Introduction

A statistician by training, I have been involved in the design, implementation and analysis of epidemiological studies throughout my career.  Initially working in cancer research in 1997 I moved to the MRC Biostatistics Unit in Cambridge to work on the Cognitive Function and Ageing study (www.cfas.ac.uk) and am now deputy director and principal statistician on this suite of studies. Over the years I have developed a programme of research around developing and using state of the art statistical methods to the issues of understanding ageing. Moving to Newcastle University in 2014, my research programme covers both the development of statistical methods (complex synthesis, multi-state models and Bayesian models) and the use of techniques for estimates of public health importance (prevalence, incidence, understanding risk and protective effects and healthy life expectancy) across a range of outcomes from dementia, cognition through to frailty. Further research consists of understanding the biological underpinning of dementia with neuropathology and clinical research on dementia with Lewy Bodies, but also research designs for complex conditions such as dementia and autism. 

My Google Scholar Profile , ORCID (0000-0002-1728-2388) or Scopus

Ageing and Geroscience theme lead, Faculty of Medical Sciences, Newcastle University

Qualifications

BSc (Hons) Statistics, University of Reading  (1991)

MSc Medical Statistics, London School of Hygiene and Tropical Medicine, University of London (1993)

PhD University of Cambridge (2005)

Member of the RSS Academic Affairs Advisory Group

Previous Positions

Professor of Epidemiology, Institute of Health and Society, Newcastle University (2014-2018 part time)

Programme leader – Senior scientist. Lead of programme on statistical epidemiology in ageing research. MRC Biostatistics Unit, Cambridge. 2008 - 2014 (2014-2018 part time)

MRC CFAS statistician. Senior research associate. MRC Biostatistics Unit, Cambridge. 2000-2009

MRC CFAS statistician. Research Associate. MRC Biostatistics Unit, Cambridge. 1997-2000

Non-clinical research scientist, Institute of Cancer Research, Sutton, Surrey. 1993-1997

Computer officer, Institute of Cancer Research, Sutton, Surrey. 1990-1993

Honours and Awards

RCGP Neurology, Mental Health and Dementia Paper of the Year (2013)

Gopal Kanji Prize for best article in Journal of Applied Statistics. (2011)

Research Interests

Statistical methodology:

• Analysis of complex outcomes
• Missing data models for epidemiological investigations
• Multi-state models
• Longitudinal models of epidemiological data
• Study design for epidemiological studies for complex outcomes
• Healthy life expectancy methods
• Dyadic analysis

Applied Epidemiology:

• Prevalence, incidence and survival with dementia and cognitive impairment, depression, frailty and other chronic diseases
• Risk and protective influences on ageing health
• Time trends and changing nature of ageing health
• Population changes in dementia and cognitive impairment
• Frailty and comorbidity of the older population
• Understanding quality of life of people with dementia and their carers
• Autism prevalence and risk factors for autism in populations
• Impact of inequality on health

Research Roles

Deputy director and Principal Statistician Cognitive Function and Ageing studies

Principal Statistician Improving the experience of Dementia and Enhancing Active Life (IDEAL) 

Postgraduate Supervision

Supervise PhD Students across any of the research interests mentioned above, including the use of cohort studies and routine data to address epidemiological investigations, through to developing statistical methodology. 

I currently have five PhD students and am happy to take on new students.

Current research grants

ESRC Identifying and mitigating the individual and dyadic impact of COVID19 and life under physical distancing on people with dementia and carers (INCLUDE). PI Clare (Exeter). £732,655. June 2020 for 18months

MRC-NHMRC The impact of the environment and pollution on cognitive health (EPOCH): Building on the knowledge based through international collaboration. UK PI Matthews, Australian PI Ester Cerin. £538,705 UK and AU$681,240.00 (~£373,000). May 2020 for 36 months

Dam Foundation PhD Studentship Depression, anxiety and social relationships as risk factors for dementia January 2020 for 36 months 3,420,000kr (~£290,000) (PI Selbæk, Oslo)

NHMRC Translating the evidence on dementia risk reduction to generate assessments, advice and training for health professionals, policy makers, patients and public November 2019 for 60 months AUS$ 1,995,480 (~£1,000,000) (PI Anstey, UNSW) (APP1171279)

Alzheimer’s Research UK Neuronal senescence as a contributory mechanism to dementia ARUK-PG2019A-003  £309,035 (PI Wharton, Sheffield) November 2019 for 36 months

NIHR RfPB Improving the Accuracy and Efficiency of Autism Assessment for Adults £295,092 (PI Mandy, UCL) September 2019 for 24 months [delayed due to COVID-19]

NIHR Understanding multimorbidity, frailty and disability trajectories in the very old: A longitudinal study in primary care. £30,816 (PI Kingston, Newcastle). July 2019 for 12 months.

ARUK PhD Fellowship Understanding the Contributions of Multiple Pathologies to Dementia in the BDR Programme. £71,208.87 (PI Thomas, Newcastle). October 2019 for 3 years.

Scientia PhD Fellowship Joint Studentship with Kaarin Anstey, University of New South Wales Australia. Jan 2019 for 36 months.

NIHR Older people and frailty £4,999,999 (PI Todd, Manchester, Newcastle director Hanratty, Newcastle deputy director Matthews) January 2019 for 60 months

Dunhill Trust Making the extra years count: the contribution of disease, multi-morbidity and socio-economic differentials to trends in disability-free life expectancy £135,099 (PI Jagger, Newcastle) January 2019 for 24 months

Alzheimer’s Society Understanding and improving support to help people with dementia and their carers prepare for advanced illness and end of life: a development study £241,238 (PI Knapp, LSE) Jan 2019 for 36 months

BRC Pilot Investigation of Predictors of Cognitive Decline in Mild Cognitive Impairment due to Lewy Body Disease £111,218 (PI Thomas, Newcastle) October 2018 for 30 months

Alzheimer’s Society Improving the experience of dementia and enhancing active life: a longitudinal perspective on living well with dementia (the IDEAL-2 study) £1,999,704 (PI Clare, Exeter) Jan 2018 (60 months)

ARUK The feasibility and practicality of dementia risk reduction in the older population: A pilot trial of multi-domain internet counselling. 2018-2020 (PI Brayne, Cambridge) £784,375 (30 months)

Alzheimer’s Society (PhD Fellowship) Cognitive Lifestyle: Impact of a changing society on the ageing brain. Principal Investigator and supervisor. 2016-2019 £80,918                                                                           [AS-PhD-2015-026]

MRC BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study) (PI John Isaacs, Newcastle) 2017-2021 £3,461,217

I teach epidemiology on a number of courses both Undergraduate and Masters Courses. 

I have supervised a number of PhD studentship projects and am happy to consider new students.

• Wolters FJ, Chibnik LB, Waziry R, Anderson R, Berr C, Beiser AS, Bis JC, Blacker D, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikran MA, Ikram MK, Joas E, Kern S, Kuller L, Launer L, Lopez O, Matthews F, McRae-McKee K, Meirelles O, Mosley TH, Pase MP, Psaty BM, Satizabal C, Seshadri S, Skoog I, Stephan BCM, Wetterberg H, Wong MM, Zettergren A, Hofman A. 27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium. Neurology 2020. In Press.
• Chambers A, Bury JJ, Minett T, Richardson CD, Brayne C, Ince PG, Shaw PJ, Garwood CJ, Heath PR, Simpson JE, Matthews FE, Wharton SB, CFAS. Advanced Glycation End Product Formation in Human Cerebral Cortex Increases with Alzheimer-type Neuropathologic Changes but is Not Independently Associated with Dementia in a Population-Derived Ageing Brain Cohort. Journal of Neuropathology and Experimental Neurology 2020. In Press.
• Pieper NT, Grossi CM, Chan WY, Loke YK, Savva GM, Haroulis C, Steel N, Fox C, Maidment ID, Arthur A, Myint PK, Smith TO, Robinson L, Matthews FE, Brayne C, Richardson K. Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: a meta-analysis. Age and Ageing 2020, ePub ahead of print.
• Zheng L, Matthews FE, Anstey K. Cognitive Health Expectancies of Cardiovascular Risk Factors for Cognitive Decline and Dementia. Age and Ageing 2020. In Press.
• Brayne CE, Barnes LE, Breteler MMB, Brooks RL, Dufouil C, Fox C, Fratiglioni L, Ikram MA, Kenny RA, Kivipelto M, Lobo A, Musicco M, Qiu C, Richard E, Riedel-Heller SG, Ritchie C, Skoog I, Stephan BCM, Venneri A, Matthews FE. Dementia Research Fit for the Planet: Reflections on Population Studies of Dementia for Researchers and Policy Makers Alike. Neuroepidemiology 2020, ePub ahead of print.
• Makker SR, Lipnicki DM, Crawford JD, Kochan NA, Castro-Costa E, Lima-Costa MF, Diniz BS, Brayne C, Stephan B, Matthews FE, Llibre-Rodriguez JJ, Llibre-Guerra JJ, Valhuerdi-Cepero AJ, Lipton RB, Katz MJ, Zammit A, Ritchie K, Carles S, Carriere I, Scarmeas N, Yannakoulia M, Kosmidis M, Lam L, Fung A, Chan W, Guaita A, Vaccaro R, Davin A, Kim K, Han JW, Suh SW, Riedel-Heller SG, Roehr S, Pabst A, Ganguli M, Hughes TF, Jacobsen EP, Anstey KJ, Cherbuin N, Haan MN, Aiello AE, Dang K, Kumagai S, Narazaki K, Chen S, Ng TP, Gao Q, Nyunt MSZ, Meguro K, Yamaguchi S, Ishii H, Lobo A, Escola EL, De-laCámara C, Brodaty H, Trollor JN, Leung Y, Lo JW, Sachdev P. Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment. Archives of Gerontology and Geriatrics 2020, 91, 104112.
• Wu YT, Nelis GM, Quinn C, Martyr A, Jones IR, Victor CR, Knapp M, Henderson C, Hindle JV, Jones RW, Kopelman MD, Morris RG, Pickett RA, Rusted JM, Thom JM, Litherland R, Matthews FE, Clare L. Factors associated with self- and informant ratings of quality of life, wellbeing and life satisfaction in people with mild-to-moderate dementia: Results from the Improving the experience of Dementia and Enhancing Active Life. Age and Ageing 2020, 49(3), 446-452.
• Fadul MM, Garwood CJ, Waller R, Garrett N, Heath PR, Matthews FE, Brayne C, Wharton SB, Simpson JE. NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain. International Journal of Molecular Sciences 2020, 21(1), 340.
• Richardson K, Wharton SB, Grossia CM, Matthews FE, Fox C, Maidment I, Loke YK, Steel N, Arthur A, Myint PK, Boustanig M, Campbell N, Robinson L, Brayne C, Savva GM. Neuropathological correlates of cumulative benzodiazepine and anticholinergic drug use. Journal of Alzheimer's Disease 2020, 74(3), 999-1009.
• Victor CR, Rippon I, Nelis SM, Martyr A, Litherland R, Pickett J, Hart N, Henley J, Matthews F, Clare L. Prevalence and determinants of loneliness in people living with dementia: findings from the IDEAL programme. International Journal of Geriatric Psychiatry 2020, (ePub ahead of Print).
• Hamilton CA, Matthews FE, Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, McKeith IG, Thomas AJ. Prospective predictors of decline versus stability in mild cognitive impairment with Lewy bodies or Alzheimer’s disease. Psychological Medicine 2020, ePub ahead of print.
• Hokkanen SRK, Kero M, Kaivola K, Hunter S, Keage HAD, Kiviharju A, Raunio A, Tienari PJ, Paetau A, Matthews FE, Fleming J, Graff C, Polvikoski TM, Myllykangas L, Brayne C. Putative risk alleles for LATE‐NC with hippocampal sclerosis in population‐representative autopsy cohorts. Brain Pathology 2020, 30(2), 364-372.
• Waheed W, Mirza N, Waheed MW, Blakemore A, Kenning C, Massod Y, Matthews F, Bower P. Recruitment and methodological issues in conducting dementia research in British ethnic minorities: A qualitative systematic review. International Journal of Methods in Psychiatric Research 2020, 29(1), e1806.
• Bambra C, Riordan R, Ford J, Matthews FE. The COVID-19 Pandemic and Health Inequalities. Journal of Epidemiology and Community Health 2020. In Press.
• Aldus CF, Arthur A, Dennington-Price A, Millac P, Richmond P, Dening T, Fox C, Matthews FE, Robinson L, Stephan BCM, Brayne C, Savva GM. Undiagnosed dementia in primary care: a record linkage study. Health Services and Delivery Research 2020, 8, 20.
• Stow D, Matthews FE, Hanratty B. When do GPs recognise end-of-life in people age 75+? Evidence from electronic healthcare records in primary care. British Journal of General Practice 2020. In Press.
• Clare L, Wu Y-T, Quinn C, Jones IR, Victor CR, Nelis SM, Martyr A, Litherland R, Pickett JA, Hindle JV, Jones RW, Knapp M, Kopelman MD, Morris RG, Rusted JM, Thom JM, Lamont RA, Henderson C, Rippon I, Hillman A, Matthews FE, on behalf of the IDEAL study team. A Comprehensive Model of Factors Associated With Capability to “Live Well” for Family Caregivers of People Living With Mild-to-Moderate Dementia: Findings From the IDEAL Study. Alzheimer Disease and Associated Disorders 2019, 33(1), 29-35.
• Clare L, Wu Y-T, Jones IR, Victor CR, Nelis SM, Martyr A, Quinn C, Litherland R, Pickett JA, Hindle JV, Jones RW, Knapp M, Kopelman MD, Morris RG, Rusted JM, Thom JM, Lamont RA, Henderson C, Rippon I, Hillman A, Matthews FE, on behalf of the IDEAL study team. A Comprehensive Model of Factors Associated With Subjective Perceptions of “Living Well” With Dementia: Findings From the IDEAL Study. Alzheimer’s Disease and Associated Disorders 2019, 33(1), 36-41.
• Grossi CM, Richardson K, Fox C, Maidment I, Steel N, Loke Y, Arthur A, Myint PK, Campbell N, Boustani M, Robinson L, Brayne C, Matthews FE, Savva GM. Anticholinergic and benzodiazepine medication use and risk of incident dementia: a UK cohort study. BMC Geriatrics 2019, 19, 276.
• Sun X, Allison C, Wei L, Matthews FE, Auyeung B, Wu YY, Griffiths S, Zhang J, Baron-Cohen S, Brayne C. Autism prevalence in China is comparable to Western prevalence. Molecular Autism 2019, 10, 7.
• Arthur A, Savva GM, Barnes LE, Borjian-Boroojeny A, Dening T, Jagger C, Matthews FE, Robinson L, Brayne C. Changing prevalence and treatment of depression among the over-65s over two decades: findings from the Cognitive Function and Ageing Studies. British Journal of Psychiatry 2019, ePub ahead of print.
• Shafto MA, Henson RN, Matthews FE, Taylor JR, Emery T, Erzinclioglu S, Hanley C, Rowe JB, Cusack R, Calder AJ, Marslen-Wilson WD, Duncan J, Dalgleish T, Brayne C, Cam-CAN, Tyler LK. Cognitive diversity in a healthy aging cohort: Cross-domain cognition in the Cam-CAN project. Journal of Aging and Health 2019, ePub ahead of print.
• Spiers G, Matthews FE, Moffatt S, Barker R, Jarvis H, Stow D, Kingston A, Hanratty B. Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence. Health & Social Care in the Community 2019, 27(5), e651-e662.
• Wharton SB, Wang D, Parikh C, Matthews FE, Brayne C, Ince PG. Epidemiological Pathology of Aβ Deposition in the Ageing Brain in CFAS: Addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches. Acta Neuropathologica Communications 2019, 7, 198.
• van den Hout A, Chan MS, Matthews FE. Estimation of Life Expectancies Using Continuous-Time Multi-State Models. Computer Methods and Programs in Biomedicine 2019, 178, 11-18.
• Richardson K, Mattishent K, Loke YK, Steel N, Fox C, Grossi CM, Bennett K, Maidment I, Boustani M, Matthews FE, Myint PK, Campbell NL, Brayne C, Robinson L, Savva G. History of Benzodiazepine Prescriptions and Risk of Dementia: Possible Bias Due to Prevalent Users and Covariate Measurement Timing in a Nested Case-Control Study. American Journal of Epidemiology 2019, 188(7), 1228–1236.
• Spiers G, Matthews FE, Moffatt S, Barker R, Jarvis H, Stow D, Kingston A, Hanratty B. Impact of social care supply on healthcare utilisation by older adults: A systematic review and meta-analysis. Age and Ageing 2019, 48(1), 57-66.
• Evans IEM, Llewellyn DJ, Matthews FE, Woods RT, Brayne C, Clare L. Living alone and cognitive function in later life. Archives of Gerontology and Geriatrics 2019, 81, 222-233.
• Wu YT, Clare L, Matthews FE, IDEAL Study. Relationship between depressive symptoms and capability to live well in people with mild to moderate dementia and their carers: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) programme. Aging and Mental Health 2019, epub ahead of print.
• Evans IEM, Llewellyn DJ, Matthews FE, Woods RT, Brayne C, Clare L. Social isolation, cognitive reserve, and cognition in older people with depression and anxiety. Aging and Mental Health 2019, 23(12), 1691-1700.
• Chan MS, van den Hout A, Pujades-Rodriguez M, Jones M, Matthews F, Jagger C, Raine R, Bajekal M. Socio-economic inequalities in life expectancy of older adults with and without multimorbidity: a record linkage study of 1.1 million people in England. International Journal of Epidemiology 2019, 48(4), 1340–1351.
• Brayne C, Matthews FE. The determinants of cognitive decline and dementia. BMJ 2019, 366, l4946.
• Nelis SM, Wu YT, Matthews FE, Martyr A, Quinn C, Rippon I, Rusted J, Thom JM, Kopelmann MD, Hindle JV, Jones RW, Clare L. The impact of comorbidity on the quality of life of people with dementia: findings from the IDEAL study. Age and Ageing 2019, 48(3), 361-367.
• Perneczky R, Kempermann G, Korczyn A, Matthews FE, Ikram MA, Scarmeas N, Chetelat G, Stern Y, Ewers M. Translational research on reserve against neurodegenerative disease: consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer’s Association Reserve, Resilience and Protective Factors Professional Interest Area working groups. BMC Medicine 2019, 17, 47.
• Richardson C, Stephan BCM, Robinson L, Brayne C, Matthews FE. Two-decade change in prevalence of cognitive impairment in the UK. European Journal of Epidemiology 2019, 34, 1085-1092.
• Henderson C, Knapp M, Nelis SM, Quinn C, Martyr A, Wu Y-T, Jones IR, Victor CR, Pickett JA, Hindle JV, Jones RW, Kopelman MD, Matthews FE, Morris RG, Rusted JM, Thom JM, Clare L. Use and costs of services and unpaid care for people with mild-to-moderate dementia: Baseline results from the IDEAL cohort study. Alzheimer's and Dementia: Translational Research and Clinical Interventions 2019, 5, 685-696.
• Stow D, Spiers G, Matthews FE, Hanratty B. What is the evidence that people with frailty have needs for palliative care at the end of life? A systematic review and narrative synthesis. Palliative Medicine 2019, 33(4), 399-414.
• Gao L, Calloway R, Zhao E, Brayne C, Matthews FE, CFAS. Accuracy of death certification of dementia in population-based samples of older people: analysis over time. Age and Ageing 2018, 47(4), 589–594.
• Richardson K, Fox C, Maidment I, Steel N, Loke YK, Arthur A, Myint PK, Grossi CM, Mattishent K, Bennett K, Campbell NL, Boustani M, Robinson L, Brayne C, Matthews FE, Savva GM. Anticholinergic drugs and risk of dementia: case-control study. BMJ 2018, 361, k1315.
• Opdebeeck C, Matthews FE, Wu YT, Woods RT, Brayne C, Clare L. Cognitive reserve as a moderator of the negative association between mood and cognition: evidence from a population-representative cohort. Psychological Medicine 2018, 48(1), 61-71.
• Wu YT, Clare L, Hindle J, Nelis S, Martyr A, Matthews FE. Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study. BMC Medicine 2018, 16, 140.
• Stow D, Matthews FE, Barclay S, Iliffe S, Clegg A, De Biase S, Robinson L, Hanratty B. Evaluating frailty scores to predict mortality in older adults using data from population based electronic health records: case control study. Age and Ageing 2018, 47(4), 564-569.
• Grasset L, Matthews FE, Pérès K, Foubert-Samier A, Helmer C, Dartigues JF, Brayne C. Evolution of dementia diagnosis over time (1988-2013): Evidence from French and English cohorts. Implication for secular trends analyses. Alzheimer's & Dementia: Diagnosis Assessment & Disease Monitoring 2018, 10, 490-497.
• Green E, Bennett H, Brayne C, Tyler LK, Bullmore ET, Calder AC, Cusack R, Dalgleish T, Duncan J, Henson RN, Marslen-Wilson WD, Rowe JB, Shafto MA, Campbell K, Cheung T, Davis S, Geerligs L, Kievit R, McCarrey A, Mustafa A, Price D, Samu D, Taylor JR, Treder M, Tsvetanov K, Van Belle J, Williams N, Bates L, Emery T, Erzinclioglu S, Gadie A, Gerbase S, Georgieva S, Hanley C, Parkin B, Troy D, Auer T, Correia M, Gao L, Henriques R, Allen J, Amery G, Amunts L, Barcroft A, Castle A, Dias C, Dowrick J, Fair M, Fisher H, Goulding A, Grewal A, Hale G, Hilton A, Johnson F, Johnston P, Kavanagh-Williamson T, Kwasniewska M, McMinn A, Norman K, Penrose J, Roby F, Rowland D, Sargeant J, Squire M, Stevens B, Stoddart A, Stone C, Thompson T, Yazlik O, Barnes D, Dixon M, Hillman J, Mitchell J, Villis L, Matthews FE. Exploring patterns of response across the lifespan: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study. BMC Public Health 2018, 18(1), 760.
• Stow D, Matthews FE, Hanratty B. Frailty trajectories to identify end of life: a longitudinal population based study. BMC Medicine 2018, 16(171), 1-7.
• Hokkanen SRK, Hunter S, Polvikoski TM, Keage HAD, Minett T, Matthews FE, Brayne C. Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. Brain Pathology 2018, 28(4), 548-559.
• Wu YT, Clare L, Rees-Jones I, Martyr A, Nelis SM, Quinn C, Victor CR, Lamont RA, Rippon I, Matthews FE. Inequalities in living well with dementia – the impact of deprivation on wellbeing, quality of life and life satisfaction: results from the Improving the experience of Dementia and Enhancing Active Life study. International Journal of Geriatric Psychiatry 2018, 33(12), 1736-1742.
• Mousa A, Savva GM, Mitnitski A, Rockwood K, Jagger C, Brayne C, Matthews FE. Is frailty a stable predictor of mortality across time? Evidence from the Cognitive Function and Ageing Studies. Age and Ageing 2018, 47(5), 721-727.
• Chan D, Shafto M, Kievit RA, Matthews FE, Spink M, Valenzuela M, Henson RN. Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities. Neurobiology of Ageing 2018, 70, 180-183.
• Hanratty B, Stow D, Collingridge Moore D, Valtorta NK, Matthews FE. Loneliness as a risk factor for care home admission in the English Longitudinal Study of Ageing. Age and Ageing 2018, 47(6), 896-900.
• Gao L, Maidment I, Matthews FE, Brayne C, CFAS. Medication usage change in older people (65+) in England over 20 years: findings from CFAS I and CFAS II. Age and Ageing 2018, 47(2), 220-225.
• Waller R, Murphy M, Garwood C, Jennings L, Health P, Chambers A, Matthews FE, Brayne C, Ince P, Wharton S, Simpson J. Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the ageing brain. Glia 2018, 66(11), 2316-2323.
• Silarova B, Nelis SM, Ashworth RM, Ballard C, Bienkiewicz M, Henderson C, Hillman A, Hindle JV, Hughes JC, Lamont RA, Litherland R, Jones IR, Jones RW, Knapp M, Kotting P, Martyr A, Matthews FE, Morris RG, Quinn C, Regan J, Rusted JM, van den Heuvel EA, Victor CT, Wu YT, Clare L. Protocol for the IDEAL-2 longitudinal study: following the experiences of people with dementia and their primary carers to understand what contributes to living well with dementia and enhances active life. BMC Public Health 2018, 18, 1214.
• Richardson C, Stephan BCM, Robinson L, Matthews F, The Cognitive Function and Ageing Study. Risk of Two-Year Progression from Mild Cognitive Impairment to Dementia: Results from the Cognitive Function and Ageing Study. In: Alzheimer's Association International Conference (AAIC 2018). 2018, Chicago, Illinois: Elsevier.
• White SR, Muniz-Terrera G, Matthews FE. Sample size and classification error for Bayesian change-point models with unlabelled sub-groups and incomplete follow-up. Statistical Methods in Medical Research 2018, 27(5), 1476-1497.
• Evans IEM, Llewellyn DJ, Matthews FE, Woods RT, Brayne C, Clare L. Social isolation, cognitive reserve, and cognition in healthy older people. PLoS ONE 2018, 13(8), e0201008.
• Bennett H, Norton S, Bunn F, Robinson L, Rait G, Goodman C, Brayne C, Matthews FE. The impact of dementia on service use by individuals with a comorbid health condition: a comparison of two cross-sectional analyses conducted approximately 10 years apart. BMC Medicine 2018, 16, 114.
• Hayat SA, Luben R, Dalzell N, Moore S, Hogervorst E, Matthews FE, Wareham N, Brayne C, Khaw KT. Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality. European Journal of Epidemiology 2018, 33(11), 1049-1062.
• Lipnicki D, Crawford JD, Dutta R, Thalamuthu A, Kochan NA, Andrews A, Lima-Costa MF, Castro Costa E, Brayne C, Matthews FE, Stephan BCM, Lipton RB, Katz MJ, Ritchie K, Scali J, Ancelin ML, Scarmeas N, Yannakoulia M, Dardiotis E, Lam LCW, Wong CHY, Fung AWT, Guaita A, Vaccaro R, Davin A, Woong-Kim K, Han JW, Hui Kim T, Anstey KJ, Cherbuin N, Butterworth P, Scazufca M, Kumagai S, Chen S, Narazaki K, Ng TP, Gao Q, Reppermund S, Brodaty H, Lobo A, Lopez-Anton R, Santabárbara J, Sachdev PS. Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. PLoS Medicine 2017, 14(3), e1002261.
• Davis DHJ, Muniz-Terrera G, Keage HAD, Stephan BCM, Fleming J, Ince PG, Matthews FE, Cunningham C, Ely EW, MacLullich AMJ, Brayne C. Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies. JAMA Psychiatry 2017, 74(3), 244-251.
• Green I, Stow D, Matthews FE, Hanratty B. Changes over time in the health and functioning of older people moving into care homes: Analysis of data from the English Longitudinal Study of Ageing. Age and Ageing 2017, 46(4), 693-696.
• van Bussel EF, Richard E, Arts DL, Noovens AC, Coloma PM, de Wall MWM, van den Akker M, Biermans MC, Nielen MMJ, van Boven K, Smeets H, Matthews FE, Brayne C, Busshers WB, van Gool WA, Moll van Charante EP. Dementia incidence trend over 1992-2014: analysis of primary care data in the Netherlands. PLOS Medicine 2017, 14(3), e1002235.
• Kingston A, Wohland P, Wittenberg R, Robinson L, Brayne C, Matthews FE, Jagger C. Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). The Lancet 2017, 390(10103), 1676-1684.
• Taga M, Minett T, Classey J, Matthews FE, Brayne C, Ince PG, Nicoll JA, Hugon J, Boche D, MRC CFAS. Metaflammasome components in the human brain: a role in dementia with alzheimer's pathology?. Brain Pathology 2017, 27(3), 266-275.
• Wu Y-T, Prina AM, Jones A, Barnes LE, Matthews FE, Brayne C. Micro-scale environment and mental health in later life: Results from the Cognitive Function and Ageing Study II (CFAS II). Journal of Affective Disorders 2017, 218, 359-364.
• Stephan BCM, Minett T, Muniz-Terrera G, Harrison SL, Matthews FE, Brayne C. Neuropsychological profiles of vascular disease and risk of dementia: Implications for defining vascular cognitive impairment no dementia (VCI-ND). Age and Ageing 2017, 46(5), 755-760.
• van der Linde RM, Matthews FE, Dening R, Brayne C. Patterns and persistence of behavioural and psychological symptoms in those with cognitive impairment: the importance of apathy. International Journal of Geriatric Psychiatry 2017, 32(3), 306-315.
• Stephan BCM, Richardson K, Savva GM, Matthews FE, Brayne C, Hachinski V. Potential Value of Impaired Cognition in Stroke Prediction: A U.K. Population-Based Study. Journal of the American Geriatrics Society 2017, 65(8), 1756–1762.
• Clare L, Wu YT, Teale JC, MacLeod C, Matthews F, Brayne C, Woods B. Potentially-modifiable Lifestyle Factors, Cognitive Reserve and Cognitive Function in Later Life: a Cross-sectional Study. Plos Medicine 2017, 14(3), e1002259.
• Wu Y-T, Prina AM, Jones A, Matthews FE, Brayne C. The Built Environment and Cognitive Disorders: Results From the Cognitive Function and Ageing Study II. American Journal of Preventive Medicine 2017, 53(1), 25-32.
• Richardson C, Stephan B, Robinson L, Brayne C, Matthews F. The Changing Face of Mild Cognitive Impairment (MCI) and Mild Dementia. In: Alzheimer's Association International Conference 2017. 2017, London, UK: Alzheimer's & Dementia: The Journal of the Alzheimer's Association.
• Wu YT, Beiser AS, Breterler MMB, Fratiglioni L, Helmer C, Hendrie HC, Honda H, Ikram MA, Langa KM, Lobo A, Matthews FE, Ohara T, Peres K, Qiu C, Seshadri S, Sjolund BM, Skoog I, Brayne C. The changing prevalence and incidence of dementia over time — current evidence. Nature Reviews Neurology 2017, 13(6), 327-339.
• Crosby D, Bossutt P, Brockehurst P, Chamberlain C, Dive C, Holmes C, Isaacs J, Kennedy R, Matthews F, Parmer M, Pearce J, Westhead D, Whittaker J, Holgate S. The MRC Framework for the Development, Design and Analysis of Stratified Medicine Research: Enabling Stratified, Precision and Personalised Medicine. London: Medical Research Council, 2017. Available at: https://www.mrc.ac.uk/research/initiatives/stratified-medicine/stratified-medicine-methodology-framework/.
• Chibnik LB, Wolters FJ, Backman K, Beiser A, Berr C, Bis JC, Boerwinkle E, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Debette S, Davis-Plourde KL, Dufouil C, Fornage M, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Kern C, Kuller L, Launer L, Lopez OL, Matthews F, Meirelles O, Mosley T, Ower A, Psaty BM, Satizabel CL, Seshadri S, Skoog I, Stephan BCM, Tzourio C, Waziry R, Wong MM, Zettergren A, Hofman A. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. European Journal of Epidemiology 2017, 32(10), 931-938.
• Jagger C, Matthews FE, Wohland P, Fouweather T, Stephan BCM, Robinson L, Arthur A, Brayne C, on behalf of the Medical Research Council Cognitive Function and Ageing Collaboration. A comparison of health expectancies over two decades in England: results of the Cognitive Function and Ageing Study I and II. The Lancet 2016, 387(10020), 779-786.
• Matthews FE, Stephan BCM, Robinson L, Jagger C, Barnes LE, Arthur A, Brayne C. A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II . Nature Communications 2016, 7, 11398.
• Hayat SA, Luben R, Dalzelli N, Moore S, Anuj S, Matthews FE, Wareham N, Brayne C, Khaw KT. Cross Sectional Associations Between Socio-demographic Factors and Cognitive Performance in an Older British Population: The European Investigation of Cancer in Norfolk (EPIC-Norfolk) Study. PLoS One 2016, 11(12), e0166779.
• Wu Y-T, Fratiglioni L, Matthews FE, Lobo A, Breteler MMB, Skoog I, Brayne C. Dementia in western Europe: epidemiological evidence and implications for policy making. Lancet Neurology 2016, 15(1), 116-124.
• Orr JG, Thomas RC, Stow D, Matthews F, Hanratty B, Jones D, Hudson M. Eleven-year mortality and referral practices associated with abnormal alanine aminotransferase (ALT) results. In: 67th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016. 2016, Washington DC: Wiley-Blackwell.
• Grossi CM, Maidment I, Richardson K, Fox C, Brayne C, Matthews F, Robinson L, Savva GM. Increasing Prevalence Of Anticholinergic Medication Use Over 20 Years In The UK Older Population: Cognitive Function And Ageing Study I and II. In: 32nd International Conference on Pharmacoepidemiology & Therapeutic Risk Management. 2016, Dublin: John Wiley & Sons Ltd.
• Wu Y-T, Prina AM, Jones A, Barnes LE, Matthews FE, Brayne C, CFAS MRC. Land use mix and five-year mortality in later life: Results from the Cognitive Function and Ageing Study. Health and Place 2016, 38, 54-60.
• Richardson K, Fox C, Maidment I, Steel N, Loke Y, Arthur A, Grossi C, Bennett K, Myint P, Campbell N, Brayne C, Matthews FE, Boustani M, Robinson L, Savva G. Medications with Potent Anticholinergic Activity and Incident Dementia Diagnosis in the UK Older Population. In: 32nd International Conference on Pharmacoepidemiology & Therapeutic Risk Management. 2016, Dublin: John Wiley & Sons Ltd.
• Minnett T, Classey J, Matthews FE, Fahrenhold M, Taga M, Brayne C, Ince P, Nicoll J, Boche D. Microglial immunophenotype in dementia with Alzheimer's pathology. Journal of Neuroinflammation 2016, 13, 1-10.
• Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C, Rattray M, Wharton SB. Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology 2016, 42(2), 167-179.
• Hokkanen S, Kero M, Hunter S, Lilius L, Paetau A, Matthews F, Polvikoski T, Myllykangas L, Graff C, Brayne C. Old-age hippocampal sclerosis associates with GRN and TMEM106B but not with ABCC9 variation in population-based cohorts. In: 117th meeting of the British Neuropathological Society. 2016, London, UK: Wiley-Blackwell.
• Khawaja AP, Chan MP, Yip JL, Broadway DC, Garway-Heath DF, Luben R, Hayat S, Matthews FE, Brayne C, Khaw KT, Foster PJ. Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study. Investigative Ophthalmology & Visual Science 2016, 57(4), 1921-1926.
• Matthews FE, Bennett H, Wittenberg R, Jagger C, Dening T, Brayne C, Cognitive Function Ageing Studies (CFAS) collaboration. Who lives where and does it matter? Changes in the health profiles of older people living in long term care and the community over two decades in a high income country. PLoS One 2016, 11(9), e0161705.
• Green E, Shafto MA, Matthews FE, Cam-CAN, White SR. Adult Lifespan Cognitive Variability in the Cross-Sectional Cam-CAN Cohort. International Journal of Environmental Research and Public Health 2015, 12(12), 15516-15530.
• Newton JN, Briggs ADM, Murray CJL, Dicker D, Foreman KJ, Wang H, Naghavi M, Forouzanfar MH, Ohno SL, Barber RM, Vos T, Stanaway JD, Schmidt JC, Hughes AJ, Fay DFJ, Ecob R, Gresser C, McKee M, Rutter H, Abubakar I, Alli R, Anderson HR, Banerjee A, Bernabé E, Bhui KS, Biryukov SM, Bennett DA, Bourne RR, Brayne CEG, Bruce NG, Brugha TS, Burch M, Capewell S, Casey D, Chowdhury R, Coates MM, Cooper C, Critchley JA, Dargan PI, Dherani MK, Elliott P, Ezzati M, Fenton KA, Fraser MS, Fürst T, Greaves F, Green MA, Gunnell DJ, Hannigan BM, Hay RJ, Hay SI, Hemmingway H, Larson HJ, Looker KJ, Lunevicius R, Lyons R, Marcenes W, Mason-Jones A, Matthews FE, Moller H, Murdoch ME, Newton CR, Pearce N, Piel FB, Pope D, Rahimi K, Rodriguez A, Scarborough P, Schumacher AE, Shiue I, Smeeth L, Tedstone A, Valabhji J, Williams HC, Wolfe CDA, Woolf AD, Davis A. Changes in health in England, with analysis by English regions and areas of deprivation, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet 2015, 386(10010), 2257-2274.
• Gao L, Green E, Barnes LE, Brayne C, Matthews FE, Robinson L, Arthur A, MRC CFAS. Changing non-participation in epidemiological studies of older people: evidence from the Cognitive Function and Ageing Study I and II. Age and Ageing 2015, 44(5), 867-873.
• Wu Y-T, Prina AM, Jones AP, Barnes LE, Matthews FE, Brayne C. Community environment, cognitive impairment and dementia in later life: Results from the Cognitive Function and Ageing Study. Age and Ageing 2015, 44(6), 1005-1011.
• Stephan BCM, Minett T, Terrera GM, Matthews FE, Brayne C. Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept?. Age and Ageing 2015, 44(1), 78-83.
• Wu YT, Prina AM, Jones A, Matthews FE, Brayne C, MRC CFAS. Older people, the natural environment and common mental disorders: cross-sectional results from the Cognitive Function and Ageing Study. BMJ Open 2015, 5(9), e007936.
• Wu Y-T, Brayne C, Matthews FE. Prevalence of dementia in East Asia: A synthetic review of time trends. International Journal of Geriatric Psychiatry 2015, 30(8), 793-801.
• Wu Y-T, Prina AM, Barnes LE, Matthews FE, Brayne C. Relocation at older age: Results from the Cognitive Function and Ageing Study. Journal of Public Health 2015, 37(3), 480-487.
• Yates JA, Clare L, Woods RT, Matthews FE, CFAS Wales. Subjective Memory Complaints are Involved in the Relationship between Mood and Mild Cognitive Impairment. Journal of Alzheimer's Disease 2015, 48(S1), S115-S123.
• Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ, Wharton SB, Simpson JE, MRC Cognitive Function Ageing. The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters 2015, 609, 11-17.
• Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Thalamuthu A, Andrews G, Brayne C, Matthews FE, Stephan BCM, Lipton RB, Katz MJ, Ritchie K, Carriere I, Ancelin ML, Lam LCW, Wong CHY, Fung AWT, Guaita A, Vaccaro R, Davin A, Ganguli M, Dodge H, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabarbara J, Cohort Studies Memory Internationa. The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. PLoS One 2015, 10(11), e0142388.
• Wu Y-T, Nash P, Barnes LE, Minett T, Matthews FE, Jones A, Brayne C. Assessing environmental features related to mental health: A reliability study of visual streetscape images. BMC Public Health 2014, 14(1), 1094.
• Wu Y-T, Matthews FE, Brayne C. Dementia: Time trends and policy responses. Maturitas 2014, 79(2), 191-195.
• Wu Y-T, Lee H-Y, Norton S, Prina AM, Fleming J, Matthews FE, Brayne C. Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis. International Journal of Geriatric Psychiatry 2014, 29(12), 1212-1220.
• Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurology 2014, 13(8), 788-794.
• Davis DHJ, Barnes LE, Stephan BCM, MacLullich AMJ, Meagher D, Copeland J, Matthews FE, Brayne C, on behalf of the MRC Cognitive Function and Ageing Study. The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). BMC Geriatrics 2014, 14, 87.
• Stephan BC, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE, Brayne C. The neuropathological profile of mild cognitive impairment (MCI): a systematic review. Molecular Psychiatry 2012, 17(11), 1056-1076.
• Brayne C, Stephan BC, Matthews FE. A European perspective on population studies of dementia. Alzheimer's & Dementia 2011, 7(1), 3-9.
• Muniz-Terrera G, Matthews FE, Stephan B, Brayne C, CC75C Collaboration Group. Are terminal decline and its potential indicators detectable in population studies of the oldest old?. International Journal of Geriatric Psychiatry 2011, 26(5), 584-592.
• Matthews FE, Stephan BC, Khaw KT, Hayat S, Luben R, Bhaniani A, Moore S, Brayne C. Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version. Journal of Clinical Epidemiology 2011, 64(9), 1005-1013.
• Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C. Dementia risk prediction in the population: are screening models accurate?. Nature Reviews Neurology 2010, 6(6), 318-326.
• Brayne C, Ince PG, Keage HAD, McKeith IG, Matthews FE, Polvikoski T, Sulkava R. Education, the brain and dementia: neuroprotection or compensation? EClipSE Collaborative Members. Brain 2010, 133(8), 2210-2216.
• Stephan BC, Matthews FE, Khaw KT, Dufouil C, Brayne C. Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). Alzheimer's Research & Therapy 2009, 1(1), 4.
• Matthews FE, Jagger C, Miller LL, Brayne C, MRC CFAS. Education Differences in Life Expectancy with Cognitive Impairment. Journal of Gerontology Medical Sciences 2009, 64A(1), 125-131.
• van den Hout A, Jagger C, Matthews FE. Estimating life expectancy in health and ill health using a hidden Markov model. Journal of the Royal Statistical Society Series C 2009, 58(4), 449-465.
• Byford M, Brayne C, McKeith I, Chatfield M, Ince PG, Matthews FE, MRC CFAS Neuropathology Group. Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study. BMC Geriatrics 2009, 9(22), 9.
• Seidel D, Crilly N, Matthews FE, Jagger C, Brayne C, Clarkson PJ. Patterns of Functional Loss Among Older People: A Prospective Analysis. Human Factors 2009, 51(5), 669-680.
• Peres K, Jagger C, Matthews FE, MRC CFAS. Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: results from the MRC Cognitive Function and Ageing Study. International Journal of Geriatric Psychiatry 2008, 23(6), 643-649.
• Jagger C, Matthews R, Melzer D, Matthews F, Brayne C, MRC CFAS. Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). International Journal of Epidemiology 2007, 36(2), 358-365.
• Matthews FE, McKeith I, Bond J, Brayne C. Reaching the population with dementia drugs: What are the challenges?. International Journal of Geriatric Psychiatry 2007, 22(7), 627-631.