Institute of Neuroscience

Electrophysiological phenotyping of mitochondrial

Electrophysiological phenotyping of mitochondrial disease

Mitochondria are essential to life and their dysfunction may contribute significantly to the processes of ageing and neurodegeneration.

Understanding genotype-phenotype interactions in hereditary genetic diseases, such as mitochondrial disorders, can provide important insights into disease mechanisms in the sporadic neurodegenerative diseases. We not only use standard electrophysiological techniques, such as peripheral nerve stimulation, quantitative EMG, TMS, SEPs and EEG, to characterise clinical and subclinical phenotypes, but are also developing novel techniques to probe other parts of the nervous system.

Newcastle University staff and students linked to the project:

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