Dr Fiona LeBeau
- Email: email@example.com
- Telephone: +44 (0) 191 208 5729
- Fax: +44 (0) 191 208 5227
- Address: Institute of Neuroscience
The Medical School
Newcastle upon Tyne.
BackgroundNormal 0 false false false EN-US JA X-NONE
Roles and Responsibilities
Member of the Faculty of Medical Sciences Impact Case Committee
BSc Physiology (1st class) Sheffield University
PhD Neuroscience (Newcastle University)
Post-doctoral Fellow, University of Maryland, Baltimore, MD.
Non-Clinical Scientist MRC Anatomical Neuropharmacology Unit, Oxford, UK.
Senior Post-doctoral Research Fellow, School of Biomedical Sciences, University of Leeds, UK.
British Neuroscience Association
The Physiological Society
Society for Neuroscience
My main interests are in understanding the mechanisms involved in the generation of cortical network activity. In particularly we are keen to understand the role of different types of network oscillations e.g. theta (4-12 Hz) and gamma (30-80 Hz) frequency oscillations in the hippocampus and prefrontal cortex. These oscillations are important for many higher cognitive functions including learning, memory and attention. I am also interested in understanding how these oscillations are modulated by the brain's different neuromodulator systems including dopamine and noradrenaline.
In my lab we use a combination of in vitro electrophysiological and in vivo approaches in rodents to study cortical network oscillations and their modulation by monoamine neurotransmitter systems. We are also involved in a large multi-group project using EEG recordings and optogenetics to record and manipulate the abnormal cortical activity occurring in epilepsy. I have close collaborations with many other researchers within the Institute of Neuroscience and long standing collaborations with Prof Nancy Kopell (Boston Uni) and Prof. Ed Boyden (MIT) and with Professor Miles Whittington (York Uni).
We are currently working on a number of projects elucidating the role of network oscillations in the hippocampus and prefrontal cortex. Changes in these key brain areas are implicated in many diseases such as schizophrenia, Alzheimer's disease, and dementia with Lewy bodies. We are currently investigating changes in the monoamine systems and network oscillations in a variety of animal models of these diseases.
Current lab members
Clare Tweedy, Myrto Stylianou, Nelson Manzanza.
Past Lab members
Joanne Driver, Daniel C Haggerty, Bernadette O'Donovan, Dorcas C Eden, Claire Gillougley, Natalie Adams, Vasilis Glykos, Sabine Gretenkord.
Royal Society Research Grant; Newcastle University Studentship; Lena Teague Bequest Fund; BBSRC equipment grant; EPSRC studentship; BBSRC/CASE studentship; Wellcome Trust studentship.
MRC Case studentship, Alzheimer's Society studentship. UK Innovate Grant.
Co-I on CANDO (Wellcome Trust project).
I am Module Leader for the Biomedical Sciences undergraduate module The Nervous System (BMS2011).
I teach on the Pharmacology BSc course and the Mres in Neuroscience.
I regularly supervise undergraduate and postgraduate laboratory projects.
- Glykos V, Whittington MA, LeBeau FEN. Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro. The Journal of Physiology 2015, 593(16), 3597-3615.
- Haggerty DC, Glykos V, Adams NE, LeBeau FE. Bidirectional modulation of hippocampal gamma (20–80 Hz) frequency activity in vitro via alpha(α)- and beta(β)-adrenergic receptors (AR). Neuroscience 2013, 253, 142-154.
- Börgers C, Talei Franzesi G, LeBeau FEN, Boyden S, Kopell NJ. Minimal size of cell assemblies coordinated by gamma oscillations. PLoS Computational Biology 2012, 8(2), e1002362.
- Whittington MA, Cunningham MO, LeBeau FE, Racca C, Traub RD. Multiple origins of the cortical gamma rhythm. Developmental Neurobiology 2011, 71(1), 92-106.
- Bernstein HG, Johnson M, Perry RH, LeBeau FEN, Dobrowolny H, Bogerts B, Perry EK. Partial loss of parvalbumin-containing hippocampal interneurons in dementia with Lewy bodies. Neuropathology 2011, 31(1), 1-10.
- Roopun AK, LeBeau FEN, Rammell J, Cunningham MO, Traub RD, Whittington MA. Cholinergic neuromodulation controls directed temporal communication in neocortex in vitro. Frontiers in Neural Circuits 2010, 4(1), 8.
- Cox DJ, Racca C, LeBeau FEN. β-adrenergic receptors are differentially expressed in distinct interneuron subtypes in the rat hippocampus. Journal of Comparative Neurology 2008, 509(6), 551-565.
- Bibbig A, Middleton S, Racca C, Gillies MJ, Garner H, Le Beau FEN, Davies CH, Whittington MA. Beta rhythms (15-20 Hz) generated by nonreciprocal communication in hippocampus. Journal of Neurophysiology 2007, 97(4), 2812-2823.
- Driver JE, Racca C, Cunningham MO, Towers SK, Davies CH, Whittington MA, Le Beau FEN. Impairment of hippocampal gamma (γ)-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP). European Journal of Neuroscience 2007, 26(5), 1280-1288.
- Fuchs EC, Zivkovic AR, Cunningham MO, Middleton S, Le Beau FEN, Bannerman DM, Rozov A, Whittington MA, Traub RD, Rawlins JNP, Monyer H. Recruitment of Parvalbumin-Positive Interneurons Determines Hippocampal Function and Associated Behavior. Neuron 2007, 53(4), 591-604.
- Roopun AK, Middleton SJ, Cunningham MO, Le Beau FEN, Bibbig A, Whittington MA, Traub RD. A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(42), 15646-15650.
- Cunningham MO, Hunt J, Middleton S, Le Beau FEN, Gillies MG, Davies CH, Maycox PR, Whittington MA, Racca C. Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness. Journal of Neuroscience 2006, 26(10), 2767-2776.
- Grillner S, Markram H, De Schutter E, Silberberg G, Le Beau FEN. Microcircuits in action - From CPGs to neocortex. Trends in Neurosciences 2005, 28(10), 525-533.
- Traub RD, Bibbig A, Le Beau FE, Cunningham MO, Whittington MA. Persistent gamma oscillations in superficial layers of rat auditory neocortex: experiment and model. Journal of Physiology 2005, 562(1), 3-8.
- Traub RD, Contreras D, Cunningham MO, Murray H, Le Beau FEN, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA. Single-Column Thalamocortical Network Model Exhibiting Gamma Oscillations, Sleep Spindles, and Epileptogenic Bursts. Journal of Neurophysiology 2005, 93(4), 2194-2232.
- Silberberg G, Grillner S, Le Beau FEN, Maex R, Markram H. Synaptic pathways in neural microcircuits. Trends in Neurosciences 2005, 28(10), 541-551.
- Traub RD, Pais I, Bibbig A, Lebeau FE, Buhl EH, Garner H, Monyer H, Whittington MA. Transient Depression of Excitatory Synapses on Interneurons Contributes to Epileptiform Bursts During Gamma Oscillations in the Mouse Hippocampal Slice. Journal of Neurophysiology 2005, 94(2), 1225-1235.
- Le Beau FEN, El Manira A, Griller S. Tuning the network: Modulation of neuronal microcircuits in the spinal cord and hippocampus. Trends in Neurosciences 2005, 28(10), 552-561.
- Cunningham MO, Whittington MA, Bibbig A, Roopun A, Le Beau FE, Vogt A, Monyer H, Buhl EH, Traub RD. A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro. Proceedings of the National Academy of Sciences 2004, 101(18), 7152-7157.
- Traub RD, Bibbig A, Le Beau FE, Buhl EH, Whittington MA. Cellular mechanisms of neuronal population oscillations in the hippocampus in vitro. Annu. Rev. Neurosci 2004, 27(1), 247-278.
- Traub RD, Pais I, Bibbig A, LeBeau FEN, Buhl EH, Hormizdi S, Monyer H, Whittington MA. Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations. Proceedings of the National Academy of Sciences of the United States of America 2003, 100(3), 1370-1374.
- Traub RD, Cunningham MO, Gloveli T, LeBeau FE, Bibbig A, Buhl EH, Whittington MA. GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations. Proceedings of the National Academy of Sciences of the United States of America 2003, 100(19), 11047-11052.
- Pais I, Hormuzdi SG, Monyer H, Traub RD, Wood IC, Buhl EH, Whittington MA, LeBeau FE. Sharp Wave-Like Activity in the Hippocampus In Vitro in Mice Lacking the Gap Junction Protein Connexin 36. Journal of Neurophysiology 2003, 89(4), 2046-2054.
- LeBeau FEN, Traub RD, Monyer H, Whittington MA, Buhl EH. The role of electrical signalling via gap junctions in the generation of fast network oscillations. Brain Research Bulletin 2003, 62(1), 3-13.
- Gillies MJ, Traub RD, LeBeau FEN, Davies CH, Gloveli T, Buhl EH, Whittington MA. A model of atropine-resistant theta oscillations in rat hippocampal area CA1. Journal of Physiology 2002, 543(3), 779-793.
- Towers SK, LeBeau FEN, Gloveli T, Traub RD, Whittington MA, Buhl EH. Fast network oscillations in the rat dentate gyrus in vitro. Journal of Neurophysiology 2002, 87(2), 1165-1168.
- LeBeau FE, Towers SK, Traub RD, Whittington MA, Buhl EH. Fast network oscillations induced by potassium transients in the rat hippocampus in vitro. Journal of Physiology 2002, 542(1), 167-179.
- LeBeau FEN, Towers SK, Traub RD, Whittington MA, Buhl EH. Fast network oscillations induced by potassium transients in the rat hippocampus in vitro. Journal of Physiology 2002, 542(1), 167-179.
- Traub RD, Whittington MA, Buhl EH, LeBeau FEN, Bibbig A, Boyd S, Cross H, Baldeweg T. A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures. Epilepsia 2001, 42(2), 153-170.
- Whittington MA, Doheny HC, Traub RD, LeBeau FEN, Buhl EH. Differential expression of synaptic and non-synaptic mechanisms underlying stimulus-induced gamma oscillations in vitro. The Journal of Neuroscience 2001, 21(5), 1727-1738.
- Traub RD, Kopell N, Bibbig A, Buhl EH, LeBeau FEN, Whittington MA. Gap junctions between interneuron dendrites can enhance synchrony of gamma oscillations in distributed networks. Journal of Neuroscience 2001, 21(23), 9478-9486.
- Hormuzdi SG, Pais I, LeBeau FEN, Towers SK, Rozov A, Buhl EH, Whittington MA, Monyer H. Impaired Electrical Signaling Disrupts Gamma Frequency Oscillations in Connexin 36-Deficient Mice. Neuron 2001, 31(3), 487-495.
- LeBeau FEN, Malmierca MS, Rees A. Iontophoresis in vivo demonstrates a key role for GABAA and glycinergic inhibition in shaping frequency response areas in the inferior colliculus of guinea pig. The Journal of Neuroscience 2001, 15, 7303-7312.
- LeBeau FEN, Malmierca MS, Rees A. Iontophoretic studies in the inferior colliculus in vivo demonstrate a key role for GABA and glycine receptor mediated inhibition in shaping frequency response areas. Journal of Neuroscience 2001, 21(18), 7303-7312.
- Gretenkord S, Rees A, Whittington MA, Gartside SE, Lebeau FEN. Dorsal vs. ventral differences in fast Up-state-associated oscillations in the medial prefrontal cortex of the urethane-anesthetized rat. Journal of Neurophysiology 2017, 117(3), 1126-1142.
- Adams NE, Sherfey JS, Kopell NJ, Whittington MA, LeBeau FEN. Hetereogeneity in Neuronal Intrinsic Properties: A Possible Mechanism for Hub-Like Properties of the Rat Anterior Cingulate Cortex during Network Activity. eNeuro 2017, 4(1).
- Taylor J-P, Collerton D, LeBeau F, Perry E. Cholinergic pathology in dementia with Lewy bodies. In: Kosaka K, ed. Dementia with Lewy Bodies: Clinical and Biological Aspects. Tokyo: Springer Japan, 2016, pp.23-39.
- LeBeau FEN. Cortical network oscillations in Alzheimer's disease: insights from rodent models. Drug Discovery Today: Therapeutic Strategies 2013, 10(2), e79-e83.
- Robson E, Tweedy C, Manzanza N, Taylor J-P, Atkinson P, Randall F, Reeve A, Clowry GJ, LeBeau FEN. Impaired Fast Network Oscillations and Mitochondrial Dysfunction in a Mouse Model of Alpha-synucleinopathy (A30P). Neuroscience 2018, 377, 161-173.
- Stylianou M, Murphy N, Peraza LR, Graziadio S, Cromarty R, Killen A, O'Brien JT, Thomas AJ, LeBeau FEN, Taylor J-P. Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and aid to differential diagnosis. Clinical Neurophysiology 2018, Epub ahead of print.