Institute of Neuroscience

STABILISE Study: Stroke an evaluation of

The STABILISE Study: Stroke an evaluation of thrombectomy in the ageing brain - including where IV thrombolysis fails or is contraindicated

Patients with large artery occlusion (LAO) have the most severe strokes and poorest outcomes. Intravenous thrombolysis (IVT) increases the proportion of patients recanalising and achieving independence 3 months after stroke but recanalisation rates in proximal LAO are poor - 10%-33%. Recanalisation rates with IA thrombectomy (IAT) are much higher than IVT in LAO - typically now 80+%.

Current thrombectomy devices are limited in longer occlusions and where access is tortuous. A novel device (ERIC™) may enable IAT to be delivered more effectively in some patients (eg elderly with tortuous vessels).

In a randomised phase II trial we will assess safety and technical equivalence of the ERIC device compared with existing devices. We will determine clinical/imaging differences between those with LAO stroke successfully treated by thrombectomy compared with those who have successful thrombectomy without a good clinical outcome. This occurs frequently but is poorly understood.

STABILISE will explore utility of MRI post thrombectomy at detecting complications & as a predictor (biomarker) of longer term clinical outcome.

Newcastle University staff and students linked to the project:

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