Institute of Neuroscience

Pan-retinal information processing and network ac

Pan-retinal information processing and network activity

In the retina, visual information is processed through two synaptic layers before encoding by retinal ganglion cells (RGCs) into trains of action potentials, transmitted to the brain via the optic nerve. But even before vision is possible, immature RGCs generate spontaneous waves of activity with highly specific spatiotemporal patterns. These waves are important for wiring the developing visual system. In our lab, we investigate the role of retinal waves for the maturation of retinal receptive fields and retinal projections.

Taking a developmental approach, we also investigate how RGCs encode complex visual scenes into trains of action potentials. To this aim, we use arrays of electrodes to record simultaneously from hundreds to thousands of RGCs. We use a 4096 channels array spanning most of the mouse retina, giving us the unique opportunity to record network activity at pan-retinal level and investigate long range interactions at unprecedented spatiotemporal resolution.

Newcastle University staff and students linked to the project:

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