Institute of Neuroscience

Staff Profile

Professor Simon Thomas

Prof of Clin Pharmacology & Therapeutics

Background

Roles and Responsibilities

Professor of Clinical Pharmacology and Therapeutiics, Newcastle University

Consultant Physician, Newcastle Hospitals NHS Foundation Trust 

Qualifications

MBBS, MRCP(UK), MD (London University), FRCP, FRCP (Edin)

Previous Positions

Senior Registrar in Clinical Pharmacology, Freeman Hospital, Newcastle
Lecturer in Clinical Pharmacology, UMDS (St Thomas' Campus), London University

Memberships

British Pharmacological Society

British Toxicology Society

British Hypertension Society

European Association of Poisons Centres and Clinical Toxicologists (Fellow)

American Academy of Clinical Toxicology (Fellow)

Asia Pacific Association of Medical Toxicology

Research

Research Interests

Adverse drug reactions

Pharmacovigilance

Drug-induced arrhythmia

Poisoning and Clinical Toxicology

Drugs of misuse including novel psychoactive substances

Hypertension

 

Other Expertise

Ethics and research governance

 

Current Research

Current research projects include

(a) Toxicity of novel psychoactive substances
(d) Fetal toxicity associated with maternal exposure to drugs and chemicals
(e) Health effects and management of chemical weapons exposure

Research Roles

Principle investigator
Research student supervisor



Esteem indicators


Committees

North of Tyne and Gateshead Area Prescribing Committee, Vice Chair (2007-2017)

North of Tyne and Gateshead Area Prescribing Committee, Formulary subcommittee, Chair (2007-present)

Northern Treatment Advisory Group (previously North East Treatment Advisory Group), Member (2009-Present)

Regional Medicines Optimisation Coimmittee (Northern), member (2017-)

Advisory Council on the Misuse of Drugs, Main council (2017-), Technical Subcommittee, Co-opted member (1999-), Novel Psychoactive Substances Group (2014-)

Committee on Safety of Medicines Northern and Yorkshire Yellow Card Centre (previoulsy Regional Monitoring Centre), Director (1995-)

Commission on Human Medicines, member   (2009-2015)

National Poisons Information Service Clinical Standards Group, Chair (2005-Present)

Ministry of Defence Advisory Group on Military and Emergency Response Medicine, Member (2007-)

European Association of Poisons Centres and Clinical Toxicologists, President (2010-12)

 

 

Clinical Trial Steering committees, Boards and DSMB activities

MICA study steering committee (1996-1999)

EPOS study Management Board (2000-2003)

AstraZeneca SURVEIL study Steering committee (1998-2003)

Lundbeck SCOP study IMC (2003-present)

Pfizer Sildenafil study A1481189 DSMB (2006-7)

Symphogen Study 001 DSMB Chair (2008-10)

PIL-FAST study DSMB Chair (2011)

SLICE Study IDMEC chair (2012-13)

POP study SDMC chair (2017-)

 

Invited lectures

British Toxicology Society (1998,2004, 2016)

In Vitro Toxicology Society (1999)

Royal College of Physicians of London (1999, 2011)

European Association of Poisons Centres and Clinical Toxicologists (2000, 2003, 2005, 2006, 2007, 2008, 2009, 2010, 2012, 2013, 2014, 2015)

International Association for Accident and Emergency Medicine (2002,2004)

SCIPharm (2004)

Faculty of Medical Sciences (2004)

Association of Clinical Biochemists, FOCUS (2003, 2007, 2017)

Royal College of Physicians of Edinburgh (2005, 2015, 2016, 2017)

North American Congress of Clinical Toxicology (2005, 2006, 2007, 2013)

Vanderbilt University, Nashville, USA (2006)

IUTOX (2007, 2013)

College of Emergency Medicine (2008, 2012)

Irish Congress of Anaesthesia (2010)

Asia Pacific Association of Medical Toxicology (2012, 2013, 2015)

TAPNA Australia (2014)

Eurotox (2012, 2016)

 

Editorial boards

British Journal of Clinical Pharmacology, International Editorial Board (2002-2010)

Clinical Toxicology

Editorial Board (2005-Present)

Senior Editorial Board (2007-2017)

Deputy Editor (2017-)

 

Grants and funding

 

Wellcome trust. Training fellowships in translational medicine and therapeutics (2008-12). £2.9M. With Prof D Jones, Prof GA Ford, Prof P Chinnery


FP7-HEALTH-2009- single-stage (2009-12). Arrhythmogenic potential of drugs (ARITMO). €160,000


EU Innovative Medicines Initiative. Pharmacoepidemiological Research on Outcomes of Therapeutics by a European ConsorTium (PROTECT-EU). €238,890


EU Innovative Medicines Initiative. Pharmaceutical Medicine Training Programmes (PharmaTrain). €18,333

National Institute for Health Research. Influenza A/H1N1v in pregnancy. £108,899 (with Dr L Yates, Dr S Stephens)

Department of Health Policy Research Programme (2010-13) £109,384. Antidote Pharmacokinetics following Intra- Osseous Administration (with Prof P Blain)

National Institute for Health Research (2014-19) £3,352,468. Health Protection Research Unit - Chemical and Radiation Threats and Hazards (with Prof P Blain, Prof M Birch-Machin, Prof M Wright)

National Institute for Health Research (2014-19) £762,496. Health Protection Research Unit - Emergency Preparedness and Response (with Prof P Blain and Kings College, London)

Epilepsy Research. £37,550. Sensitivity of electronic health care data to investigate neurodevelopmental outcomes following prenatal exposure to antiepileptic drugs. (with With Dr R Charlton, Dr L Yates and others)

Ministry of Defence £103,133. Prophylactic efficacy of novel antidotes to cyanide exposure

National Institute for Health Research (2019-20). £670,494. Health Protection Research Unit - Chemical and Radiation Threats and Hazards. (with Prof P Blain, Prof M Birch-Machin, Prof M Wright)

National Institute for Health Research (2019-20). £152,499      Health Protection Research Unit - Emergency Preparedness and Response (with Prof P Blain and Kings College, London)

 

Industrial Relevance

None

Patents

None

 

Teaching

Postgraduate Supervision

Supervisor of students for MRes, MD, MPhil and PhD


Strand leader, MRes in Translational Medicine and Therapeutics




Publications