Institute of Genetic Medicine

Staff Profile

Dr Bill Chaudhry

Senior Lecturer

Background


Background

Parrs Wood High School, Manchester: 1977 - 1983

Medicine (MBBS) University of Newcastle upon Tyne Medical School: 1983-1988

Adult and Paediatric Medical training, Newcastle, Liverpool and London: 1988-1995

MRCP:1992

FRCPCH: 2006

British Heart Foundation Clinical Research Fellowship and PhD, University College London: 1995-1998

Cardiac and General Paediatric Intensive Care training, Great Ormond Street and Guy's Hospitals: 1998-2002

Consultant Paediatric Intensivist, Newcastle upon Tyne Hospitals NHS Trust: 2002-2009

Senior lecturer in cardiovascular development and disease: 2009-present

Links

ORCID iD: 0000-0003-2833-8882

Administration

Newcastle University Zebrafish Facility

Established and expanded the Newcastle University Zebrafish facility, at the Institute of Genetic Medicine. Academic support to comparative biology centre (CBC) technical staff.

Newcastle University Cardiovascular Research Centre

Produced web site

Organiser of the congenital heart disease and development seminar programs

Organiser of Trainee and Principle investigator annual conferences

European Society of Cardiology

Ex-officio member of the committee (nucleus) of the Working Group on Development Anatomy and Pathology.


Co-workers

Deborah Henderson, Professor of Cardiac Development

Louise Coats, Consultant in ACHD and NU Fellow

Robert Anderson, Visiting Professor of Cardiac Morphology

Sri Annavarapu, Consultant Paediatric Pathologist

John O'Sullivan, Consultant PaediatricCardiologist

Lorraine Eley, BHF Senior Research Associate

Adrian Santos, BHF Senior Research Associate

Tamil Dhanaseelan, BHF Research Associate

Mashael Alarady PhD student

Ahlam Alqahtani, PhD Student

Research


Research themes

Cardiovascular developmental molecular biology and disease modelling using mice and zebrafish, asking:

What are the developmental origins of congenital heart disease?

How can we prevent genetic cardiomyopathies progressing to heart failure?

How can we promote resilience in adults with congenital heart disease?

Hypoplastic left heart syndrome

Hypoplastic Left Heart Syndrome (HLHS) is a rare but serious congenital heart malformation, in which there is severe underdevelopment of the left ventricle and aorta. Deborah HendersonJohn O'SullivanSri Annavarapu and I are looking for abnormalities in the genes of patients and combining this with our knowledge of how the heart forms, to discover if there is a genetic cause for HLHS.

Left-right signalling and planar cell polarity in cardiac development

Disturbances in the planar cell polarity pathway and in left-right specification cause heart malformations in mice and zebrafish. Together with Deborah Henderson, I am asking if these pathways are linked and if they may point to a genetic cause for malformations such as double outlet right ventricle and atrial/ventricular septal defects.

Resilience in cardiomyopathy

Whilst genetic cardiomyopathies cannot be prevented we can seek ways to maintain cardiac function. Deborah Henderson and I are exploring how biochemical stresses within cardiomyocytes can be controlled to prevent decompensation into heart failure and arrhythmia.

Resilience in ACHD

Children with congenital heart disease now survive into adulthood and are an expanding patient group. As part of a collaborative research effort with Louise Coats and Deborah Henderson I am interested in understanding their issues, both medical and psychosocial, with the aim of maintaining their holistic wellbeing. We want to find biomarkers that will indicate problems before they become clinically apparent and nvestigate how we can give this divers patient group the type and degree of support they need.

 

Technical expertise

  • Laboratory models of genetic heart disease, including Crispr Cas9 genome editing in zebrafish and Cre-lox mice.
  • Next Generation Sequencing (Whole exome and RNASeq) 
  • Live imaging (including sheet light microscopy)
  • Computer programming in biology (Unix, C, R, Matlab, Labview Arduino and RasperryPi)
  • 3D reconstruction (Amira) and printing (Reprap Ormerod).

Teaching

My teaching responsibilities at Newcastle University are closely linked with my research activity. I provide undergraduate and postgraduate teaching cardiovascular development and congenital heart disease. In the laboratory I provide supervision for PhD, master’s and undergraduate students from our own biomedical sciences course and from other universities across the UK and abroad.

Genetics of Development and its Disorders (BGM3062)

Cardiovascular Science in Health and Disease (MMB8037)

Biomedical Sciences BSc Honours - Module leader for final year undergraduate research projects and dissertation (CMB3000)

Publications