Dr Lilian Nwosu
- Email: email@example.com
- Telephone: +44 (0) 191 208 2789
- Address: Institute of Cellular Medicine
M3.127, William Leech Building
I have a long standing background in the chronic pain field especially osteoarthritis pain (OA). This was as a result of my PhD which investigated structural and pain modifications in models of osteoarthritis pain within the Arthritis Research UK (ARUK) Pain Centre at the University of Nottingham. Prior to joining Newcastle University as a research associate, I took up a 1 year position as a research associate within the ARUK Pain Centre group and continued my research in OA pain.
BSc in Pharmacology with Extramural year, King's College London
Google scholar: Click here.
My Research Interests include:
- Chronic pain: neuropathic, inflammatory
- Osteoarthritis; sources of OA pain – subchondral bone biology, synovitis (inflammation), cartilage biology, nociception and sensitization
- Mechanisms of osteoclasts in contributing to pain in osteoarthritis
- Animal models of disease
- Rheumatoid arthritis
- Psoriatic Arthritis
- Synovial fibroblasts
- Dendritic cells
My research applies single cell RNA-sequencing to synovial biopsies from rheumatoid arthritis and psoriatic arthritis patients.
- Nwosu LN, Allen M, Wyatt L, Huebner JL, Chapman V, Walsh DA, Kraus VB. Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA. Osteoarthritis and Cartilage 2017, epub ahead of print.
- Nwosu LN, Mapp P, Chapman V, Walsh DA. Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA). Osteoarthritis and Cartilage 2016, 24(11), 1910-1917.
- Xu L, Nwosu LN, Burston JB, Millns PJ, Sagar DR, Mapp PI, Meesawatsom P, Li L, Bennett AJ, Walsh DA, Chapman V. The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain. Osteoarthritis and Cartilage 2016, 24(9), 1587-1595.
- Nwosu LN, Allen M, Wyatt L, Huebner JL, Chapman V, Walsh DA, Kraus VB. Serum TRAP5b predicts pain progression in knee osteoarthritis. In: 16th World Congress on Pain. 2016, Yokohama, Japan: International Association for the Study of Pain.
- Nwosu LN, Chapman V, Walsh DA, Kraus VB. Subchondral bone biomarkers as predictors of pain progression; linking pathology and pain. In: OARSI World Congress on Osteoarthritis (OA). 2016, Amsterdam, Netherlands.
- Nwosu LN, Mapp P, Chapman V, Walsh DA. Blocking the Tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis. Annals of Rheumatic Diseases 2015, 75(6), 1246-1254.
- Sagar DR, Nwosu L, Walsh DA, Chapman V. Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. Osteoarthritis and Cartilage 2015, 23(6), 906-913.
- Nwosu LN, Walsh DA. Response to: ‘Role of nerve growth factor (NGF) and tropomyosin receptor kinase A (TrkA) in the pathogenesis of osteoarthritis. Might NGF be the link interwinding obesity and OA?’ by Iannone et al. Annals of Rheumatic Diseases 2015, 74(12), e71-e71.
- Nwosu LN, Mapp PI, Chapman V, Walsh DA. Tropomyosin receptor kinase (Trk) A receptor inhibition reduces pain behaviour in a rodent model of osteoarthritis (OA). In: 9th Congress of the European Pain Federation EFIC. 2015, Vienna, Austria.
- Nwosu LN, Mapp PI, Chapman V, Walsh DA. Alterations in central pain processing are not restricted to end stage osteoarthritis in the monosodium-iodoacetate model of osteoarthritis (OA). In: OARSI World Congress on Osteoarthritis (OA). 2014, Paris, France: Elsevier.
- Nwosu LN, Mapp PI, Bouhana KS, Andrews SW, Chapman V, Walsh DA. Effects of anti-NGF strategies in two animal models of osteoarthritis (OA). In: American College of Rheumatology (ACR)/ARHP annual meeting. 2014, Boston, MA, USA.