Staff Profile

Specialty Area: Otolaryngology

Qualifications:  MBBS MRes (Distinction) MRCS (ENT)

Responsibilities: British Society of Otology juniors committee (research lead), reviewer for Annals of Otology, Rhinology and Laryngology, INSPIRE committee at the Academy of Medical Sciences.

Please provide any links to research that you have been or are involved in: Please see related sections above

ORCID ID: https://orcid.org/0000-0001-7972-7111

What is your research about?

I am a Clinical Fellow in Otolaryngology currently undertaking a PhD, funded by Action Medical Research (www.action.org.uk), to investigate why some acute ear infections become chronic whereas for others they seem to get better by themselves. We hope that by identifying what goes wrong will allow us in the future to design treatments to interrupt disease progression.

Supervisor for MBBS research SSC

Supervisor for Academic Foundation Programme Doctors

Part-time MA in Clinical Education

OSCE examiner for Newcastle medical school

• Jardine L, Webb S, Goh I, Quiroga Londono M, Reynolds G, Mather M, Olabi B, Stephenson E, Botting RA, Horsfall D, Engelbert J, Maunder D, Mende N, Murnane C, Dann E, McGrath J, King H, Kucinski I, Queen R, Carey CD, Shrubsole C, Poyner E, Acres M, Jones C, Ness T, Coulthard R, Elliott N, O'Byrne S, Haltalli MLR, Lawrence JE, Lisgo S, Balogh P, Meyer KB, Prigmore E, Ambridge K, Jain MS, Efremova M, Pickard K, Creasey T, Bacardit J, Henderson D, Coxhead J, Filby A, Hussain R, Dixon D, McDonald D, Popescu D-M, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Regev A, Behjati S, Laurenti E, Wilson NK, Roy A, Gottgens B, Roberts I, Teichmann SA, Haniffa M. Blood and immune development in human fetal bone marrow and Down syndrome. Nature 2021, 598, 327-331.
• Mather MW, Jardine L, Talks B, Gardner L, Haniffa M. Complexity of immune responses in COVID-19. Seminars in Immunology 2021, 55, 101545.
• Mather MW, Verdon B, Botting RA, Engelbert J, Delpiano L, Xu X, Hatton C, Davey T, Lisgo S, Yates P, Dawe N, Bingle CD, Haniffa M, Powell J, Ward C. Development of a physiological model of human middle ear epithelium. Laryngoscope Investigative Otolaryngology 2021, 6(5), 1167-1174.
• Mather MW, Powell S, Talks B, Ward C, Bingle CD, Haniffa M, Powell J. Dysregulation of immune response in otitis media. Expert Reviews in Molecular Medicine 2021, 18(23), e10.
• Mohammed H, Mather MW, Lumb J, Butler CC, Wilson JA. Otitis externa - what is the problem with getting it right? A mixed-methods study in primary and secondary care. Journal of Laryngology and Otology 2022, 136(6), 486-491.
• Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan MD, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M, Kumasaka N, Kania K, Engelbert J, Olabi B, Spegarova JS, Wilson NK, Mende N, Jardine L, Gardner LCS, Goh I, Horsfall D, McGrath J, Webb S, Mather MW, Lindeboom RGH, Dann E, Huang N, Polanski K, Prigmore E, Gothe F, Scott J, Payne RP, Baker KF, Hanrath AT, Schim van der Loeff ICD, Barr AS, Sanchez-Gonzalez A, Bergamaschi L, Mescia F, Barnes JL, Kilich E, de Wilton A, Saigal A, Saleh A, Janes SM, Smith CM, Gopee N, Wilson C, Coupland P, Coxhead JM, Kiselev VY, van Dongen S, Bacardit J, King HW, Rostron AJ, Simpson AJ, Hambleton S, Laurenti E, Lyons PA, Meyer KB, Nikolic MZ, Duncan CJA, Smith KGC, Teichmann SA, Clatworthy MR, Marioni JC, Göttgens B, Haniffa M. Single-cell multi-omics analysis of the immune response in COVID-19. Nature Medicine 2021, 27, 904-916.
• Mather MW, Powell S, Yates PD, Powell J. Acute mastoiditis in children: contemporary opportunities and challenges. The Journal of Laryngology & Otology 2020, 134(5), 434-439.
• Mather MW, Drinnan M, Perry J, Powell S, Wilson JA, Powell J. A Systematic Review and Meta-Analysis of Antimicrobial Resistance in Paediatric Acute Otitis Media. International Journal of Pediatric Otorhinolaryngology 2019, 123, 102-109.
• Popescu DM, Botting RA, Stephenson E, Green K, Webb S, Jardine L, Calderbank EF, Polanski K, Goh I, Efremova M, Acres M, Maunder D, Vegh P, Gitton Y, Park JE, Vento-Tormo R, Miao Z, Dixon D, Rowell R, McDonald D, Fletcher J, Poyner E, Reynolds G, Mather M, Moldovan C, Mamanova L, Greig F, Young MD, Meyer KB, Lisgo S, Bacardit J, Fuller A, Millar B, Innes B, Lindsay S, Stubbington MJT, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Filby A, Carey P, Villani AC, Roy A, Regev A, Chédotal A, Roberts I, Göttgens B, Behjati S, Laurenti E, Teichmann SA, Haniffa M. Decoding human fetal liver haematopoiesis. Nature 2019, 574, 365–371.
• Mather MW, Yates PD, Powell J, Zammit-Maempel I. Radiology of acute mastoiditis and its complications: a pictorial review and interpretation checklist. Journal of Laryngology & Otology 2019, 133(10), 856-861.
• Roberts J, Powell J, Mather M, Powell S, Brodlie M. A review of adenotonsillar hypertrophy and adenotonsillectomy in children after solid organ transplantation. International Journal of Paediatric Otorhinolaryngology 2018, 114, 29-35.
• Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ. Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients. American Journal of Respiratory and Critical Care Medicine 2018, 198(3), 340-349.
• Mather MW, Hamilton D, Robalino S, Rousseau N. Going where other methods cannot: A systematic mapping review of 25 years of qualitative research in Otolaryngology. Clinical Otolaryngology 2018, 43(6), 1443-1453.
• Mather MW, Dawe N, Wilson J. Inconsistent availability of hearing aids during acute admission. BMJ 2018, 361, k1944.
• Mather MW, Musgrave K, Dawe N. Is anticoagulation beneficial in acute mastoiditis complicated by sigmoid sinus thrombosis?. Laryngoscope 2018, 128(11), 2435-2436.
• Shellman Z, Aldhahrani A, Verdon B, Mather M, Paleri V, Wilson JA, Pearson J, Ward C, Powell J. Bile acids: a potential role in the pathogenesis of pharyngeal malignancy. Clinical Otolaryngology 2017, 42(5), 969-973.
• Schwalbe EC, Hicks D, Rafiee G, Bashton M, Gohlke H, Enshaei A, Potluri S, Matthiesen J, Mather M, Taleongpong P, Chaston R, Silmon A, Curtis A, Lindsey JC, Crosier S, Smith AJ, Goschzik T, Doz F, Rutkowski S, Lannering B, Pietsch T, Bailey S, Williamson D, Clifford SC. Minimal methylation classifier (MIMIC): A novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures. Scientific Reports 2017, 7, 13421.
• Schwalbe E, Hicks D, Rafiee G, Bashton M, Gohlke H, Enshaei A, Potluri S, Matthiesen J, Mather M, Taleongpong P, Chaston R, Crosier S, Smith A, Bordeaut F, Doz F, Rutkowski S, Lannering B, Bailey S, Pietsch T, Williamson D, Clifford S. Routine Diagnostic Medulloblastoma Subgrouping Using Low-Cost, Low-Input DNA Methylomics: Application to Trials Cohorts Previously Refractory-to-Analysis. In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO). 2016, Liverpool, UK: Oxford University Press.
• Schwalbe E, Hicks D, Rafiee G, Bashton M, Gohlke H, Enshaei A, Potluri S, Matthiesen J, Mather M, Taleongpong P, Chaston R, Crosier S, Smith A, Williamson D, Bailey S, Clifford S. Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost, mass spectrometry-based DNA methylomics. In: 41st ESMO Congress (ESMO 2016). 2016, Copenhagen, Denmark: Oxford University Press.
• Kelly G, Mobbs S, Pritkin JN, Mayston M, Mather M, Rosenbaum P, Henderson R, Forsyth R. Gross Motor Function Measure-66 trajectories in children recovering after severe acquired brain injury. Developmental Medicine and Child Neurology 2015, 57(3), 241–247.
• Mather MW, Hayhurst H, Bacon CM, Cole TS, Pan-Hammarstrom Q, Misbah S, Gennery AR. Mutation of TNFRSF13B in a child with 22q11 deletion syndrome associated with granulomatous lymphoproliferation. Journal of Allergy and Clinical Immunology 2015, 135(2), 559-561.
• Mather MW, Piper R, Gupta J, Dbeis R. A Career in Academic Medicine. Student BMJ 2014, June.
• Mather MW, Messer B, Hamilton M. Gastric perforation due to naso-gastric tube insertion. Journal of the Intensive Care Society 2014, 15(3), 264-264.
• Mather MW, Hutchison C. Influence of ROS-induced DNA damage pathways on premature ageing using cell assays. Scottish Medical Journal 2013, 58(1), e65-81.