Institute of Neuroscience

Staff Profile

Professor Avan Sayer

Director, NIHR Newcastle Biomedical Research Centre & Professor of Geriatric Medicine

Background

Introduction

I am Director of the NIHR Newcastle Biomedical Research Centre (BRC) and we were delighted to be awarded £16.2M for a further 5 years funding in the most recent national competition. Newcastle’s reputation for excellence in ageing research across the translational pathway combined with the opportunity to lead the BRC, considered by many to be the ‘jewel in the crown’ of NIHR research infrastructure, were key to my decision to move to Newcastle. My clinical speciality is geriatric medicine and I have international recognition in the field of Geriatrics and Gerontology for my research on ageing, sarcopenia (the age-related loss of skeletal muscle mass and function), physical frailty and multimorbidity. Major research contributions to date include i) discovery of early life influences on human ageing; ii) development of a life course approach to sarcopenia and frailty using clinical, epidemiological and biological approaches; and  iii) innovative ageing experimental medicine to optimise health and healthcare in later life.

Research Priorities

Our research vison is world-class research in ageing and long-term conditions and the three main aims of the BRC are: to drive innovation in the prevention, diagnosis and treatment of ill-health through early translational (experimental medicine) research; to translate advances in biomedical research into benefits for patients, the health system and for broader economic gain; and to provide a key component of the NHS contribution to national and international competitiveness. So we are perfectly positioned to exploit Newcastle’s established track record in experimental medicine and apply it to optimising health and healthcare in ageing and long-term conditions. A particular focus will be team science and sustainable capacity building in ageing experimental medicine in the North East and wider, building on my track record of developing an innovative interdisciplinary gerontology group and setting up a flourishing NIHR integrated academic training programme in geriatric medicine in Southampton prior to moving to Newcastle.

Other Positions

Other current positions include Co-Chair British Geriatrics Society Sarcopenia and Frailty Research Special Interest Group, Secretary to the UK Association of Academic Geriatric Medicine, Member of the Academic Board of the European Geriatric Medicine Society and Associate Editor at Age and Ageing. I serve on a number of UK and international advisory committees and expert panels. I was previously an MRC Principal Investigator, Programme Leader and Professor of Geriatric Medicine at the MRC Lifecourse Epidemiology Unit, University of Southampton where I now hold a Visiting Professor position and have been a Raine Visiting Professor at the University of Western Australia.

Research

The importance of skeletal muscle in ageing, health, and disease

The age-related loss of skeletal muscle mass and function (sarcopenia) is associated with profound adverse consequences for health including frailty, disability, morbidity and mortality. My research focuses on the life course causes, consequences and treatment of this loss of skeletal muscle. It exploits the wealth of unique data available in UK ageing and birth cohorts and includes first in world muscle biopsy studies in birth cohort participants allowing investigation of cellular and molecular mechanisms in relation to detailed clinical and physiological characterisation of skeletal muscle. A novel discovery was the association between low birth weight and sarcopenia 60 or 70 years later, suggesting that early influences were having lifelong effects on skeletal muscle. This has had led to progress in several areas of ageing experimental medicine including aetiology in terms of understanding mechanisms across the life course; prediction leading to consideration of earlier identification of individuals at risk; prevention with investigation of the role of implementing strategies earlier in life; and intervention in terms of developing novel agents.

Translational research

Discovery science has been followed by early translational studies of different types of intervention. The demonstration of an association between birth weight, leisure time physical activity and physical performance in older people led to an aetiological trial investigating differential response to an aerobic exercise intervention stratified by birth weight. An observational epidemiological study showing relationships between use of common cardiovascular drugs and reduced grip strength independent of co-morbidity has led to a major trial now underway investigating the effect of angiotensin converting enzyme inhibitors and leucine to enhance skeletal muscle function in sarcopenia. A candidate gene approach to studying gene expression in skeletal muscle found increased expression of pro-inflammatory genes and loss of strength in older men and a major ‘omics’ collaboration to identify potential drug targets is now underway.

Collaboration and Impact

I have extensive collaborative links with research groups in the UK and internationally but also across a number of key organisations to ensure that our research has maximum impact on the health needs of older people, the NHS and the UK economy. An example of patient impact has been translation of epidemiological findings on grip strength into change in clinical practice. We published a series of papers demonstrating that grip strength, as a marker of sarcopenia, was a powerful predictor of future disability, morbidity and mortality which then led to work describing both UK and global normative data. Measurement of grip is now increasingly used across UK hospital and community settings to stratify care and specialist intervention.

Taking the research forward

This research will be taken forward by the AGE Research Group  https://research.ncl.ac.uk/ageresearchgroup/ which has strong links to the NIHR Newcastle BRC cross-cutting theme in ageing syndromes.  The talented researchers in this new group currently span the disciplines of academic geriatric medicine, epidemiology, trials, nutrition, exercise physiology, computing science and biomedical research. Our vision is improving lives through world-class research in ageing and long-term conditions. We take a life course approach to understanding ageing syndromes such as sarcopenia, frailty and multimorbidity with translation of the findings into new new approaches to diagnosis, treatment and prevention.

Teaching

I have the opportunity to lecture on the MBBS and Biomedical Sciences undergraduate degree courses and enjoy supervising undergraduate and postgraduate students in research projects and higher degrees.

Publications

  • Cox NJ, Ibrahim K, Sayer AA, Robinson SM, Roberts HC. Assessment and Treatment of the Anorexia of Aging: A Systematic Review. Nutrients 2019, 11(1), 144.
  • Granic A, Mendonça N, Sayer AA, Hill TR, Davies K, Siervo M, Mathers JC, Jagger C. Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: the Newcastle 85+ Study. Clinical Nutrition 2019, Epub ahead of print.
  • Witham MD, Roberts HC, Gladman J, Stott DJ, Sayer AA. Growing research in Geriatric Medicine. Age and Ageing 2019, Epub ahead of print.
  • Farre-Garros R, Lee J, Natanek SA, Connolly M, Sayer AA, Patel H, Cooper C, Polkey M, Kemp P. Quadriceps miR-542-3p and 5p are elevated in COPD and reduce function by inhibiting ribosomal and protein synthesis. Journal of Applied Physiology 2019, Epub ahead of print.
  • Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M, Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing 2019, 48(1), 16-31.
  • Ibrahim K, Howson F, Culliford D, Sayer AA, Roberts HC. The feasibility of assessing frailty and sarcopenia in hospitalised older people: a comparison of commonly used tools. BMC Geriatrics 2019, 19, 42.
  • Dodds RM, Pakpahan E, Granic A, Davies K, Sayer AA. The recent secular trend in grip strength among older adults: findings from the English Longitudinal Study of Ageing. European Geriatric Medicine 2019, 10(3), 395-401.
  • Robinson SM, Westbury LD, Cooper R, Kuh D, Ward K, Syddall HE, Sayer AA, Cooper C. Adult Lifetime Diet Quality and Physical Performance in Older Age: Findings From a British Birth Cohort. The Journals of Gerontology, Series A 2018, 73(11), 1532-1537.
  • Lim SER, Ibrahim K, Sayer AA, Roberts HC. Assessment of physical activity of hospitalised older adults: a systematic review. Journal of Nutrition, Health & Aging 2018, 22(3), 377-386.
  • Westbury LD, Dodds RM, Syddall HE, Baczynska AM, Shaw SC, Dennison EM, Roberts HC, Sayer AA, Cooper C, Patel HP. Associations Between Objectively Measured Physical Activity, Body Composition and Sarcopenia: Findings from the Hertfordshire Sarcopenia Study (HSS). Calcified Tissue International 2018, 103(3), 237-245.
  • Dodds RM, Kuh D, Sayer AA, Cooper R. Can measures of physical performance in mid-life improve the clinical prediction of disability in early old age? Findings from a British birth cohort study. Experimental Gerontology 2018, 110, 118-124.
  • Howson FA, Robinson SM, Lin SX, Orlando R, Cooper C, Sayer AA, Roberts HC. Can trained volunteers improve the mealtime care of older hospital patients? An implementation study in one English hospital. BMJ Open 2018, 8(8), e022285.
  • Bridges J, Pickering R, Barker H, Chable R, Fuller A, Gould L, Libberton P, Mesa-Eguiagaray I, Raferty J, Sayer AA, Westwood G, Wigley W, Yao G, Zhu S, Griffiths P. Creating learning environments for compassionate care (CLECC): a feasibilty study. Health Services and Delivery Research 2018.
  • Granic A, Mossop H, Engstrom G, Davies K, Dodds R, Galvin JE, Ouslander JG, Tappen R, Sayer AA. Factors associated with physical performance measures in a multiethnic cohort of older adults. Gerontology and Geriatric Medicine 2018, 4, 1-14.
  • Ibrahim K, May CR, Patel HP, Baxter M, Sayer AA, Roberts HC. Implementation of grip strength measurement in medicine for older people wards as part of routine admission assessment: identifying facilitators and barriers using a theory-led intervention. BMC Geriatrics 2018, 18, 79.
  • Ramsay SE, Papachristou E, Watt RG, Tsakos G, Lennon LT, Papacosta AO, Moynihan P, Sayer AA, Whincup PH, Wannamethee SG. Influence of Poor Oral Health on Physical Frailty: A Population-Based Cohort Study of Older British Men. Journal of the American Geriatrics Society 2018, 66(3), 473–479.
  • Connolly M, Paul R, Farre-Garros R, Natanek SA, Bloch S, Lee J, Lorenzo JP, Patel H, Cooper C, Sayer AA, Wort SJ, Griffiths M, Polkey MI, Kemp P. miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting. Journal of Cachexia, Sarcopenia and Muscle 2018, 9(2), 400-416.
  • Dodds RM, Davies K, Granic A, Hollingsworth KG, Warren C, Gorman G, Turnbull DM, Sayer AA. Mitochondrial respiratory chain function and content are preserved in the skeletal muscle of active very old men and women. Experimental Gerontology 2018, 113, 80-85.
  • Gravell R, Duncan GW, Khoo TK, Burn DJ, Sayer AA, Barker RA, Lawson RA, Yarnall AJ. Multimorbidity predicts quality of life but not motor severity in early Parkinson's disease. Journal of Parkinson's Disease 2018, 8(4), 511-515.
  • Patel HP, Dawson A, Westbury LD, Hasnaoui G, Syddall HE, Shaw S, Sayer AA, Cooper C, Dennison EM. Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS). Calcified Tissue International 2018, 103(1), 35-43.
  • Granic A, Mendonça N, Hill TR, Jagger C, Stevenson EJ, Mathers JC, Sayer AA. Nutrition in the Very Old. Nutrients 2018, 10(3), 269.
  • Lim SER, Dodds R, Bacon D, Sayer AA, Roberts HC. Physical activity among hospitalised older people: insights from upper and lower limb accelerometry. Aging Clinical and Experimental Research 2018, 30(11), 1363-1369.
  • Keevil VL, Luben R, Hayat S, Sayer AA, Wareham NJ, Khaw KT. Physical capability predicts mortality in late mid-life as well as in old age: findings from a large British cohort study. Archives of Gerontology and Geriatrics 2018, 74, 77-82.
  • Parker SG, Corner L, Laing K, Nestor G, Craig D, Collerton J, Frith J, Roberts HC, Sayer AA, Allan LM, Robinson L, Cowan K. Priorities for research in multiple conditions in later life (multi-morbidity): findings from a James Lind Alliance Priority Setting Partnership. Age and Ageing 2019, epub ahead of print.
  • Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel K, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology 2018, 84(2), 289-301.
  • Ibrahim K, Owen C, Patel HP, May C, Baxter M, Sayer AA, Roberts HC. Can routine clinical data identify older patients at risk of poor healthcare outcomes on admission to hospital?. BMC Research Notes 2017, 10, 384.
  • Robinson SM, Jameson KA, Bloom I, Ntani G, Crozier SR, Syddall H, Dennison EM, Cooper C, Sayer AA. Development of a short questionnaire to assess diet quality among older community-dwelling adults. Journal of Nutrition, Health and Aging 2017, 21(3), 247-253.
  • Dennison EM, Sayer AA, Cooper C. Epidemiology of sarcopenia and insight into possible therapeutic targets. Nature Reviews Rheumatology 2017, 13, 340-347.
  • Hannam K, Clark EM, Hartley A, Sayer AA, Tobias JH, Gregson C. Feasibility and acceptability of using jumping mechanography to detect early components of sarcopenia in community-dwelling older women. Journal of Musculoskeletal and Neuronal Interactions 2017, 17(3), 246-257.
  • Palmer KT, DAngelo S, Harris EC, Linaker C, Gale CR, Evandrou M, Syddall H, vanStaa T, Cooper C, Sayer AA, Coggon D, Walker-Bone K. Frailty, pre-frailty and employment outcomes in the Health and Employment after Fifty (HEAF) study. Occupational & Environmental Medicine 2017, 74(7), 476-482.
  • Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Sayer AA. Grip strength and inflammatory biomarker profiles in very old adults. Age and Ageing 2017, 46(6), 976-982.
  • Bruyère O, Buckinx F, Beaudart C, Reginster JY, Bauer J, Cederholm T, Cherubini A, Cooper C, Cruz-Jentoft AJ, Landi F, Maggi S, Rizzoli R, Sayer AA, Sieber C, Vellas B, Cesari M. How clinical practitioners assess frailty in their daily practice: an international survey. Ageing Clinical and Experimental Research 2017, 29(5), 905-912.
  • Bloom I, Edwards M, Jameson K, Syddall H, Dennison E, Gale C, Baird J, Cooper C, Sayer AA, Robinson S. Influences on diet quality in older age: the importance of social factors. Age & Ageing 2017, 46(2), 277-283.
  • Granic A, Davies K, Jagger C, Dodds R, Kirkwood TBL, Sayer AA. Initial level and rate of change in grip strength predict all-cause mortality in very old adults. Age and Ageing 2017, 46(6), 970-976.
  • Baczynska AM, Shaw SC, Patel HP, Sayer AA, Roberts HC. Learning from older peoples’ reasons for participating in demanding, intensive epidemiological studies: a qualitative study. Medical Research Methodology 2017, 17, 167.
  • Granic A, Mendonca N, Sayer AA, Hill TR, Davies K, Adamson A, Siervo M, Mathers JC, Jagger C. Low protein intake, muscle strength and physical performance in the very old: the Newcastle 85+ Study. Clinical Nutrition 2017, 37(6), 2260-2270.
  • Kalula SZ, Ferreira M, Swingler GH, Badri M, Sayer AA. Methodological challenges in a study on falls in an older population of Cape Town, South Africa. African Health Sciences 2017, 17(3), 912-922.
  • Rygiel KA, Dodds RM, Patel HP, Syddall HE, Westbury LD, Granic A, Cooper C, Cliff J, Rocha MC, Turnbull DM, Sayer AA. Mitochondrial respiratory chain deficiency in older men and its relationship with muscle mass and performance. Journal of Cachexia, Sarcopenia and Muscle - Clinical Reports 2017, 2(2), e00035.
  • Syddall HE, Westbury L, Dodds R, Dennison EM, Cooper C, Sayer AA. Mortality in the Hertfordshire Ageing Study: association with level and loss of grip strength in later life. Age and Ageing 2017, 46(3), 407-412.
  • Yarnall AJ, Sayer AA, Clegg A, Rockwood K, Parker S, Hindle JV. New Horizons in Multimorbidity in Older Adults. Age and Ageing 2017, 46(6), 882-888.
  • Gale CR, Mõttus R, Deary IJ, Cooper C, Sayer AA. Personality and Risk of Frailty: the English Longitudinal Study of Ageing. Annals of Behavioral Medicine 2017, 51(1), 128-136.
  • Dodds RM, Granic A, Davies K, Kirkwood TBL, Jagger C, Sayer AA. Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study. Journal of Cachexia, Sarcopenia and Muscle 2017, 8(2), 229-237.
  • Kilsby AJ, Sayer AA, Witham MD. Selecting Potential Pharmacological Interventions in Sarcopenia. Drugs & Aging 2017, 34(4), 233-240.
  • Palmer KT, D'Angelo S, Harris EC, Linaker C, Sayer AA, Gale CR, Evandrou M, van Staa T, Cooper C, Coggon D, Walker-Bone K. Sleep disturbance and the older worker: findings from the Health and Employment After Fifty study. Scandinavian Journal of Work, Environment & Health 2017, 43(2), 136-145.
  • Roberts HC, Pilgrim A, Jameson KA, Cooper C, Sayer AA, Robinson SM. The impact of trained volunteer mealtime assistants on the dietary intake of older female in-patients: the Southampton Mealtime Assistance Study. Journal of Nutrition, Health and Aging 2017, 21(3), 320-328.
  • Lansbury LN, Robert HC, Clift E, Herklots A, Robinson N, Sayer AA. Use of the electronic Frailty Index to identify vulnerable patients: a pilot study in primary care. British Journal of General Practice 2017, 67(664), e751-e756.
  • Granic A, Hill TR, Davies K, Jagger C, Adamson A, Siervo M, Kirkwood TBL, Mathers JC, Sayer AA. Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study. Nutrients 2017, 9(4), 379.
  • Bloom I, Lawrence W, Barker M, Baird J, Dennison E, Sayer AA, Cooper C, Robinson S. What influences diet quality in older people? A qualitative study among community-dwelling older adults from the Hertfordshire Cohort Study, UK. Public Health Nutrition 2017, 20(15), 2685-2693.
  • Baczynska AM, Shaw SC, Patel HP, Sayer AA, Roberts HC. Why do older people participate in intensive research: A qualitative study. Age and Ageing 2017, 46(2), 15-16.
  • Ibrahim K, May C, Patel H, Baxter M, Sayer AA, Roberts H. A feasibility study of implementing grip strength measurement into routine hospital practice (GRImP): study protocol. Pilot and Feasibility Studies 2016, 2, 1-10.
  • North TL, Ben-Shlomo Y, Cooper C, Deary IJ, Gallacher J, Kivimaki M, Kumari M, Martin RM, Pattie A, Sayer AA, Starr JM, Wong A, Kuh D, Rodriguez S, Day IN. A study of common Mendelian disease carriers across ageing British cohorts: meta-analyses reveal heterozygosity for alpha 1-antitrypsin deficiency increases respiratory capacity and height. Journal of Medical Genetics 2016, 53(4), 280-288.
  • Zhang J, Jameson K, Sayer AA, Robinson S, Cooper C, Dennison E. Accumulation of risk factors associated with poor bone health in older adults. Archives of Osteoporosis 2016, 11(3), 1-7.
  • Hanson MA, Cooper C, Aihie SayerA, Eendebak RJ, Clough GF, Beard JR. Developmental aspects of a life course approach to healthy ageing. Journal of Physiology 2016, 594(8), 2147-2160.
  • Dodds RM, Sayer AA. Editorial: Sarcopenia, frailty and mortality: the evidence is growing. Age and Ageing 2016, 45(5), 570-571.
  • Granic A, Jagger C, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Sayer AA. Effect of dietary patterns of muscle strength and physical performance in the very old: findings from the Newcastle 85+ Study. PLOS One 2016, 11(3), e0149699.
  • Jackson VE, Ntalla I, Sayers I, Morris R, Whincup P, Casas J-P, Amuzu A, Choi M, Dale C, Kumari M, Engmann J, Kalsheker N, Chappell S, Guetta-Baranes T, McKeever TM, Palmer CNA, Tavendale R, Holloway JW, Sayer AA, Dennison EM, Cooper C, Bafadhel M, Barker B, Brightling C, Bolton CE, John ME, Parker SG, Moffat MF, Wardlaw AJ, Connolly MJ, Porteous DJ, Smith BH, Padmanabhan S, Hocking L, Stirrups KE, Deloukas P, Strachan DP, Hall IP, Tobin MD, Wain LV. Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax 2016, 71(6), 501-509.
  • Dodds RM, Syddall HE, Cooper R, Kuh D, Cooper C, Sayer AA. Global variation in grip strength: a systematic review and meta-analysis of normative data. Age and Ageing 2016, 45(2), 209-216.
  • Granic A, Davies K, Jagger C, Kirkwood T, Syddall HE, Sayer AA. Grip strength decline and its determinants in the very old: longitudinal findings from the Newcastle 85+ Study. PLoS ONE 2016, 11(9), e0163183.
  • Granic A, Davies K, Jagger C, Kirkwood T, Syddal HE, Sayer AA. Grip strength decline and its determinants in the very old: longitudinal findings from the Newcastle 85+ Study. In: 60th Annual Scientific Meeting Society for Social Medicine. 2016, York: BMJ Group.
  • Walker-Bone K, D'Angelo S, Syddall HE, Palmer KT, Cooper C, Coggon D, Sayer AA. Heavy manual work throughout the working lifetime and muscle strength among men at retirement age. Occupational and Environmental Medicine 2016, 73(4), 284-286.
  • Baczynska AM, Shaw S, Roberts HC, Cooper C, Aihie SayerA, Patel HP. Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome. Journal of Visualized Experiments 2016, 4(109), e53075.
  • Westbury LD, Syddall HE, Simmonds SJ, Cooper C, Sayer AA. Identification of risk factors for hospital admission using multiple-failure survival models: a toolkit for researchers. BMC Medical Research Methodology 2016, 16(1), 46.
  • Lewis A, Lee JY, Donaldson AV, Natanek A, Vaidyanathan S, Man WD, Hopkinson NS, Sayer AA, Patel HP, Cooper C, Syddall H, Polkey MI, Kemp P. Increased expression of H19/miR-675 is associated with a low fat-free mass index in patients with COPD. Journal of Cachexia, Sarcopenia and Muscle 2016, 7(3), 330-344.
  • Witham MD, Sayer AA. Introduction to the Age and Ageing sarcopenia collection. Age and Ageing 2016, 45(6), 752-753.
  • D'Angelo S, Coggon D, Harris EC, Linaker C, Sayer AA, Gale CR, Evandrou M, vanStaa T, Cooper C, Walker-Bone K, Palmer KT. Job dissatisfaction and the older worker: Baseline findings from the Health and Employment After Fifty study. Occupational and Environmental Medicine 2016, 73(8), 512-519.
  • Pilgrim AL, Baylis D, Jameson KA, Cooper C, Sayer AA, Robinson SM, Roberts HC. Measuring Appetite with the Simplified Nutritional Appetite Questionnaire Identifies Hospitalised Older People at Risk of Worse Health Outcomes. Journal of Nutrition, Health & Aging 2016, 20(1), 3-7.
  • Litwic AE, Clynes M, Denison HJ, Jameson KA, Edwards MH, Sayer AA, Taylor P, Cooper C, Dennison EM. Non-invasive Assessment of Lower Limb Geometry and Strength Using Hip Structural Analysis and Peripheral Quantitative Computed Tomography: A Population-Based Comparison. CALCIFIED TISSUE INTERNATIONAL 2016, 98(2), 158-164.
  • Gale CR, Cooper C, Sayer AA. Prevalence and risk factors for falls in older men and women: The English Longitudinal Study of Ageing. Age and Ageing 2016, 45(6), 789-794.
  • Dawson A, Westbury L, Sayer AA, Patel H, Cooper C, Dennison E. Relationships between muscle morphology and bone health among older adults: findings from the Hertfordshire Sarcopenia Study. In: Osteoporosis Conference 2016. 2016, Birmingham, UK: Springer.
  • Dodds RM, Sayer AA. Sarcopenia and frailty: New challenges for clinical practice. Clinical Medicine 2016, 16(5), 455-458.
  • Howson F, Sayer AA, Roberts HC. The impact of trained volunteer mealtime assistants on dietary intake and satisfaction with mealtime care in adult hospital inpatients: A systematic review. Journal of Nutrition, Health and Aging 2016, 21(3), 320-328.
  • Baczynska A, Lim S, Sayer AA, Roberts HC. The use of volunteers to help older medical patients mobilise in hospital: a systematic review. Journal of Clinical Nursing 2016, 25(21-22), 3102-3112.
  • Syddall HE, Westbury LD, Simmonds SJ, Robinson S, Cooper C, Sayer AA. Understanding poor health behaviours as predictors of different types of hospital admission in older people: findings from the Hertfordshire Cohort Study. Journal of Epidemiology & Community Health 2016, 70(3), 292-298.
  • Sayer AA, Gill TM. Value of the life course approach to the health care of older people. International Journal of Epidemiology 2016, 45(4), 1011-1013.
  • Pilgrim AL, Robinson SM, Sayer AA, Roberts HC. An overview of appetite decline in older people. Nursing Older People 2015, 27(5), 29-35.
  • Witham MD, Sayer AA. Biological resilience in older people – a step beyond frailty?. European Geriatric Medicine 2015, 6(2), 101-102.
  • Baylis D, Syddall HE, Jameson KA, Cooper C, Lord JM, Roberts HC, Sayer AA. Cachexia, sarcopenia, inflammaging and outcomes in hospitalised older people (the CaSIO study): Study protocol and preliminary results. European Geriatric Medicine 2015, 6(5), 495-501.
  • Robison J, Pilgrim AL, Rood G, Diaper N, Elia M, Jackson AA, Cooper C, AihieSayer A, Robinson S, Roberts HC. Can trained volunteers make a difference at mealtimes for older people in hospital? A qualitative study of the views and experience of nurses, patients, relatives and volunteers in the Southampton Mealtime Assistance Study. International Journal of Older People Nursing 2015, 10(2), 136-145.
  • Nead KT, Li A, Wehner MR, Neupane B, Gustafsson S, Butterworth A, Engert JC, Davis AD, Hegele RA, Miller R, den Hoed M, Khaw KT, Kilpeläinen TO, Wareham N, Edwards TL, Hallmans G, Varga TV, Kardia SL, Smith JA, Zhao W, Faul JD, Weir D, et al. Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Human Molecular Genetics 2015, 24(12), 3582-3594.
  • Keevil VL, Luben R, Dalzell N, Hayat S, Sayer AA, Wareham NJ, Khaw KT. Cross-sectional associations between different measures of obesity and muscle strength in men and women in a British cohort study. Journal of Nutrition, Health and Aging 2015, 19(1), 3-11.
  • Roberts HC, Dodds R, Sayer AA. Current Clinical Care of Older Adults With Sarcopenia. Journal of Clinical Densitometry 2015, 18(4), 493-498.
  • North TL, Palmer TM, Lewis SJ, Cooper R, Power C, Pattie A, Starr JM, Deary IJ, Martin RM, Aihie SayerA, Kumari M, Cooper C, Kivimaki M, Kuh D, Ben-Shlomo Y, Day IN. Effect of smoking on physical and cognitive capability in later life: a multicohort study using observational and genetic approaches. BMJ Open 2015, 5(12), e008393.
  • Simmonds SJ, Syddall HE, Westbury LD, Dodds RM, Cooper C, Aihie Sayer A. Grip strength among community-dwelling older people predicts hospital admission during the following decade. Age and Ageing 2015, 44(6), 954-959.
  • Sayer AA, Kirkwood TBL. Grip strength and mortality: a biomarker of ageing?. Lancet 2015, 386(9990), 226-227.
  • Palmer KT, Walker-Bone K, Harris EC, Linaker C, D'Angelo S, Sayer AA, Gale CR, Evandrou M, van Staa T, Cooper C, Coggon D. Health and Employment after Fifty (HEAF): a new prospective cohort study. BMC Public Health 2015, 15, 1071.
  • Edwards MH, Ward KA, Ntani G, Parsons C, Thompson J, Sayer AA, Dennison EM, Cooper C. Lean mass and fat mass have differing associations with bone microarchitecture assessed by high resolution peripheral quantitative computed tomography in men and women from the Hertfordshire Cohort Study. Bone 2015, 81, 145-151.
  • Edwards MH, Dennison EM, Aihie Sayer A, Fielding R, Cooper C. Osteoporosis and sarcopenia in older age. Bone 2015, 80, 126-130.
  • ZimbaKalula S, Ferreira M, Swingler G, Badri M, AihieSayer A. Prevalence of Falls in an Urban Community-Dwelling Older Population of Cape Town, South Africa. Journal of Nutrition, Health & Aging 2015, 19(10), 1024-1031.
  • Gale CR, Cooper C, Sayer AA. Prevalence of frailty and disability: findings from the English Longitudinal Study of Ageing. Age and Ageing 2015, 44(1), 162-165.
  • Denison HJ, Cooper C, Sayer AA, Robinson SM. Prevention and optimal management of sarcopenia: a review of combined exercise and nutrition interventions to improve muscle outcomes in older people. Clinical Interventions in Aging 2015, 10, 859-869.
  • Dodds R, Sayer AA. Sarcopenia and frailty: new challenges for clinical practice. Clinical Medicine 2015, 15(Suppl. 6), 88-91.
  • Syddall HE, Westbury LD, Cooper C, Sayer AA. Self-reported walking speed: a useful marker of physical performance among community-dwelling older people?. Journal of the American Medical Directors Association 2015, 16(4), 323-328.
  • Patel HP, White MC, Westbury L, Syddall HE, Stephens PJ, Clough GF, Cooper C, Sayer AA. Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS). BMC Geriatrics 2015, 18(15), 171.
  • Keevil VL, Wijndaele K, Luben R, Sayer AA, Wareham NJ, Khaw KT. Television viewing, walking speed, and grip strength in a prospective cohort study. Medicine & Science in Sports & Exercise 2015, 47(4), 735-42.
  • Roberts HC, Syddall HE, Butchart JW, Stack EL, Cooper C, Sayer AA. The Association of Grip Strength With Severity and Duration of Parkinson's: A Cross-Sectional Study. Neurorehabilitation & Neural Repair 2015, 29(9), 889-896.
  • Dodds R, Roberts HC, Sayer AA, Cooper C. The Epidemiology of Sarcopenia. Journal of Clinical Densitometry 2015, 18(4), 461-466.
  • Monteserín R, Roberts HC, Sayer AA. [Role of primary care professionals in the management of sarcopenia]. Atencion Primaria 2014, 46(9), 455-456.
  • Witham MD, Syddall HE, Dennison E, Cooper C, McMurdo ME, Sayer AA. ACE inhibitors, statins and thiazides: no association with change in grip strength among community dwelling older men and women from the Hertfordshire Cohort Study. Age and Ageing 2014, 43(5), 661-666.
  • Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, Elliott J, Gunnell D, Harris SE, Kivimaki M, Kumari M, Martin RM, Power C, Sayer AA, Starr JM, Kuh D, Day IN, HALCyonStudy Team. Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme. Age 2014, 36(4), 9673.
  • Bann D, Wills A, Cooper R, Hardy R, AihieSayer A, Adams J, Kuh D, NSHDScientificandDataCollection Team. Birth weight and growth from infancy to late adolescence in relation to fat and lean mass in early old age: findings from the MRC National Survey of Health and Development. International Journal of Obesity 2014, 38(1), 69-75.
  • Cooper R, Hardy R, Bann D, Aihie Sayer A, Ward KA, Adams JE, Kuh D, MRC National Survey of Health and Development Scientific and Data Collection Team. Body mass index from age 15 years onwards and muscle mass, strength, and quality in early old age: findings from the MRC National Survey of Health and Development. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences 2014, 69(10), 1253-1259.
  • Okubo H, Syddall HE, Phillips DI, Sayer AA, Dennison EM, Cooper C, Robinson SM, Hertfordshire Cohort Study Group. Dietary total antioxidant capacity is related to glucose tolerance in older people: the Hertfordshire Cohort Study. Nutrition, Metabolism and Cardiovascular Diseases 2014, 24(3), 301-308.
  • Woo J, Arai H, Ng TP, Sayer AA, Wong M, Syddall H, Yamada M, Zeng P, Wu S, Zhang TM. Ethnic and geographic variations in muscle mass, muscle strength and physical performance measures. European Geriatric Medicine 2014, 5(3), 155-164.
  • Gale CR, Cooper C, Sayer AA. Framingham cardiovascular disease risk scores and incident frailty: the English longitudinal study of ageing. Age 2014, 36(4), 9692-9696.
  • Clynes MA, Parsons C, Edwards MH, Jameson KA, Harvey NC, Sayer AA, Cooper C, Dennison EM. Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study. Journal of Developmental Origins of Health and Disease 2014, 5(6), 453-458.
  • Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels P, Sayer AA, Barbieri M, Bekaert S, Bischoff C, Brooks-Wilson A, Chen W, Cooper C, Christensen K, DeMeyer T, Deary I, Der G, DiezRoux A, Fitzpatrick A, Hajat A, Halaschek-Wiener J, Harris S, Hunt SC, Jagger C, Jeon HS, Kaplan R, Kimura M, Lansdorp P, Li C, Maeda T, Mangino M, Nawrot TS, Nilsson P, Nordfjall K, Paolisso G, Ren F, Riabowol K, Robertson T, Roos G, Staessen JA, Spector T, Tang N, Unryn B, van der Harst P, Woo J, Xing C, Yadegarfar ME, Park JY, Young N, Kuh D, von Zglinicki T, Ben-Shlomo Y. Gender and telomere length: systematic review and meta-analysis. Experimental Gerontology 2014, 51, 15-27.
  • Dodds RM, Syddall HE, Cooper R, Benzeval M, Deary IJ, Dennison EM, Der G, Gale CR, Inskip HM, Jagger C, Kirkwood TB, Lawlor DA, Robinson SM, Starr JM, Steptoe A, Tilling K, Kuh D, Cooper C, Sayer AA. Grip Strength across the Life Course: Normative Data from Twelve British Studies. PLoS ONE 2014, 9(12), e113637.
  • Roberts HC, Syddall HE, Sparkes J, Ritchie J, Butchart J, Kerr A, Cooper C, Sayer AA. Grip strength and its determinants among older people in different healthcare settings. Age and Ageing 2014, 43(2), 241-246.
  • Baylis D, Ntani G, Edwards MH, Syddall HE, Bartlett DB, Dennison EM, Martin-Ruiz C, von Zglinicki T, Kuh D, Lord JM, Aihie Sayer A, Cooper C. Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcified Tissue International 2014, 95(1), 54-63.
  • Patel HP, Al-Shanti N, Davies LC, Barton SJ, Grounds MD, Tellam RL, Stewart CE, Cooper C, Sayer AA. Lean mass, muscle strength and gene expression in community dwelling older men: findings from the Hertfordshire Sarcopenia Study (HSS). Calcified Tissue International 2014, 95(4), 308-316.
  • Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Aihie Sayer A, Cooper C, Griffin SJ, Wareham NJ. Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals. Diabetology & Metabolic Syndrome 2014, 6(43).
  • Harvey NC, Moon RJ, Sayer AA, Ntani G, Davies JH, Javaid MK, Robinson SM, Godfrey KM, Inskip HM, Cooper C, Southampton Women's Survey Study Group. Maternal antenatal vitamin D status and offspring muscle development: findings from the Southampton Women's Survey. Journal of Clinical Endocrinology and Metabolism 2014, 99(1), 330-337.
  • Dennison EM, Jameson KA, Edwards MH, Denison HJ, Aihie Sayer A, Cooper C. Peripheral quantitative computed tomography measures are associated with adult fracture risk: the Hertfordshire Cohort Study. Bone 2014, 64, 13-17.
  • Cooper R, Stafford M, Hardy R, Aihie Sayer A, Ben-Shlomo Y, Cooper C, Craig L, Deary IJ, Gallacher J, McNeill G, Starr JM, Kuh D, Gale CR, HALCyonstudy team. Physical capability and subsequent positive mental wellbeing in older people: findings from five HALCyon cohorts. Age 2014, 36(1), 445-456.
  • Okubo H, Shaheen SO, Ntani G, Jameson KA, Syddall HE, Sayer AA, Dennison EM, Cooper C, Robinson SM, Hertfordshire Cohort Study Group. Processed meat consumption and lung function: modification by antioxidants and smoking. European Respiratory Journal 2014, 43(4), 972-982.
  • Suetterlin KJ, Sayer AA. Proprioception: where are we now? A commentary on clinical assessment, changes across the life course, functional implications and future intervention. Age Ageing 2014, 43(3), 313-318.
  • Gale CR, Cooper C, Deary IJ, Aihie Sayer A. Psychological well-being and incident frailty in men and women: the English Longitudinal Study of Ageing. Psychological Medicine 2014, 44(4), 697-706.
  • Dodds RM, Aihie Sayer A. Sarcopenia. Arquivos Brasileiros de Endocrinologia & Metabologia 2014, 58(5), 464-469.
  • Sayer AA. Sarcopenia the new geriatric giant: time to translate research findings into clinical practice. Age Ageing 2014, 43(6), 736-737.
  • Roberts HC, Lowry AF, AihieSayer A. The assessment and management of older people with sarcopenia. Nursing Older People 2014, 26(5), 18-22.
  • Gale CR, Allerhand M, Sayer AA, Cooper C, Deary IJ. The dynamic relationship between cognitive function and walking speed: the English Longitudinal Study of Ageing. Age 2014, 36(4), 9682.
  • Roberts HC, DeWet S, Porter K, Rood G, Diaper N, Robison J, Pilgrim AL, Elia M, Jackson AA, Cooper C, AihieSayer A, Robinson S. The feasibility and acceptability of training volunteer mealtime assistants to help older acute hospital inpatients: the Southampton Mealtime Assistance Study. Journal of Clinical Nursing 2014, 23(21-22), 3240-3249.
  • Simmonds SJ, Syddall HE, Walsh B, Evandrou M, Dennison EM, Cooper C, AihieSayer A. Understanding NHS hospital admissions in England: linkage of Hospital Episode Statistics to the Hertfordshire Cohort Study. Age and Ageing 2014, 43(5), 653-60.
  • Schlotz W, Phillips DI, HertfordshireCohortStudy Group. Birth weight and perceived stress reactivity in older age. Stress and Health 2013, 29(1), 56-63.
  • Hardy R, Cooper R, Aihie Sayer A, Ben-Shlomo Y, Cooper C, Deary IJ, Demakakos P, Gallacher J, Martin RM, McNeill G, Starr JM, Steptoe A, Syddall H, Kuh D, HALCyon study team. Body mass index, muscle strength and physical performance in older adults from eight cohort studies: the HALCyon programme. PLoS One 2013, 8(2), e56483.
  • Edwards MH, Jameson K, Denison H, Harvey NC, Sayer AA, Dennison EM, Cooper C. Clinical risk factors, bone density and fall history in the prediction of incident fracture among men and women. Bone 2013, 52(2), 241-7.
  • Robinson SM, Jameson KA, Syddall HE, Dennison EM, Cooper C, AihieSayer A, HertfordshireCohortStudy Group. Clustering of lifestyle risk factors and poor physical function in older adults: the Hertfordshire cohort study. J Am Geriatr Soc 2013, 61(10), 1684-91.
  • Gardner MP, Lightman S, Sayer AA, Cooper C, Cooper R, Deeg D, Ebrahim S, Gallacher J, Kivimaki M, Kumari M, Kuh D, Martin RM, Peeters G, Ben-Shlomo Y, HalcyonStudy Team. Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: an individual participant meta-analysis. Psychoneuroendocrinology 2013, 38(1), 40-9.
  • Denison HJ, Syddall HE, Dodds R, Martin HJ, Finucane FM, Griffin SJ, Wareham NJ, Cooper C, Sayer AA. Effects of aerobic exercise on muscle strength and physical performance in community-dwelling older people from the Hertfordshire cohort study: a randomized controlled trial. J Am Geriatr Soc 2013, 61(6), 1034-6.
  • denHoed M, Luan J, Langenberg C, Cooper C, Sayer AA, Jameson K, Kumari M, Kivimaki M, Hingorani AD, Grøntved A, Khaw KT, Ekelund U, Wareham NJ, Loos RJ. Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples. Int J Obes (Lond) 2013, 37(2), 191-6.
  • Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, Gunnell D, Harris SE, Kumari M, Martin RM, Sayer AA, Starr JM, Kuh D, Day IN, HALCyonstudy team. Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme. Bone 2013, 52(1), 278-85.
  • Keevil V, MazzuinRazali R, Chin AV, Jameson K, AihieSayer A, Roberts H. Grip strength in a cohort of older medical inpatients in Malaysia: a pilot study to describe the range, determinants and association with length of hospital stay. Arch Gerontol Geriatr 2013, 56(1), 155-9.
  • Denison HJ, Dodds RM, Ntani G, Cooper R, Cooper C, Sayer AA, Baird J. How to get started with a systematic review in epidemiology: an introductory guide for early career researchers. Archives of Public Health 2013, 71, 1-8.
  • Baylis D, Bartlett DB, Syddall HE, Ntani G, Gale CR, Cooper C, Lord JM, Sayer AA. Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people. Age (Dordr) 2013, 35(3), 963-71.
  • Gale CR, Baylis D, Cooper C, Sayer AA. Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing. Age (Dordr) 2013, 35(6), 2493-501.
  • Finucane FM, Sharp SJ, Hatunic M, Sleigh A, DeLuciaRolfe E, Sayer AA, Cooper C, Griffin SJ, Savage DB, Wareham NJ. Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals. Int J Endocrinol 2013.
  • Dennison EM, Dhanwal DK, Shaheen SO, Azagra R, Reading I, Jameson KA, Sayer AA, Cooper C. Is lung function associated with bone mineral density? Results from the Hertfordshire Cohort Study. Arch Osteoporos 2013, 8, 115.
  • Costello PM, Hollis LJ, Cripps RL, Bearpark N, Patel HP, Sayer AA, Cooper C, Hanson MA, Ozanne SE, Green LR. Lower maternal body condition during pregnancy affects skeletal muscle structure and glut-4 protein levels but not glucose tolerance in mature adult sheep. Reprod Sci 2013, 20(10), 1144-55.
  • Edwards MH, Gregson CL, Patel HP, Jameson KA, Harvey NC, Sayer AA, Dennison EM, Cooper C. Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study. J Bone Miner Res 2013, 28(11), 2295-304.
  • Sayer AA, Robinson SM, Patel HP, Shavlakadze T, Cooper C, Grounds MD. New horizons in the pathogenesis, diagnosis and management of sarcopenia. Age and Ageing 2013, 42(2), 145-150.
  • Dodds R, Kuh D, AihieSayer A, Cooper R. Physical activity levels across adult life and grip strength in early old age: updating findings from a British birth cohort. Age Ageing 2013, 42(6), 794-8.
  • Patel HP, Syddall HE, Jameson K, Robinson S, Denison H, Roberts HC, Edwards M, Dennison E, Cooper C, AihieSayer A. Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: findings from the Hertfordshire Cohort Study (HCS). Age Ageing 2013, 42(3), 378-84.
  • Rizzoli R, Reginster JY, Arnal JF, Bautmans I, Beaudart C, Bischoff-Ferrari H, Biver E, Boonen S, Brandi ML, Chines A, Cooper C, Epstein S, Fielding RA, Goodpaster B, Kanis JA, Kaufman JM, Laslop A, Malafarina V, Mañas LR, Mitlak BH, Oreffo RO, Petermans J, et al. Quality of life in sarcopenia and frailty. Calcif Tissue Int 2013, 93(2), 101-20.
  • Roberts HC, Pilgrim AL, Elia M, Jackson AA, Cooper C, Sayer AA, Robinson SM. Southampton Mealtime Assistance Study: design and methods. BMC Geriatr 2013, 13.
  • Gardner MP, Martin-Ruiz C, Cooper R, Hardy R, Sayer AA, Cooper C, Deary IJ, Gallacher J, Harris SE, Shiels PG, Starr JM, Kuh D, vonZglinicki T, Ben-Shlomo Y, Halcyonstudy team. Telomere length and physical performance at older ages: an individual participant meta-analysis. PLoS One 2013, 26(8(7)).
  • Cesari M, AbellanVanKan G, Ariogul S, Baeyens JP, Bauer J, Cankurtaran M, Cederholm T, Cherubini A, Cruz-Jentoft AJ, Curgunlu A, Landi F, Sayer AA, Strandberg T, Topinkova E, VanAsselt D, Vellas B, Zekry D, Michel JP. The European Union Geriatric Medicine Society (EUGMS) Working Group on Frailty inOlder Persons. Journal of Frailty & Aging 2013, 2(3), 118-120.
  • Edwards MH, Jameson KA, Denison H, Harvey NC, Sayer AA, Dennison EM, Cooper C. The importance of fall history in fracture risk assessment. Bone 2013, 53(2), 598-598.
  • Cooper C, Fielding R, Visser M, vanLoon LJ, Rolland Y, Orwoll E, Reid K, Boonen S, Dere W, Epstein S, Mitlak B, Tsouderos Y, Sayer AA, Rizzoli R, Reginster JY, Kanis JA. Tools in the Assessment of Sarcopenia. Calcified Tissue International 2013, 93(3), 201-210.
  • Robinson S, Ntani G, Simmonds S, Syddall H, Dennison E, Sayer AA, Barker D, Cooper C, HertfordshireCohortStudy Group. Type of milk feeding in infancy and health behaviours in adult life: findings from the Hertfordshire Cohort Study. British Journal of Nutrition 2013, 109(6), 1114-1122.
  • Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, DIAGRAM Consortium, MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D, Adeyemo A, Rotimi CN, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012, 7(1).
  • Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, Gaunt TR, Gunnell D, Harris SE, Kumari M, Martin RM, Sayer AA, Starr JM, Kuh D, Day IN, HALCyonstudy team. A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme. PLoS One 2012, 7(1).
  • Samuel D, Wilson K, Martin HJ, Allen R, Sayer AA, Stokes M. Age-associated changes in hand grip and quadriceps muscle strength ratios in healthy adults. Aging Clin Exp Res 2012, 24(3), 245-50.
  • Inskip H, Macdonald-Wallis C, Kapasi T, Robinson S, Godfrey K, Cooper C, Harvey N, Sayer AA, SouthamptonWomen'sSurveyStudy Group. Associations between grip strength of parents and their 4-year-old children: findings from the Southampton Women's Survey. Paediatr Perinat Epidemiol 2012, 26(1), 27-33.
  • Dodds R, Denison HJ, Ntani G, Cooper R, Cooper C, Sayer AA, Baird J. Birth weight and muscle strength: a systematic review and meta-analysis. J Nutr Health Aging 2012, 52(7), 609-15.
  • Gale CR, Syddall HE, Cooper C, Sayer AA, Bergman H, Brunner EJ. Close relationships and risk of frailty: the Hertfordshire Cohort Study. J Am Geriatr Soc 2012, 60(2), 390-2.
  • Patel HP, Jameson KA, Syddall HE, Martin HJ, Stewart CE, Cooper C, Sayer AA. Developmental influences, muscle morphology, and sarcopenia in community-dwelling older men. J Gerontol A Biol Sci Med Sci 2012, 67(1), 82-7.
  • Cooper C, Dere W, Evans W, Kanis JA, Rizzoli R, Sayer AA, Sieber CC, Kaufman JM, AbellanvanKan G, Boonen S, Adachi J, Mitlak B, Tsouderos Y, Rolland Y, Reginster JY. Frailty and sarcopenia: definitions and outcome parameters. Osteoporosis International 2012, 23(7), 1839-1848.
  • Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, GIANT Consortium, MAGIC Consortium, GLGC Consortium, Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L, Garcia M, Eiriksdottir G, et al. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet 2012, 8(5).
  • Dodds R, Macdonald-Wallis C, Kapasi T, Sayer AA, Robinson S, Godfrey K, Cooper C, Harvey N, Inskip H, SWSStudy Team. Grip strength at 4 years in relation to birth weight. J Dev Orig Health Dis 2012, 3(2), 111-5.
  • Stevens PJ, Syddall HE, Patel HP, Martin HJ, Cooper C, AihieSayer A. Is grip strength a good marker of physical performance among community-dwelling older people?. J Nutr Health Aging 2012, 16(9), 769-74.
  • Roberts HC, Syddall HE, Cooper C, AihieSayer A. Is grip strength associated with length of stay in hospitalised older patients admitted for rehabilitation? Findings from the Southampton grip strength study. Age Ageing 2012, 41(5), 641-6.
  • Roberts HC, Sparkes J, Syddall H, Butchart J, Ritchie J, Cooper C, Sayer AA. Is measuring grip strength acceptable to older people ? Views from four healthcare settings. J Aging Res Clin Prac 2012, 1(2), 135-140.
  • Verschuur CA, Dowell A, Syddall HE, Ntani G, Simmonds SJ, Baylis D, Gale CR, Walsh B, Cooper C, Lord JM, Sayer AA. Markers of inflammatory status are associated with hearing threshold in older people: findings from the Hertfordshire Ageing Study. Age Ageing 2012, 41(1), 92-7.
  • Robinson SM, Simmonds SJ, Jameson KA, Syddall HE, Dennison EM, Cooper C, Sayer AA, HertfordshireCohortStudy Group. Muscle strength in older community-dwelling men is related to type of milk feeding in infancy. J Gerontol A Biol Sci Med Sci 2012, 67(9), 990-6.
  • Scott RA, Chu AY, Grarup N, Manning AK, Hivert MF, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadahl M, Arking DE, Bergmann S, Boerwinkle E, et al. No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes 2012, 61(5), 121-6.
  • Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh HW, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012, 8(3).
  • Robinson SM, Cooper C, Sayer AA. Nutrition and Sarcopenia: A Review of the Evidence and Implications for Preventive Strategies. Journal of Aging Research 2012, 1-6.
  • Denison HJ, Jameson KA, Syddall HE, Dennison EM, Cooper C, Sayer AA, Robinson SM. Patterns of dietary supplement use among older men and women in the UK: findings from the Hertfordshire Cohort Study. J Nutr Health Aging 2012, 16(4), 307-11.
  • Wills AK, Lawlor DA, Muniz-Terrera G, Matthews F, Cooper R, Ghosh AK, Kuh D, Hardy R, FALConStudy Team. Population heterogeneity in trajectories of midlife blood pressure. Epidemiology 2012, 23(2), 203-11.
  • Syddall HE, Evandrou M, Dennison EM, Cooper C, Sayer AA. Social inequalities in osteoporosis and fracture among community-dwelling older men and women: findings from the Hertfordshire Cohort Study. Arch Osteoporos 2012, 7, 37-48.
  • Gale CR, Dennison EM, Edwards M, Sayer AA, Cooper C. Symptoms of anxiety or depression and risk of fracture in older people: the Hertfordshire Cohort Study. Arch Osteoporos 2012, 7, 59-65.
  • Bartlett DB, Firth CM, Phillips AC, Moss P, Baylis D, Syddall H, Sayer AA, Cooper C, Lord JM. The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell 2012, 11(5), 912-15.
  • Cesari M, AbellanvanKan G, Ariogul S, Baeyens JP, Bauer J, Cankurtaran M, Cederholm T, Cherubini A, CruzJentoft AJ, Curgunlu A, Landi F, Sayer AA, Strandberg T, Topinkova E, vanAsselt D, Vellas B, Zekry D, Michel JP. The European Union Geriatric Medicine Society (EUGMS) Working Group on‘Frailty in Older Persons’. J Frailty Aging 2012, 2(3), 118-120.
  • Denison HJ, Simmonds SJ, Syddall HE, Robinson SM, Dennison EM, Cooper C, Sayer AA, HertfordshireCohortStudy Group. The Hertfordshire Cohort Study: from historical to high-tech studies of musculoskeletal ageing in men and women entering their ninth decade. Int J Epidemiol 2012, 41(2), 386-9.
  • Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, Sayer AA. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing 2011, 40(4), 423-9.
  • Green SM, Martin HJ, Roberts HC, Sayer AA. A systematic review of the use of volunteers to improve mealtime care of adult patients or residents in institutional settings. J Clin Nurs 2011, 20(13-14), 1810-23.
  • Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, Elliott J, Gunnell D, Harris SE, Kivimaki M, Kumari M, Martin RM, Power C, Sayer AA, Starr JM, Kuh D, Day IN, HALCyonStudy Team. Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme. Aging Cell 2011, 10(3), 520-32.
  • Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, Gunnell D, Harris SE, Kumari M, Martin RM, Moran CN, Pitsiladis YP, Ring SM, Sayer AA, Smith GD, Starr JM, Kuh D, Day IN, HALCyonstudy team. ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies. Hum Mutat 2011, 32(9), 1008-18.
  • Cooper R, Hardy R, AihieSayer A, Ben-Shlomo Y, Birnie K, Cooper C, Craig L, Deary IJ, Demakakos P, Gallacher J, McNeill G, Martin RM, Starr JM, Steptoe A, Kuh D, HALCyonstudy team. Age and gender differences in physical capability levels from mid-life onwards: the harmonisation and meta-analysis of data from eight UK cohort studie. PLoS One 2011, 6(11).
  • Birnie K, Cooper R, Martin RM, Kuh D, Sayer AA, Alvarado BE, Bayer A, Christensen K, Cho SI, Cooper C, Corley J, Craig L, Deary IJ, Demakakos P, Ebrahim S, Gallacher J, Gow AJ, Gunnell D, Haas S, Hemmingsson T, Inskip H, Jang SN, et al. Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis. PLoS One 2011, 6(1).
  • Poynter L, Kwan J, Sayer AA, Vassallo M. Does cognitive impairment affect rehabilitation outcome?. J Am Geriatr Soc 2011, 59(11), 2108-11.
  • Martin H, AihieSayer A, Jameson K, Syddall H, Dennison EM, Cooper C, Robinson S. Does diet influence physical performance in community-dwelling older people? Findings from the Hertfordshire Cohort Study. Age Ageing 2011, 40(2), 181-6.
  • Gale CR, Sayer AA, Cooper C, Dennison EM, Starr JM, Whalley LJ, Gallacher JE, Ben-Shlomo Y, Kuh D, Hardy R, Craig L, Deary IJ, HALCyonStudy Team. Factors associated with symptoms of anxiety and depression in five cohorts of community-based older people: the HALCyon (Healthy Ageing across the Life Course) Programme. Psychol Med 2011, 41(10), 2057-73.
  • Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 2011, 7(3).
  • SolerArtigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet 2011, 43(11), 1082-90.
  • Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, Almgren P, Barker DJ, et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011, 60(10), 1624-34.
  • Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, VanderHarst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, MateoLeach I, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 2011, 16(11), 1131-8.
  • Mishra GD, Gale CR, Sayer AA, Cooper C, Dennison EM, Whalley LJ, Craig L, Kuh D, Deary IJ, HALCyonStudy Team. How useful are the SF-36 sub-scales in older people? Mokken scaling of data from the HALCyon programme. Qual Life Res 2011, 20(7), 1005-10.
  • Wills AK, Lawlor DA, Matthews FE, Sayer AA, Bakra E, Ben-Shlomo Y, Benzeval M, Brunner E, Cooper R, Kivimaki M, Kuh D, Muniz-Terrera G, Hardy R. Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts. PLoS Med 2011, 8(6).
  • Gale CR, Dennison EM, Cooper C, Sayer AA. Neighbourhood environment and positive mental health in older people: the Hertfordshire Cohort Study. Health Place 2011, 17(4), 867-74.
  • Cooper R, Kuh D, Cooper C, Gale CR, Lawlor DA, Matthews F, Hardy R, FALConandHALCyonStudy Teams. Objective measures of physical capability and subsequent health: a systematic review. Age Ageing 2011, 40(1), 14-23.
  • Alharbi KK, Hou G, Chen XH, Gaunt TR, Syddall HE, Sayer AA, Dennison EM, Phillips DI, Cooper C, Day IN. Population mutation scanning of human GHR by meltMADGE and identification of a paucimorphic variant. Genet Test Mol Biomarkers 2011, 15(12), 855-60.
  • Shaheen SO, Jameson KA, Robinson SM, Boucher BJ, Syddall HE, Sayer AA, Cooper C, Holloway JW, Dennison EM. Relationship of vitamin D status to adult lung function and COPD. Thorax 2011, 66(8), 692-8.
  • Patel H, Syddall HE, Martin HJ, Cooper C, Stewart C, Sayer AA. The feasibility and acceptability of muscle biopsy in epidemiological studies: findings from the Hertfordshire Sarcopenia Study (HSS). J Nutr Health Aging 2011, 15(1), 10-5.
  • Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI, DIAGRAM Consortium, MAGIC Investigators, Altshuler D, Daley GQ. The Lin28/let-7 axis regulates glucose metabolism. Cell 2011, 30(1), 81-94.
  • Dennison EM, Jameson KA, Syddall HE, Martin HJ, Cushnaghan J, AihieSayer A, Cooper C. Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study. Osteoporos Int 2010, 21(11), 1817-24.
  • Syddall HE, Simmonds SJ, Martin HJ, Watson C, Dennison EM, Cooper C, Sayer AA, HertfordshireCohortStudy Group. Cohort profile: The Hertfordshire Ageing Study (HAS). Int J Epidemiol 2010, 39(1), 36-43.
  • Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, Mägi R, Sharp S, Jackson AU, Assimes TL, Shrader P, Knowles JW, Zethelius B, Abbasi FA, Bergman RN, Bergmann A, Berne C, Boehnke M, Bonnycastle LL, Bornstein SR, Buchanan TA, Bumpstead SJ, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes 2010, 59(5), 1266-75.
  • Kalula SZ, Swingler GH, Sayer AA, Badri M, Ferreira M. Does chair type influence outcome in the timed "Up and Go" test in older persons?". J Nutr Health Aging 2010, 14(4), 319-23.
  • Roberts HC, Sayer AA, Anderson F, Bowman C. Finding the right outcome measures for care home research. Age Ageing 2010, 39(4), 517.
  • Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, Stringham HM, Prokopenko I, Johnson T, Grarup N, Boesgaard TW, Lecoeur C, Shrader P, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010, 42(2), 142-8.
  • Ashfield TA, Syddall HE, Martin HJ, Dennison EM, Cooper C, AihieSayer A. Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire Cohort Study. Age Ageing 2010, 39(2), 185-91.
  • Patel HP, Syddall HE, Martin HJ, Stewart CE, Cooper C, Sayer AA. Hertfordshire sarcopenia study: design and methods. BMC Geriatr 2010.
  • Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, vanRooij FJ, Sonestedt E, Wojczynski MK, Ye Z, Tanaka T, Garcia M, Anderson JS, Follis JL, Djousse L, Mukamal K, Papoutsakis C, Mozaffarian D, Zillikens MC, Bandinelli S, Bennett AJ, Borecki IB, et al. Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care 2010, 33(12), 2684-91.
  • Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010, 42(2), 105-16.
  • Cooper R, Kuh D, Hardy R, MortalityReview Group, FALConandHALCyonStudy Teams. Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ 2010.
  • Syddall H, Roberts HC, Evandrou M, Cooper C, Bergman H, AihieSayer A. Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire Cohort Study. Age Ageing 2010, 39(2), 197-203.
  • Sayer AA. Sarcopenia. BMJ 2010, c4097.
  • Sayer AA, Baylis D, Cooper C, Dennison EM. Sarcopenia: its role in falls and fractures. Osteoporosis Review 2010, 18(4), 12-15.
  • Sayer AA, Stewart C, Patel H, Cooper C. The developmental origins of sarcopenia: from epidemiological evidence to underlying mechanisms. J DOHaD 2010, 1(3), 150-157.
  • Finucane FM, Sharp SJ, Purslow LR, Horton K, Horton J, Savage DB, Brage S, Besson H, DeLuciaRolfe E, Sleigh A, Martin HJ, AihieSayer A, Cooper C, Ekelund U, Griffin SJ, Wareham NJ. The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial. Diabetologia 2010, 53(4), 624-31.
  • Barr JG, Veena SR, Kiran KN, Wills AK, Winder NR, Kehoe S, Fall CH, Sayer AA, Krishnaveni GV. The relationship of birthweight, muscle size at birth and post-natal growth to grip strength in 9-year-old Indian children: findings from the Mysore Parthenon study. J Dev Orig Health Dis 2010, 1(5), 329-37.
  • Shaheen SO, Jameson KA, Syddall HE, AihieSayer A, Dennison EM, Cooper C, Robinson SM, HertfordshireCohortStudy Group. The relationship of dietary patterns with adult lung function and COPD. Eur Respir J 2010, 36(2), 277-84.
  • Gale CR, Allerhand M, Sayer AA, Cooper C, Dennison EM, Starr JM, Ben-Shlomo Y, Gallacher JE, Kuh D, Deary IJ, HALCyonStudy Team. The structure of the Hospital Anxiety and Depression Scale in four cohorts of community-based, healthy older people: the HALCyon program. Int Psychogeriatr 2010, 22(4), 559-71.
  • Dennison EM, Syddall HE, Jameson KA, Sayer AA, Gaunt TR, Rodriguez S, Day IN, Cooper C, Lips MA, HertfordshireCohortStudy Group. A study of relationships between single nucleotide polymorphisms from the growth hormone-insulin-like growth factor axis and bone mass: the Hertfordshire cohort study. J Rheumatol 2009, 36(7), 1520-6.
  • Robinson S, Syddall H, Jameson K, Batelaan S, Martin H, Dennison EM, Cooper C, Sayer AA, HertfordshireStudy Group. Current patterns of diet in community-dwelling older men and women: results from the Hertfordshire Cohort Study. Age Ageing 2009, 38(5), 594-9.
  • Martin HJ, Syddall HE, Dennison EM, Cooper C, Sayer AA. Physical performance and physical activity in older people: are developmental influences important?. Gerontology 2009, 55(2), 186-93.
  • Finucane FM, Horton J, Purslow LR, Savage DB, Brage S, Besson H, Horton K, RolfeEde L, Sleigh A, Sharp SJ, Martin HJ, Sayer AA, Cooper C, Ekelund U, Griffin SJ, Wareham NJ. Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial. BMC Endocr Disord 2009, 9.
  • Syddall H, Evandrou M, Cooper C, Sayer AA. Social inequalities in grip strength, physical function, and falls among community dwelling older men and women: findings from the Hertfordshire Cohort Study. J Aging Health 2009, 21(6), 913-39.
  • Syddall HE, Martin HJ, Harwood RH, Cooper C, AihieSayer A. The SF-36: a simple, effective measure of mobility-disability for epidemiological studies. J Nutr Health Aging 2009, 13(1), 57-62.
  • Moinuddin MM, Jameson KA, Syddall HE, Sayer AA, Martin HJ, Robinson S, Cooper C, Dennison EM. Cigarette smoking, birthweight and osteoporosis in adulthood: results from the Hertfordshire Cohort SOpen Rheumatol Jtudy. Open Rheumatol J 2008, 2, 33-7.
  • Ugboma I, Syddall HE, Cox V, Cooper C, Briggs R, Sayer AA. Coding Geriatric syndromes: How good are we?. CME J Geriatr Med 2008, 10(1), 34-36.
  • Robinson SM, Jameson KA, Batelaan SF, Martin HJ, Syddall HE, Dennison EM, Cooper C, Sayer AA, HertfordshireCohortStudy Group. Diet and its relationship with grip strength in community-dwelling older men and women: the Hertfordshire cohort study. J Am Geriatr Soc 2008, 56(1), 94-90.
  • Poynter L, Kwan J, AihieSayer A, Vassallo M. Do cognitively impaired patients benefit fromrehabilitation?. Rev Clin Gerontol 2008, 18, 53-64.
  • Costello PM, Rowlerson A, Astaman NA, Anthony FE, Sayer AA, Cooper C, Hanson MA, Green LR. Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development. J Physiol 2008, 586(9), 2371-9.
  • Martin HJ, Syddall HE, Dennison EM, Cooper C, Sayer AA. Relationship between customary physical activity, muscle strength and physical performance in older men and women: findings from the Hertfordshire Cohort Study. Age Ageing 2008, 37(5), 589-93.
  • Sayer AA, Syddall H, Martin H, Patel H, Baylis D, Cooper C. The developmental origins of sarcopenia. Journal of Nutrition Health and Aging 2008, 12(7), 427-432.
  • Sayer AA, Dennison EM, Syddall HE, Jameson K, Martin HJ, Cooper C. The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people. J Gerontol A Biol Sci Med Sci 2008, 63(8), 835-40.
  • Sayer AA, Cooper C. Aging, sarcopenia and the life-course. Rev Clin Gerontol 2007, 16, 265-274.
  • Batty GD, Smith GD, Fall CH, Sayer AA, Dennison E, Cooper C, Gale CR. Association of diarrhoea in childhood with blood pressure and coronary heart disease in older age: analyses of two UK cohort studies. Int J Epidemiol 2007, 36(6), 1349-55.
  • Sayer AA, Syddall HE, Dennison EM, Martin HJ, Phillips DI, Cooper C, Byrne CD, Hertfordshire Cohort. Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study. QJM 2007, 100(11), 707-13.
  • Gale CR, Martyn CN, Cooper C, Sayer AA. Grip strength, body composition, and mortality. Int J Epidemiol 2007, 36(1), 228-35.
  • Oliver H, Jameson KA, Sayer AA, Cooper C, Dennison EM, HertfordshireCohortStudy Group. Growth in early life predicts bone strength in late adulthood: the Hertfordshire Cohort Study. Bone 2007, 41(3), 400-5.
  • Dennison EM, Syddall HE, AihieSayer A, Martin HJ, Cooper C, HertfordshireCohortStudy Group. Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study. QJM 2007, 100(5), 297-303.
  • Harvey NC, Poole JR, Javaid MK, Dennison EM, Robinson S, Inskip HM, Godfrey KM, Cooper C, Sayer AA, SWSStudy Group. Parental determinants of neonatal body composition. J Clin Endocrinol Metab 2007, 92(2), 523-6.
  • Alharbi KK, Spanakis E, Tan K, Smith MJ, Aldahmesh MA, O'Dell SD, Sayer AA, Lawlor DA, Ebrahim S, DaveySmith G, O'Rahilly S, Farooqi S, Cooper C, Phillips DI, Day IN. Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE. Hum Mutat 2007, 28(3), 294-302.
  • Pain H, Gale CR, Watson C, Cox V, Cooper C, Sayer AA. Readiness of elders to use assistive devices to maintain their independence in the home. Age Ageing 2007, 36(4), 465-7.
  • Inskip HM, Godfrey KM, Martin HJ, Simmonds SJ, Cooper C, Sayer AA, SouthamptonWomen'sSurveyStudy Group. Size at birth and its relation to muscle strength in young adult women. J Intern Med 2007, 262(3), 368-74.
  • Schlotz W, Ambery P, Syddall HE, Crozier SR, Sayer AA, Cooper C, Phillips DI, HertfordshireCohortStudy Group. Specific associations of insulin resistance with impaired health-related quality of life in the Hertfordshire Cohort Study. Qual Life Res 2007, 16(3), 429-36.
  • Robinson SM, Batelaan SF, Syddall HE, Sayer AA, Dennison EM, Martin HJ, Barker DJ, Cooper C, HertfordshireCohort Study. Combined effects of dietary fat and birth weight on serum cholesterol concentrations: the Hertfordshire Cohort Study. Am J Clin Nutr 2006, 84(1), 237-44.
  • Kuh D, Hardy R, Butterworth S, Okell L, Wadsworth M, Cooper C, AihieSayer A. Developmental origins of midlife grip strength: findings from a birth cohort study. J Gerontol A Biol Sci Med Sci 2006, 61(7), 702-6.
  • Kuh D, Hardy R, Butterworth S, Okell L, Richards M, Wadsworth M, Cooper C, Sayer AA. Developmental origins of midlife physical performance: evidence from a British birth cohort. Am J Epidemiol 2006, 164(2), 110-21.
  • Kerr A, Syddall HE, Cooper C, Turner GF, Briggs RS, Sayer AA. Does admission grip strength predict length of stay in hospitalised older patients?. Age Ageing 2006, 35(1), 82-4.
  • Sayer AA, Syddall HE, Martin HJ, Dennison EM, Anderson FH, Cooper C. Falls, sarcopenia, and growth in early life: findings from the Hertfordshire cohort study. Am J Epidemiol 2006, 164(7), 665-71.
  • Sayer AA, Syddall HE, Martin HJ, Dennison EM, Roberts HC, Cooper C. Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort Study. Age Ageing 2006, 35(4), 409-15.
  • Martin HJ, Yule V, Syddall HE, Dennison EM, Cooper C, AihieSayer A. Is hand-held dynamometry useful for the measurement of quadriceps strength in older people? A comparison with the gold standard Bodex dynamometry. Gerontology 2006, 52(3), 154-9.
  • Roberts HC, Hemsley ZM, Thomas G, Meakins P, Powell J, Robison J, Gove I, Turner G, Sayer AA. Nurse-led implementation of the single assessment process in primary care: a descriptive feasibility study. Age Ageing 2006, 35(4), 394-8.
  • Dennison EM, Syddall HE, Statham C, AihieSayer A, Cooper C. Relationships between SF-36 health profile and bone mineral density: the Hertfordshire Cohort Study. Osteoporos Int 2006, 17(9), 1435-42.
  • Jordan KM, Syddall HE, Garnero P, Gineyts E, Dennison EM, Sayer AA, Delmas PD, Cooper C, Arden NK. Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men. Ann Rheum Dis 2006, 65(7), 871-7.
  • Dennison EM, Syddall HE, Sayer AA, Gilbody HJ, Cooper C. Birth weight and weight at 1 year are independent determinants of bone mass in the seventh decade: the Hertfordshire cohort study. Pediatr Res 2005, 57(4), 582-6.
  • Syddall HE, Sayer AA, Simmonds SJ, Osmond C, Cox V, Dennison EM, Barker DJ, Cooper C. Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study. Am J Epidemiol 2005, 161(11), 1074-80.
  • Syddall HE, AihieSayer A, Dennison EM, Martin HJ, Barker DJ, Cooper C. Cohort profile: the Hertfordshire cohort study. Int J Epidemiol 2005, 34(6), 1234-42.
  • Phillips DI, Goulden P, Syddall HE, AihieSayer A, Dennison EM, Martin H, Cooper C, HertfordshireCohortStudy Group. Fetal and infant growth and glucose tolerance in the Hertfordshire Cohort Study: a study of men and women born between 1931 and 1939. Diabetes 2005.
  • Sayer AA, Cooper C. Fetal programming of body composition and musculoskeletal development. Early Human Development 2005, 81(9), 735-744.
  • Sayer AA, Dennison EM, Syddall HE, Gilbody HJ, Phillips DI, Cooper C. Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg?. Diabetes Care 2005, 28(10), 2541-2.
  • Sayer AA, Syddall HE, Dennison EM, Gilbody HJ, Duggleby SL, Cooper C, Barker DJ, Phillips DI. Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire Cohort Study. Am J Clin Nutr 2004, 80(1), 199-203.
  • Harwood RH, Sayer AA, Hirschfeld M. Current and future worldwide prevalence of dependency, its relationship to total population, and dependency ratios. Bull World Health Organ 2004, 82(4), 251-8.
  • Sayer AA, Syddall HE, Gilbody HJ, Dennison EM, Cooper C. Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study. J Gerontol A Biol Sci Med Sci 2004, 59(9), M30-4.
  • Day IN, Chen XH, Gaunt TR, King TH, Voropanov A, Ye S, Rodriguez S, Syddall HE, Sayer AA, Dennison EM, Tabassum F, Barker DJ, Cooper C, Phillips DI. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. J Clin Endocrinol Metab 2004, 89(11), 5569-76.
  • Dennison EM, Syddall HE, AihieSayer A, Craighead S, Phillips DI, Cooper C. Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance?. Diabetologia 2004, 47(11), 1963-8.
  • Zhang B, Ye S, Sayer AA, Hammans SR, Adio S, Hinks LJ, Smythe PJ, Groot D, Cooper C, Day IN. A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort. Biochem Soc Trans 2003, 31(2), 444-6.
  • Poole J, Sayer AA, Cox V, Cooper C, Kuh D, Hardy R, Wadsworth M. Birth weight, osteoarthritis of the hand, and cardiovascular disease in men. Ann Rheum Dis 2003, 62(10), 1029.
  • Syddall H, Cooper C, Martin F, Briggs R, AihieSayer A. Is grip strength a useful single marker of frailty?. Age Ageing 2003, 32(6), 650-6.
  • Poole J, Sayer AA, Hardy R, Wadsworth M, Kuh D, Cooper C. Patterns of interphalangeal hand joint involvement of osteoarthritis among men and women: a British cohort study. Arthritis Rheum 2003, 48(12), 3371-6.
  • Sayer AA, Poole J, Cox V, Kuh D, Hardy R, Wadsworth M, Cooper C. Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis. Arthritis Rheum 2003, 48(4), 1030-3.
  • Kuh D, Bassey J, Hardy R, AihieSayer A, Wadsworth M, Cooper C. Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study. Am J Epidemiol 2002, 156(7), 627-33.
  • AihieSayer A, Barker DJP. Developmental influences on ageing. Rev Clin Gerontol 2002, 12, 205-211.
  • Sayer AA, Cooper C. Early diet and growth: impact on ageing. Proceedings of the Nutrition Society 2002, 61(1), 79-85.
  • AihieSayer A, Cooper C. Early life effects on aging. In: Nestle Nutr Workshop Ser Clin Perform Programme. 2002.
  • AihieSayer A, Cooper C. Getting started right: the influence of early growth and nutrition on aging. Veterinary Learning Systems 2002, 24(9A), 4-7.
  • Day IN, King TH, Chen XH, Voropanov AM, Ye S, Syddall HE, Sayer AA, Cooper C, Barker DJ, Phillips DI. Insulin-like growth factor-I genotype and birthweight. Lancet 2002, 360(9337).
  • Mehta G, Roach HI, Langley-Evans S, Taylor P, Reading I, Oreffo RO, Aihie-Sayer A, Clarke NM, Cooper C. Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats. Calcif Tissue Int 2002, 71(6), 493-8.
  • O'Dell SD, Syddall HE, Sayer AA, Cooper C, Fall CH, Dennison EM, Phillips DI, Gaunt TR, Briggs PJ, Day IN. Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males. Eur J Hum Genet 2002, 10(11), 749-52.
  • Sayer AA, Syddall H, O'Dell SD, Chen XH, Briggs PJ, Briggs R, Day IN, Cooper C. Polymorphism of the IGF2 gene, birth weight and grip strength in adult men. Age Ageing 2002, 31(6), 468-70.
  • AihieSayer A. First World Congress on the Fetal Origins of Adult Disease. J Pediatr Endocrinol Metab 2001, 14(7), 921-4.
  • AihieSayer A, Dunn R, Langley-Evans S, Cooper C. Prenatal exposure to a maternal low protein diet shortens life span in rats. Gerontology 2001, 47(1), 9-14.
  • AihieSayer A, Osmond C, Briggs R, Cooper C. Do all systems age together?. Gerontology 1999, 45(2), 83-6.
  • Evans JR, Rauf A, AihieSayer A, Wormald RP, Cooper C. Age-related nuclear lens opacities are associated with reduced growth before 1 year of age. Invest Ophthalmol Vis Sci 1998, 39(9), 1740-4.
  • Sayer AA, Cooper C, Evans JR, Rauf A, Wormald RP, Osmond C, Barker DJ. Are rates of ageing determined in utero?. Age Ageing 1998, 27(5), 579-83.
  • Foss AJ, Rauf A, AihieSayer A, Evans JR, Cooper C, Wormald RP, Barker DJ. Does raised intraocular pressure begin in utero?. Br J Ophthalmol 1998, 82(10), 112530.
  • Hall N, Sayer AA, Evans J, Rauf A, Cooper C, Wormald R. Visual acuity and its relationship to early growth, eye disease, and aging in north Hertfordshire. Ophthalmic Epidemiol 1998, 5(2), 83-90.
  • Sayer AA, Cooper C, Barker DJ. Is lifespan determined in utero?. Arch Dis Child Fetal Neonatal Ed 1997, 77(3), F162-4.
  • Chapman N, Mohamudally A, Cerutti A, Stanton A, Sayer AA, Cooper C, Barker D, Rauf A, Evans J, Wormald R, Sever P, Hughes A, Thom S. Retinal vascular network architecture in low-birth-weight men. J Hypertens 1997, 15(12Pt1), 1449-53.
  • AihieSayer A, Cooper C. Undernutrition and aging. Gerontology 1997, 43(4), 203-5.
  • Sayer AP. Aspartame pharmacokinetics: the effect of ageing. Age Ageing 1996, 25(5), 413.
  • Martyn CN, Gale CR, Sayer AA, Fall C. Growth in utero and cognitive function in adult life: follow up study of people born between 1920 and 1943. BMJ 1996, 312(7043), 393-6.
  • Cooper C, Aihie A. Osteoporosis. Baillieres Clin Rheumatol 1995, 9(3), 555-64.
  • Cooper C, Aihie A. Osteoporosis: recent advances in pathogenesis and treatment. Q J Med 1994, 87(4), 203-9.
  • Aihie AP, Halpern SM, Streete PJ, Crome P. Slow release aspirin in the elderly. J R Soc Med 1994, 87(3), 183.
  • Kew J, Morris C, Aihie A, Fysh R, Jones S, Brooks D. Arsenic and mercury intoxication due to Indian ethnic remedies. BMJ 1993, 306(6876), 506-7.