Staff Profile
Dr Ian Wilson
Lecturer
- Email: ian.wilson@ncl.ac.uk
- Telephone: +44 (0) 191 241 8689
- Personal Website: https://ijwilson.github.io
- Address: Biosciences Institute
Newcastle University
International Centre for Life
Central Parkway
Newcastle upon Tyne
NE1 3BZ
Research Interests
Development of Statistical Methods for Population Genomic Data
My main research focuses on building models for statistical inference of the processes underlying genetic variation in large datasets of closely linked genetic markers. Publicly accessible datasets are now available that give detailed pictures of haplotype diversity from a sample of human populations. Genomic data of this form is likely to be increasingly important studying the genetic of disease: successful use of this data requires new statistical techniques. My main interest is in how we use known human evolutionary history to inform genetic studies of common human disease – such as type 1 and type II diabetes, hypertension and coronary artery disease.
I am developing models that describe genomic data and can be used to estimate genetic parameters from subdivided populations, and, more importantly, can sample from the conditional distribution of an unseen variant, conditional on genomic variation. A large number of population genomic problems can be described under this prediction-with-subdivision framework and problems of immediate interest can be made to conform such as fine-scale mapping for case-control studies of genetic variation, and the search for loci that have undergone different selective regimes in sampled subpopulations.
Recent work has focussed on methods for inferring human evolutionary history from worldwide DNA samples. Projects have concentrated on the X and Y chromosomes and mitochondrial DNA. I am the author of BATWING, which has been used extensively in inferring human history using the Y chromosome.
- How can we make best use of large databases of genetic variation?
How do we use known human history to
How can we best make use of complete genetic information?
What approximations can be made so that calculations are feasible for thousands of SNPs at the same time?
What evidence do we have for the genetic basis of difference between populations?
What proportion of selected loci could one hope to find?
How widespread are functional genetic variants between populations?
- Pogoryelova O, Wilson IJ, Mansbach H, Argov Z, Nishino I, Lochmüller H. GNE genotype explains 20% of phenotypic variability in GNE myopathy. Neurology Genetics 2019, 5(1), e308.
- Chen Y, Nasrulloh AV, Wilson I, Geenen C, Habib M, Obara B, Steel DHW. Macular hole morphology and measurement using an automated three-dimensional image segmentation algorithm. BMJ Open Ophthalmology 2020, 5, e000404.
- Verhaart IEC, Robertson A, Wilson IJ, Aartsma-Rus A, Cameron S, Jones CC, Cook SF, Lochmuller H. Prevalence, incidence and carrier frequency of 5q-linked spinal muscular atrophy - A literature review. Orphanet Journal of Rare Diseases 2017, 12(1).
- Wilson IJ, Carling PJ, Alston CL, Floros VI, Pyle A, Hudson G, Sallevelt SCEH, Lamperti C, Carelli V, Bindoff LA, Samuels DC, Wonnapinij P, Zeviani M, Taylor RW, Smeets HJM, Horvath R, Chinnery PF. Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneck. Human Molecular Genetics 2016, 25(5), 1031-1041.
- Pickett SJ, Blain A, Ng YS, Wilson IJ, Taylor RW, McFarland R, Turnbull DM, Gorman GS. Mitochondrial donation - Which women could benefit?. New England Journal of Medicine 2019, 380(20), 1971-1972.
- Maheshwari S, Gudur VY, Shafik R, Wilson I, Yakovlev A, Acharyya A. CORAL: Verification-aware OpenCL based Read Mapper for Heterogeneous Systems. IEEE/ACM Transactions On Computational Biology And Bioinformatics 2021, 18(4), 1426-1438.
- Manning W, Ghosh M, Wilson I, Hide G, Longstaff L, Deehan D. Improved mediolateral load distribution without adverse laxity pattern in robot-assisted knee arthroplasty compared to a standard manual measured resection technique. Knee Surgery, Sports Traumatology, Arthroscopy 2020, 28, 2835-2845.
- Pickett S, Grady JP, Ng YS, Gorman GS, Schaefer AM, Wilson IJ, Cordell HJ, Turnbull DM, Taylor RW, McFarland R. Phenotypic heterogeneity in m.3243A>G mitochondrial disease: The role of nuclear factors. Annals of Clinical and Translational Neurology 2018, 5(3), 333-345.
- Rankin KS, Ramaskandhan J, Bardgett M, Merrie K, Gangadharan R, Wilson I, Deehan D. Synovectomy during total knee arthroplasty: a pilot single-centre randomised controlled trial. Pilot and Feasibility Studies 2018, (4), 145.
- Elder A, Bomken S, Wilson I, Blair HJ, Cockell S, Ponthan F, Dormon K, Pal D, Heidenreich O, Vormoor J. Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia. Leukemia 2017, 31, 2577-2586.
- Wilson BT, Stark Z, Sutton RE, Danda S, Ekbote AV, Elsayed SM, Gibson L, Goodship JA, Jackson AP, Keng WT, King MD, McCann E, Motojima T, Murray JE, Omata T, Pilz D, Pope K, Sugita K, White SM, Wilson IJ. The Cockayne Syndrome Natural History (CoSyNH) study: clinical findings in 102 individuals and recommendations for care. Genetics in Medicine 2016, 18(5), 483-493.
- Pyle A, Hudson G, Wilson IJ, Coxhead J, Smertenko T, Herbert M, Santibanez-Koref M, Chinnery PF. Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans. PLoS Genetics 2015, 11(5), e1005040.
- Napier C, Mitchell AL, Gan E, Wilson I, Pearce SHS. Role of the X-Linked Gene GPR174 in Autoimmune Addison's Disease. Journal of Clinical Endocrinology and Metabolism 2015, 100(1), E187-E190.
- Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, Sharma A, Blair H, Hide IG, Heidenreich O, Vormoor J, Maxwell RJ, Bacon CM. Development of a Preclinical Orthotopic Xenograft Model of Ewing Sarcoma and Other Human Malignant Bone Disease Using Advanced In Vivo Imaging. PLoS ONE 2014, 9(1), e85128.
- Pfeffer G, Joseph JT, Innes AM, Frizzell JB, Wilson IJ, Brownell AKW, Chinnery PF. Titinopathy in a Canadian Family Sharing the British Founder Haplotype. Canadian Journal of Neurological Sciences 2014, 41(1), 90-94.
- Hudson G, Gomez-Duran A, Wilson IJ, Chinnery PF. Recent Mitochondrial DNA Mutations Increase the Risk of Developing Common Late-Onset Human Diseases. PLoS Genetics 2014, 10(5), e1004369.
- Hudson G, Wilson I, Payne BI, Elson J, Samuels DC, Santibanez-Korev M, Hall SJ, Chinnery PF. Unique mitochondrial DNA in highly inbred feral cattle. Mitochondrion 2012, 12(4), 438-440.
- Wilson IJ, Howey RAJ, Houniet DT, Santibanez-Koref M. Finding genes that influence quantitative traits with tree-based clustering. BMC Proceedings 2011, 5(s9), S98.
- Santos-Lopes SS, Pereira RW, Wilson IJ, Pena SDJ. A worldwide phylogeography for the human X chromosome. PLoS ONE 2007, 2(6), e557.
- Wilson IJ, Weale ME, Balding DJ. Inferences from DNA data: population histories, evolutionary processes and forensic match probabilities. Journal of the Royal Statistical Society, Series A: Statistics in Society 2003, 166(2), 155-188.
- Vickers MA, McLeod E, Spector TD, Wilson IJ. Assessment of mechanism of acquired skewed X inactivation by analysis of twins. Blood 2001, 97(5), 1274-1281.
- Emery AM, Wilson IJ, Craig S, Boyle PR, Noble LR. Assignment of paternity groups without access to parental genotypes: multiple mating and developmental plasticity in squid. Molecular Ecology 2001, 10(5), 1265-1278.
- Ermini L, Wilson IJ, Goodship THJ, Sheerin NS. Complement polymorphisms: Geographical distribution and relevance to disease. Immunobiology 2012, 217(2), 265-271.
- Soemedi R, Topf A, Wilson IJ, Darlay R, Rahman T, Glen E, Hall D, Huang N, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Setchfield K, Bu'lock F, Thornborough C, Devreindt K, Breckpot J, Hofbeck M, Lathrop M, Rauch A, Blue G, Winlaw D, Hurles M, Santibanez-Koref M, Cordell H, Goodship J, Keavney B. Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Human Molecular Genetics 2012, 21(7), 1513-1520.
- Estoup A, Wilson IJ, Sullivan C, Cornuet JM, Moritz C. Inferring population history from microsatellite and enzyme data in serially introduced cane toads, Bufo marinus. Genetics 2001, 159(4), 1671-1687.
- Wilson I.J., and Balding D. J. Genealogical inference from microsatellite data. Genetics 1998, 150, 499-510.
- Wilson IJ, Dawson KJ. A Markov chain Monte Carlo strategy for sampling from the joint posterior distribution of pedigrees and population parameters under a Fisher-Wright model with partial selfing. Theoretical Population Biology 2007, 72(3), 436-458.
- Balaresque P, Bowden GR, Adams SM, Leung HY, King TE, Rosser ZH, Goodwin J, Moisan JP, Richard C, Millward A, Demaine AG, Barbujani G, Previdere C, Wilson IJ, Tyler-Smith C, Jobling MA. A Predominantly Neolithic Origin for European Paternal Lineages. PLoS Biology 2010, 8(1), e1000285.
- Wilson IJ. Demography, Ascertainment and the Genealogy of haplotype blocks. In: Matsumura, S; Forster, P; Renfrew, C, ed. Simulations, Genetics and Human Prehistory. Cambridge, UK: MacDonald Institute, 2008, pp.155-172.