Institute of Neuroscience

Staff Profile

Dr Amy Vincent

Research Associate

Background

I completed my undergraduate study at The University of Nottingham, graduating with an upper second class MSci degree in Biochemistry and Genetics in 2013.

I moved to the Wellcome Centre for Mitochondrial Research (Newcastle University) in 2013 to complete my PhD, with Professors Doug Tunrbull, Robert Taylor and Dr Rita Barresi. My PhD, spanned a number of projects with the aim to investigate mitochondrial dysfunction in both mitochondrial myopathy and other neuromuscular diseases. I completed my PhD in May 2017 and am now a Research Associate working with Professor Sir Doug Turnbull in the Wellcome Centre for Mitochondrial Research and MRC Centre for Ageing and Vitality.

My current work looks to understand how mitochondrial DNA mutations accumulate in skeletal muscle with age and disease with a focus on the impact of cytoskeletal architecture, signalling and mitochondrial morphology.

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Research

Mitochondrial DNA mutations and mitochondrial respiratory chain deficiency arise in a mosaic pattern within the skeletal muscle of patients with mitochondrial myopathy. However, they are also found in a number of other myopathies and in aging skeletal muscle.
My work looks to investigate mitochondria dysfunction and associated pathogenic mechanisms in both mitochondrial and other myopathies. This is being approached from three angles:
1) Characterising mitochondrial dysfunction in myofibrillar myopathy, dysferlinopathy and centronucelar myopathy and looking for potential links to disease pathology.
2) Attempting to understand mechanisms and factors effecting clonal expansion of mitochondrial DNA mutations.
3) Looking to make links between mitochondrial morphology, ultrastructure and function.

Teaching

I am regularly involved with supervision and teaching of project students within the lab.

Publications