Dr Gerrit Hilgen
- Email: firstname.lastname@example.org
- Telephone: +44(0)191 208 8933
- Address: Institute of Neuroscience
MG 178 Cookson Building
Newcastle upon Tyne
I am a postdoctoral Research Associate in the Institute of Neuroscience. My area of expertise is retinal/cellular neuroscience, neuroanatomy, cell biology, sensory systems & computational neuroscience
My general scientific interest is on sensory signal processing in large neuronal networks and how the different neurons work together. During my PhD, I shed light on specialised cell-cell connections in the retina which form dynamic networks between neurons. After my PhD, I assembled a voltage-sensitive dye imaging system and developed my own image processing approaches to study how the tactile networks accomplish the integration of sensory input. In 2013, I switched back to retinal networks and started using large-scale high-density MEA recordings in combination with high-resolution structural imaging. I found that the maturation of retinal functionality is not spatially homogeneous, likely reflecting special ecological requirements, and established tools for automated quality control and unit selection for thousands of neurons. More recently, I became interested in the development of light responses in retinal organoids derived from human pluripotent stem cells.
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Academic Positions Held
Sept. 2013- Postdoctoral Research Associate, Retinal Neurobiology, Dr. E. Sernagor, Institute of Neuroscience, Newcastle University, UK
2012-2013 Postdoctoral Research Associate, Computational Neuroscience, Prof. J.Kretzberg, University of Oldenburg, Germany
2012 PhD in Neurobiology, University of Oldenburg, Mathematics and Sciences, Germany.
2007 Diploma in Cell Biology, Biochemistry and Physiology, University of Oldenburg, Mathematics and Sciences, Germany.
1999 General Qualification for University Entrance (Abitur), Bad Zwischenahn, Germany
I possess the certificate for “Introduction to Learning and Teaching in Higher Education UK” (ILTHE) and supervised undergraduate project, master project and PhD students in Newcastle. I also participated as a seminar leader (Biochemistry) and I am engaged as a tutor in the ION summer school. I enjoy working with students and my dedication is always to make sure that they get the most out of their time.
- Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, Hewitt P, Schmitt M, Uteng M, Kustermann S, STEEL D, Nicholds M, Thomas R, Treumann A, Porter A, Sernagor E, Armstrong L, Lako M. Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency. Stem Cells 2018. In Press.
- Fathiazar E, Hilgen G, Kretzberg J. Higher Network Activity Induced by Tactile Compared to Electrical Stimulation of Leech Mechanoreceptors. Frontiers in Physiology 2018, 9, 173.
- Pirschel F, Hilgen G, Kretzberg J. Effects of Touch Location and Intensity on Interneurons of the Leech Local Bend Network. Scientific Reports 2018, 8(1), 3046.
- Hilgen G, Sorbaro M, Pirmoradian S, Muthmann JO, Kepiro IE, Ullo S, Ramirez CJ, Puente Encinas A, Maccione A, Berdondini L, Murino V, Sona D, Cella Zanacchi F, Sernagor E, Hennig MH. Unsupervised Spike Sorting for Large-Scale, High-Density Multielectrode Arrays. Cell Reports 2017, 18(10), 2521–2532.
- Hilgen G, Pirmoradian S, Pamplona D, Kornprobst P, Cessac B, Hennig MH, Sernagor E. Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina. Scientific Reports 2017, 7, 42330.
- Barrett JM, Hilgen G, Sernagor E. Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses. Scientific Reports 2016, 6, 33565.
- Kretzberg J, Pirschel F, Fathiazar E, Hilgen G. Encoding of Tactile Stimuli by Mechanoreceptors and Interneurons of the Medicinal Leech. Frontiers in Physiology 2016, 7, 1-15.
- Portelli G, Barrett JM, Hilgen G, Masquelier T, Maccione A, DiMarco S, Berdondini L, Kornprobst P, Sernagor E. Rank Order Coding: a Retinal Information Decoding Strategy Revealed by Large-Scale Multielectrode Array Retinal Recordings. eNeuro 2016, 3(3), 1-18.
- Pamplona D, Hilgen G, Pirmoradian S, Hennig MH, Cessac B, Sernagor E, Kornprobst P. A super-resolution approach for receptive fields estimation of neuronal ensembles. BMC Neuroscience 2015, 16(Suppl. 1), 1-2.
- Meyer A, Hilgen G, Dorgau B, Sammler EM, Weiler R, Monyer H, Dedek K, Hormuzdi SG. AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions. Journal of Cell Science 2014, 127, 1190-1202.
- Fathiazar F, Hilgen G, Kretzberg J. Removing bleaching artifacts from voltage sensitive dye recordings with ICA. BMC Neuroscience 2013, 14(Suppl. 1), P222.
- Hilgen G, Huebner AK, Tanimoto N, Sothilingam V, Seide C, Garrido MG, Schmidt KF, Seeliger MW, Löwel S, Weiler R, Hübner CA, Dedek K. Lack of the sodium-driven chloride bicarbonate exchanger NCBE impairs visual function in the mouse retina. PLoS ONE 2012, 7(10), e46155.
- Hilgen G, Maltzahn J, Willecke K, Weiler R, Dedek K. Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina. Journal of Comparative Neurology 2011, 519(3), 433-450.
- Janssen-Bienhold U, Trümpler J, Hilgen G, Schultz K, Müller LP, Sonntag S, Dedek K, Dirks P, Willecke K, Weiler R. Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light. J Comp Neurol 2009, 513(4), 363-74.
- Baglietto S, Kepiro IE, Hilgen G, Sernagor E, Murino V, Sona D. Segmentation of retinal ganglion cells from fluorescent microscopy imaging. In: Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2017). 2017, Porto, Portugal: SciTePress.