Institute of Cellular Medicine

Staff Profile

Professor Mark Birch-Machin

(1) Associate Dean of Business Development and Commercial interface (2) Professor of Molecular Dermatology (3) Deputy Degree Programme Director MRes (Biotechnology) (4) Co-Founder:Genesis Genomics (now Mitomics) Inc (5) Co-Founder PB Bioscience Ltd

Background

Mark Birch-Machin, Ph.D., is Professor of Molecular Dermatology and Associate Dean (Business Development and Commercial Interface)  at the Newcastle University Institute of Cellular Medicine.  Prof. Birch-Machin pursued his Post-Doctoral career at the University of Oregon (USA), INSERM Paris, University of Toronto as well as Clinical Neuroscience and Biochemistry, Newcastle University (1986-1995) where he held several academic positions in the Department of Dermatology (1996-current).  During this time, he was elected Treasurer of the British Society of Investigative Dermatology (BSID) and co-editor of Experimental Dermatology.  He advanced to the position of Professor of Molecular Dermatology at Newcastle University in 2005 and Associate Dean in 2014.

Prof. Birch-Machin’s research group focuses on the response of human skin to ultraviolet radiation particularly within the context of skin ageing and cancer, particularly involving the role of mitochondria and has published extensively including 3 different Nature journals.  He also has interest in understanding the role of mitochondrial DNA in UV-induced oxidative stress, cancer and the relationship between oxidative stress, nutritional status and skin aging as well as the science and use of sunscreens.  He has received research funding (multi-million total) from Cancer Research UK, British Skin Foundation, BBSRC, MRC, EPSRC, Wellcome Trust, NESRF, KTP, BRC, Innovate UK, NC3R, Royal Society and global commercial companies.  In addition, he is also a co-inventor on multiple patents arising from the commercialization of parts of this research, including the invention of a product that sold in over a 1,000 stores in Canada as part of a Canadian spin out company which Mark co-founded in 2003.  In 2010, Mark was awarded the Newcastle University Spirit of Entrepreneurship award and has gone on to be a co-founder of a second spin out company in 2012 which is now called PB Bioscience.  Prof. Birch-Machin has been an internationally and nationally invited keynote speaker at numerous prestigious conferences and symposia.  He has been Chair of several international Scientific Advisory Boards; member of the Cancer Research UK sunsmart advisory board, expert advisor for Clearcast, RACC and the ASA, and is a member of the grants awarding committee for the British Skin Foundation as well as the Editorial board for Experimental Dermatology.

Prof. Birch-Machin is regularly a National Press Spokesperson on ‘Sunburnt DNA,’ DNA damage, skin ageing and skin cancer risk related to his current and previous roles with national skin charities.  His research and quotes on sun awareness have appeared on multiple European and American TV segments (including 10 full TV programmes on BBC, ITN, Sky, Discovery), more than 250 radio programs, online columns, over 240 national and local UK newspapers and over 230 popular magazine articles. In addition, I have regularly and extensively contributed to the national education of sun-awareness using the popular media as well as public lectures (The Royal Institution and The Wellcome Collection). I have also given a mini-roadshow on sun-awareness to local schools, a regular Invited Public Speaker at the Discovery Museum Science Show (Newcastle), an ‘expert’ speaker at the European Union Excellence in Cities- Specialist Bioscience Summer School (EU funded).

As the original Degree Programme Director, Prof Birch-Machin designed, created and managed the team which administers the MRes in Medical and Molecular Biosciences which in 2 years became the largest postgraduate taught programme in the Faculty of Medical Sciences. Prof Birch-Machin has various University/Faculty including Chairing the Faculty Business Opportunities committee and the Faculty Commercialisation committee. 

 Google Scholar profile: Click here.

Qualifications

July 1983 B.Sc. (Hons) II(i) Biological Sciences
specialising in biochemistry. University of East Anglia

July 1987 Ph.D. in biochemistry, University of East Anglia.

June 1997 Certificate in Learning and Teaching in Higher Education
(Faculty of Education), University of Newcastle upon Tyne

Previous Positions

August 2014 Associate Dean in Development and Commercial Interface

August 2005: Professor in Molecular Dermatology
2003-2005: Reader in Molecular Dermatology
2001-2003: Senior Lecturer, Department of Dermatology, University of Newcastle upon Tyne
1995 - 2001: Lecturer, Department of Dermatology, University of Newcastle upon Tyne
1994 - 1995: Senior INSERM scientist (1 year appt.) Hôpital Necker, Paris, France
1992 - 1994: Lecturer, Department of Biochemistry and Genetics, University of Newcastle upon Tyne
1986 - 1992: Post-Doctoral Research Associate, Division of Clinical Neuroscience, School of Neurosciences, University of Newcastle upon Tyne. (including 4 months during 1989 at the University of Oregon, USA.

Memberships

Co-editor/editorial Board of International Journals:
Clinical and Experimental Dermatology (2004-2007), Experimental Dermatology (2009-current).

International Advisory/editorial Boards:
•  Expert Advisor for the Complaints and Investigations Board of the UK Advertising Standards Authority (2006-current)
• Member of the Editorial board of Experimental Dermatology (2010-current)
• Invited Member of the SunSmart Advisory Board, Cancer Research UK, April 2010-current

• Panel member for the British Skin Foundation grants committee

 

Member of the British Skin Foundation small grants award committee (2010-current)
Elected Treasurer (2002-2006) and Member of the organising and abstract selection committee of the British Society of Investigative Dermatology (BSID)which is the national body for investigative dermatology research in the UK.· Elected Committee member and Treasurer of the British Society of Investigative Dermatology 1999-2006(BSID), Director on the North Eastern Skin Research Fund.
Advisory panel member for the Science Media Centre (London)

Google Scholar: Click here.
 

Research

Research Interests

The work in my research group focuses on the cutaneous response to ultraviolet radiation (UVR) in terms of skin ageing and cancer and the molecular genetics of skin cancer. Specific areas of research are:

-Skin Ageing,Sun protection and sunscreens, environmental pollution and skin
- Mitochondria and UVR; in particular the novel approach of using mitochondrial DNA, rather than nuclear DNA, as a biomarker of cumulative UVR exposure. 
-Molecular genetics of skin cancer; in particular the role of mitochondrial DNA mutations in the development of human non-melanoma skin cancer. 
-The cutaneous response to ultraviolet radiation, including signalling mechanisms and the therapeutic use of UVR in skin disease.
-The role of mitochondria in the therapeutic action of dithranol in psoriasis
- The role of mitochondria in UV-induced oxidative stress.
- The relationship between oxidative stress, ageing and nutritional status.
- The role of mitochondrial DNA mutations in the ageing process
- Mitochondrial DNA damage and Oral Cancer
- Anti-Oxidants and free radicals (dietary and cosmetic (topical))

-Blood oxidative stress and sports training

Other Expertise

·Mitochondrial DNA and ageing.
·Mitochondrial DNA and cancer (e.g prostate cancer).

·Sunscreen Testing
·Sun Awareness

Esteem Indicators

Selected
1a. International keynote speaker: 

·         European Thyroid Cancer Research meeting, Warsaw, POLAND (August, 2001).

·         Universidad de Los Andes, Bogota, COLOMBIA (January 2004)

·         7th International Symposium, Predictive Oncology Strategies, Nice, France,  (Feb. 2004)

·         European Society of Dermatological Research (ESDR), Vienna, Austria, (Sept. 2004)

·         Sun Protection conference, Royal Society, London (2005)

·         Proctor and Gamble International Science Symposium, UK (2005)

·         European Academy of Dermatology and Venereology (EADV), Rhodes, Greece (2006)

·         European Academy of Dermatology and Venereology,Vienna (2007) (two invited keynote lectures)

·         Unilever Anti-aging symposium, Trumbull, USA (February 2008)

·         Dermatology update, Whistler, Canada (April 2008)

·         Anti-ageing skin care conference, Royal College of Physicians, London, UK, June 2008

·         Innovative anti-cancer drugs  and strategies, 1st symposium, UK 2010

·         Targeting Mitochondria, Berlin 2011

·         European Society for Photobiology, Geneva 2011

·         ESDR, Barcelona, 2011

·         Mitochondria symposium, Luebeck, Universitätsklinikum Schleswig-Holstein, Germany 2011

·         Irish Radiation Research Society Conference 2011, Sligo, Ireland

·         Targeting Mitochondria 2011 International Conference, Berlin, Germany 2011

·          5th Skin academy symposium, challenges in Skin disease management, Barcelona, Spain 2012

·         Tomatoes and Health, Royal Society of Medicine, London, UK 2012

·         American Society for Dermatologic Surgery, Atlanta, 2012

·         European Radiation Research, Dublin 2013

·         6th Asia and Oceania conference on photobiology, Sydney 2013.          

·              Chinese Dermatological mini symposium, Beijing 2013

·         FACE (international Facial Aesthetic Conference and Exhibition), keynote lecture, London 2015

·         World Congress of Dermatology, Vancouver Canada 2015-keynote lecture; skin ageing

·         World Congress of Dermatology, Vancouver Canada 2015-keynote lecture; hair and ox. stress

  • Anti-ageing Skin Care Conference, Royal College of Physicians, London 2016

  • 6th Annual World Congress of Molecular and Cell Biology, Dalian, China, 2016

  • Anti-ageing Skin Care Conference, Singapore 2016.

  • FACE (international Facial Aesthetic Conference and Exhibition), keynote lecture, London 2016.

  • EADV, Vienna 2016

  • Society of Cosmetic Chemists, Singapore 2017 

  • FACE (international Facial Aesthetic Conference and Exhibition), keynote lecture, London 2017.

  • 7th Annual World Congress of Molecular and Cell Biology, Xian, China, 2017

  • European Society of Photobiology, Pisa, Italy 2017

 

1(b) National keynote speaker:

·         Biogerontology Research Symposium, June 2002.

·         Cancer Research UK Sunsmart Campaign launch, London, Feb. 2003.

·         Practical Update in Dermatology, Lumley Castle, Durham, March 2004.

·         Practical Update in Dermatology, Lumley Castle, Durham, February 2006

·         British Association of Cosmetic Doctors, March 2006

·         Health Protection Agency (Toxicology), University of Surrey, May 2006

·         70th Anniversary Oral Surgery Association of Great Britain, November 2006

·         The Academy of Pharmaceutical Sciences, London, April 2007

·         British Association of Dermatologists annual conference (BPG symposium), Birmingham 2007

·         United Kingdom Environmental Mutagen Society, Newcastle, June 2008

·         CPTA (cosmetic, toiletry, and perfumery association) meeting, London (April 2009)

·         Almirall annual meeting, Telford, May 2009

·         British Society for Research on Ageing, Manchester (June 2009)

·         British Cosmetic Dermatology Group, Manchester 2010

·         Public Lecture, Royal Institution, London 2011

·         Primary Care Dermatology Society, Oxford 2011

·         Cosmetics Toiletry and Perfumery Association (CPTA), London 2012

.         British Skin Foundation 20th Anniversary, London 2106

.         British Society of Investigative Dermatology, Manchester  UK, 2017 

.         London College of Fashion 2018

 

1 (c) Invited lectures                   a) International

·        Department of Molecular Biology, Eugene, University of Oregon USA (1989). 

·        Symposium on mitochondrial myopathies, Nijmegen, Netherlands (1990).

·        2nd International Congress on Human Mitochondrial Pathology, Rome, Italy (1992).

·        Unité de Recherches sur les Handicaps Génétiques de l'Enfant, Hôpital Necker, Paris, France (1994).

·        3rd International Congress on Human Mitochondrial Pathology, Chantilly, France (1995).

·     Department of Neurology, McMaster University Medical Center, Hamilton, Ontario, Canada

     (May 2000).

·     Mitochondria 2001, San Diego, USA (1st March, 2001)

·     Metabolism Research Instititute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada (July 2001).

·     Metabolism Research Instititute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada (August 2002).

·     Lakehead University, Northwestern Ontario Regional Cancer Centre and Genesis Genomics, Thunder Bay, Ontario, Canada (August 2002).

·     McMaster University Medical Center, Hamilton, Ontario, Canada (August 2006).

·        European Society of Dermatological Research (ESDR), Paris, Austria, (Sept. 2006).

·        European Society of Dermatological Research (ESDR), Zurich, Switzerland, (Sept. 2007).

·        European Academy of Dermatology and Venereology, Paris (2008)

·        Procter and Gamble, Cincinatti, USA 2010

·        Melanoma 2010, Sydney, Australia 2010

·        World Congress of Dermatology, Seoul, South Korea, 2011

·        Oregon Health and Science University, Portland, Oregon  2011

·        Mount Sinai Hospital, New York, USA, 2012

·        Guangxi Medical University, Nanning, China 2012

·        Procter and Gamble, Vision House Event, Abu Dhabi and Bangkok, 2012

·        Procter and Gamble, Vision House Event, Beijing 2013

 ·       University of Sydney, Bosch Lecture 2014

 ·       World Congress of Dermatology, Vancouver Canada 2015, oral session

-       3rd International Conference on UV and Skin Cancer Prevention, Melbourne, Australia 2015

-      University of Otago Christchurch, New Zealand 2015

-      University of Otago Dunedin, New Zealand 2015

-      Invitational speaker: Summit of Global Research VPs, Croda, Manchester UK, Dec 2017

-    Estee Lauder Global meeting, Long Island, New York, USA December 2017

-    Society of Cosmetic Chemists, Florida 2017

-    The Bosch Institute, University of Sydney 2018

-     L’Oreal SE Asia meeting, Singapore 2018

-     Procter and Gamble Symposium, Singapore, 2018

  

1 (d) National

·        Advanced course in neuromuscular diseases, University of Newcastle upon Tyne (1988 and 1990).

·        Department of Biochemistry, University of Cambridge (1992).

·        Annual Meeting of the British Society for Investigative Dermatology, Bristol, UK (1997).

·        Department of Biological Sciences, University of East Anglia, Norwich, (1999).

·        Unilever Research, Colworth Laboratory, Bedford (2000).

·        Department of Dermatology and Photobiology, University of Dundee, 2001.

·        Northern Institute for Cancer Research, University of Newcastle, April 2002

·        Department of Dermatology, Hope Hospital, Salford, July 2002

·        Café Scientifique, Manchester, June 2003.

·        Café Scientifique, PEALS seminars, Newcastle, July 2003

·        Cancer Research UK Legacy Symposium, Newcastle, July 2003

·        Centre for Cutaneous Research, Barts and The London, Nov 2003.

·        The Court House Clinic Network UK, 2005.

·        RAFT Institute, London, 2006

·        British Association of Dermatologists annual conference, BSF prize, Birmingham 2007

·        Procter and Gamble, Egham, Surrey, 2008

·        Department of Pathology, RVI, Newcastle 2009

·        Institute of Ageing and Health, Newcastle 2009

·        Primary Care network, South East, UK, 2009

·        Primary Care network, Midlands UK, 2009

·        University of Bradford, School of Life Sciences, July 2009

·        Dundee University and Dermatology (Ninewells), October 2009

·        Primary Care Network, Scotland, 2010

·        National Journalist Beauty School, Royal Institution, London 2012

·        Procter and Gamble, Egham, Surrey, 2012

·        CPTA, London 2013

 ·       Bioenergetics Symposium, London, 2014

 ·      Public Lecture, University of Derby 2015

 ·      The Wellcome Collection Public Lecture, London 2015

-       Regional Phototherapy meeting Durham 2015

-      British Skin Foundation 20th Anniversary, London 2106

-     Life Sciences Student Conference, Coventry 2017

-      Bionow conference, Newcastle 2017

-      Skin Forum at Bath University, Bath UK, Dec 2017


 2. Co-editor/editorial Board of International Journals:
Clinical and Experimental Dermatology (2004-2007), Experimental Dermatology (2009-current).

3. International Advisory/editorial Boards:
•  Expert Advisor for the Complaints and Investigations Board of the UK Advertising Standards Authority (2006-current)
• Member of the Editorial board of Experimental Dermatology (2010-current)
• Invited Member of the SunSmart Advisory Board, Cancer Research UK, April 2010-current

• Panel member for the British Skin Foundation grants committee

• Member of the Procter and Gamble Alliance Global Advisory Board 2010-2014

4. National Dermatology:
Member of the British Skin Foundation small grants award committee (2010-current)
Elected Treasurer (2002-2006) and Member of the organising and abstract selection committee of the British Society of Investigative Dermatology (BSID)which is the national body for investigative dermatology research in the UK.

Other esteem indicators

• Global Advisor for Procter and Gamble beauty (Alliance team), 2010-2014
• Global Advisory Board of Skinceuticals (New York)
• Advisor for Procter and Gamble beauty (Olay Regenerist team (Vision House), 2012-2014
• Invited member on NESTA (July 2011) to inform the Labour party policy review led by Chi Onwurah MP, Shadow Minister for Innovation and Science,
• Member of the British Skin Foundation small grants award committee (2010-current)
• Member of the Editorial board of Experimental Dermatology (2010-current)
• Co-editor of Clinical and Experimental Dermatology (2004-2007)
• Treasurer (2001-2006) of the British Society of Investigative Dermatology. 
• Member of the Abstract Selection Committee for the British Society of Investigative Dermatology (1998-2006).
• Invited Member of the SunSmart Advisory Board, Cancer Research UK, April 2010-2015.
• Member of the connectmedical working party to develop a consensus guideline for the management of actinic keratosis in primary care. London July 2004.
• Member of the national scientific site visit panel for peer review of the RAFT Research Charity, Mount Vernon Hospital, Middlesex, UK (2005-06)
• Expert Advisor for the Complaints and Investigations Department of the UK Advertising Standards Authority (2006-2008)
• Expert Advisor for the Cosmetic Toiletry and Perfumery Association (CPTA) (2008-current)
• Scientific expert for the European Food Safety Authority (EFSA) 2008-current
• Peer Reviewer for SickKids Foundation, Toronto, Canada (2010-current)
• Expert reviewer for the Natural Sciences and Engineering Research Council of Canada (NSERC) 2008-current.

• I have reviewed numerous papers for many international peer reviewed Journals including: the Biochim Biophys Acta, European Journal of Human Genetics, British Journal of Cancer, European Journal of Biochemistry, the International Journal of Biochemistry, the Journal of Investigative Dermatology, the British Journal of Dermatology, Clinical Endocrinology, International Journal of Experimental Pathology, Clinical and Experimental Dermatology, Aging Cell, Clin Chim Acta, Experimental Dermatology, British Journal of Nutrition, Photochemistry and Photobiological sciences, International Journal of Radiation Biology, Journal of Experimental & Clinical Cancer Research, Carcinogenesis, Molecular Carcinogenesis and International Journal of Cosmetic science. 

• I have also reviewed many grant applications including the MRC, Wellcome Trust, BBSRC, British Skin Foundation, Cancer Research UK, Association for International Cancer Research, Ontario Healthcare Trust (Canada) and The Sheffield Hospitals Charitable Trust and Oxford Hospitals Charitable Trust. 

• PhD thesis external examiner on many occasions over the last 15 years including Universities of Edinburgh, Bradford, Queen Mary London, Dublin, Galway, Manchester, Liverpool, Coventry.

• Designed, created and established and became Degree Programme Director of (September 2002-2007) postgraduate degree, MRes in Biomolecular Sciences, Faculty of Medical Sciences, University of Newcastle. This was and is still the largest Masters programme in FMS.

• Programme Director for the MRes in Biotechnology and Business Enterprise, Newcastle University (2010-2017)

• Director of the North Eastern Skin Research Fund (2005-current).

• Chairman of the Scientific Advisory Board for Genesis Genomics Inc., Thunder Bay, Canada (2001-2006)

• Conference Organisation: Organised and chaired the workshop on practical problems of assessment of respiratory chain activities, at the 3rd International Congress on Human Mitochondrial Pathology, Chantilly, France (1995).

• Conference Organisation: Member of the organizing committee and chaired sessions at 7 Annual meetings of the British Society of Investigative Dermatology meetings from 1999 to 2006 

Dissemination of knowledge to the general public and Engagement
Television.  -  
• Feature on Sunburnt DNA research on ITN News, May 2002.
• Discovery Health Satellite Channel, Health issues (August 2002)
• ITN Tonight with Trevor McDonald, July 2003 (full 30 min. programme)
• Makeovers from Hell, prime time ITV, August 2003
• Live expert interviews on BBC News 24 and Sky News  
• (September 2003)
• BBC Look North Live Studio Interview (5 mins), March and July 2004
• Tyne Tees Interview, March and July 2004
• Swiss National TV documentary (2004)
• Medstar TV: America’s leading Medical and Health News (August and September 2004)
• Launch of Genesis Genomics UK, ITN news and local BBC TV November 2005
• This Morning ITV- 10 minute live studio interview, Schofield and Britten, 2006
• Truth About Food, BBC2 (2007)
• Discovery Channel, USA 2007 
• Truth About Food, Discovery Channel (2007)
• Tomato/Lycopene story- Look North and Tyne Tees, May 2008
• Northern Eye, Stay Young Forever, Tyne Tees, ITV1, August 2008
• Look North news items, throughout 2009 to current
• BBC1 : Bang goes the Theory 2012
• BBC ONE show 2011 and 2018
• BBC Breakfast (Whale stories 2013 and Tiron stories 2014)
• Embarrassing Bodies 2014
• ITV Tonight  2014, 2016 and 2017
• BBC How to Look Young 2017 (with Angela Rippon)
• BBC World Service 2017 and 2018 
 
• National Press Spokesperson on DNA damage and Skin Cancer for Cancer Research UK (Many occasions during 2002 - 2015).  Principal invited speaker at the National Press Launch of the Sunsmart campaign 2003.    
 
• 250 National Radio broadcasts. For example, BBC Radio 4 (The Material World), BBC Radio 4 (Today Programme) and Radio 2, BBC Radio Five Live, BBC Radio Newcastle (Mike Parr Show, Sound Advice, The Zoo news bulletins), LBC (London), BBC Radio Cleveland, Independent Radio News network (250 national and local radio stations), BBC Radio Oxford, BBC 3 Counties Radio, Century Radio, Metro Radio, Viking Radio, BBC Radio Scotland, BBC World Service. International Radio: World Service, The International Media Line Service.

• Online Advice/News: BBC online, Channel 4 and BBC, Daily Mail online (Femail.co.uk), Hero (Higher Education and Resource Opportunities in the UK). Reddit (number 2 rated story of the day 2017) 

• 470 National Magazines and National/Regional Newspapers.  Examples are: New Scientist. Nature, National Geographic, The Sunday Telegraph, The Times, Independent, The Guardian, Daily Star, The Sun, The Daily Mail, Daily Mirror, The Evening Chronicle, The Journal, The Northern Echo, Sunday Sun, Belfast Telegraph. In addition, I have been interviewed for articles published in NOW Magazine, Marie Claire, Saga Magazine, She Magazine, Woman’s Own, Superdrug Magazine, Readers Digest, Pharmacy Magazine, Company Magazine, Good Housekeeping, Zest, Eve, Marie Claire, Vogue, Cosmopolitan, Sunday Times Travel magazine, Grazia. International Newspapers such as The New York Times, Sydney Herald.

• Science Media Centre, London. Current member of the panel of experts called on to speak to the national press.  (2003-current). 

• A Guest Expert for media workshops, Newcastle University April 2014-2017 and Faculty of medical Sciences 2010-2016 and Procter and Gamble scientists (2012)

•    Invited Public Speaker at the Discovery Museum Science Show, Newcastle upon Tyne (2004 and 2005).

•   Media expert at the European Union Excellence in Cities Specialist Bioscience Summer School: funded by the EU social fund. University of Newcastle, July 2004 and 2005. 

• Invited public lecture on sun-awareness at the Wellness show, Newcastle (2005)

• Mini Medical School: research talk to lay audience Autumn 2008 and 2010

• Expert speaker at Faculty wide media training workshops (2009-current)

• Global media roadshow as part of my consultancy with Procter and Gamble. Presented to audiences of 300 international journalists at various events  in Bangkok, Beverly Hills, Abu Dhabi, New York ,Beijing sharing the stage with Hollywood names such as Gwyneth Paltrow and Liv Tyler.

Funding

Research (including consultancy research contracts) have been funded over the years by:

Cancer Research UK
Cancer Research Technology
The Wellcome Trust
BBSRC
EPSRC
MRC
British Skin Foundation
Royal Society
University of Newcastle

NC3R

Public Health England

Innovate UK

RVI Trustees

A large number of global commercial companies plus:

Genesis Genomics
North Star Investments
One North East
Department of Trade and Industry
PB Bioscience

 

 

Industrial Relevance

Founder and CEO of the UK subsidiary:Genesis Genomics UK (now called Mitomics)  

  • I invented a product that sold in over a 1,000 stores in Canada and in another commercial application I played a key role in the PCMT prostate cancer test used as a case study in UoA5 REF return

Founder: PB Bioscience Ltd http://www.pbbioscience.co.uk/

 

    In May 2010, awarded the Newcastle University Spirit of Entrepreneurship Staff award

    ·        Contract Research with global cosmetic companies over the last 15 years which have also attracted many business vouchers.

    ·        6 KTP (Knowledge Transfer partnerships)  funded projects

    ·        2 KTS (Knowledge Transfer secondments)

    ·        7 CASE Studentships with global companies

    • Newcastle University representative on the UK innovation round table for the Labour Shadow Cabinet (London 2011).

    • As Associate Dean and lead PI of the MRC Proximity to discovery award to FMS, I designed and lead the launch of the Exploring Life-Science partnerships showcase event first in London (London campus) in 2017 and then in Singapore (NewRIIS campus) in 2018, the latter SE Asia event with Monash University, Melbourne and the respective Malaysian campuses. 

    Patents.

    • Co-Inventor of the world-wide umbrella patent for Genesis Genomics (GGI) (2003) ((PCT: wo 02101086) complete mitochondrial genome sequences as a diagnostic tool for the health sciences)
    • Co-inventor for 2 recent (Oct 2005) GGI patents (US patent office) on Mitochondrial Rearrangements to Diagnose Sun exposure and Cancer a mtDNA deletion (2004) (Number 31726-2017) and The Use of a 3895 BP Mitochondrial DNA Deletion as a Marker for Sunlight Exposure in Human Skin (serial no. is 2,480,184 and the file no: 102222-02).
    • Co-inventor : MITOCHONDRIAL SITES AND GENES ASSOCIATED WITH PROSTATE CANCER,United States of America patent office Serial Number: 11/339,751.
    • University of Newcastle upon Tyne patent no GB 0600903.9. The use of at least one agent which induces ER stress together with at least one agent which gives rise to protein disulfide isomerase inhibition for the preparation of a medicament for the treatment of cancer.
    Secured Jan 2006 Inventors: PE Lovat, CPF Redfern, MA Birch-Machin

    Teaching

    Teaching

    I have previously taught, assessed and contributed to curriculum development on three degree courses, the Pharmacology BSc., Biomedical Sciences BSc. and the MBBS.  In the 2001/2002 academic year, as I created, designed and was the Degree Programme Director for the new MRes degree. I grew the degree from 7 students to more than 80 in 3 years. During this time I secured student bursaries worth £378,800. During this time I established the MRes team and handed the directorship over to one of the team in 2006/2007 when the numbers were over 100 (the current intake is now around 250).

    Until 2106, I was the programme leader for the MRes in biotechnology and business enterprise which I created in 2007/08.

    PhD teaching
    Contribute to the new training programme for research students (implemented 2004) in particular teaching on promoting public understanding (links with media profile above) and commercialisation lectures.

    PhD Supervision: I have been involved in annually supervising/co-supervising PhD students for at least 18 years and all my students have written up and submitted within the allowed timescale of 4 years. I currently supervise 7 PhD students with 3 new students starting in September 2018.

    Examiner
    External Examiner for 30 PhD and MD students in the UK and Europe. Internal Examiner for 2-3 PhD students per year for the last 10 years.

    Assessement
    For the last 15 years I have been a PhD assessor for between 4-7 students per year.

    Deputy Programme Director for the MRes in Medical and Molecular Biosciences. 

    Strand Leader for the Mres Biotechnology and Business Enterprise.
    Module Leader for Medical Biotechnology and Enterprise (MRes)


    Administration

    Current Committees (mainly through my position as Associate Dean of Business Development
    • Chair the FMS Enterprise Team Opportunities Committee and facilitate the development of these opportunities
    • Chair the FMS Commercialisation committee which has proposed changes to the Faculty corporate engagement strategy
    • Represent FMS on the Newcastle University Enterprise sub-committee
    • Represent FMS on the University Equity Case Committee
    • Represent FMS on the University Founderships Management Group
    • Represent FMS on the University Engagement Committee
    • Represent FMS on the NELEP
    • Represent FMS on the Joint Business Executive with the Trusts
    • Represent FMS on the University KTP Steering Group
    • Represent FMS on the University Engagement Committee and panel member for the 2016 Engagement Fund
    • Represent FMS (Faculty Academic Champion) on the National Innovation Centre for Ageing (NICA)
    • Member of the Faculty Research and Innovation Committee (FRIC)
    • Chair the FRSC Impact sub-committee
    • Lead of the FMS Proximity to Discovery Team
    • Member of the AHSN Health Grand Challenge Steering Group
    • Degree Programme Director MRes (FMS)
    • Strand Director of the MRes in Biotechnology and Business Enterprise

    Relevant historical responsibilities
    • Member of the MRes degree programme lead team
    • Member of the curriculum committee for the MRes
    • Member of the Exam Board for the MRes
    • Faculty Research Strategy committee FRSC (leading on innovation) 2008-2016 
    • Chair of the Research Impact FRSC working group
    • Chair of the Institute of Cellular Medicine- commercialisation team 2009-2016
    • Faculty of Medical Sciences member for the University Rise Up Stakeholders Group (Careers service) 2010-2016
    • Lead of the commercialisation team in the Institute of Cellular Medicine Research Board (2009-current), Newcastle University
    • Member of the Faculty Research Strategy committee (innovation role), Newcastle University 2009-2016
    • Member of Graduate School Committee, Faculty of Medical Sciences, University of Newcastle
    • Member of the University's Learning and Teaching Strategy Review (with Professor Katharine Perera, University of Manchester).


    Publications