Institute of Neuroscience

Modelling Human Brain Development

Modelling Human Brain Development

Many brain diseases, such as epilepsy, autism, or schizophrenia, are due to changes during brain development. Structural connectivity shows massive restructuring during brain development.

This project is the first to computationally model the development of the human brain at the level of fibre tracts between brain regions. Validating such models has become possible through the rise of neuroimaging techniques such as diffusion tensor imaging (DTI) which allows us to observe connections in the human embryonic brain through to the mature brain around 20 years of age.

Our objectives are to develop a simulation of human brain development, to analyse network features of real human brains at different developmental stages, and to compare simulations with real data to discover the underlying developmental mechanisms. Understanding how parameters lead to (adult) network features will help to evaluate the contribution of these parameters to both healthy and pathological development.

Newcastle University staff and students linked to the project:

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