Institute of Cellular Medicine

Staff Profile

Dr Stuart McPherson

Honorary Clinical Senior Lecturer

Background

Dr Stuart McPherson is a Consultant Hepatologist at the Liver Transplant Unit at the Newcastle upon Tyne Hospitals NHS Foundation Trust and an Honorary Clinical Senior lecturer at Newcastle University.

Stuart’s major clinical interests include viral hepatitis, fatty liver disease, cirrhosis and liver transplantation.

Dr McPherson is research active with several recent publications in viral hepatitis, non-alcoholic fatty liver and cirrhosis. He is also PI for multiple commercial clinical trials.

Other roles:

Clinical Lead for North East and North Cumbria Hepatitis C Network  2015-

Secretary of the British Society of Gastroenterolog  2017-

Chair of BTS Guideline development group for hepatitis B and E   2016 -

NICE Clinical Advisor   2018-

Hepatology speciality lead for North East and North Cumbria CRN   2012 – 2017

British Society of Gastroenterology liver committee member  2013 – 2016

Research

Non-alcoholic fatty liver disease (NAFLD)

My current focus for research in fatty liver disease is around risk stratification of patients using non-invasive markers of liver fibrosis. In addition, I am conducting a pan-European study assessing the natural history of NAFLD using a large cohort of patients with paired liver biopsies. This research will help to define more effective clinical trial endpoints for therapeutic studies.

My current research in fatty liver disease is around risk I am a core member of the €34M Newcastle led pan-European LITMUS consortium that is developing biomarkers to stage and monitor disease activity in NAFLD.

Viral Hepatitis

My current research in viral hepatitis is focused around assessing the efficacy of innovative methods of delivery of blood borne virus testing in drug treatment services, community pharmacies and prisons. In addition, we are evaluating the efficacy of novel hepatitis treatment services, such as the use of telemedicine, aiming to eliminate hepatitis C from the region by 2025.

I am the CI for the ENHANCE study, which is assessing the impact of metabolic risk on quality of life in patients with hepatitis C.

Cirrhosis

I am passionate about improving the care of patients with cirrhosis. I led the development of a care bundle for patients with decompensated cirrhosis, which is now endorsed by the British Society of Gastroenterology and widely used across the UK. We have now demonstrated, in a multicentre study that use of the bundle substantially improves care of these patients. We were awarded the Royal College of Physicians Quality Improvement award in 2017. We are now developing other care bundles for patients with chronic liver disease to help reduce variation in patient care.


Teaching

Lead for the 4th year CSIM2 course liver week

Contribute to FOCP GI week

SSC supervisor - currently arranged privately

Publications