Institute of Genetic Medicine

Cardiovascular Disease

Cardiovascular Disease

Cardiovascular research at the Institute of Genetic Medicine (IGM) uses a range of complementary approaches to investigate cardiovascular disease.

Research

Our research teams investigate cardiovascular function across the lifespan, from in utero to the elderly, with a shared goal of understanding pathogenesis, decreasing disease prevalence and improving patient outcomes.

Our approach involves next generation high-throughput Omic technologies (genomics, transcriptomics and proteomics), bioinformatics and animal disease modeling. To achieve this we work in close partnership with our colleagues within the medical faculty and NHS services as part of the Newcastle University Cardiovascular Research Centre.

 

Teaching

Teaching

All the members of the cardiovascular research group at IGM deliver research-informed teaching and supervise laboratory-based research projects for undergraduate and post graduate students.

Our Masters by Research (MRes) program allows students to obtain a Masters degree in a Cardiovascular related theme or just include the core module into their studies. All these MRes programmes are suitable for both science graduates and intercalating medical students.

The MRes Programme in Cardiovascular Science in Health and Disease (MMB8037) is the principle cardiovascular module and programme at Newcastle University led by Michael Taggart. The taught components provide a detailed understanding of the development and function of the heart and vasculature and insight to the dysfunctional processes that underlie many cardiovascular diseases. This prepares the student for an intensive 6 month laboratory project and dissertation.

The MRes Programme in Stem Cells and Regenerative Medicine (MMB8031) module and programme is led by Annette Meeson. It concerns an important focus of research at IGM, stem cell biology. There is a strong emphasis on stem cells in cardiovascular development and disease, and a range of cardiovascular projects are available.

MRes module Developmental Genetics (MMB8031). Simon Bamforth leads this module which provides a broad training in fundamental aspects of developmental biology including cardiac development. The cardiovascular group at IGM use mice and zebrafish to study development providing unique opportunities to learn key skills.

Undergraduate teaching

Undergraduates can study a number of courses that include modules with lectures delivered by members of the cardiovascular groups. These include:

Expertise

Principal InvestigatorArea of Expertise
Prof Helen Arthur TGFB signalling, angiogenesis, preclinical models and genetic models of disease
Dr Simon Bamforth Small animal models, Imaging, Transcriptomics
Dr Bill Chaudhry
NGS of whole exomes and RNASeq; cardiac development in human, zebrafish and mouse; CRISPR-Cas9 genome editing; congenital heart disease; cardiomyopathy
Dr Louise Coats Adult congenital heart disease, Fontan circulation, cardiac imaging, patient related research
Prof Deborah Henderson Cardiac outflow-tract development; Cre-lox mice, bicuspid aortic valve; congenital heart defects
Dr Guy MacGowan MR studies of age-related changes in cardiac function and energetics, cardiomyopathy, heart failure
Dr Annette Meeson Stem cells in cardiac development and regeneration
Dr Andrew Owens Native cardiac stem cells, Cardiac fibrosis, Aortic valve surgery
Dr Helen Phillips Heart development, mouse models, imaging, cardiovascular disease, autophagy
Dr Gavin Richardson Regeneration, senescence, stem cells, telomere biology
Prof Ioakim Spyridopoulos Telomere length, T-cell immunity, acute myocardial infarction, clinical trials
Prof Konstantinos Stellos RNA modifications, RNA metabolism, inflammation, coronary heart disease, heart failure, biomarkers, prevention, RNA therapeutics
Prof Mike Taggart Pregnancy & fetal development, proteomics, live cell/tissue imaging, 3D electron microscopy



 

Staff

Professor Robert Anderson
Honorary Visiting Professor

Professor Helen Arthur
Professor of Cardiovascular Biology

Email:
Telephone: +44 (0) 191 241 8648

Dr Kate Bailey
Research Associate

Email:
Telephone: +44 (0)191 241 8653

Email:
Telephone: +44 (0) 191 241 8764

Dr Karim Bennaceur
Research Associate

Email:
Telephone: +44 (0)191 241 8612

Dr Bill Chaudhry
Senior Lecturer

Email:
Telephone: +44 (0) 191 241 8681

Dr Louise Coats
Clinical Intermediate Fellow and Honorary Consultant Adult Congenital Heart Disease

Dr David Crossland
Associate Clinical Lecturer

Dr Lorraine Eley
Research Associate

Email:
Telephone: +44 (0) 191 241 8653

Professor Deborah Henderson
Professor of Cardiac Development

Email:
Telephone: +44 (0) 191 241 8644

Dr Guy MacGowan
Honorary Professor of Heart Failure

Email:
Telephone: +44 (0) 191 223 1546

Email:
Telephone: +44 (0) 191 241 8856

Dr John O'Sullivan
Associate Clinical Researcher

Dr Andrew Owens
Honorary Clinical Reader

Email:
Telephone: 0191 241 8859

Email:
Telephone: +44 (0) 191 241 8698

Dr Gavin Richardson
Newcastle Uni Research Fellow (Cardio)

Email:
Telephone: +44 (0)191 241 8615

Dr Adrian Santos
Research Associate

Dr Wasay Shaikh Qureshi
Research Associate

Professor Ioakim Spyridopoulos
Prof of Cardiovascular Gerontology

Email:
Telephone: +44 (0) 191 241 8675

Professor Konstantinos Stellos
Prof of Cardiovascular Medicine & Epitranscriptomics

Email:

Julie Taggart
Research Technician

Email:
Telephone: +44 (0) 191 2418720

Dr Winnie Tong
Associate Researcher

Dr Simon Tual-Chalot
Research Associate

Email:
Telephone: +44 (0) 191 241 8690

Dr Anna Walaszczyk
Research Associate

Rachael Watson
Teaching Technican

Email:

PhD Students

Meet our current PhD students.

StudentLead supervisor
Mashael Alaradi Prof Debroah Henderson
Ahlam Alqahtani Dr Bill Chaudhry
Danielle Brown Dr Simon Bamforth
Erin Cocks Prof Mike Taggart
Emily Dookun Dr Gavin Richardson
Lilia Dragonova Prof Iokim Sypridopolous
Jeremy Henning Dr Andrew Owens
Hanan Khasbour Prof Mike Taggart
Nani Harlina Latar Dr Annette Meeson
Kamilla Mahkamova Dr Annette Meeson
Sarah Marsh Prof Helen Arthur
Ashfaq Mohammed  Prof Iokim Sypridopolous
Lauren Phillips Dr Helen Phillips
Esha Singh Prof Helen Arthur
Catherine Stothard Dr Simon Bamforth

 

Contact

Do you want to find out more about Cardiovascular Disease?

Please contact theme representative Prof Michael Taggart.