Institute of Health & Society

Methodology research

Methodology research

The methodology group develops, disseminates and implements new statistical methods to improve the efficiency of clinical trials.


-    Dr Michael Grayling
-    Prof John Matthews
-    Prof James Wason
-    Dr Haiyan Zheng

Current areas of research

-    Basket and Umbrella trials
-    Bayesian methods
-    Cluster-randomised and Stepped Wedge trials
-    Composite endpoints
-    Crossover trial designs
-    Early phase adaptive trials
-    Multi Arm Multi Stage (MAMS) trials
-    Platform trials
-    Using historical data

Selected recent papers

McMenamin, M., Berglind, A. and Wason, J.M., 2018. Improving the analysis of composite endpoints in rare disease trials. Orphanet journal of rare diseases, 13(1), p.81.

Pallmann, P et al. 2018. Adaptive designs in clinical trials: why use them, and how to run and report them. BMC medicine, 16(1), p.29.

Grayling, M.J., Wason, J.M. and Mander, A.P., 2018. Group sequential crossover trial designs with strong control of the familywise error rate. Sequential analysis, 37(2), pp.174-203.

Hemming, K., Taljaard, M., McKenzie, J.E., Hooper, R., Copas, A., Thompson, J.A., Dixon-Woods, M., Aldcroft, A., Doussau, A., Grayling, M. and Kristunas, C., 2018. Reporting of stepped wedge cluster randomised trials: extension of the CONSORT 2010 statement with explanation and elaboration. BMJ, 363, p.k1614.

Grayling, M.J., Wason, J.M. and Mander, A.P., 2018. An optimised multi-arm multi-stage clinical trial design for unknown variance. Contemporary clinical trials, 67, pp.116-120.

Wason, J.M., Abraham, J.E., Baird, R.D., Gournaris, I., Vallier, A.L., Brenton, J.D., Earl, H.M. and Mander, A.P., 2015. A Bayesian adaptive design for biomarker trials with linked treatments. British journal of cancer, 113(5), p.699.

Villar, S.S., Wason, J. and Bowden, J., 2015. Response‐adaptive randomization for multi‐arm clinical trials using the forward looking Gittins index rule. Biometrics, 71(4), pp.969-978.