Dr Richard McQuade
- Email: email@example.com
- Telephone: +44 (0) 191 2082362
- Address: School of Pharmacy
The Faculty of Medical Sciences
King George VI Building
Newcastle upon Tyne
Roles and Responsibilities
Deputy Head of School, School of Pharmacy
Director of Excellence in Learning and Teaching
University, South Africa, 1987)
DPhil (Oxford University, UK, 1997)
British Pharmacological Society
British Association for Psychopharmacology
I teach pharmacology and psychopharmacology on a number of degree courses including, MPharm, BSc Honours in Pharmacology, BSc Honours in Biomedical Sciences, BDS, MRes and MBBS.
Investigating the effect of lithium on dopamine signalling through glycogen synthase kinase 3β (GSK-3β)
The aim of this study is to further our understanding of the mechanism of action of the mood stabiliser lithium. Two neurobiological effects of the mood stabiliser lithium which may be relevant to its therapeutic mechanism of action are attenuation of dopamine neurotransmission and inhibition of the intracellular signalling enzyme glycogen synthase kinase 3β (GSK-3β). Recent reports that GSK-3β is involved dopamine receptor signalling suggest that these two neurobiological effects of lithium may be related. In this project we are investigating the effect of lithium on dopamine receptor signalling through GSK-3β.
Interpreting the effects of lithium on the structural neuroimaging signal.
There is a growing body of evidence from structural neuroimaging studies in bipolar patients that chronic treatment with the mood stabiliser lithium increases grey matters volume in a number of brain areas. The origin of this apparent increase in grey matter is unclear- neurotrophic effects of lithium on the brain tissue is one obvious possibility. However, another possibility is that the increase in grey matter is not ‘real’, but is rather an artefact produced by lithium’s interaction with water molecules during the neuroimaging scan. In this project we are using MRI in laboratory rodents to investigate this and determine whether the increase in grey matter volume detected in neuroimaging studies is indeed an indication of neurotrophism. (In collaboration with Prof Nicol Ferrier, Prof Andy Blamire and Dr David Cousins)
Understanding the neurobiology of cognitive abnormalities in psychiatric disorders.
Pharmacological and lesion studies have highlighted the role for the prefrontal cortex in a number of cognitive functions including executive function, attention, planning and impulse control. These processes are altered in a number of disorders including affective disorders, schizophrenia and addiction. There are a number of manipulations that can affect the structure of prefrontal cortical neurones. For example, chronic glucocorticoids and stress have all been shown to cause dendritic pruning in PFC neurones. However, the functional consequences of these structural changes in particular in relation to cognition are unclear. This project seeks to explore the relationships between neuronal structure and function in the PFC and PFC-mediated cognitive performance. We are testing the hypotheses that changes in neuronal structure necessarily result in changes in cognition and that subtle changes in dendritic branching caused by factors relevant to the aetiology of affective disorders (e.g. stress or corticosterone) are sufficient to cause significant cognitive changes. (In collaboration with Dr Sasha Gartside, Joanne Wallace)
- Savage MA, McQuade R, Thiele A. Segregated fronto-cortical and midbrain connections in the mouse and their relation to approach and avoidance orienting behaviors. Journal of Comparative Neurology 2017, 525(8), 1980-1999.
- Savy CY, Fitchett AE, McQuade R, Gartside SE, Morris CM, Blain PG, Judge SJ. Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour. Neurotoxicology 2015, 50, 149-156.
- Wallace J, Marston HM, McQuade R, Gartside SE. Evidence that aetiological risk factors for psychiatric disorders cause distinct patterns of cognitive deficits. European Neuropsychopharmacology 2014, 24(6), 879-889.
- Wallace J, Marston HM, McQuade R, Gartside SE. Evidence that the attentional set shifting test in rats can be applied in repeated testing paradigms. Journal of Psychopharmacology 2014, 28(7), 691-696.
- Wallace J, Jackson RK, Shotton TL, Munjal I, McQuade R, Gartside SE. Characterization of electrically evoked field potentials in the medial prefrontal cortex and orbitofrontal cortex of the rat: Modulation by monoamines. European Neuropsychopharmacology 2013, n/a, n/a.
- Ayissi Mbomo R, Gartside SE, Ngo Bum E, Njikam N, Okello E, McQuade R. Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse. Journal of Psychopharmacology 2012, 26(4), 575-583.
- Wallace J, McQuade R, Marston HM, Gartside SE. Subchronic flattening of the glucocorticoid rhythm induces performance deficits in the attentional set shifting task. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2011, Harrogate: Sage Publications Ltd.
- Minton GO, Young AH, McQuade R, Fairchild G, Ingram CD, Gartside SE. Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder. Neuropsychopharmacology 2009, 34(10), 2265-2274.
- Ferrie LJ, Gartside SE, Martin KM, Young AH, McQuade R. Effect of chronic lithium treatment on D2/3 autoreceptor regulation of dopaminergic function in the rat. Pharmacology Biochemistry and Behavior 2008, 90(2), 218-225.
- Young AH, McQuade R. Encephalopathy with combined lithium-risperidone administration. Acta Psychiatrica Scandinavica 2008, 117(5), 396.
- Gartside SE, Cole AJ, Williams AP, McQuade R, Judge SJ. AMPA and NMDA receptor regulation of firing activity in 5-HT neurons of the dorsal and median raphe nuclei. European Journal of Neuroscience 2007, 25(10), 3001-3008.
- Ferrie L, Young AH, McQuade R. Effect of lithium and lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat. International Journal of Neuropsychopharmacology 2006, 9(6), 729-735.
- Ferrie L, Young AH, McQuade R. Effect of chronic lithium and withdrawal from chronic lithium on presynaptic dopamine function in the rat. Journal of Psychopharmacology 2005, 19(3), 229-234.
- McQuade R, Leitch MM, Gartside SE, Young AH. Effect of chronic lithium treatment on glucocorticoid and 5-HT1A receptor messenger RNA in hippocampal and dorsal raphe nucleus regions of the rat brain. Journal of Psychopharmacology 2004, 18(4), 496-501.
- Leitch MM, Ingram CD, Young AH, McQuade R, Gartside SE. Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. Neuropsychopharmacology 2003, 28(1), 119-125.
- Gartside SE, Leitch MM, McQuade R, Swarbrick DJ. Flattening the glucocorticoid rhythm causes changes in hippocampal expression of messenger RNAs coding structural and functional proteins: implications for aging and depression. Neuropsychopharmacology 2003, 28(5), 821-829.
- McQuade R, Young AH, McLaughin DP, Ahmed FP, Stamford JA. Maudsley reactive and nonreactive rats exhibit differences in brain glucocorticoid and mineralocorticoid receptor mRNA. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2003, Cambridge, UK: Sage Publications Ltd.
- Leitch MM, McQuade R, Gartside SE, Young AH. Corticosterone rhythm regulates 5-HT1A autoreceptor function and glucocorticoid receptor mRNA in the rat dorsal raphe nucleus. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2002, Harrogate: Sage Publications Ltd.
- Leitch MM, McQuade R, Gartside SE, Young AH. Corticosterone, rhythm regulates 5-HT1A autoreceptor function and glucocorticoid receptor mRNA in the rat dorsal raphe nucleus. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2002, Harrogate: Sage Publications Ltd.
- McQuade R, Clare Stanford S. Differences in central noradrenergic and behavioural responses of Maudsley non-reactive and Maudsley reactive inbred rats on exposure to an aversive novel environment. Journal of Neurochemistry 2001, 76(1), 21-28.
- McQuade R, Stanford SC. A microdialysis study of the noradrenergic response in rat frontal cortex and hypothalamus to a conditioned cue for aversive, naturalistic environmental stimuli. Psychopharmacology 2000, 148(2), 201-208.
- McQuade R, Young AH. Future therapeutic targets in mood disorders: the glucocorticoid receptor. British Journal of Psychiatry 2000, 177, 390-395.
- McQuade R, Creton D, Stanford SC. Effect of novel environmental stimuli on rat behaviour and central noradrenaline function measured by in vivo microdialysis. Psychopharmacology 1999, 145(4), 393-400.
- Hajos-Korcsok E, McQuade R, Sharp T. Influence of 5-HT1A receptors on central noradrenergic activity: microdialysis studies using (+-) MDL 73005EF and its enantiomers. Neuropharmacology 1999, 38(2), 299-306.
- T. Sharp, R. McQuade, S. Gartside, V. Umbers and M. Hajos. Antidepressant action on anatomically distinct 5-HT pathways: Combined electrophysiological and neurochemical studies. Journal of Neurochemistry 1996, 66, S35-S35.