Professor Deborah Henderson
Professor of Cardiac Development
- Email: firstname.lastname@example.org
- Telephone: +44 (0) 191 241 8644
- Fax: +44 (0) 191 241 8666
- Address: Institute of Genetic Medicine
Centre for Life
Newcastle upon Tyne
Conyers School, Yarm, Stockton-on-Tees 1977-1984
BSc Applied Biology - Coventry Polytechnic (including 1 year sandwich placement) 1984-1988
PhD - Royal Postgraduate Medical School, University of London (Molecular Biology) 1989-1992
Post Doctoral research – Institute of Child Health, University College London 1993-1999
British Heart Foundation Basic Science Lectureship - Institute of Child Health, University College 1999-2002
British Heart Foundation Basic Science Lectureship (renewed in 2005) - Institute of Human Genetics, Newcastle University 2002 – 2010 (promotion to Senior Lecturer in 2006)
Chair in Cardiovascular Development Institute Genetic Medicine, Newcastle University 2008– present
Deputy Director Institute of Genetic Medicine 2011-2014; 2017-2018
Deputy Dean of Research, Faculty of Medical Sciences, Newcastle University 2011-2015
Dean of Research, Faculty of Medical Sciences, Newcastle University 2015-2016
Director of Scientific Core Facilities, Faculty of Medical Sciences, Newcastle University 2016-present
Google SCHOLAR: https://scholar.google.co.uk/citations?user=56u7zckAAAAJ&hl=en
Orcid number: 000-0002-2705-5998
Cardiovascular developmental and disease modelling using mice and zebrafish, asking:
What are the developmental origins of congenital heart disease? Can we stratify congenital heart disease on the basis of the lineage of origin of the malformations?
How do the arterial valves form and what are the developmental origins of valve anomalies such as bicuspid aortic valve?
How can we promote resilience in adults with congenital heart disease?
What are the morphogenetic mechanisms that underlie common outflow anomalies?
Over one third of cardiac malformations affect the outflow region of the heart. During development a number of embryonic cell lineages come together to form the complex architecture of the aorta and pulmonary trunk. Together with Bill Chaudhry, we are discovering how different cellular and molecular signalling pathways – particularly the non canonical Wnt, planar cell polarity pathway - are necessary for the normal development of the outflow vessels and are linked to outflow malformations.
The developmental origins of bicuspid aortic valve
Bicuspid aortic valve (BAV) is the most common congenital anomaly that predisposes to adult cardiovascular disease. Bill Chaudhryand I are investigating how the normal aortic valve forms and elaborating the pathological mechanisms that lead to BAV.
Left-right signalling and planar cell polarity in cardiac development
Disturbances in the planar cell polarity pathway and in left-right specification cause heart malformations in mice and zebrafish. Together with Bill Chaudhry,I am asking if these pathways are linked and if they may point to a genetic cause for malformations such as double outlet right ventricle and atrial/ventricular septal defects.
Resilience in ACHD
Children with congenital heart disease now survive into adulthood and are a growing patient group. As part of a collaborative research effort with Louise Coatsand Bill ChaudhryI am interested in understanding their issues, both medical and psychosocial, with the aim of maintaining their holistic wellbeing through finding biomarkers that will indicate problems before they become clinically apparent and by investigating how we can give this divers patient group the type and degree of support they need.
Laboratory models of cardiovascular disease disease, particularly utilising Cre-lox mice.
Cardiac morphology and developmental anatomy
Robert Anderson, Visiting Professor of cardiac morphology
Lorraine Eley, BHF Senior Research Associate
Adrian Santos, BHF Senior Research Associate
Tamil Dhanaseelan, BHF Research Associate
Ahlam Alqahtani, PhD Student
Mashael Alaradi, PhD student
My teaching responsibilities at Newcastle University are closely linked with my research activity. I provide undergraduate and postgraduate teaching in developmental genetics, cardiovascular development and congenital heart disease. In the laboratory I provide supervision for PhD, master’s and undergraduate students from our own biomedical sciences course and from other universities across the UK and abroad.
Cardiovascular Science in Health and Disease (MMB8037)
- Richardson R, Eley L, Donald-Wilson C, Davis J, Curley N, Alqahtani A, Murphy L, Anderson RH, Henderson DJ, Chaudhry B. Development and maturation of the fibrous components of the arterial roots in the mouse heart. Journal of Anatomy 2018, 232(4), 554-567.
- Galea GL, Nychyk O, Mole MA, Moulding D, Savery D, Nikolopoulou E, Henderson DJ, Greene NDE, Copp AJ. Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos. DMM Disease Models and Mechanisms 2018, 11(3), dmm032219.
- Anderson RH, Henderson DJ, Chaudhry B. Development and maintenance of the arterial valves. European Heart Journal 2017, 38(9), 687-689.
- Crucean A, Alqahtani A, Barron DJ, Brawn WJ, Richardson RV, O'Sullivan J, Anderson RH, Henderson DJ, Chaudhry B. Re-evaluation of hypoplastic left heart syndrome from a developmental and morphological perspective. Orphanet Journal of Rare Diseases 2017, 12, 138.
- Anderson RH, Bamforth SD, Spicer DE, Henderson DJ, Chaudhry B, Brown NA, Mohun TJ. Development and maldevelopment of the ventricular outflow tracts. In: Lacour-Gayet F; Bove EL; Hraška V; Morell V; Spray T, ed. Surgery of Conotruncal Anomalies. Cham, Switzerland: Springer International Publishing, 2016, pp.27-59.
- Findlay AS, Panzica DA, Walczysko P, Holt AB, Henderson DJ, West JD, Rajnicek A, Collinson JM. The core planar cell polarity gene, Vangl2, directs adult corneal epithelial cell alignment and migration. Royal Society Open Science 2016, 3(10), 160658.
- Spicer DE, Henderson DJ, Chaudhry B, Mohun TJ, Anderson RH. The anatomy and development of normal and abnormal coronary arteries. Cardiology in the Young 2015, 25(8), 1493-1503.
- Chaudhry B, Burns D, Murphy L, Henderson D. Exercise and cardiomyocyte turnover in the aging zebrafish heart. In: Third Congress of the ESC Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2014, Barcelona, Spain: Oxford University Press.
- Chaudhry B, Ramsbottom S, Henderson DJ. Genetics of Cardiovascular Development. In: Timothy J.A. Chico, ed. Genetics of Cardiovascular Disease. Academic Press, 2014, pp.19-41.
- Anderson RH, Mohun TJ, Spicer DE, Bamforth SD, Brown NA, Chaudhry B, Henderson DJ. Myths and Realities Relating to Development of the Arterial Valves. Journal of Cardiovascular Development and Disease 2014, 1(3), 177 - 200.
- Anderson RH, Moorman AFM, Brown NA, Bamforth SD, Chaudhry B, Henderson DJ, Mohun TJ. Normal and abnormal development of the heart. In: Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. London: Springer-Verlag, 2014, pp.151-177.
- Boczonadi V, Gillespie R, Keenan ID, Ramsbottom SA, Donald-Wilson C, Al Nazer M, Humbert P, Schwarz RJ, Chaudhry B, Henderson DJ. Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium. Cardiovascular Research 2014, 104(1), 103-115.
- Henderson DJ, Ramsbottom SA, Sharma V, Chaudhry B. Vangl2-regulated polarisation of second heart field cells is required for outflow tract lengthening. In: Frontiers in CardioVascular Biology. 2014, Barcelona, Spain: Oxford University Press.
- Ramsbottom SA, Sharma V, Rhee HJ, Eley L, Phillips HM, Rigby HF, Dean C, Chaudhry B, Henderson DJ. Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development. PLoS Genetics 2014, 10(12), e1004871.
- Hunt NC, Shelton RM, Henderson DJ, Grover LM. Calcium-Alginate Hydrogel-Encapsulated Fibroblasts Provide Sustained Release of Vascular Endothelial Growth Factor. Tissue Engineering Part A 2013, 19(7-8), 905-914.
- Bamforth SD, Chaudhry B, Bennett M, Wilson R, Mohun TJ, van Mierop LHS, Henderson DJ, Anderson RH. Clarification of the identity of the mammalian fifth pharyngeal arch artery. Clinical Anatomy 2013, 26(2), 173-182.
- Palomino Doza J, Topf A, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Bu'Lock FA, O'Sullivan J, Stuart AG, Parsons J, Relton C, Goodship J, Henderson DJ, Keavney B. Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to Tetralogy of Fallot. BMC Genetics 2013, 14, 57.
- Phillips HM, Mahendran P, Singh E, Anderson RH, Chaudhry B, Henderson DJ. Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets. Cardiovascular Research 2013, 99(3), 452-460.
- Chaudhry B, Burns D, Henderson DJ. Cardiomyocyte aging: swimming against the clock. In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
- Henderson DJ, Boczonadi V, Humbert P, Chaudhry B. Conditional deletion of Scrib gene in the developing myocardium leads to congenital heart defects. In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
- Bell E, Richardson G, Jahoda CA, Gledhill K, Phillips HM, Henderson D, Owens WA, Hole N. Dermal stem cells can differentiate down an endothelial lineage. Stem Cells and Development 2012, 21(16), 3019-3030.
- Hunt NC, Batsivari A, Chaudhry B, Henderson DJ. ECM control of neural crest cell (NCC) behaviour and implications for heart development. In: Autumn Meeting of the British Society for Matrix Biology (BSMB). 2012, Newcastle upon Tyne, UK: Wiley-Blackwell Publishing Ltd.
- Chaudhry B, Chrystal P, Henderson DJ. Fast Digital Laser Sheet Microscopy: swimaging in 6 dimensions. In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
- Doza JP, Topf A, Bentham J, Bhattacharya S, Cosgrove C, Granados-Riveron J, Goodship J, Henderson D, O'Sullivan J, Keavney BD. Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to congenital heart disease. In: Congress of the European Society of Cardiology (ESC). 2012, Munchen, Germany: Oxford University Press.
- Phillips HM, Papoutsi T, Soenen H, Ybot-Gonzalez P, Henderson DJ, Chaudhry B. Neural Crest Cell Survival is Dependent on Rho Kinase and is Required for Development of the Mid Face in Mouse Embryos. PLoS One 2012, 7(5), e37685.
- Anderson RH, Chaudhry B, Mohun TJ, Bamforth SD, Hoyland D, Phillips HM, Webb S, Moorman AF, Brown NA, Henderson DJ. Normal and abnormal development of the intrapericardial arterial trunks in humans and mice. Cardiovascular Research 2012, 95(1), 108-115.
- Keenan ID, Rhee HJ, Chaudhry B, Henderson DJ. Origin of non-cardiac endothelial cells from an Isl1+ lineage. FEBS Letters 2012, 586(13), 1790-1794.
- Henderson DJ, Chaudhry B. Getting to the Heart of Planar Cell Polarity Signaling. Birth Defects Research Part A: Clinical and Molecular Teratology 2011, 91(6), 460-467.
- Cesca F, Yabe A, Spencer-Dene B, Arrigoni A, Al-Qatari M, Henderson D, Phillips H, Koltzenburg H, Benfenati F, Schiavo G. Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development. Cell Death and Disease 2011, 2, e226.
- Taylor JM, Saunter CD, Love GD, Girkin JM, Henderson DJ, Chaudhry B. Real-time optical gating for three-dimensional beating heart imaging. Journal of Biomedical Optics 2011, 16(11), 116021.
- Ioannides AS, Massa V, Ferraro E, Cecconi F, Spitz L, Henderson DJ, Copp AJ. Foregut separation and tracheo-oesophageal malformations: The role of tracheal outgrowth, dorso-ventral patterning and programmed cell death. Developmental Biology 2010, 337(2), 351-262.
- Dhomen N, Da Rocha Dias S, Hayward R, Ogilvie L, Hedley D, Delmas V, Henderson D, Springer CJ, Pritchard C, Larue L, Marais R. Inducible expression of V600EBraf using tyrosinase-driven Cre recombinase results in embryonic lethality. Pigment Cell & Melanoma Research 2010, 23(1), 112-120.
- Hildreth V, Anderson RH, Henderson DJ. Autonomic Innervation of the Developing Heart: Origins and Function. Clinical Anatomy 2009, 22(1), 36-46.
- Bradshaw L, Chaudhry B, Hildreth V, Webb S, Henderson DJ. Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H). Journal of Anatomy 2009, 214(2), 245-257.
- Hildreth V, Webb S, Chaudhry B, Peat JD, Phillips HM, Brown N, Anderson RH, Henderson DJ. Left cardiac isomerism in the Sonic hedgehog null mouse. Journal of Anatomy 2009, 214(6), 894-904.
- Henderson DJ, Anderson RH. The Development and Structure of the Ventricles in the Human Heart. In: Pediatric Cardiology: Riley Heart Center Symposium on Cardiac Development. 2009, Bloomington, Indiana, USA: Springer.
- Farooqui-Kabir SR, Diss JKJ, Henderson D, Marber MS, Latchman DS, Budhram-Mahadeo V, Heads RJ. Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Cell Stress and Chaperones 2008, 13(3), 297-312.
- Hildreth V, Webb S, Bradshaw L, Brown NA, Anderson RH, Henderson DJ. Cells migrating from the neural crest contribute to the innervation of the venous pole of the heart. Journal of Anatomy 2008, 212(1), 1-11.
- Phillips HM, Hildreth V, Peat JD, Murdoch JN, Kobayashi K, Chaudhry B, Henderson DJ. Non-cell-autonomous roles for the planar cell polarity gene vangl2 in development of the coronary circulation. Circulation Research 2008, 102(5), 615-623.
- Phillips HM, Rhee HJ, Murdoch JN, Hildreth V, Peat JD, Anderson RH, Copp AJ, Chaudhry B, Henderson DJ. Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization. Circulation Research 2007, 101(2), 137-145.
- Henderson DJ, Phillips HM, Chaudhry B. Vang-like 2 and noncanonical Wnt signaling in outflow tract development. Trends in Cardiovascular Medicine 2006, 16(2), 38-45.
- O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TVP, Henderson DJ, Nizetic D, Tybulewicz VLJ, Fisher EMC. An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 2005, 309(5743), 2033-2037.
- Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot M-M, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A, Beales PL. Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nature Genetics 2005, 37(10), 1135-1140.
- Phillips HM, Murdoch JN, Chaudhry B, Copp AJ, Henderson DJ. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circulation Research 2005, 96(3), 292-299.
- Gaston-Massuet C, Henderson DJ, Greene NDE, Copp AJ. Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system. Developmental Dynamics 2005, 233(3), 1110-1115.
- Hudson CD, Podesta J, Henderson D, Latchman DS, Budhram-Mahadeo V. Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis. Journal of Neuroscience Research 2004, 78(6), 803-814.
- Sharma PR, Anderson RH, Copp AJ, Henderson DJ. Spatio-temporal analysis of programmed cell death during mouse cardiac septation. Anatomical Record 2004, 277A(2), 355-369.
- Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C, Arkell R, Stanier P, Copp AJ. Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Human Molecular Genetics 2003, 12(2), 87-98.
- Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, Nolan PM, Steel KP, Brown SDM, Gray IC, Murdoch JN. Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Current Biology 2003, 13(13), 1129-1133.
- Ioannides AS, Henderson DJ, Spitz L, Copp AJ. Role for Sonic hedgehog in the development of the trachea and the oesophagus. Journal of Pediatric Surgery 2003, 38(1), 29-36.
- Goodship J, Henderson D. Cardiac development and cardiovascular malformation. In: European Journal of Human Genetics: European Society of Human Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics. 2002, Strasbourg, France: Nature Publishing Group.
- Braybrook C, Lisgo S, Doudney K, Henderson D, Marcano ACB, Strachan T, Patton MA, Villard L, Moore GE, Stanier P, Lindsay S. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPx patients. Human Molecular Genetics 2002, 11(22), 2793-2804.
- Ioannides AS, Chaudhry B, Henderson DJ, Spitz L, Copp AJ. Dorsoventral patterning in oesophageal atresia with tracheo-oesophageal fistula: Evidence from a new mouse model. Journal of Pediatric Surgery 2002, 37(2), 185-191.
- Henderson DJ and Copp AJ. Versican expression is associated with chamber specification, septation, and valvulogenesis in the developing mouse heart. Circ. Res. 83, 523-532 1998.
- Conway SJ, Henderson DJ and Copp AJ. Pax3 is required for cardiac neural crest cell migration in the mouse: evidence from the splotch (Sp2H) mutant. Development, 124, 505-514 1997.