Institute of Cellular Medicine

Staff Profile

Dr Shoba Amarnath

Newcastle University Research Fellow

Background

Background

I obtained a B.Sc. in Biochemistry from University of Madras, Chennai, India. I then moved to the University of Hull to pursue a M.Sc in Biotechnology and Molecular Biology. I stayed on in Hull on an Overseas Research Scholarship (ORS) award to continue my PhD with Prof. John Greenman. In 2005, I moved to the National Institute of Dental and Craniofacial Institute at the National Institutes of Health, to pursue a post-doctoral fellowship with Dr.Wanjun Chen. In 2007, I joined Dr.Daniel H. Fowler's laboratory at the Experimental Transplantation Immunology Branch, NCI, NIH. During my time at the NIH, the main focus of my research has been understanding the basic biology of regulatory T cells and the various signalling networks that maintain regulatory T cell function. My research at NIH has led to two clinical trials, patents, FOCIS awards etc. 


Qualifications

2000- B.Sc. Biochemistry, Madras University, Tamil Nadu, India

2001- M.Sc. Biotechnology & Molecular Biology, University of Hull, Hull, UK

2005- Ph.D Immunology, University of Hull, Hull, UK


Previous Positions

2015-Present: Newcastle University Research Fellowship, Newcastle University

2011-2015: Research Assistant Professor, NCI, NIH, USA

2007-2011: Post-doctoral Fellow, NCI, NIH, USA

2005-2007: Visiting Post-doctoral Fellow, NIDCR, NIH, USA


Active collaborators include

Dr. Ethan Shevach, NIAID, NIH, USA

Dr. Sander van-kasteren, Leiden University

Prof. Colin Watts, Dundee University

Prof. Ruth Plummer, Newcastle University

Prof. Penny Lovat, Newcastle University


Funding

1. MRC DTP-DiMEN PhD Studentship

2. Springboard Award from the Academy of Medical Sciences 

3. Lonza


For any lab related resources/protocols please visit our laboratory website at

https://blogs.ncl.ac.uk/amarnath



Research

The research vision of my laboratory is to decipher the intricate immunological networks that regulate immune tolerance in health and disease. Specifically, we focus on understanding how a clinically relevant coreceptor molecule called programmed death-1 receptor (PD-1) dampens T cell and Innate lymphoid cell function. We aim to understand how regulatory T cells and ILC2s are affected by PD-1 signaling and identify key molecules that are involved in these processes.  Our laboratory uses in-vitro biochemical approaches and experimental murine models to fully understand these processes in tumour, autoimmune and alloimmune diseases.

Teaching

I have mentored numerous undergraduate, medical students, clinical fellows at the NIH.

I also lecture on T cells which is part of the curriculum for the M.Res Immunobiology Module 

Publications