Staff Profile
Dr Marie Ruchaud-Sparagano
Research Associate
- Email: marie.ruchaud-sparagano@ncl.ac.uk
- Telephone: +44 (0) 191 208 5262
- Address: Institute of Cellular Medicine
The Medical School
University of Newcastle
3rd Floor, Leech Building
Framlington Place
Newcastle
NE2 4HH
Publications
- Scott J, Harris GJ, Pinder EM, Macfarlane JG, Hellyer TP, Rostron AJ, Morris AC, Thickett DR, Perkins GD, McAuley DF, Widdrington JD, Wiscombe S, Baudouin SV, Roy AI, Linnett VC, Wright SE, Ruchaud-Sparagano MH, Simpson AJ. Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by beta(2)-agonists, corticosteroids, and critical illness. Journal of Allergy and Clinical Immunology 2016, 137(2), 535-544.
- Hellyer TP, Morris AC, McAuley DF, Walsh TS, Anderson NH, Singh S, Dark P, Roy AI, Baudouin SV, Wright SE, Perkins GD, Kefala K, Jeffels M, McMullan R, O'Kane CM, Spencer C, Laha S, Robin N, Gossain S, Gould K, Ruchaud-Sparagano MH, Scott J, Browne EM, MacFarlane JG, Wiscombe S, Widdrington JD, Dimmick I, Laurenson IF, Nauwelaers F, Simpson AJ. Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia. Thorax 2015, 70(1), 41-47.
- Ruchaud-Sparagano MH, Mills R, Scott J, Simpson AJ. MPLA inhibits release of cytotoxic mediators from human neutrophils while preserving efficient bacterial killing. Immunology and Cell Biology 2014, 92(9), 799-809.
- Popplewell CR, Ruchaud-Sparagano MH, Scott J, Corris PA, Simpson AJ. Carboplatin and Gemcitabine Impair Neutrophil Phagocytic Function. In: British Thoracic Society Winter Meeting. 2013, London, UK: BMJ Publishing Group.
- Ruchaud-Sparagano MH, Gertig H, Hester KL, Macfarlane JG, Corris P, Simpson AJ, De Soyza A. Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis. Respirology 2013, 18(8), 1230-1235.
- Macfarlane JG, Ruchaud-Sparagano MH, Scott JA, Bulmer DA, Khan CMA, Simpson AJ. Src Kinase Inhibition Attenuates Neutrophil Degranulation Without Impairing Bacterial Killing: A Possible Therapeutic Strategy for Acute Lung Injury?. In: British Thoracic Society Winter Meeting. 2013, London, UK: BMJ Publishing Group.
- Mühlen S, Ruchaud-Sparagano M, Kenny B. Proteasome-independent degradation of canonical NFκB complex components by the NleC protein of pathogenic Escherichia coli. Journal of Biological Chemistry 2011, 286(7), 5100-5107.
- Ruchaud-Sparagano MH, Mühlen S, Dean P, Kenny B. The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors. PLoS Pathogens 2011, 7(12), e1002414.
- Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ. Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients. American Journal of Respiratory and Critical Care Medicine 2018, 198(3), 340-349.
- Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Conway Morris A, Simpson AJ. Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis. Thorax 2018, 73(10), 918-925.
- Widdrington JD, Gomez-Duran A, Steyn JS, Pyle A, Ruchaud-Sparagano M-H, Scott J, Baudouin SV, Rostron AJ, Simpson J, Chinnery PF. Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ. Journal of Allergy and Clinical Immunology 2017, 140(5), 1461-1464.e8.
- Ruchaud-Sparagano MH, Grant J, Thirugnanasothy L, Sithamparanathan S, Simpson J, Corris P. Investigation Of Neutrophil Function In Ipah Patients. In: American Thoracic Society 2016 International Conference. 2016, San Francisco: American Thoracic Society.
- Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Allen T, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather A, Bowett S, Parker J, Corris PA, McAuley DF, Morris AC, Simpson AJ. Randomised Controlled Trial Of Granulocyte Macrophage Colony Stimulating Factor In Critically Ill Patients With Impaired Neutrophil Function. In: American Thoracic Society 2016 International Conference. 2016, San Francisco: American Thoracic Society.