Institute of Neuroscience

Mitochondrial disease research

Mitochondrial disease research

Mitochondrial diseases affect patients of all ages - the more severe the mitochondrial defect the earlier the onset is likely to be. The disease can start immediately after birth with severe muscle weakness, heart involvement and impaired overall brain function. Unfortunately these children die in the first few days of life. More commonly mitochondrial disease presents later in childhood, in adolescence and in adulthood. In the vast majority of patients this is a progressive illness with major disability and often leading to early death (certainly in those patients who present in childhood with severe symptoms).

This project aims to determine the nature, mechanisms and potential therapies for the neurological deficits in patients with mitochondrial DNA disease.

The different areas of Mitochondrial Disease Research  include:

  • Clinical Research
  • Molecular Pathology
  • Neuropathology
  • Treatments

Newcastle University staff and students linked to the project:

Return to the main Mitochondrial Research page