Institute of Neuroscience

Staff Profile

Dr Christopher Price

Stroke Association HRH Princess Margaret Senior Reader in Stroke Medicine

Background

As a clinical researcher, I work with national and international academic and industry collaborators to evaluate and implement interventions which improve patient access to emergency stroke treatments. These include novel point of care diagnostics, enhanced clinical assessment processes and evidence-based reconfiguration of clinical services.

I am chief investigator for single and multi-site phase II and III clinical trials, including multi-region ambulance trials funded by the National Institute for Health Research, Medical Research Council and Innovate UK to examine the clinical and cost-effectiveness of new paramedic assessment processes and portable diagnostics for suspected stroke.

For implementation, I contribute towards national and European clinical guidelines and consensus statements for emergency stroke treatments and service configurations. I developed and direct a clinical training module to improve stroke identification and reduce treatment delays which has been attended by more than 2000 NHS personnel.

In 2017 I was awarded The Stroke Association HRH Princess Margaret Senior Reader Fellowship in recognition of my ambition to improve emergency access to time-critical treatments for patients with suspected stroke. 

My interest in the application of new technology to enhance patient outcomes goes beyond the acute phase of stroke treatment, including wristband accelerometry to encourage upper limb activity and collect recovery biomarker data. I have also been lead investigator for health services research awards to observe and predict the impact of clinical service reconfigurations for both stroke and mixed patient populations seeking emergency medical assistance.

Hear about our work with the Stroke Association in Karen's Story.  

Read more about our NIHR Paramedic Acute Stroke Treatment Assessment Trial here: PASTA.    

Find out more about my publications at Google Scholar.

Areas of expertise

  • Clinical trials of non-pharmaceutical technologies in stroke care (emergency assessment and rehabilitation)
  • Translational studies of diagnostics
  • Evaluation of service provision models

Roles and Responsibilities

  • The Stroke Association HRH Princess Margaret Senior Clinical Reader
  • Honorary Consultant Stroke Physician, Northumbria Healthcare NHS Foundation Trust
  • Member of the National Stroke Clinical Guidelines Group (pre-hospital care and prevention)
  • UK representative on the European Pre-hospital Guidelines Task Force
  • UK Stroke Forum Scientific Committee member
  • Steering committee member of the UK Network exploring Ethics of Ambulance Trials
  • UK Lead Investigator for phase III CONVINCE trial
  • Trial steering committee for phase III ATTEST-2 trial
  • Trial steering committee for phase III ICONS-2 trial

Qualifications

  • MB ChB (hons) 1992 (Birmingham)
  • MD 2003 (Newcastle)
  • FRCP 2006 (London)
  • MClinEd 2006 (Newcastle) 

Previous Positions

  • 2010-2017: Stroke Lead for the North East & North Cumbria NIHR Clinical Research Network
  • 2013-2016: Stroke Association HRH Princess Margaret Research Development Fellow
  • 2011-2015: Workforce Lead Stroke Medicine Specialist Advisory Committee (RCP)
  • 2009-2012: Chair of the British Association Stroke Physicians Training Committee

Google Scholar: Click here.

ORCID: Click here.


Research

EMERGENCY STROKE CARE

Electrical Bioimpedance Cerebral Spectroscopy detection of large vessel occlusion amongst patients with symptoms of acute stroke.

Price CI, Graziadio S, Shaw L, White P, Rodgers H, Mitra D, Dixit A.

MRC Confidence in Concept (Newcastle University) in partnership with Cerebrotech Inc.

October 2017 – December 2018: £25,305

 

Purines for Rapid Identification of Stroke Mimics (PRISM)

Price CI, Dale NE, Ford GA, Graziadio S, Imray C, Lendrum D, McMeekin P, Philips N, Roffe C, Shaw L, Smith C.

Innovate UK SBRI Phase 2: Stratified medicine: connecting the UK infrastructure

April 2017 – March 2020: £711,974

 

The Stroke Association HRH Princess Margaret Senior Reader Fellowship

Price CI.  The Stroke Association

April 2017 – March 2021: £202,953

 

Point of Care Stroke In Vivo Diagnostic for Paramedic Use

Mascarenhas E, Dale N, Price C, McMeekin P.

SBRI Innovate UK Stratified Medicine: connecting the UK infrastructure

Awarded to Sarissa Biomedical Ltd

01/01/2016 – 31/12/2016: £149,500

 

Stroke Association Postgraduate Fellowship

PhD student Graham McClelland “Development of a stroke mimic probability score”

Price C, Rodgers H.

01/09/2015 – 30/08/2018: £105,000

 

Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2): Assessment of safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trial.

Bath P, Siriwardena N, England T, Potter J, Montgomery A, Wardlaw JM, Sprigg N, Robinson T, Roffe C, Jarvis M, Price C.

The British Heart Foundation. Nottingham University.

April 2015 – March 2018: £1,370,708

 

Promoting Effective And Rapid Stroke Care

Ford G, Price C, White P, McMeekin P, Vale L, Exley C, Flynn D, Snooks H, Russell I, Tyrrell P, Fell P, Dodd P.

NIHR Programme Grant for Applied Research RP-PG-1211-20012. Newcastle Hospitals.

May 2014 – April 2019: £1,958,330

 

A new approach to hosting pre-hospital clinical trials.

Price C, Byers S. (North East Ambulance Service NHS Foundation Trust)

Academic Health Science Network North East & North Cumbria. North East Ambulance.

April 2014 – March 2015: £72,000; http://www.ahsn-nenc.org.uk/project/78/

 

The Stroke Association Princess Margaret Research Development Fellowship

Price CI, Rodgers H. 

The Stroke Association

August 2013 – July 2016 £152,808

 

Pre-hospital identification of stroke patients suitable for thrombolysis.

Price CI, Ford GA, White P.

Teaching & Research Fellowship (Northumbria Healthcare/Newcastle University)

Apr 2013 – March 2015: £70,000

 

Understanding clinicians’ decisions to offer intravenous thrombolytic treatment to patients with acute ischaemic stroke: a discrete choice experiment

Thomson RG, Lancsar E, Ternent L, Flynn D, Rodgers H, Price C, Ford GA.

National Institute for Health Research, Health Services and Delivery Research Programme, (Project:12/5001/45)

April 2013-  March 2015: £241,345

 

NIHR Hyperacute Stroke Research Centre

Price C, Dixit A, Williams P on behalf of the North East Stroke Research Network

NIHR CRN.

April 2010 – March 2013: £390,000

 

ASTUTE: Acute Stroke Telemedicine: Utility, Training and Evaluation

Watkins CL, Ford GA, Emsley H, Price C, O'Donnell M, May C, Lightbody E.

NIHR Research For Patient Benefit.  University of Central Lancashire.

April 2010 - August 2013: £249,992

 

Stroke TIA Assessment Training (STAT) Programme for North East England

Price CI

North of England Cardiovascular Network, Stroke Improvement Programme.

November 2008 – March 2011: £190,679

 

Development and evaluation of hyperacute services for patients with acute stroke

Ford G, Rodgers H, Thomson R, Donaldson C, Price C, Murtagh M, White M, Gray J. 

NIHR Programme Grant for Applied Research

Newcastle Upon Tyne Hospitals, Northumbria Healthcare, North East Ambulance Service and Newcastle University.

August 2007 – July 2012: £1,773,616

 

 


EMERGENCY MEDICAL SERVICES

Improving Cardiac Arrest Recognition and Effectiveness (ICARE).

Watkins C, Leathley M, Jones S, Gibson J, Sutton C, Price C, Siriwardena N, Roberts D, Quinn T, Dewitt D, Mackway-Jones K.

Department of Health Policy Research Programme. UCLAN

January 2015 – May 2016: £604,680

 

Development of a validated model to predict how the centralisation of emergency medical services will affect the health of older patients.

Price C, McMeekin P, Bhattarai N.

The Dunhill Medical Trust. Northumbria Healthcare.

May 2015 – April 2017: £ 92,341

 

Using economic evaluation and preference elicitation methods to inform decisions about how best to reorganise services: A case study of the redesign of emergency medical services.

Vale L, McMeekin P, Price C.

The Health Foundation PhD Award for Improvement Science.

March 2014 – February 2017: £138,280

 

Examination of emergency medical services modelling methods and patient outcome measures.

Price CI, McMeekin P

NIHR Flexibility and Sustainability Funding, Northumbria Healthcare NHS Foundation Trust. September 2012 – August 2013: £50,492

 

Evaluation of a clinical simulation programme to improve patient safety

Price CI, Piper M.

North East Strategic Health Authority Workforce Development and Innovation Fund

April 2009 – March 2011: £149,826

 



STROKE RECOVERY


Study in Novel Neuro-muscular Imaging Biomarkers for Motor Outcome in Stroke

Mitra D, Blamire A, Price C, Rodgers H.

NIHR Newcastle Biomedical Research Centre BRC Project Funding

July 2018 – June 2021; £119,649

 

Development and clinical trial feasibility evaluation of auditory rhythmical cueing to improve gait and physical activity in community dwelling stroke survivors.

Moore SA, Rochester L, Price C, Rodgers H, Shaw L, Godfrey A, Lord S, Lambert A.

The Stroke Association.

01/08/2016 – 31/07/2019: £207,511

 

Development and feasibility of a clinically integrated behaviour modification toolkit to promote personalised physical activity routines following recent stroke.

NIHR ICA Clinical Lectureship 2016 awarded to Sarah Moore.

Moore SA, Price CI, Rodgers H, Rochester L, Flynn D, Trennell M.

01/04/2016 – 31/03/2020: £221,515           

 

Low Dose Colchicine for Stroke Prevention (CONVINCE)

Kelly P, Price CI. The Irish Stroke Research Network (UK Chief Investigator and TSC)

Irish Health Research Board, Dublin.

01/04/2016 – 01/04/2020: £329,757

 

NIHR Doctoral Research Fellowship

PhD student Eugene Tsang “Identification and Care of Patients at Risk of Post-Stroke Dementia”

Tsang E, Robinson L, Price C, Stephan B, Exley C.

01/09/2015 – 30/08/2018: £241,600

 

Protocol development and clinical trial feasibility evaluation of a wrist-worn

accelerometer to monitor, prompt and report impaired upper limb activity during

self-supervised rehabilitation after stroke.

Price C, Balaam M, Brittain K, Brkic L, Ploetz T. Rodgers H, Shaw L, van Wijck F.

The Stroke Association. Newcastle University. 

January 2015 – December 2017: £209,994

 

Assessment of stroke rehabilitation with a wearable sensing platform and computational analysis methods.

Ploetz T, Price C, Brittain K.

SAgE Doctoral Training Awards Scheme, Newcastle University

May 2014 – April 2018: £80,000

 

Development, implementation and evaluation of a standardised nurse-led protocol to recognise and address the risk of poor oral fluid intake amongst older inpatients with complex needs following unscheduled hospital admission.

Price C, Laverty A, Riddell V, Brown M.

The Health Foundation. Northumbria Healthcare.

April 2014 – March 2015: £73,896

 

RATULS: Robot Assisted Training for the Upper Limb after Stroke

Rodgers H, Aird L, Darawil K, Dawson J, Eyre J, Finch T, Ford G, Hogg S, Howel D, Hughes N, Krebs H, Price C, Rochester L, Shaw L, Turner D, Ternent L, Vale L.

NIHR HTA

January 2014 -  July 2018  £3,094,000

 

A trial to evaluate an extended rehabilitation service for stroke patients

Rodgers H, Drummond A, Ford G, Forster A, Howel D, Laverty A, McKevitt C, McMeekin P, Price C, Shaw L, Cant R

NIHR HTA

October 2012 – September 2017: £1,646,334

 

Limbs Alive - Monitoring of upper limb rehabilitation and recovery after stroke

Eyre J, Ford G, Rodgers H, Price C, Rochester L, Watson P, McGough S, Li F, Neill S, Troughton, Gaukroger N

Department of Health/Wellcome Trust Health Innovation Challenge Fund

December 2011 – January 2014:  £1,618,833

 

Development and feasibility evaluation of a repetitive functional task practice (RFTP) programme for upper limb recovery early after stroke

Rodgers H, Price C, Shaw L, van Wijck F, Watkins C, Forster A, Langhorne P.

Stroke Association

April 2011 – March 2014: £157,925

 

Needs Survey - Information Mapping Exercise

French B, Burton B, Dey P, Langhorne P, Leathley M, Marsden J, McAdam J, Price CI, Radford K, Rodgers H, Sackley C, Sharma A, Sutton C, Walker M, Watkins C.

The Stroke Association. University of Central Lancashire.

April 2008 – October 2008: £22,861

 

Evaluation of a multidisciplinary training programme for implementation of the new National Stroke Strategy

Price CI, Laverty A, Rana B, Russell S.

NHS North East Workforce Development Fund.

Jan 2008 – October 2010: £364,861

 

A systematic review of repetitive task training with modelling of resource use, costs and effectiveness

Watkins CL, French B, Price CI, Forster A, Walker A, Sutton CJ, Leathley JM.

NIHR HTA Programme.

University of Central Lancashire.

November 2005 – Jan 2007: £69,361

 

What is the clinical effect and cost effectiveness of treating upper limb spasticity due to stroke with botulinum toxin?

Rodgers H, Price CI, Van Wijck F, Johnson GR, Shackley P, Barnes MP, Steen IN, Gray C, Ford GA, Cassidy T, Field, Gani A, Graham L.

NIHR HTA Programme

Feb 2005 – Feb 2009: £862,373

 

Does surface neuromuscular electrical stimulation (NMES) to the upper limb following acute stroke improve outcome?

Rodgers H, Price CI, Pandyan AD.

Teaching & Research Fellowship (Northumbria Healthcare/Newcastle University)

Oct 2001 – Dec 2003: £70,000

 

Biomechanical analysis of the reflex response in the measurement of spasticity

Johnson GR, Pandyan AD, Price CI, Barnes MP.

Action Research

CREST, Newcastle University

Apr 2001 – March 2004: £85,701

 

Does an early intensive interdisciplinary upper limb therapy programme following acute stroke improve outcome?

Rodgers H, Curless RH, Campbell MD, Stoddart GD, Price CI, McNamee P.

Northern and Yorkshire Regional R&D Directorate Combined Therapy Grant

Jan 1999 – Dec 2002: £149,926

 

Clinical and biomechanical predictors of upper limb recovery after stroke (MD)

Price CI, Curless RH, Rodgers H.

Teaching & Research Fellowship (Northumbria Healthcare/Newcastle University)

Apr 1997 – Sept 1999: £55,000

 

Publications