Dr David Swan
- Email: email@example.com
- Telephone: +44 (0)191 208 2796
- Address: M3.121 (Office)
Third Floor Leech Building
Newcastle Medical School
Newcastle upon Tyne
I am a post-doctoral Research Associate in the Primary Immunodeficiency Group at Newcastle University.
The group is led by Professor Sophie Hambleton, who is an academic and consultant paediatric immunologist at the Great North Children's Hospital.
We are based in the Inflammation, Immunology and Immunotherapy (III) Laboratory in the Medical School.
The PID group
The clinical team in the Great North Children's Hospital identify and treat patients born with genetic defects that affect their immune system. Various methods - including next-generation exome sequencing - are used to find the causative genetic mutation(s) in each patient. The details of mutations in: a) known immune genes that have not already been reported to be disease-causing; and b) 'new' genes (i.e. genes that are not known to be important for proper functioning of the immune system) are passed to the lab for further investigation.
I spend most of my time investigating the role of a metal ion transporter in B cell development. I also help the rest of the group look for disease-causing mutations in patients with primary immunodeficiencies.
- Duncan CJA, Dinnigan E, Theobald R, Grainger A, Skelton AJ, Hussain R, Willet JDP, Swan DJ, Coxhead J, Thomas MF, Thomas J, Zamvar V, Slatter MA, Cant AJ, Engelhardt KR, Hambleton S. Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in TNFAIP3 (A20). Annals of the Rheumatic Diseases 2018, 77(5), 783-786.
- Engelhardt KR, Xu Y, Grainger A, Germani Batacchi MGC, Swan DJ, Willet JDP, Abd Hamid IJ, Agyeman P, Barge D, Bibi S, Jenkins L, Flood TJ, Abinun M, Slatter MA, Gennery AR, Cant AJ, Santibanez Koref M, Gilmour K, Hambleton S. Identification of Heterozygous Single- and Multi-exon Deletions in IL7R by Whole Exome Sequencing. Journal of Clinical Immunology 2017, 37(1), 42-50.
- Taylor K, Swan DJ, Affleck A, Flohr C, Reynolds NJ. Treatment of moderate-to-severe atopic eczema in adults within the UK: Results of a national survey of dermatologists. British Journal of Dermatology 2017, 176(6), 1617-1623.
- Anderson AE, Swan DJ, Wong OY, Buck M, Eltherington O, Harry RA, Patterson AM, Pratt AG, Reynolds G, Doran JP, Kirby JA, Isaacs JD, Hilkens CM. Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T-cells partly via TGF-β1. Clinical & Experimental Immunology 2016, (ePub ahead of Print).
- Al Qayoodhi A, Hambleton S, Hattersley AT, Cant AJ, Flanagan SE, Engelhardt K, Swan D, Willet J, Xu YB, Koref MS, Leahy TR. Autoimmunity In STAT3 Gain Of Function Mutations; Broadening The Phenotype. In: UKPIN 2015 Meeting. 2015, Belfast, Northern Ireland: Wiley-Blackwell Publishing Ltd.
- Milner JD, Vogel TP, Forbes L, Ma CA, Stray-Pedersen A, Niemela JE, Lyons JJ, Engelhardt KR, Zhang Y, Topcagic N, Roberson EDO, Matthews H, Verbsky JW, Dasu T, Vargas-Hernandez A, Varghese N, McClain KL, Karam LB, Nahmod K, Makedonas G, Mace EM, Sorte HS, Perminow G, Rao VK, O'Connell MP, Price S, Su HC, Butrick M, McElwee J, Hughes JD, Willet J, Swan D, Xu Y, Santibanez-Koref M, Slowik V, Dinwiddie DL, Ciaccio CE, Saunders CJ, Septer S, Kingsmore SF, White AJ, Cant AJ, Hambleton S, Cooper MA. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood 2015, 125(4), 591-599.
- Taylor K, Swan D, Affleck A, Flohr C, Reynolds N. Treatment of moderate-to-severe atopic eczema in adults within the UK: results of a national survey. In: 95th Annual Meeting of the British Association of Dermatologists. 2015, Manchester, UK: Wiley-Blackwell.
- Swan DJ, Kirby JA, Ali S. Post-Transplant Immunosuppression: Regulation of the Efflux of Allospecific Effector T Cells from Lymphoid Tissues. PLoS One 2012, 7(9), e45548.
- Swan DJ, Kirby JA, Ali S. Modulation of T lymphocyte responses to chemokines by sphingosine 1-phosphate. In: Immunology: Annual Congress of the British Society for Immunology. 2010, Liverpool, UK: Wiley-Blackwell Publishing, Inc.
- Swan DJ, Kirby JA, Ali S. Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. Journal of Cellular and Molecular Medicine 2010, 14(9), 2211-2222.
- Anderson AE, Swan DJ, Sayers BL, Harry RA, Patterson AM, von Delwig A, Robinson JH, Isaacs JD, Hilkens CM. LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells. Journal of Leukocyte Biology 2009, 85(2), 243-250.
- Swan DJ, O'Boyle G, Kirby JA, Ali S. Differential effects of S1P on responses to homeostatic versus inflammatory chemokines. In: Annual Congress of the British Society of Immunology. 2008, Glasgow, Scotland: Wiley-Blackwell.
- Anderson AE, Sayers BL, Haniffa MA, Swan DJ, Diboll J, Wang XN, Isaacs JD, Hilkens CMU. Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells. Journal of Leukocyte Biology 2008, 84(1), 124-133.
- Anderson AE, Sayers BL, Swan DJ, Isaacs JD, Hilkens CM. Tolerogenic dendritic cell therapy for rheumatoid arthritis. In: BSR Annual Meeting and BHPR Spring Meeting. 2008, Liverpool: Oxford University Press.