Dr Simon Wilkinson
- Email: firstname.lastname@example.org
- Telephone: +44 (0) 191 208 8537
- Address: Medical Toxicology Centre
School of Clinical & Laboratory Sciences
University of Newcastle upon Tyne
Roles and Responsibilities
Research - As Prinicipal Investigator: HPA core research funding and HPA-funded studentship. As project manager: Home Office funded research project (biomonitoring). As contributor and co-applicant: DEFRA/PSD funded research contract, Home office fudned project (dermal absorption).
Teaching - undergraduate teaching on Pharmacology module, supervision of under- and postgraduate researchers
Service - advice on public health aspects of environmental chemical exposure (acute incidents)
Wolfson Unit radiation protection supervisor and information security officer
BSc Applied Biology (upper second class honours) CNAA
PhD (Univ Central Lancs)
Scientific Toxicologist, Chemical Hazards and Poisons Division (Newcastle), Health Protection Agency (2004-2006)
Research Associate, School of Clinical and Laboratory Sciences, University of Newcastle (2001-2004)
Research Associate, Dept of Environmental and Occupational Medicine, University of Newcastle (1999-2000)
British Toxicology Society (since 1999)
Committee member of Skin Forum since 2003
UK Safety Science Forum (secretary)
Some written and spoken French and German
Dermal absorption, dermal metabolism and dermal toxicology
In vitro methods for dermal absorption and metabolism
Dermal absorption of components from liquid mixtures
Detection of exposure during accidental and deliberate chemical release
Predictive modelling for dermal absorption and metabolism
Dermal absorption and metabolism of mono- and polyaromatic hydrocarbons in vitro
Rapid methods for detection of chemical exposure during chemical incidents
Prediction of dermal absorption of chemicals of concern using mathematical modelling and other approaches
Influence of xenobiotics on dermal endobiotic metabolic pathways
Influence of xenobiotics on response to oxidative stress in skin
Proteomic markers of chemical exposure
Investigator on HPA-funded research studentship
Project manager on Home Office project grant and HPA-funded core research project
Co-applicant on Home Office project grants and DEFRA funded research project
Currently lead supervisor for PhD student
Co-supervisor for PhD student
Founder member of In vitro percutaneous absorption technique Expert Users' Group
Five invited book chapters published or in submission
HPA Studentship (2005-2008) £60,000
DEFRA/PSD project grant (2005-2006) £80,000 (Joint with Prof Faith Williams)
HPA core funding (2006-2009 rolling) £TBA (Joint with Prof Faith Williams and Prof Peter Blain
HSE studentship (2002-2005) £100,000 (Joint with Prof Faith Williams)
Dermal absorption of chemicals in the workplace and consequences for health
Biological monitoring methods for early detection of exposure
Undegraduate research project supervision (Pharmacology and Biomedical Sciences)
MRes Drug Discovery
- Ashrafi P, Sun Y, Davey N, Adams RG, Wilkinson SC, Moss GP. Model fitting for small skin permeability data sets: Hyperparameter optimisation in Gaussian Process Regression. Journal of Pharmacy and Pharmacology 2018, Epub ahead of print.
- Carroll B, Otten E, Manni D, Stefanatos R, Menzies F, Smith G, Jurk D, Kenneth N, Wilkinson S, Passos J, Attems J, Veal E, Teyssou E, Seilhean D, Millecamps S, Eskelinen E-L, Bronowska A, Rubinsztein DC, Sanz A, Korolchuk V. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nature Communications 2018, 9, 256.
- Carter H, Weston D, Betts N, Wilkinson S, Amlot R. Public perceptions of emergency decontamination: Effects of intervention type and responder management strategy during a focus group study. PLoS ONE 2018, 13(4), e0195922.
- Kizhedath A, Wilkinson S, Glassey J. Applicability of predictive toxicology methods for monoclonal antibody therapeutics: status Quo and scope. Archives of Toxicology 2017, 91(4), 1595-1612.
- Koogoli R, Hudson L, Naidoo K, Wilkinson S, Chavan B, Birch-Machin M. Bad air gets under your skin. Experimental Dermatology 2017, epub ahead of print.
- Wargniez W, Jungman E, Wilkinson S, Seyler N, Gregoire S. Inter-laboratory skin distribution study of 4-n-butyl resorcinol: The importance of liquid chromatography/mass spectrometry (HPLC–MS/MS) bioanalytical validation. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2017, 1060, 416-423.
- Moss GP, Sun Y, Davey N, Wilkinson SC, Brown MB. Linear or non-linear models for percutaneous absorption?. In: Stratum Corneum VIII Conference - 8th International Symposium. 2015, Cardiff, UK: Wiley-Blackwell Publishing Ltd.
- Moss GP, Gullick DR, Wilkinson SC. Predictive Methods in Percutaneous Absorption. Springer Berlin Heidelberg, 2015.
- Ashrafi P, Moss GP, Wilkinson SC, Davey N, Sun Y. The application of machine learning to the modelling of percutaneous absorption: An overview and guide. SAR and QSAR in Environmental Research 2015, 26(3), 181-204.
- Eilstein J, Lereaux G, Arbey E, Daronnat E, Wilkinson S, Duche D. Xenobiotic metabolizing enzymes in human skin and SkinEthic reconstructed human skin models. Experimental Dermatology 2015, 24(7), 547-549.
- Dodou K, Armstrong A, Kelly I, Wilkinson S, Carr K, Shattock P, Whiteley P. Ex vivo studies for the passive transdermal delivery of low-dose naltrexone from a cream; detection of naltrexone and its active metabolite, 6β-naltrexol, using a novel LC Q-ToF MS assay. Pharmaceutical Development and Technology 2014, 1-8.
- Frasch HF, Dotson GS, Bunge AL, Chen C-P, Cherrie JW, Kasting GB, Kissel JC, Sahmel J, Semple S, Wilkinson S. Analysis of finite dose dermal absorption data: Implications for dermal exposure assessment. Journal of Exposure Science and Environmental Epidemiology 2014, 24(1), 65-73.
- Eilstein J, Léreaux G, Budimir N, Hussler G, Wilkinson S, Duché D. Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic. Archives of Toxicology 2014, 88(9), 1681-1694.
- Mistry T, Staff K, Anjum K, Owen JD, Stair J, Wilkinson SC, Moss GP. Effect of occlusion on the percutaneous absorption of aluminium from antiperspirant products. In: Robert Chilcott, Keith R. Brain, ed. Advances in Dermatological Sciences. Royal Society of Chemistry, 2014, pp.256-264.
- Williams FM, Ravi V, McGarry D, Boulton SJ, Mutch E, Jewell C, Wilkinson SC. Factors influencing expression and specificity of carboxylesterases in skin: Implications for local and systemic paraben ester toxicity. In: Chilcott R Brain K, ed. Advances in Dermatological Sciences. Cambridge, UK: RSC PUblishing, 2014, pp.6-16.
- Binjumah WM, Sun Y, Hewitt M, Adams R, Davey N, Gullick DR, Wilkinson SC, Cronin M, Moss GP. Feature Selection Modelling for Percutaneous Absorption across Synthetic Membranes. In: 2014 IEEE 26th International Conference on Tools with Artificial Intelligence (ICTAI). 2014, Limassol, Cyprus: IEEE.
- Moore CA, Wilkinson SC, Blain PG, Dunn M, Aust GA, Williams FM. Percutaneous absorption and distribution of organophosphates (chlorpyrifos and dichlorvos) following dermal exposure and decontamination scenarios using in vitro human skin model. Toxicology Letters 2014, 229(1), 66-27.
- Moore CA, Wilkinson SC, Blain PG, Dunn M, Aust GA, Williams FM. Use of a human skin in vitro model to investigate the influence of 'every-day' clothing and skin surface decontamination on the percutaneous penetration of organophosphates. Toxicology Letters 2014, 229(1), 257-264.
- Moss GP, Sun Y, Davey N, Adams RG, Wilkinson SC, Gullick DR. The application of gaussian processes in the prediction of permeability across a polydimethlysiloxane membrane. In: Issues in Toxicology. 2013, Royal Society of Chemistry.
- Moss GP, Wilkinson SC, Sun Y. Mathematical modelling of percutaneous absorption. Current Opinion in Colloid & Interface Science 2012, 17(3), 166-172.
- Moss GP, Kyriacou T, Wilkinson SC, Judd A, Gullick DR. Modelling of absorption across skin and silicone membranes using non-linear auto-regressive moving average with exogenous input (NARMAX) methods. In: Stratum Corneum Vll Conference. 2012, Cardiff, UK: Wiley-Blackwell Publishing Ltd.
- Moss GP, Shah AJ, Adams RG, Davey N, Wilkinson SC, Pugh WJ, Sun Y. The application of discriminant analysis and Machine Learning methods as tools to identify and classify compounds with potential as transdermal enhancers. European Journal of Pharmaceutical Sciences 2012, 45(1-2), 116-127.
- Moss GP, Shah AJ, Judd A, Adams RG, Davey N, Wilkinson SC, Pugh WJ, Sun Y. The application of machine learning methods to identify and classify potential transdermal enhancers. In: Stratum Corneum Vll Conference. 2012, Cardiff, UK: Wiley-Blackwell Publishing Ltd.
- Moss GP, Kyriacou T, Wilkinson SC. The application of non-linear auto-regressive moving average with exogenous input (NARMAX) to modelling the absorption across human skin. In: Issues in Toxicology. 2012, La Grande Motte, France: Royal Society of Chemistry.
- Mossa GP, Sun Y, Wilkinson SC, Davey N, Adams R, Martin GP, Prapopopolou M, Brown MB. The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes. Journal of Pharmacy and Pharmacology 2011, 63(11), 1411-1427.
- Traynor MJ, Wilkinson SC, Williams FM. Effects of water on the absorption of two glycol ethers through human skin in vitro. In: BTS 2004 Annual Congress. 2004, Edinburgh, Scotland: Toxicology: Elsevier.
- Wilkinson SC, Williams FM. Percutaneous penetration of malathion and parathion: Dose and vehicle effects. In: BTS 2004 Annual Congress. 2004, Heriot Watt University, Edinburgh: Toxicology: Elsevier.
- Wilkinson SC, Williams FM. Effects of experimental conditions on absorption of glycol ethers through human skin in vitro. International Archives of Occupational and Environmental Health 2002, 75(8), 519-527.
- Greaves LC, Wilkinson SC, Williams FM. Factors affecting percutaneous absorption of caffeine in vitro. Toxicology 2002, 178(1), 65-66.
- Wilkinson SC, Williams FM. Dermal absorption of pyridine and some methyl pyridines in vitro. In: British Toxicology Society Annual Congress. 2001, Keele University: Elsevier.