Staff Profile
PhD Cancer Biology
Qualifications
BSc : Scottish Church College, University of Calcutta (2007), Kolkata, India
MSc: University of Calcutta (2009), Kolkata, India
PhD: "Human Papillomavirus (HPV) driven pathogenesis of cervical cancer" from National Institute of Biomedical Genomics, Affiliated to University of Calcutta (2017), Kolkata, India
Previous Positions
2017-2018: Laboratory Technologist (Translational Studies) at Tata Medical Centre, Kolkata, India working on the project "Integrated cervical cancer prevention and treatment stratification study: Systems Medicine Cluster Approach (ICC SyMeC)
2018: Post-doctoral Researcher at the Haematology/Oncology Section, Department of Medicine, University of Chicago, USA on the project "Combinatorial Immunotherapy strategies to reverse immunosuppression in PTEN-deficient Prostate Cancer"
Research Interests
My research interests include understanding the relevance of molecular features (genomic, transcriptomic and epigenomic) of cancers in determining response to available therapy and using these molecular features to identify alternative targets for therapy.
Currently, I am working to understand the mechanism/markers of response to clinically approved chemotherapeutic agents in High Grade Serous Ovarian Cancer (HGSOC). Another area of current research is targeting DNA damage response pathway molecules for ovarian cancer therapy and studying their impact on the tumour immune microenvironment.
- Saha SS, Gentles L, Bradbury A, Brecht D, Robinson R, O'Donnell R, Curtin NJ, Drew Y. Genomic, transcriptomic, and functional alterations in DNA damage response pathways as putative biomarkers of chemotherapy response in ovarian cancer. Cancers 2021, 13(6), 1420.
- Bradbury A, O'Donnell R, Drew Y, Curtin NJ, Sharma Saha S. Characterisation of ovarian cancer cell line NIH-OVCAR3 and implications of genomic, transcriptomic, proteomic and functional DNA damage response biomarkers for therapeutic targeting. Cancers 2020, 12(7), 1939.
- Duttagupta P, Chaudagar K, Sharma-Saha S, Bynoe K, Parkes E, Patnaik A. Abstract LB-B03: PARP and PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages. 2019. In Preparation.
- Mandal P, Sharma Saha S, Sen S, Bhattacharya A, Bhattacharya NP, Bucha S, Sinha M, Roy Chowdhury R, Mondal NR, Chakravarty B, Chatterjee T, Roy S, Sengupta S. Cervical cancer subtypes harbouring integrated and/or episomal HPV16 portray distinct molecular phenotypes based on transcriptome profiling of mRNAs and miRNAs. Cell Death Discovery 2019, 5, 81.
- Curtin NJ, Drew Y, Sharma-Saha S. Why BRCA mutations are not tumour-agnostic biomarkers for PARP inhibitor therapy. Nature Reviews Clinical Oncology 2019, 16, 725–726.
- Sharma Saha S, Sengupta S. Chapter 28 - Future Directions and Challenges Involved in Cancer Noncoding RNomics. In: Cancer and Non-coding RNAs. Translational Epigenetics, 2018. In Preparation.
- Bhattacharya A, Sen S, Mandal P, Sharma Saha S, Sarkar S, Pathak O, Biswas L, Roy J, Banerjee R, Roy Chowdhury R, Pal M, Mukherjee A, Sengupta S. Prevalence and age-wise distribution of Human Papillomavirus type 16/18 infections among hospital screened women of a peri-urban area in West Bengal: Impact of socio-demographic factors. Cancer Epidemiology 2018, 54, 31-37.
- Sharma Saha S, Roy Chowdhury R, Mondal NR, Chakravarty B, Chatterjee T, Roy S, Sengupta S. Expression signatures of HOX cluster genes in cervical cancer pathogenesis: Impact of human papillomavirus type 16 oncoprotein E7. Oncotarget 2017, 8, 36591-36602.
- Sharma Saha S, Roy Chowdhury R, Mondal NR, Chakravarty B, Chatterjee T, Roy S, Sengupta S. Identification of genetic variation in the lncRNA HOTAIR associated with HPV16-related cervical cancer pathogenesis. Cellular Oncology 2016, 39, 559-572.
- Sharma S, Mandal P, Sadhukhan T, Roy Chowdhury R, Mondal NR, Chakravarty B, Chatterjee T, Roy S, Sengupta S. Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis. Scientific Reports 2015, 5, 11724.