Dr Michael Jackson
- Email: firstname.lastname@example.org
- Telephone: +44 (0) 191 241 8677
- Fax: +44 (0) 191 241 8666
- Address: Institute of Genetic Medicine
International Centre for Life
Newcastle upon Tyne
After graduating with a BSc in Genetics from Nottingham in 1984, I did a PhD with Gabby Dover in Cambridge on P-element transposon regulation in Drosophila. I used P-elements as a mutagen to investigate quantitative trait variation during my first postdoctoral position, in Trudy MacKay’s lab in North Carolina State University, before returning to Cambridge in 1990 to work with Bruce Ponder. While there, I became involved in the Human Genome Project, and chose to focus on centromeric regions. These were proving refractory to standard mapping techniques, due to their low recombination rates and highly repetitive sequence organisation. In 1993 I was awarded a Royal Society University Postdoctoral Fellowship to continue this work, and I chose to take this up in Newcastle. As well as generating physical and sequence maps which form part of the human genome reference sequence I pursued my interest in processes underpinning molecular evolution, working on topics as diverse as gene conversion, chromosomal rearrangements in childhood cancers and, more recently, the function of circular RNAs. I am also involved in clinically oriented collaborations focusing on sequence instability within colorectal cancer.
Areas of expertise
- Circular RNA
- Genome instability
Circular RNA. Dynamics and Function
Circular RNAs (circRNAs) were first identified over 20 years ago, but until recently have been assumed to be rare errors of normal splicing reactions. However, advances in sequencing technologies have now established that thousands of genes generate circRNA isoforms and that these are the most abundant transcripts from some genes. There is now evidence that some act as microRNA sponges,and some have been implicated in both normal development and diseases states such as cancer. Some are even translated at low efficiency, indicating that circRNAs are functionally diverse. Despite this, basic information concerning their expression dynamics, regulation, normal function, and interaction with other regulatory RNAs remains poor. We are currently using high depth sequencing techniques, and manipulation of individual transcripts in both human and murine cell culture models, to better understand this novel class of transcripts
Genetics Instability in Cancer
I have a longstanding interest in the mechanisms underpinning genetic instability as these can have a profound impact upon human development and disease pathology. Although most of this research has involved the childhood cancers neuroblastoma and medulloblastoma, current research involves utilising high throughput sequencing approaches to investigate the impact of microsatellite instability in Lynch syndrome, and investigating the clinical utility of these approaches in patient management and treatment. This work is in collaboration with my colleagues Professor Sir John Burn and Dr. Mauro Santibanez-Koref.
Degree Programme Director: Genomic Medicine MSc Programme.
MRes Strand leader: Medical Genetics.
Module Leader: GNM8002 Omics Techniques.
Module Leader: BGM2058 Evolution.
Lecturer: BGM2057 Medical Genomics - From DNA to Disease.
Lecturer: MMB8030 Genetic Medicine.
Lecturer: MMB8031 Developmental Genetics.
Lecturer: GNM8000/8001 Introduction to Human Genetics and Genomics.
Lecturer: GNM8004 Molecular Pathology of Cancer
Seminar Lead: BGM1004 Genetics
- Izuogu O, Alhasan AA, Mellough C, Collin J, Gallon R, Hyslop J, Mastrorosa FK, Ehrmann I, Lako M, Elliott DJ, Santibanez-Koref M, Jackson MS. Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular. BMC Genomics 2018, 19(1), 276.
- Sheth H, Northwood E, Ulrich CM, Scherer D, Elliott F, Barrett JH, Forman D, Wolf CR, Smith G, Jackson MS, Santibanez-Koref M, Haile R, Casey G, Jenkins M, Win AK, Hopper JL, Marchand LL, Lindor NM, Thibodeau SN, Potter JD, Burn J, Bishop DT. Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations. PLoS ONE 2018, 13, e0192223.
- Alhasan A, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Circular RNA enrichment in platelets is a signature of transcriptome degradation. Blood 2016, 127(9), E1-E11.
- Sheth H, Jackson MS, Koref MS, Parikh K, Sheth J, Sheth F, Tyson J, Daly AK, Burn J. Relevance of genetic factors to warfarin dosing in India. Blood 2015, 126(4).
- Łastowska M, Al-Afghani H, Al-Balool HH, Sheth H, Mercer E, Coxhead JM, Redfern CPF, Peters H, Burt AD, Santibanez-Koref M, Bacon CM, Chesler L, Rust AG, Adams DJ, Williamson D, Clifford SC, Jackson MS. Identification of a neuronal transcription factor network involved in medulloblastoma development. Acta Neuropathologica Communications 2013, 1, 35.
- Grellscheid S, Dalgliesh C, Storbeck M, Best A, Liu Y, Jakubik M, Mende Y, Ehrmann I, Curk T, Rossbach K, Bourgeois CF, Stévenin J, Grellscheid D, Jackson MS, Wirth B, Elliott DJ. Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development. PLoS Genetics 2011, 7(12), e1002390.
- Al-Balool HH, Weber D, Liu Y, Wade M, Guleria K, Nam PL, Clayton J, Rowe W, Coxhead J, Irving J, Elliott DJ, Hall AG, Santibanez-Koref M, Jackson MS. Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. Genome Research 2011, 21(11), 1788-1799.
- Ehrmann I, Dalgliesh C, Tsaousi A, Paronetto MP, Heinrich B, Kist R, Cairns P, Li W, Mueller C, Jackson M, Peters H, Nayernia K, Saunders P, Mitchell M, Stamm S, Sette C, Elliott DJ. Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse. Human Molecular Genetics 2008, 17(18), 2803-2818.
- Moore HC, Wood KM, Jackson MS, Lastowska MA, Hall D, Imrie H, Redfern CPF, Lovat PE, Ponthan FM, O'Toole KT, Lunec J, Tweddle DA. Histological profile of tumours from MYCN transgenic mice. Journal of Clinical Pathology 2008, 61(10), 1098-1103.
- Viprey VF, Lastowska MA, Corrias MV, Swerts K, Jackson MS, Burchill SA. Minimal disease monitoring by QRT–PCR: guidelines for identification and systematic validation of molecular markers prior to evaluation in prospective clinical trials. Journal of Pathology 2008, 216(2), 245-252.
- Cheng AJ, Ching Cheng N, Ford J, Smith J, Murray JE, Flemming C, Lastowska M, Jackson MS, Hackett CS, Weiss WA, Marshall GM, Kees UR, Norris MD, Haber M. Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. European Journal of Cancer 2007, 43(9), 1467-1475.
- Łastowska MA, Viprey V, Santibanez-Koref MF, Wappler I, Peters HH, Cullinane C, Roberts P, Hall AG, Tweddle DA, Pearson ADJ, Lewis I, Burchill S, Jackson MS. Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data. Oncogene 2007, 26(53), 7432-7444.
- Venables JP, Strain L, Routledge D, Bourn D, Powell HM, Warwicker P, Diaz-Torres ML, Sampson A, Mead P, Webb M, Pirson Y, Jackson MS, Hughes A, Wood KM, Goodship JA, Goodship THJ. Atypical haemolytic uraemic syndrome associated with a hybrid complement gene. PLoS Medicine 2006, 3(10), e431 (1957-1967).
- Heinen S, Sanchez-Corral P, Jackson MS, Strain L, Goodship JA, Kemp EJ, Skerka C, Jokiranta TS, Meyers K, Wagner E, Robitaille P, Esparza-Gordillo J, Rodriguez de Cordoba S, Zipfel PF, Goodship THJ. De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome. Human Mutation 2006, 27(3), 292-293.
- Jackson MS, Oliver K, Loveland J, Humphray S, Dunham I, Rocchi M, Viggiano L, Park JP, Hurles ME, Santibanez-Koref M. Evidence for widespread reticulate evolution within human duplicons. American Journal of Human Genetics 2005, 77(5), 824-840.
- Mudge JM, Jackson MS. Evolutionary implications of pericentromeric gene expression in humans. Cytogenetic and Genome Research 2005, 108(1-3), 47-57.
- Tonkin ET, Smith M, Eichhorn P, Jones S, Imamwerdi B, Lindsay S, Jackson M, Wang T-J, Ireland M, Burn J, Krantz ID, Carr P, Strachan T. A giant novel gene undergoing extensive alternative splicing is severed by a Cornelia de Lange-associated translocation breakpoint at 3q26.3. Human Genetics 2004, 115(2), 139-148.
- Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blöcker H, Durbin R, Sulston JE, Hubbard T, Jackson MS, Bentley DR, Beck S, Rogers J, Dunham I. DNA sequence and analysis of human chromosome 9. Nature 2004, 429, 369-74.
- Lastowska M, Chung Y-J, Ching NC, Haber M, Norris MD, Kees UR, Pearson ADJ, Jackson MS. Regions Syntenic to Human 17q Are Gained in Mouse and Rat Neuroblastoma. Genes Chromosomes and Cancer 2004, 40(2), 158-163.
- Jackson M. Duplicate, decouple, disperse: The evolutionary transience of human centromeric regions. Current Opinion in Genetics and Development 2003, 13(6), 629-635.
- Guy J, Hearn T, Crosier M, Mudge J, Viggiano L, Koczan D, Thiesen H-J, Bailey JA, Horvath JE, Eichler EE, Earthrowl ME, Deloukas P, French L, Rogers J, Bentley D, Jackson MS. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. Genome Research 2003, 13(2), 159-172.
- Ventura M, Mudge JM, Palumbo V, Burn S, Blennow E, Pierluigi M, Giorda R, Zuffardi O, Archidiacono N, Jackson MS, Rocchi M. Neocentromeres in 15q24-26 map to duplicons which flanked an ancestral centromere in 15q25. Genome Research 2003, 13(9), 2059-2068.
- Lastowska, M., Cotterill, C., Bown, N., Cullinane, C., Variend, S., Lunec, J., Strachan, T., Pearson, A.D.J., Jackson, M.S. Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors. Genes Chromosomes and Cancer 2002, 34(4), 428-436.
- Crosier M, Viggiano L, Guy J, Misceo D, Stones R, Wei WB, Hearn T, Ventura M, Archidiacono N, Rocchi M, Jackson MS. Human paralogs of KIAA0187 were created through independent pericentromeric-directed and chromosome-specific duplication mechanisms. Genome Research 2002, 12(1), 67-80.
- Phillips HM, Renforth GL, Spalluto C, Hearn T, Curtis ARJ, Craven L, Havarani B, Clement-Jones M, English C, Stumper O, Salmon T, Hutchinson S, Jackson MS, Wilson DI. Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis. Genomics 2002, 79(4), 475-478.
- Lastowska MA, Cullinane C, Variend S, Cotterill SJ, Bown NP, O'Neill S, Mazzocco K, Roberts P, Nicholson J, Ellershaw C, Pearson ADJ, Jackson MS. Comprehensive genetic and histopathologic study reveals three types of neuroblastoma tumors. Journal of Clinical Oncology 2001, 19(12), 3080-3090.
- Lastowska M, Van Roy N, Bown N, Roberts P, Speleman F, Lunec J, Strachan T, Pearson ADJ, Jackson MS. Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma. Pediatric Blood and Cancer 2001, 36(1), 20-23.
- Guy J, Spalluto C, McMurray A, Hearn T, Crosier M, Viggiano L, Miolla V, Archidiacono N, Rocchi M, Scott C, Lee PA, Sulston J, Rogers J, Bentley D, Jackson MS. Genomic sequence and transcriptional profile of the boundary between pericentrometric satellites and genes on human chromosome arm 10q. Human Molecular Genetics 2000, 9(13), 2029-2042.
- Jackson MS, Rocchi M, Thompson G, Hearn T, Crosier M, Guy J, Kirk D, Mulligan L, Ricco A, Piccininni S, Marzella R, Viggiano L, Archidiacono N. Sequences flanking the centromere of human chromosome 10 are a complex patchwork of arm-specific sequences, stable duplications and unstable sequences with homologies to telomeric and other centromeric locations. Human Molecular Genetics 1999, 8(2), 205-215.
- Lastowska, M., Van Roy, N., Bown, N.P., Speleman, F., Lunec, J., Strachan, T., Pearson, A.D.J., Jackson, M.S. Molecular cytogenetic delineation of 17q translocation breakpoints in neuroblastoma cell lines. Genes Chromosomes and Cancer 1998, 23(2), 116-122.
- Jackson MS, See CG, Mulligan LM, Lauffart BF. A 9.75-Mb map across the centromere of human chromosome 10. Genomics 1996, 33, 258-70.
- Tunnacliffe A, Jackson MS, Gardner E, Love DR, Moore JK, Mole SE, Mulligan LM, Graham A, Finocchiaro G, Orstavik S, Ponder BA. A multiple interval physical map of the pericentromeric region of human chromosome 10. Human Genetics 1994, 93, 313-318.
- Mole SE, Jackson MS, Tokino T, Nakamura Y, Ponder BA. Assignment of fifty-four cosmid clones to five regions of chromosome 10. Genomics 1993, 15, 457-458.
- Tunnacliffe A, Liu L, Moore JK, Leversha MA, Jackson MS, Papi L, Ferguson-Smith MA, Thiesen HJ, Ponder BA. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Nucleic Acids Research 1993, 21, 1409-1417.
- Jackson MS, Slijepcevic P, Ponder BA. The organisation of repetitive sequences in the pericentromeric region of human chromosome 10. Nucleic Acids Research 1993, 21, 5865-5874.
- Jackson MS, Mole SE, Ponder BA. Characterisation of a boundary between satellite III and alphoid sequences on human chromosome 10. Nucleic Acids Research 1992, 20, 4781-4787.
- Mackay TF, Lyman RF, Jackson MS. Effects of P element insertions on quantitative traits in Drosophila melanogaster. Genetics 1992, 130, 315-332.
- Mackay, T.F.C., Lyman, R.F., Jackson, M.S., Terzian, C. & Hill, W.G. Polygenic mutation in Drosophila melanogaster: Estimates from divergence among inbred strains. Evolution 1992, 46, 300-316.
- Jackson MS, Black DM, Dover GA. Amplification of KP elements associated with the repression of hybrid dysgenesis in Drosophila melanogaster. Genetics 1988, 120, 1003-1013.
- Black DM, Jackson MS, Kidwell MG, Dover GA. KP elements repress P-induced hybrid dysgenesis in Drosophila melanogaster. EMBO J 1987, 6, 4125-4135.