Faculty of Medical Sciences

Pharmacology, Toxicology & Therapeutics

Pharmacology, Toxicology and Therapeutics Research Group

Theme Leader

Professor Ann Daly

Major Research Themes

We may all be affected by chemicals, particularly those in our food, such as preservatives, and in the medicines we use, but also sometimes in our working environment. Some chemicals are harmless, while others are helpful because they can prevent or treat disease. Our research projects are concerned with the harmful effects of chemicals, including prescribed drugs, and finding ways to prevent and minimise these effects.


The response to chemicals by the body is variable and may be affected by factors like genetic make-up. Harmful effects can also depend on how the chemicals enter the body. Effects can differ depending on whether the chemical is swallowed, breathed in or simply in contact with the skin. We are attempting to measure the effects of fairly small amounts of chemicals, to provide ways of giving early warning of the start of harmful effects. We also study the adverse side-effects of medicines, including how conditions such as liver disease and heart disease can develop in people taking medicines for completely different medical conditions.

Related websites:

Staff List

Professor Peter Blain CBE
Professor of Environmental Medicine

Telephone: +44 (0) 191 208 7195

Dr Sally Coulthard
Senior Research Associate

Telephone: +44 (0) 191 208 5232

Professor Ann Daly
Professor of Pharmacogenetics

Telephone: +44 (0) 191 208 7031

Dr Simon Hill
Honorary Clinical Senior Lecturer

Telephone: 0191 2826167

Telephone: +44 (0) 191 208 8043

Dr Ruben Thanacoody
Honorary Clinical Senior Lecturer


Professor Simon Thomas
Prof of Clin Pharmacology & Therapeutics

Telephone: +44 (0) 191 208 8094

Dr Simon Wilkinson
Staff Scientist

Telephone: +44 (0) 191 208 8537

Professor Matthew Wright
Professor of Toxicology

Telephone: +44 (0) 191 208 7094