I work in Sasha Kraskov's Motor Neuroscience group, specialising in histology of the human motor system. I locate, characterise and image healthy and disease states of the motor system, such as motor neuron disease, using histochemistry, fluorescent immunohistochemistry & optogenetic viruses. I also hold extensive experience in brightfield, fluorescent and electron microscopy, as well as automated microscopy, image processing and quantitative and qualitative image analysis, and purification of optogenetic viruses.

• McCardle CE, Gartside SE. Effects of general anaesthetics on 5-HT neuronal activity in the dorsal raphe nucleus. Neuropharmacology 2012, 62(4), 1787-1796.
• Lemos H, Mohamed E, Ou R, McCardle C, Zheng X, McGuire K, Homer N, Mole DJ, Huang L, Mellor AL. Co-treatments to boost IDO activity and inhibit production of downstream catabolites induce durable suppression of Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology 2020, 11, 1256.
• Lemos H, Ou R, McCardle C, Lin Y, Calver J, Minett J, Chadli A, Huang L, Mellor AL. Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity. Journal for ImmunoTherapy of Cancer 2020, 8(2), e001182.