Dr Dean Hallam
- Email: email@example.com
- Telephone: 0191 241 8817
- Address: Dean Hallam BSc (Hons), MSc, PhD
Institute of Genetic Medicine
International Centre for Life
Newcastle NE1 3BZ
In 2010 I completed a MSc in Molecular Genetics at the University of Leicester. In 2011 I moved to Newcastle and completed my PhD in 2015 under the supervision of Dr. Gabriele Saretzki in the Institute for Cell and Molecular Biosciences. Since April 2014 I started working as a Research Associate with Professor Majlinda Lako at the Institute of Genetic Medicine working on age related macular degeneration.
In 2011 I was awarded £3,000 worth of qPCR consumables from Primer Design. In the same year I was invited to the present at the first round of biotechnology YES in Edinburgh. During 2013 I received a travel grant from Newcastle University worth £800 to attend ARVO in Seattle Washington where I presented a poster using results from my PhD.
I enjoy running, cycling and baking in my spare time. I completed the Great North Run 3 times where I raised a total of £1000 for charity.
Assessing the feasibility of induced pluripotent stem cells to provide a disease model for age related macular degeneration
PhD project: The influence of ageing and culture conditions on limbal stem cells
The effect of age on myosin molecular motors
The role of telomeres in ageing
My main research focus on ageing, stem cells and the eye. I am particularly interested in cellular renewal, my PhD focused on the effects of age on the stem cell population which resides within the corneal limbus. This same interest carries forward into my current project looking at using stem cells to provide an insight into the molecular mechanism behind age related macular degeneration.
- Hallam DM, Wan T, Saretzki G. Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium. Experimental Gerontology 2015.
- Ahmad S, Stewart R, Hallam D, Osei-Bempong C, Foley L. Ocular Surface Reconstruction Using Cellular Therapies. In: Belgaris, D.J., Savarese, A.N, ed. Cell Transplantation: New Research. New York, USA: Nova Science Publishers Inc, 2012, pp.71-88.
- Chichagova V, Hallam D, Collin J, Zerti D, Dolgau B, Felemban M, Lako M, Steel DH. Cellular regeneration strategies for macular degeneration: past, present and future. Eye 2018, e-pub ahead of print.
- Felemban M, Dorgau B, Hunt NC, Hallam D, Zerti D, Bauer R, Ding Y, Collin J, Steel DH, Krasnogor N, Al-Aama J, Lindsay S, Mellough C, Lako M. Extracellular matrix components expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix. Acta Biomaterialia 2018, 74, 207-221.
- Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, Hewitt P, Schmitt M, Uteng M, Kustermann S, STEEL D, Nicholds M, Thomas R, Treumann A, Porter A, Sernagor E, Armstrong L, Lako M. Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency. Stem Cells 2018. In Press.
- Hallam D, Rawlings D, Steel D, Armstrong L, Lako M. In Reply to the Letter to the Editor from Hallam et al.: An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure. Stem Cells 2018, epub ahead of print.
- Dorgau B, Felemban N, Sharpe A, Bauer R, Hallam D, Steel DH, Lindsay S, Mellough C, Lako M. Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation. Cell Death and Disease 2018, 9(6), 615.
- Hunt NC, Hallam D, Karimi A, Mellough CB, Chen J, Steel DHW, Lako M. 3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development. Acta Biomaterialia 2017, 49, 329-343.
- Hallam D, Collin j, Bojic S, Chichagova V, Buskin A, Xu Y, Lafage L, Otten EG, Anyfantis G, Mellough C, Przyboski S, Alhart S, Korolchuk V, Lotery A, Saretzki G, McKibbin M, Armstrong L, Steel D, Kavanagh D, Lako M. An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure. Stem Cells 2017, 35(11), 2305-2320.
- Chichagova V, Hallam D, Collin J, Buskin A, Saretzki G, Armstrong L, Yu-Wai-Man P, Lako M, Steel DH. Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A>G mitochondrial DNA mutation. Scientific Reports 2017, 7, 12320.