Dr Louise Coats
Clinical Intermediate Fellow and Honorary Consultant Adult Congenital Heart Disease
- Email: email@example.com
- Address: Cardiovascular Research Centre,
Institute of Genetic Medicine,
International Centre for Life,
Newcastle upon Tyne,
I am a Principal Investigator in the Congenital Heart Disease Group within the Cardiovascular Research Centre. My work is focuses on resilience and outcomes in adult congenital heart disease, in particular understanding the markers of decompensation.
Guildford High School, Guildford 1987- 1994
St George’s Hospital Medical School, London 1994-1999
- MBBS distinction Medicine
- Anatomy prize
- Brackenbury prize for Medicine
Adult Medical Training, Plymouth and London 1999-2003
- DHMSA (Diploma in History of Medicine Society of Apothecaries) 2000
- MRCP (UK) 2002
Great Ormond Street Hospital and Institute of Child Health 2003-2006
- British Heart Foundation Junior Fellowship
- (PhD) University College London
Adult Cardiology Training, Northern Deanery 2007-2016
- NIHR Academic Clinical Lecturer
- Academy of Medical Sciences Start-Up Grant
- British Society of Echocardiography Transthoracic Accreditation
Completion of Clinical Training 2016
Google SCHOLAR: Click here.
Orcid number: https://orcid.org/0000-0003-3422-5497
- Royal College of Physicians of Edinburgh
- British Cardiac Society
- British Congenital Cardiac Society
- ESC Grown up Congenital Heart Disease Working Group
How can we promote resilience in adults with congenital heart disease?
Adults with congenital heart disease are a growing and increasingly complex patient group at risk of premature decompensation. As part of a collaborative research effort with Bill Chaudhry and Deborah Henderson I am interested in understanding both their medical and psychosocial issues that influence their general wellbeing. There are three ongoing strands to this work:
- Finding biomarkers that will indicate problems before they become clinically apparent
- Investigating the potential of microvascular function as an early marker of decompensation
- Understanding the psychosocial needs of this patient group
What is the role of transplant and mechanical assist for adults with congenital heart disease?
The growing burden of heart failure in ACHD is reflected in the rapidly increasing numbers of referrals for transplant assessment to our centre. Donor organs are a scarce commodity and mechanical assist devices are not yet developed that can adequately support the complex failing single ventricle patient. Together with clinical colleagues, Katrijn Jansen, David Crossland, John O’Sullivan and Asif Hasan I am interested in understanding the current and future role of mechanical assist and heart transplant in the decompensating adult congenital patient.
What is the relationship between flow and morphology in adults with congenital heart disease?
Surgical modification has been the main modifier of the natural history of congenital heart disease over recent decades. In the normal heart, recent work (link PFO paper) in collaboration with Kieren Hollingsworth has highlighted the potential relationship between subtle differences in cardiac morphology, flow and late pathophysiological complications in the setting of patent foramen ovale. I am interested in how this concept may be applied to more complex conditions, such as the Fontan palliation, to understand better where and how intervention might be designed and targeted to improve outcomes.
Imaging (Tissue Doppler and 4D Flow MRI)
Patient Related Research
I am lead for training in Adult Congenital Heart Disease in the Northern Deanery and sit on the Speciality Trainee Committee. I contribute to Regional and National clinical teaching programmes in Adult Congenital Heart Disease. I currently provide supervision to undergraduate and master’s students from our own medical school and others across the UK.
Co-ordinator for trainee attachments in Adult Congenital Heart Disease
Newcastle University Cardiovascular Research Centre
Organiser of trainees’ annual conference
Organiser of academic joint cardiac surgical morphology meeting
Co-ordinator of Fontan MDT
- Kenny LA, DeRita F, Nassar M, Dark J, Coats L, Hasan A. Transplantation in the single ventricle population. Annals of Cardiothoracic Surgery 2018, 7(1), 152-159.
- Parikh JD, Kakarla J, Keavney B, O'Sullivan JJ, Ford GA, Blamire AM, Hollingsworth KG, Coats L. 4D flow MRI assessment of right atrial flow patterns in the normal heart - influence of caval vein arrangement and implications for the patent foramen ovale. PLoS One 2017, 12(3), e0173046.
- Duong P, Coats L, O'Sullivan J, Crossland D, Haugk B, Babu-Narayan SV, Keegan J, Hudson M, Parry G, Manas D, Hasan A. Combined heart-liver transplantation for failing Fontan circulation in a late survivor with single-ventricle physiology. ESC Heart Failure 2017, 4(4), 675–678.
- Haugk B, Bury Y, Coats L, O'Sullivan J, Hudson M. Defining the role of liver biopsy in the assessment of liver fibrosis in patients with Fontan circulation. Human Pathology 2017, 69, 140-140.
- Cauldwell M, Steer PJ, Bonner S, Asghar O, Swan L, Hodson K, Head CEG, Jakes AD, Walker N, Simpson M, Bolger AP, Siddiqui F, English KM, Maudlin L, Abraham D, Sands AJ, Mohan AR, Curtis SL, Coats L, Johnson MR. Retrospective UK multicentre study of the pregnancy outcomes of women with a Fontan repair. Heart 2018, 104(5), 401-406.
- Coats L, Crossland D, Hudson M, O'Sullivan J, Hasan A. Fontan conversion is a dated approach to the failing Fontan. Heart 2016, 102(20), 1692-1692.
- Kakarla J, Parikh JD, Hollingsworth KG, Keavney B, Ford GA, O'Sullivan JJ, Blamire AM, Coats L. Right atrial flow patterns in the normal heart - a new clue in the patent foramen ovale and cryptogenic stroke story. In: European Society of Cardiology Congress. 2015, London, UK: Oxford University Press.
- Parikh J, Kakarla J, Hollingsworth KG, Keavney B, O'Sullivan JJ, Ford GA, Blamire AM, Coats L. Variations in right atrial flow patterns in the normal heart a potential contributor to cryptogenic stroke in the setting of patent foramen ovale. In: 18th Annual Society of Cardiovascular Magnetic Resonance Sessions. 2015, Nice, France: BioMed Central Ltd.
- Kakarla J, Coats L, Parikh JD, Hollingsworth KG, O'Sullivan J. Platydeoxia Orthopnoea – Revisiting a Rare Clinical Phenomenon with a Novel Imaging Modality. In: British Cardiovascular Society Annual Conference. 2014, Manchester: BMJ Group.
- Coats L, O'Connor S, Wren C, O'Sullivan J. The single-ventricle patient population: a current and future concern a population-based study in the North of England. Heart 2014, 1-6.
- Kunadian V, Coats L, Kini A, Mehran R. Cardiogenic Shock in Women. Interventionals Cardiology Clinics 2012, 1(2), 231-243.
- Coats L, Runnett C, Satchithananda DK. Double outlet right atrium with coexisting double inlet left ventricle and concordant ventriculoarterial connections: a fascinating variant of the Holmes heart. Cardiology in the Young 2010, 20(5), 587-589.
- Schievano S, Taylor AM, Capelli C, Coats L, Walker F, Lurz P, Nordmeyer J, Wright S, Khambadkone S, Tsang V, Carminati M, Bonhoeffer P. First-in-man implantation of a novel percutaneous valve: a new approach to medical device development. EuroIntervention 2010, 5(6), 745-750.
- Vismara R, Laganà K, Migliavacca F, Schievano S, Coats L, Taylor A, Bonhoeffer P. Experimental setup to evaluate the performance of percutaneous pulmonary valved stent in different outflow tract morphologies. Artificial Organs 2009, 33(1), 46-53.
- Lurz P, Nordmeyer J, Coats L, Taylor AM, Bonhoeffer P, Schulze-Neick I. Immediate clinical and haemodynamic benefits of restoration of pulmonary valvar competence in patients with pulmonary hypertension. Heart 2009, 95(8), 646-650.
- Ghez O, Tsang VT, Frigiola A, Coats L, Taylor A, VanDoorn C, Bonhoeffer P, DeLeval M. Right ventricular outflow tract reconstruction for pulmonary regurgitation after repair of tetralogy of Fallot. Preliminary results. Eur J Cardiothorac Surg 2007, 31(4), 654-8.
- Schievano S, Coats L, Migliavacca F, Norman W, Frigiola A, Deanfield J, Bonhoeffer P, Taylor AM. Variations in right ventricular outflow tract morphology following repair of congenital heart disease: implications for percutaneous pulmonary valve implantation. J Cardiovasc Magn Reson 2007, 9(4), 687-95.
- Coats L, Khambadkone S, Sullivan ID. An unusual appearance of the right ventricle following replacement of the pulmonary valve. Cardiol Young 2006, 16(4), 403-4.
- Sridharan S, Coats L, Khambadkone S, Taylor AM, Bonhoeffer P. Images in cardiovascular medicine. Transcatheter right ventricular outflow tract intervention: the risk to the coronary circulation. Circulation 2006, 113(25), e934-5.
- Coats L, Tsang V, Khambadkone S, vanDoorn C, Cullen S, Deanfield J, deLeval MR, Bonhoeffer P. The potential impact of percutaneous pulmonary valve stent implantation on right ventricular outflow tract re-intervention. Eur J Cardiothorac Surg 2005, 27(4), 536-43.
- Polyviou S, O'Sullivan J, Hasan A, Coats L. Mortality Risk Stratification in Small Patient Cohorts; the Heart Transplant Post Fontan Paradigm. The American Journal of Cardiology 2018, epub ahead of print.