Dr Marieke Emonts-le Clercq
Honorary Reader in Microcirculation
- Email: firstname.lastname@example.org
- Telephone: +44 191 2825984 DECT 26536
- Personal Website: https://www.linkedin.com/in/mariekeemonts/
- Address: Level 4
Clinical Resource Building
Great North Children's Hospital
Department of Paediatric Immunology & Infectious Diseases
Queen Victoria Road
Newcastle upon Tyne
As consultant Paediatric Infectious Diseases & Immunology and Honorary Senior Clinical Lecturer I have a sound background in clinic and research from the start. I studied Medicine and Biomedical Sciences in Leiden, the Netherlands, after which I combined my Paediatric training with a PhD post in the Paediatric Infectious Diseases Laboratory at Erasmus MC, Rotterdam, The Netherlands.
I completed my PhD on immunogenetics of infectious and inflammatory diseases in 2008. Initially focussing on meningococcal disease I broadened my horizon to include other bacterial infections. My PhD formed the start of wonderful collaborations resulting in participation in two large European funded consortia.
The overarching theme in activities is the promotion of therapeutic possibilities for childhood infections, particularly in an era of increasing antimicrobial resistance. This requires focus of the research on:
1. Early recognition of the type of infection: bacterial vs viral, and type of bacterial infection. This can minimise the unnecessary use of antimicrobials in patients presenting with fever at an A&E, and thus prevent antimicrobial resistance.
2. Identification of alternative therapeutic targets, particularly in recurrent infective conditions to circumvent antimicrobial resistance. Innate immune factors could be these targets and elucidating their role in infection will aid in identifying which ones could also be targeted for prevention and/or treatment.
3. Participation in randomised controlled trials facilitating registration of safe and effective antimicrobial/antiviral drugs for paediatric use.
Please click on the research tab above for further details.
This theme is also reflected in my work as consultant Paediatric Infectious Diseases & Immunology at the Great North Children's Hospital (GNCH) where I look after children with (severe) bacterial, fungal and viral infections. These include meningitis, osteomyelitis (in collaboration with the paediatric orthopaedic team) and a congenital CMV infections. With our team we provide a consultation service as part of the antimicrobial stewardship program.
My work spans basic science, observational research and randomised controlled trials (RCTs). The work focuses on infectious diseases in children with an interest in early diagnosis and innate immunity.
Additionally I conduct projects aimed at evaluation of infection management with direct impact on clinical practice.
EUCLIDS (European childhood life threatening infectious diseases study) is a large FP7 funded project looking at genetics of severity and susceptibility of infection using bacterial meningitis and sepsis as a model. Using RNA expression analysis disease specific profiles are being assessed to identify relevant pathways. Our collaborators explore findings in our patient population in in vitro and animal models.
PERFORM (Personalised medicine for febrile illness) is an €18 million collaborative project funded under the European Commission’s Horizon 2020 programme for research and innovation.
This five-year project will look at ways to reduce antibiotic misuse, through the development of improved tests used to distinguish bacterial from viral infections. Currently, doctors have very limited capacity to reliably differentiate life-threatening bacterial infections from trivial viral illnesses in children. As a result, thousands of children worldwide undergo investigations such as lumbar punctures, x-rays and blood cultures, and are treated with broad spectrum antibiotics while waiting to rule out bacterial infection. Better tests to identify those children with life threatening infection amongst the infinitely more numerous children with viral infections are urgently needed if antibiotic use is to be reduced. PERFORM will apply sophisticated genomic and proteomic methods to study thousands of febrile children with the aim of identifying and developing a better test for bacterial infection than what is currently available.
Newcastle will lead on the cohort including immunocompromised patients in whom infection risk is increased and diagnosing cause of infection can be very challenging.
I welcome contact from any students or potential collaborators who may be interested in working with us.
The EUCLIDS project involves collaboration with investigator from multiple sites in the UK, the Netherlands, Spain, Austria, Germany, Switzerland, Singapore, and Gambia.
PERFORM is conducted in UK sites (Liverpool, London, Oxford, Newcastle), the Netherlands (Rotterdam, Amsterdam, Nijmegen), Spain (Santiago de Compostella), Austria (Graz), Germany (Munich), Latvia, Greece (Athens), Gambia, Australia, Switzerland, and Singapore. Collaborators involved in Newcastle are:
Clinical: Dr Emma Lim and dr Rachel Agbeko
Business School Centre for Knowledge Innovation Technology and Enterprise (KITE): Professor Rob Wilson, Professor Mike Martin, Dr Lucille Valentine
ICM D&TT Research Group: Professor Calum McNeil and Dr Neil Keegan
We participate in recruitment of patients for other studies such as CHIMES (Oxford and Liverpool lead) and in the past Dinosaur (Southampton lead).
We are an active site for recruitment for patients for NIH (DMID-11-0069) and commercial (DAP-PEDOST) funded trials.
INIMUTI is a pilot project looking at innate immunity in UTI in collaboration with DrsJudith Hall and Philip Aldridge (Institute for Cell & Molecular Biosciences).
I am involved in the clinical teaching of medical students in paediatrics at GNCH.
I supervise undergraduate medical student SSC projects and Erasmus students in Paediatric Infectious Diseases and welcome anyone contacting me who may be interested.
- Martinon-Tores F, Salas A, Rivero I, Cebey-Lopez M, Pardo-Seco J, Herber J, Boeddha NP, Emonts M, Zenz W, Carrol ED, Van der Flier M, Levin M, EUCLIDS Consortium. Life-threatening infections in children in Europe – a prospective cohort study (The EUCLIDS Project). The Lancet Child & Adolescent Health 2018, 2(6), 404-414.
- Hoppenbrouwers T, Boeddha N, Driessen GJ, Emonts M, Hazelzet JA, de Maat MP. Neutrophil extracellular traps in children with meningococcal sepsis. Pediatric Critical Care Medicine 2018, Epub ahead of print.
- Schrier L, Hadjipanayis A, DelTorso S, Stiris T, Emonts M, Dornbusch HJ. European Antibiotic Awareness Day 2017: training the next generation of health care professionals in antibiotic stewardship. European Journal of Pediatrics 2018, 177(2), 279-283.
- Boeddha NP, Driessen GJ, Cnossen MH, Hazelzet JA, Emonts M. Circadian Variation of Plasminogen-Activator-Inhibitor-1 Levels in Children with Meningococcal Sepsis. PLOS One 2016, 11(11), e0167004.
- Boeddha NP, Emonts M, Cnossen MH, deMaat MP, Leebeek FW, Driessen GJ, Hazelzet JA. Gene variations in the protein C and fibrinolytic pathway: relevance for severity and outcome in paediatric sepsis. Seminars in Thrombosis and Hemostasis 2017, 43(1), 36-47.
- Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, deWit TD, Eichinger S, Fibbe W, Green T, deHaas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ, other authors. The European Hematology Association Roadmap for European Hematology Research. A Consensus Document. Haematologica 2016, 101(2), 115-208.
- Reynolds B, Hambleton S, Dammann D, Lambert H, Emonts M. Troublesome Thai travels. Archives of Disease in Childhood Education and Practice Edition 2015, 100(3), 166-167.
- Herberg J, Emonts M, Jacobs M, Riordan A. UK preparedness for children with Ebola infection. Archives of Disease in Childhood 2015, 100(5), 421-423.
- de Velde F, Emonts M, Verbruggen S, van der Sijs H. High tobramycin serum concentrations after tobramycin inhalation in a child with renal failure. Journal of Antimicrobial Chemotherapy 2014, 69(11), 3163-3164.
- Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart CJ, Cebey-Lopez M, Carter MJ, Janes VA, Gormley S, Shimizu C, Tremoulet AH, Barendregt AM, Salas AS, Kanegaye J, Pollard AJ, Faust SN, Patel S, Kuijpers T, Martinon-Torres F, Burns JC, Coin LJM, Levin M, for the IRIS Consortium. Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children. JAMA 2016, 316(8), 835-845.
- de Graaf H, Sukhtankar P, Arch B, Ahmad N, Lees A, Bennett A, Spowart C, Hickey H, Jeanes A, Armon K, Riordan A, Herberg J, Hackett S, Gamble C, Shingadia D, Pallett A, Clarke SC, Henman P, Emonts M, Sharland M, Finn A, Pollard AJ, Powell C, Marsh P, Ballinger C, Williamson PR, Clarke NMP, Faust SN. Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: A feasibility study. Health Technology Assessment 2017, 21(48), 1-198.
- Morillo-Gutierrez B, Waugh S, Pickering A, Flood T, Emonts M. Emerging (val)ganciclovir resistance during treatment of congenital CMV infection: A case report and review of the literature. BMC Pediatrics 2017, 17, 181.
- Boeddha NP, Schlapbach LJ, Driessen GJ, Herberg JA, Rivero-Calle I, Cebey-Lopez M, Klobassa DS, Philipsen R, de Groot R, Inwald DP, Nadel S, Paulus S, Pinnock E, Secka F, Anderson ST, Agbeko RS, Berger C, Fink CG, Carrol ED, Zenz W, Levin M, van der Flier M, Martinon-Torres F, Hazelzet JA, Emonts M. Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: A prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS). Critical Care 2018, 22(1), 143.