I am a Newcastle University Research Fellow in Biostatistics, interested in methodology for improving the design and analysis of clinical trials. As well as working on developing methodology, I am also interested in collaborating on real trials.

I have been in Newcastle since November 2018. Prior to this I was a Statistician at the MRC Biostatistics Unit, University of Cambridge.

Google Scholar: Click here.

My research focuses on statistical methodology for improving the design and analysis of clinical trials. I am particularly interested in:

1. Adaptive clinical trial designs;
2. Early phase oncology trials;
3. Crossover trial designs;
4. Cluster randomised trials.

• Grayling MJ, Dimairo M, Mander AP, Jaki TF. A Review of Perspectives on the Use of Randomization in Phase II Oncology Trials. JNCI: Journal of the National Cancer Institute 2019, epub ahead of print.
• Grayling MJ, Mander AP, Wason JMS. Admissible multiarm stepped-wedge cluster randomized trial designs. Statistics in Medicine 2019, 38(7), 1103-1119.
• Grayling MJ, Wason JMS, Mander AP. Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables. Communications in Statistics - Theory and Methods 2019, Epub ahead of print.
• Grayling MJ, Mander AP. Re-formulating Gehan's design as a flexible two-stage single-arm trial. BMC Medical Research Methodology 2019, 19, 22.
• Grayling MJ, Mander AP, Wason JMS. Two-Stage Adaptive Designs for Three-Treatment Bioequivalence Studies. Statistics in Biopharmaceutical Research 2019, 11(4), 360-374.
• Grayling MJ, Wason JMS, Mander AP. An optimised multi-arm multi-stage clinical trial design for unknown variance. Contemporary Clinical Trials 2018, 67, 116-120.
• Grayling MJ, Mander AP, Wason JMS. Blinded and unblinded sample size re-estimation in crossover trials balanced for period. Biometrical Journal 2018, 60(5), 917-933.
• Grayling MJ, Mander AP, Wason JMS. Blinded and unblinded sample size reestimation procedures for stepped-wedge cluster randomized trials. Biometrical Journal 2018, 60(5), 903-916.
• Grayling MJ, Mander AP. Calculations involving the multivariate normal and multivariate t distributions with and without truncation. The Stata Journal 2018, 18(4), 826–843.
• Grayling MJ, Wason JMS, Mander AP. Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables. The Stata Journal 2018, 18(2), 416-431.
• Grayling MJ, Wason JMS, Mander AP. Group sequential crossover trial designs with strong control of the familywise error rate. Sequential Analysis 2018, 37(2), 174-203.
• Hemming K, Taljaard M, McKenzie JE, Hooper R, Copas A, Thompson JA, Dixon-Woods M, Aldcroft A, Doussau A, Grayling M, Kristunas C, Goldstein CE, Campbell MK, Girling A, Eldridge S, Campbell MJ, Lilford RJ, Weijer C, Forbes A, Grimshaw JM. Reporting of stepped wedge cluster randomised trials: extension of the CONSORT 2010 statement with explanation and elaboration. BMJ 2018, 363, k1614.
• Grayling MJ, Wason JMS, Mander AP. Group sequential designs for stepped-wedge cluster randomised trials. Clinical Trials 2017, 14(5), 507-517.
• Grayling MJ, Wason JMS, Mander AP. Stepped wedge cluster randomized controlled trial designs: A review of reporting quality and design features. Trials 2017, 18, 33.