Institute of Genetic Medicine

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World-first research project to unlock secrets of human development

A world-first research project will unravel how human embryos develop in the first weeks and months after fertilisation, improving understanding of fertility, birth defects and regenerative medicine.

The £10 million Wellcome-funded Human Developmental Biology Initiative (HDBI) will build a ‘family tree’ of how cells divide and specialise following fertilisation, to understand how tissues and organs develop and reveal new insights into how this process can go wrong.  

Experts at Newcastle University have a leading role in the project, including studying the family tree of blood and immune cells to establish their origin, and to apply genome editing to examine the biological processes during early development.

Refining treatment approaches

Professor Muzlifah Haniffa, from Newcastle University’s Faculty of Medical Sciences, said: “Our examination of blood and immune cells will have implications for stem cell therapy and regenerative medicine and improve our understanding of childhood cancers such as leukaemia.

“Furthermore, some of our immune cells, such as macrophages, seeded early during development and persist to adulthood are involved in inflammation and disease. Understanding their family tree will help us develop new treatment approaches.

“HDBI research will complement the Human Development Cell Atlas studies pioneered at Newcastle University in collaboration with Wellcome Sanger Institute.”

Around 3% of babies are born with developmental defects – problems that often start very early in pregnancy such as heart defects, spina bifida and cleft palate. But scientists know very little about why and how they happen.

The new research initiative will create ‘family histories’ of cells from particular time-points in development or organ systems – the early human embryo, the brain and spinal cord, the blood and immune system, and the heart and lungs.

For many years, developmental studies have relied on cellular and animal models. While this has provided important information, it’s also become clear that our understanding of early human development remains extremely limited. To address this, the HDBI will tackle some of the biggest challenges that are holding the field back.

Unlike Newcastle, very few labs have access to human embryo tissue samples meaning that key pieces of research that will underpin the field have yet to be carried out. And when available, this tissue is incredibly diverse, reflecting the genetic and environmental origins, making insights hard to define.

Professor Mary Herbert, from Newcastle University’s Faculty of Medical Sciences, said: “In collaboration with researchers at the Crick Institute, my team and I aim to apply novel approaches to enable us to study fundamental biological processes in living human embryos. 

“This innovative research will, for the first time, provide an in vivo system for investigating key aspects of the very earliest stages of human development, up to the time of implantation.

“Our work has the potential to greatly advance our understanding of the causes of infertility, chromosomal abnormalities and inheritance of mitochondrial DNA.”

You can read the full press release on the University press office page.

Professor Mary Herbert
Professor Mary Herbert

published on: 31 July 2019