Research

Research Interests

Movement neuroscience, epilepsy, neurotechnology, neural prosthetics, Brain-Machine Interfaces

Current Work

PI of CANDO (Controlling Abnormal Network Dynamics using Optogenetics), a multi-site, interdisciplinary project to develop a cortical implant for optogenetic neural control of seizures. See http://www.cando.ac.uk

A neural prosthesis to restore hand function following spinal cord injury and stroke - We are developing implantable electronic devices and surgical techniques for delivering electrical stimulation to the spinal cord, controlled in real-time from neural signals recorded in the brain.

Investigating mechanisms of learning and plasticity during operation of myoelectric-controlled interfaces and brain-machine interfaces - We use tasks requiring subjects to control computer cursors directly from electrophysiological signals in order to understand the brain mechanisms that underlie learning of abstract neuromotor mappings.

Postgraduate Supervision

Thomas Hall

Felipe de Carvalho

Damar Susilaradeya 

Jennifer Tulip

Current Funding

Wellcome Trust Senior Research Fellowship "'Overcoming the scientific and technological barriers to long-term incorporation of neuroprostheses into motor networks"

Wellcome Trust and EPSRC Innovative Engineering for Health "CANDO: Controlling Abnormal Network Dynamics using Optogenetics)" 

Publications

• Hodkin EF, Lei Y, Humby J, Glover IS, Choudhury S, Kumar H, Perez MA, Rodgers H, Jackson A. Automated FES for Upper Limb Rehabilitation Following Stroke and Spinal Cord Injury. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2018, (ePub ahead of Print).
• Ramezani R, Liu Y, Dekhoda F, Soltan A, Haci D, Zhao H, Firfilionis D, Hazra A, Cunningham M, Jackson A, Constandinou T, Degenaar P. On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation. IEEE Transactions on Biomedical Circuits and Systems 2018, epub ahead of print.
• Dehkhoda F, Soltan A, Ponon N, Jackson A, ONeill A, Degenaar P. Self-sensing of temperature rises on light emitting diode based optrodes. Journal of Neural Engineering 2018, 15(2), 026012.
• Jackson A. Untangling Neural Representations in the Motor Cortex. Neuron 2018, 97(4), 736-738.
• Xia L, Fattah N, Soltan A, Jackson A, Chester G, Degenaar P. A low power flash-FPGA based brain implant micro-system of PID control. In: 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2017, Seogwipo, South Korea: IEEE.
• Tulip J, Zimmermann JB, Farningham D, Jackson A. An automated system for positive reinforcement training of group-housed macaque monkeys at breeding and research facilities. Journal of Neuroscience Methods 2017, 285, 6-18.
• Jackson A, Hall TM. Decoding local field potentials for neural interfaces. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2017, 25(10), 1705-1714.
• Davila-Montero S, Barsakcioglu DY, Jackson A, Constandinou TG, Mason AJ. Real-time clustering algorithm that adapts to dynamic changes in neural recordings. In: IEEE International Symposium on Circuits and Systems (ISCAS). 2017, Baltimore, MD, USA: Institute of Electrical and Electronics Engineers Inc.
• Sohal HS, Vassilevski K, Jackson A, Baker SN, ONeill A. Design and Microfabrication Considerations for Reliable Flexible Intracortical Implants. Frontiers in Mechanical Engineering 2016, 2(3).
• Sohal HS, Clowry GJ, Jackson A, O'Neill A, Baker SN. Mechanical Flexibility Reduces the Foreign Body Response to Long-Term Implanted Microelectrodes in Rabbit Cortex. PLoS One 2016, 11(10), e0165606.
• Jackson A. SPINAL-CORD INJURY Neural interfaces take another step forward. Nature 2016, 539(7628), 177-178.
• Williams I, Luan S, Jackson A, Constandinou TG. A Scalable 32-Channel Neural Recording and Real-Time FPGA Based Spike Sorting System. In: IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings. 2015, Atlanta, Georgia, USA: Institute of Electrical and Electronics Engineers Inc.
• Pistohl T, Joshi D, Ganesh G, Jackson A, Nazarpour K. Artificial proprioceptive feedback for myoelectric control. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2015, 23(3), 498-507.
• Graziadio S, Nazarpour K, Gretenkord S, Jackson A, Eyre J. Greater intermanual transfer in the elderly suggests age-related bilateral motor cortex activation is compensatory. Journal of Motor Behavior 2015, 47(1), 47-55.
• Hall TM, de Carvalho F, Jackson A. A Common Structure Underlies Low-Frequency Cortical Dynamics in Movement, Sleep, and Sedation. Neuron 2014, 83(5), 1185-1199.
• Barsakcioglu DY, Liu Y, Bhunjun P, Navajas J, Eftekhar A, Jackson A, Quiroga RQ, Constandinou TG. An Analogue Front-End Model for Developing Neural Spike Sorting Systems. IEEE Transactions on Biomedical Circuits and Systems 2014, 8(2), 216-227.
• Zimmermann JB, Jackson A. Closed-loop control of spinal cord stimulation to restore hand function after paralysis. Frontiers in Neuroscience 2014, 8, 87.
• Krasoulis A, Hall TM, Vijayakumar S, Jackson A, Nazarpour K. Generalizability of EMG decoding using local field potentials. In: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014). 2014, Chicago, IL, USA: IEEE.
• Krasoulis A, Hall TM, Vijayakumar S, Jackson A, Nazarpour K. Generalizability of EMG decoding using local field potentials. In: 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2014, Chicago, USA: IEEE.
• Navajas J, Barsakcioglu DY, Eftekhar A, Jackson A, Constandinou TG, Quiroga RQ. Minimum requirements for accurate and efficient real-time on-chip spike sorting. Journal of Neuroscience Methods 2014, 230, 51-64.
• Hall TM, Nazarpour K, Jackson A. Real-time estimation and biofeedback of single-neuron firing rates using local field potentials. Nature Communications 2014, 5, 5462.
• Sohal HS, Jackson A, Jackson R, Clowry GJ, Vassilevski K, O'Neill A, Baker SN. The sinusoidal probe: a new approach to improve electrode longevity . Frontiers in Neuroengineering 2014, 7, 10.
• Sharpe AN, Jackson A. Upper-limb muscle responses to epidural, subdural and intraspinal stimulation of the cervical spinal cord. Journal of Neural Engineering 2014, 11(1), 1-16.
• Nazarpour K, Al-Timemy AH, Bugmann G, Jackson A. A note on the probability distribution function of the surface electromyogram signal. Brain Research Bulletin 2013, 90, 88-91.
• Pistohl T, Cipriani C, Jackson A, Nazarpour K. Abstract and Proportional Myoelectric Control for Multi-Fingered Hand Prostheses. Annals of Biomedical Engineering 2013, 41(12), 2687-2698.
• Nazarpour K, Barnard A, Jackson A. Flexible cortical control of task-specific muscle synergies. Journal of Neuroscience 2012, 32(36), 12349-12360.
• Jackson A, Nazarpour K. Motor learning explored with myoelectric and neural interfaces. In: Gollhofer, A., Taube, W., Nielsen, J.B, ed. Routledge Handbook of Motor Control and Motor Learning. Routledge, 2012, pp.71-89.
• Jackson A, Zimmermann JB. Neural interfaces for the brain and spinal cord-restoring motor function. Nature Reviews Neurology 2012, 8(12), 690-699.
• Jackson A. Neuroscience: Brain-controlled robot grabs attention. Nature 2012, 485(7398), 317-318.
• Jackson A, Fetz EE. Interfacing With the Computational Brain. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2011, 19(5), 534-541.
• Zimmermann JB, Seki K, Jackson A. Reanimating the arm and hand with intraspinal microstimulation. Journal of Neural Engineering 2011, 8(5), 054001.
• Radhakrishnan SM, Baker SN, Jackson A. Learning a novel myoelectric-controlled interface task. Journal of Neurophysiology 2008, 100(4), 2397-2408.
• Jackson A, Fetz EE. Compact movable microwire array for long-term chronic unit recording in cerebral cortex of primates. Journal of Neurophysiology 2007, 98(5), 3109-3118.
• Jackson A, Mavoori J, Fetz EE. Correlations Between the Same Motor Cortex Cells and Arm Muscles During a Trained Task, Free Behavior, and Natural Sleep in the Macaque Monkey. Journal of Neurophysiology 2007, 97(1), 360-374.
• Jackson A, Mavoori J, Fetz EE. Long-term motor cortex plasticity induced by an electronic neural implant. Nature 2006, 444(7115), 56-60.
• Jackson A, Baker SN, Fetz EE. Tests for presynaptic modulation of corticospinal terminals from peripheral afferents and pyramidal tract in the macaque. Journal of Physiology 2006, 573(1), 107-120.
• Jackson A, Moritz CT, Mavoori J, Lucas TH, Fetz EE. The Neurochip BCI: Towards a neural prosthesis for upper limb function. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2006, 14(2), 187-190.
• Mavoori J, Jackson A, Diorio C, Fetz EE. An autonomous implantable computer for neural recording and stimulation in unrestrained primates. Journal of Neuroscience Methods 2005, 148(1), 71-77.
• Spinks RL, Baker SN, Jackson A, Khaw PT, Lemon RN. Problem of dural scarring in recording from awake, behaving monkeys: a solution using 5-flurouracil. Journal of Neurophysiology 2003, 90(2), 1324-1332.
• Jackson A, Gee VJ, Baker SN, Lemon RN. Synchrony between Neurons with Similar Muscle Fields in Monkey Motor Cortex. Neuron 2003, 38(1), 115-125.
• Kilner JM, Salenius S, Baker SN, Jackson A, Hari R, Lemon RN. Task dependent modulations of cortical oscillatory activity in human subjects during a bimanual precision grip task. NeuroImage 2003, 18(1), 67-73.
• Jackson A, Spinks RL, Freeman TCB, Wolpert DM, Lemon RN. Rhythm generation in monkey motor cortex explored using pyramidal tract stimulation. Journal of Physiology 2002, 541(3), 685-699.
• Baker SN, Spinks R, Jackson A, Lemon RN. Synchronization in Monkey Motor Cortex During a Precision Grip Task. I. Task-Dependent Modulation in Single-Unit Synchrony. Journal of Neurophysiology 2001, 85(2), 869-885.
• Burgess N, Jackson A, Hartley T, O'Keefe J. Predictions derived from modelling the hippocampal role in navigation. Biological Cybernetics 2000, 83(3), 301-312.