bioinspiration & Biomimetics 2012, 7(4), 046017.
• Nordin D, Yarkoni O, Savinykh N, Frankel D. Protein Directed Assembly of Lipids. Chemical Communications 2012, 48(5), 672-674.
• Nordin D, Yarkoni O, Savinyky N, Donlon L, Frankel D. Revealing the selective interactions of fibronectin with lipid bilayers. Soft Matter 2011, 7(22), 10666-10675.
• Chaudhry B, Ashton H, Muhamed A, Yost M, Bull S, Frankel D. Nanoscale viscoelastic properties of an aligned collagen scaffold. Journal of Materials Science: Materials in Medicine 2009, 20(1), 257-263.
• Frankel DJ, Chen Q, Richardson NV. Formation of hydrogen-bridged cytosine dimers on Cu(110). Journal of Chemical Physics 2006, 124(20), 204704.
• Manzanera M, Frankel DJ, Li H, Zhou D, Bruckbauer A, Kreutzmann P, Blackburn JM, Abell C, Rayment T, Klenerman D, Barker PD. Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes. Nano Letters 2006, 6(3), 365-370.
• Frankel DJ, Pfeiffer JR, Surviladze Z, Johnson AE, Oliver JM, Wilson BS, Burns AR. Revealing the Topography of Cellular Membrane Domains by Combined Atomic Force Microscopy/Fluorescence Imaging. Biophysical Journal 2006, 90(7), 2404–2413.
• Burns AR, Frankel DJ, Buranda T. Local Mobility in Lipid Domains of Supported Bilayers Characterized by Atomic Force Microscopy and Fluorescence Correlation Spectroscopy. Biophysical Journal 2005, 89(2), 1081-1093.
• Frankel DJ, Chen Q, Richardson NV. Adsorption of alpha-pyridone on Cu(110). Journal of Chemical Physics 2002, 116(20), 8988-8993.
• Chen Q, Frankel DJ, Richardson NV. Chemisorption induced chirality: glycine on Cu{110}. Surface Science 2002, 497(1-3), 37-46.
• Chen Q, Frankel DJ, Richardson NV. Self-assembly of adenine on Cu(110) surfaces. Langmuir 2002, 18(8), 3219-3225.
• Chen Q, Frankel DJ, Richardson NV. Dehydrogenation induced phase transitions of p-aminobenzoic acid on Cu(110). Journal of Chemical Physics 2001, 116(2), 460-470.
• Chen Q, Frankel DJ, Lee CW, Richardson NV. Linear dichroism electron scattering from chiral surfaces. Chemical Physics Letters 2001, 349(3-4), 161-171.
• Chen Q, Frankel DJ, Richardson NV. Organic adsorbate induced surface reconstruction: p-aminobenzoic acid on Cu{110}. Langmuir 2001, 17(26), 8276-8280.
• Chen Q, Frankel DJ, Richardson NV. Room-temperature surface structure of 4-aminobenzoic acid on Cu(110) surfaces. Surface and Interface Analysis 2001, 32(1), 43-48.
• Chen Q, Lee CW, Frankel DJ, Richardson NV. The formation of enantiospecific phases on a Cu(110) surface. Phys Chem Comm 1999, 1-4.