ACE2112 : Nutritional Biochemistry, Immunology and Genetics (Inactive)
- Inactive for Year: 2017/18
- Module Leader(s): Dr Saloni Dang
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
Semester 1 Credit Value:
To develop concepts of genome organisation and of eukaryotic gene expression, to discuss how gene expression is regulated, and to illustrate the significance of this regulation for cell function and development. To introduce DNA/nutrient-gene interactions and the genetic basis of nutrition related diseases. To highlight the links between nutrition and immunity. To study important metabolic pathways and to consider their activities in the liver, muscle and adipose tissue; to introduce mechanisms by which these activities are controlled and coordinated both within and between the tissues.
Outline Of Syllabus
This module introduces and develops concepts of molecular biology and metabolic integration that
are essential for the application of modern biology to understanding and improving human and
animal nutrition. It deals with genome organisation and eukaryotic gene expression, discusses how
gene expression is regulated, and illustrates the significance of this regulation for cell function and for
development. It considers the specialised metabolic activities of major mammalian tissues and the
mechanisms by which these activities are regulated.
Review of fundamentals of gene expression.
Transcription in eukaryotes: mechanisms of transcription, structure and function of promoters, RNA
polymerases, transcription termination.
The organisation of eukaryotic genomes; chromatin structure and its significance for transcription.
Introduction to transcription regulation in eukaryotes and its significance for cell differentiation.
Regulation of gene expression by external signals such as hormones.Introduction to DNA/nutrientgene
interactions, the genetic basis of obesity and other metabolic disorders including inborn errors
of metabolism will be explored in detail to show cause and effect i.e. link the biochemical
consequences to genetics.
The structure and function of the immune system will be studied in order that the links between
nutrition and immunity are appreciated.
Introduction to metabolic integration.
Allosteric proteins; allosteric control of energy metabolism; oxygen-carrying proteins.
Hormonal control of energy metabolism.
The Cori cycle, the glucose-alanine cycle.
Practical Exercise: computer-based analysis of DNA sequences; interpretatiom of gene expression
|Scheduled Learning And Teaching Activities||Lecture||30||1:00||30:00||Includes 1hr exam practice, 1hr introduction to biochemical problems|
|Guided Independent Study||Assessment preparation and completion||1||1:30||1:30||Final exam|
|Guided Independent Study||Assessment preparation and completion||27||0:15||6:45||Class test revision|
|Guided Independent Study||Assessment preparation and completion||27||0:30||13:30||Exam revision|
|Guided Independent Study||Assessment preparation and completion||3||1:00||3:00||Computer practical assessment and preparation for biochemical problems assessment|
|Scheduled Learning And Teaching Activities||Practical||1||2:00||2:00||Computer practical|
|Scheduled Learning And Teaching Activities||Practical||1||1:00||1:00||Biochemical problems|
|Guided Independent Study||Skills practice||6||1:00||6:00||Computer practical follow-up and biochemical problems homework|
|Guided Independent Study||Independent study||1||36:15||36:15||Lecture follow up, ReCap, Blackboard etc.|
Teaching Rationale And Relationship
The lectures explain key concepts, outline illustrative examples, and introduce the computer practical and biochemical problems. In one lecture, progress is assessed and feedback given through marking the biochemical problem assignment. The final lecture is a review session. The formative class tests provide further opportunities for progress assessment and feedback through an essay exam practice question and a short-answer/multiple-choice test. In the computer practicals, students use computers to analyse DNA and protein sequences with supervision and guidance and interpret data on gene expression regulation. Private study is necessary for students to absorb information presented in lectures, to deepen their knowledge and understanding through reading supporting references, to write up the computer practical, and to do the problems.
The format of resits will be determined by the Board of Examiners
|Written Examination||90||1||A||70||Short answers plus one essay|
|BIO2012||Molecular Genetics and Mammalian Biochemistry||1||N/A|
|Practical/lab report||1||M||15||Computer-based practical|
|Written exercise||1||M||15||In-course Test|
|Essay||1||M||Exam Practice Question|
|Written exercise||1||M||Class tests|
Assessment Rationale And Relationship
The formal examination uses short answer and essay questions (two sections) to test knowledge and understanding and ability to integrate knowledge and explain relevant principles. The computer practical and gene expression data interpretation report tests students' ability to use computer programs to obtain information about DNA and proteins and to interpret this information and data on gene expression in relation to their knowledge of molecular genetics. Assessment of the problem assignment tests ability to carry out specific forms of biochemical analysis and to interpret the results. The formative in-course tests provide the students with an indication of progress and provide an incentive for sustained study. An exam practice question, which will also be assessed formatively, gives students the opportunity and incentive to develop their exam technique in a situation with minimal pressure on them.