Professor Nicola Pavese
Prof of Clinical Neuroscience
- Email: firstname.lastname@example.org
- Telephone: 0191 2081264
- Address: Newcastle Magnetic Resonance Centre &
Positron Emission Tomography Centre
Campus for Ageing & Vitality
Newcastle upon Tyne NE4 5PL
Nicola Pavese is Professor of Clinical Neuroscience and Deputy Director of the Clinical Aging Research Unit at Newcastle University. He is also a Consultant Neurologist at The Newcastle upon Tyne Hospitals NHS Foundation Trust. He has more than 25 years’ experience in the treatment of patients with movement disorders and his clinical activity mainly focuses on the management of patients with advanced Parkinson’s disease, Dystonia and Essential Tremor treated with Deep Brain Stimulation.
He received his medical degree from Pisa University, Italy. After completing residency training in Neurology and subsequent training in Biochemistry and Clinical Chemistry at Pisa University, he moved to London where he achieved his PhD in Neuroimaging at Imperial College London. He had worked at the MRC Clinical Sciences Centre and Imperial College London before moving to Newcastle University.
My research involves the application of neuroimaging (Positron Emission Tomography and Magnetic Resonance Imaging) in neurodegenerative diseases to identify biomarkers of the pathological process and to elucidate the pathophysiological mechanisms responsible for the onset of specific symptoms such as dementia, depression, sleep problems, and fatigue, in patients with these conditions. My work has established for the first time that occurrence of fatigue and excessive daytime sleepiness in Parkinson’s disease are linked to definite deficits of the serotoninergic pathways in the brain which may lead to development of new drug targets and therapeutic strategies for these disabling symptoms. I have also worked extensively in the field of neuroinflammation in neurodegenerative disorders, and I currently leads an international collaboration with Aarhus University in Denmark and Barcelona University in Spain to investigate the occurrence of neuroinflammation in subjects at high risk of developing Parkinson’s disease and other parkinsonism, including patients with REM sleep behavior disorder.
I also act as Principal Investigator in several pharmaceutical sponsored clinical trials in patients with Parkinson’s disease and other parkinsonisms.
I have published over 160 reports including original articles, reviews, book chapters, and editorials.
- Stokholm MG, Iranzo A, Ostergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Borghammer P, Santamaria J, Moller A, Gaig C, Brooks DJ, Tolosa E, Pavese N. Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: A case-control study. The Lancet Neurology 2017, 16(10), 789-796.
- Strafella AP, Bohnen NI, Perlmutter JS, Eidelberg D, Pavese N, Van Eimeren T, Piccini P, Politis M, Thobois S, Ceravolo R, Higuchi M, Kaasinen V, Masellis M, Peralta MC, Obeso I, Pineda-Pardo JA, Cilia R, Ballanger B, Niethammer M, Stoessl JA. Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers. Movement Disorders 2017, 32(2), 181-192.
- Politis M, Sauerbier A, Loane C, Pavese N, Martin A, Corcoran B, Brooks DJ, Ray-Chaudhuri K, Piccini P. Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients. Movement Disorders 2017, 32(2), 235-240.
- Pagano G, Molloy S, Bain PG, Rabiner EA, Chaudhuri KR, Brooks DJ, Pavese N. Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease. Neurology 2016, 87(23), 2451-2456.
- Stokholm MG, Iranzo A, Østergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Parbo P, Borghammer P, Santamaria J, Møller A, Gaig C, Brooks DJ, Tolosa E, Pavese N. Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder. Neurobiology of Disease 2018, epub ahead of print.
- Knudsen K, Fedorova TD, Hansen AK, Sommerauer M, Otto M, Svendsen KB, Nahimi A, Stokholm MG, Pavese N, Beier CP, Brooks DJ, Borghammer P. In vivo staging of pathology in REM Sleep Behaviour Disorder – a multi-modality imaging case-control study. Lancet Neurology 2018, epub ahead of print.
- Pavese N, Tai YF. Nigrosome imaging and neuromelanin sensitive MRI in diagnostic evaluation of parkinsonism. Movement Disorders Clinical Practice 2018, Epub ahead of print.
- Lee JY, Lao-Kaim NP, Pasquini J, Deuschl G, Pavese N, Piccini P. Pallidal dopaminergic denervation and rest tremor in early Parkinson’s disease: PPMI cohort analysis. Parkinsonism & Related Disorders 2018, Epub ahead of print.
- Thevathasan W, Debu B, Aziz T, Bloem BR, Blahak C, Butson C, Czernecki V, Foltynie T, Fraix V, Grabli D, Joint C, Lozano AM, Okun MS, Ostrem J, Pavese N, Schrader C, Tai C-H, Krauss JK, Moro E. Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: A clinical review. Movement Disorders 2018, 33(1), 10-20.
- Pasquini J, Ceravolo R, Qamhawi Z, Lee JY, Deuschl G, Brooks DJ, Bonuccelli U, Pavese N. Progression of tremor in early stages of Parkinson’s disease: a clinical and neuroimaging study . Brain 2018, epub ahead of print.
- Angeles P, Tai Y, Pavese N, Wilson S, Vaidyanathan R. Automated assessment of symptom severity changes during deep brain stimulation (DBS) therapy for Parkinson's disease. In: IEEE International Conference on Rehabilitation Robotics (ICORR). 2017, London, UK: IEEE Computer Society.
- Arshad Q, Bonsu A, Lobo R, Fluri A-S, Sheriff R, Bain P, Pavese N, Bronstein AM. Biased numerical cognition impairs economic decision-making in Parkinson's disease. Annals of Clinical and Translational Neurology 2017, 739-748.
- Parbo P, Ismail R, Hansen K, Mårup F, Gottrup H, Braendgaard H, Eriksson B, Eskildsen S, Lund T, Tietze A, Edison P, Pavese N, Stokholm M, Borghammer P, Hinz R, Aanerud J, Brooks DJ. Brain inflammation accompanies amyloid in a majority of mild cognitive impairment cases due to Alzheimer’s disease. Brain 2017, 140(7), 2002-2011.